{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:35:06Z","timestamp":1787614506525,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008891","name":"Loma Linda University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.neo.2021.11.003","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T06:28:08Z","timestamp":1636612088000},"page":"1252-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ex vivo isolation, expansion and bioengineering of CCR7+CD95-\/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients\u2019 bone marrow"],"prefix":"10.1016","volume":"23","author":[{"given":"Huynh","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Moz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiksha","family":"Wasnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Baylink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Shing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saied","family":"Mirshahidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-967X","authenticated-orcid":false,"given":"Olivia","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6917-184X","authenticated-orcid":false,"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.neo.2021.11.003_bib0001","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"Dohner","year":"2015","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.neo.2021.11.003_bib0002","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1182\/blood-2017-03-772368","article-title":"Increasing use of allogeneic hematopoietic cell transplantation in patients aged 70 years and older in the United States","volume":"130","author":"Muffly","year":"2017","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.neo.2021.11.003_bib0003","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1001\/jama.2011.1558","article-title":"Long-term outcomes among older patients following nonmyeloablative conditioning and allogeneic hematopoietic cell transplantation for advanced hematologic malignancies","volume":"306","author":"Sorror","year":"2011","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.neo.2021.11.003_bib0004","doi-asserted-by":"crossref","first-page":"e427","DOI":"10.1016\/S2352-3026(15)00148-9","article-title":"Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent analysis","volume":"2","author":"Versluis","year":"2015","journal-title":"Lancet Haematol"},{"issue":"24","key":"10.1016\/j.neo.2021.11.003_bib0005","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1056\/NEJMoa1808777","article-title":"Immune escape of relapsed AML cells after allogeneic transplantation","volume":"379","author":"Christopher","year":"2018","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.neo.2021.11.003_bib0006","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nbt1350","article-title":"Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region","volume":"25","author":"Ishikawa","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"17","key":"10.1016\/j.neo.2021.11.003_bib0007","doi-asserted-by":"crossref","first-page":"17ra9","DOI":"10.1126\/scitranslmed.3000349","article-title":"Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells","volume":"2","author":"Saito","year":"2010","journal-title":"Sci Transl Med"},{"issue":"6464","key":"10.1016\/j.neo.2021.11.003_bib0008","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A cell initiating human acute myeloid leukaemia after transplantation into SCID mice","volume":"367","author":"Lapidot","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neo.2021.11.003_bib0009","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/j.seminhematol.2018.08.008","article-title":"Will CAR T cell therapy have a role in AML? Promises and pitfalls","volume":"56","author":"Cummins","year":"2019","journal-title":"Semin Hematol"},{"issue":"6","key":"10.1016\/j.neo.2021.11.003_bib0010","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.blre.2017.08.001","article-title":"Treatment of acute myeloid leukemia in the next decade - towards real-time functional testing and personalized medicine","volume":"31","author":"Lam","year":"2017","journal-title":"Blood Rev"},{"issue":"10","key":"10.1016\/j.neo.2021.11.003_bib0011","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.neo.2021.11.003_bib0012","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.cell.2016.01.049","article-title":"The basis of oncoimmunology","volume":"164","author":"Palucka","year":"2016","journal-title":"Cell"},{"issue":"7655","key":"10.1016\/j.neo.2021.11.003_bib0013","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature22395","article-title":"Therapeutic T cell engineering","volume":"545","author":"Sadelain","year":"2017","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.neo.2021.11.003_bib0014","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1158\/1078-0432.CCR-11-0116","article-title":"Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy","volume":"17","author":"Rosenberg","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"288","key":"10.1016\/j.neo.2021.11.003_bib0015","doi-asserted-by":"crossref","first-page":"288ra78","DOI":"10.1126\/scitranslmed.aaa7014","article-title":"Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma","volume":"7","author":"Noonan","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.neo.2021.11.003_bib0016","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-med-112311-083918","article-title":"Harnessing the power of the immune system to target cancer","volume":"64","author":"Lizee","year":"2013","journal-title":"Annu Rev Med"},{"issue":"4","key":"10.1016\/j.neo.2021.11.003_bib0017","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nri3191","article-title":"Adoptive immunotherapy for cancer: harnessing the T cell response","volume":"12","author":"Restifo","year":"2012","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.neo.2021.11.003_bib0018","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1073\/pnas.95.3.1178","article-title":"Induction of antigen-specific T cell anergy: an early event in the course of tumor progression","volume":"95","author":"Staveley-O'Carroll","year":"1998","journal-title":"Proc Natl Acad Sci U S A,"},{"issue":"11","key":"10.1016\/j.neo.2021.11.003_bib0019","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining 'T cell exhaustion","volume":"19","author":"Blank","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"15","key":"10.1016\/j.neo.2021.11.003_bib0020","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1182\/blood-2013-09-529537","article-title":"Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells","volume":"123","author":"Gill","year":"2014","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.neo.2021.11.003_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100869","article-title":"A