{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:13:41Z","timestamp":1770351221843,"version":"3.49.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.neo.2022.100803","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T05:57:15Z","timestamp":1651730235000},"page":"100803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Prognostic value of integrin \u03b1V expression and localization pattern in invasive breast carcinomas"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-4634","authenticated-orcid":false,"given":"Otto Luiz Dutra","family":"Cerqueira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-2220","authenticated-orcid":false,"given":"Mayara Carolline Silva","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-6589","authenticated-orcid":false,"given":"Ana Paula Zen Petisco","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-9780","authenticated-orcid":false,"given":"Cynthia Aparecida Bueno de Toledo","family":"Os\u00f3rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeka","family":"Tomasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-750X","authenticated-orcid":false,"given":"Mauro C\u00e9sar Cafund\u00f3","family":"Morais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana Ver\u00f3nica Mendoza","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Cristina","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago Andres","family":"Vilella-Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-3070","authenticated-orcid":false,"given":"Eduardo Moraes","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-2190","authenticated-orcid":false,"given":"Alexandre","family":"Bruni-Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.neo.2022.100803_bib0001","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrc1670","article-title":"Breast cancer metastasis: markers and models","volume":"5","author":"Weigelt","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0002","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell adhesion: the molecular basis of tissue architecture and morphogenesis","volume":"84","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0003","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","article-title":"The integrins","volume":"8","author":"Takada","year":"2007","journal-title":"Genome Biol"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0004","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s004410100417","article-title":"Function and interactions of integrins","volume":"305","author":"Van der Flier","year":"2001","journal-title":"Cell Tissue Res"},{"issue":"2","key":"10.1016\/j.neo.2022.100803_bib0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0092-8674(02)00831-0","article-title":"Exploring the neighborhood: adhesion-coupled cell mechanosensors","volume":"110","author":"Geiger","year":"2002","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0006","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/35094059","article-title":"Putting tumours in context","volume":"1","author":"Bissell","year":"2001","journal-title":"Nat Rev Cancer"},{"issue":"11","key":"10.1016\/j.neo.2022.100803_bib0007","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bcp.2008.07.023","article-title":"Anoikis: a necessary death program for anchorage-dependent cells","volume":"76","author":"Chiarugi","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0008","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","article-title":"Integrins and anoikis","volume":"9","author":"Frisch","year":"1997","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0009","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0955-0674(00)00251-9","article-title":"Anoikis mechanisms","volume":"13","author":"Frisch","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.neo.2022.100803_bib0010","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.matbio.2013.10.011","article-title":"Signalling pathways linking integrins with cell cycle progression","volume":"34","author":"Moreno-Layseca","year":"2014","journal-title":"Matrix Biol"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0011","doi-asserted-by":"crossref","first-page":"13855","DOI":"10.1007\/s13277-016-5133-8","article-title":"Identification of novel biomarkers associated with poor patient outcomes in invasive breast carcinoma","volume":"37","author":"Canevari","year":"2016","journal-title":"Tumour Biol"},{"issue":"7","key":"10.1016\/j.neo.2022.100803_bib0012","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/07357900701522638","article-title":"Alpha-v integrins as therapeutic targets in oncology","volume":"25","author":"Nemeth","year":"2007","journal-title":"Cancer Invest"},{"key":"10.1016\/j.neo.2022.100803_bib0013","series-title":"Cell-extracellular matrix interactions in cancer","first-page":