novel vitamin D gene therapy for acute myeloid leukemia","volume":"13","author":"Xu","year":"2020","journal-title":"Transl Oncol"},{"key":"10.1016\/j.neo.2021.11.003_bib0022","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3389\/fphar.2017.00561","article-title":"PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome","volume":"8","author":"Alsaab","year":"2017","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.neo.2021.11.003_bib0023","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41408-018-0069-4","article-title":"Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients","volume":"8","author":"Jia","year":"2018","journal-title":"Blood Cancer J"},{"issue":"25","key":"10.1016\/j.neo.2021.11.003_bib0024","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1073\/pnas.1916206117","article-title":"Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia","volume":"117","author":"Lamble","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.neo.2021.11.003_bib0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri.2017.108","article-title":"The diverse functions of the PD1 inhibitory pathway","volume":"18","author":"Sharpe","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.neo.2021.11.003_bib0026","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/eji.201343751","article-title":"The who's who of T-cell differentiation: human memory T-cell subsets","volume":"43","author":"Mahnke","year":"2013","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.neo.2021.11.003_bib0027","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1038\/bcj.2014.39","article-title":"Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia","volume":"4","author":"Ehninger","year":"2014","journal-title":"Blood Cancer J"},{"issue":"6","key":"10.1016\/j.neo.2021.11.003_bib0028","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-018-0001-y","article-title":"The full spectrum of human naive T cells","volume":"18","author":"van den Broek","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"10.1016\/j.neo.2021.11.003_bib0029","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1158\/2159-8290.CD-13-0832","article-title":"Personalized therapy for acute myeloid leukemia","volume":"3","author":"Hourigan","year":"2013","journal-title":"Cancer Discov"},{"issue":"1","key":"10.1016\/j.neo.2021.11.003_bib0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/bjc.2011.189","article-title":"The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis","volume":"105","author":"Gooden","year":"2011","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.neo.2021.11.003_bib0031","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1074-7613(00)00026-1","article-title":"Eradication of established tumors by CD8+ T cell adoptive immunotherapy","volume":"13","author":"Hanson","year":"2000","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.neo.2021.11.003_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02587.x","article-title":"Cancer immunoediting from immune surveillance to immune escape","volume":"121","author":"Kim","year":"2007","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.neo.2021.11.003_bib0033","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/84701","article-title":"11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity","volume":"7","author":"De Rosa","year":"2001","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.neo.2021.11.003_bib0034","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.immuni.2014.07.003","article-title":"Memory T cells officially join the stem cell club","volume":"41","author":"Gattinoni","year":"2014","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.neo.2021.11.003_bib0035","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.4049\/jimmunol.167.12.6869","article-title":"IL-7 enhances the survival and maintains the size of naive T cells","volume":"167","author":"Rathmell","year":"2001","journal-title":"J Immunol"},{"issue":"7749","key":"10.1016\/j.neo.2021.11.003_bib0036","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41586-019-0979-8","article-title":"Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction","volume":"567","author":"Liu","year":"2019","journal-title":"Nature"},{"issue":"7749","key":"10.1016\/j.neo.2021.11.003_bib0037","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-019-0985-x","article-title":"NR4A transcription factors limit CAR T cell function in solid tumours","volume":"567","author":"Chen","year":"2019","journal-title":"Nature"},{"issue":"7764","key":"10.1016\/j.neo.2021.11.003_bib0038","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","article-title":"TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion","volume":"571","author":"Khan","year":"2019","journal-title":"Nature"},{"issue":"7764","key":"10.1016\/j.neo.2021.11.003_bib0039","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1324-y","article-title":"TOX is a critical regulator of tumour-specific T cell differentiation","volume":"571","author":"Scott","year":"2019","journal-title":"Nature"},{"issue":"25","key":"10.1016\/j.neo.2021.11.003_bib0040","doi-asserted-by":"crossref","first-page":"12410","DOI":"10.1073\/pnas.1905675116","article-title":"TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion","volume":"116","author":"Seo","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.neo.2021.11.003_bib0041","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.immuni.2019.09.013","article-title":"TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision","volume":"51","author":"Chen","year":"2019","journal-title":"Immunity"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558621000932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558621000932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:09:08Z","timestamp":1761484148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558621000932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1476558621000932"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2021.11.003","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ex vivo isolation, expansion and bioengineering of CCR7+CD95-\/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients\u2019 bone marrow","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2021.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}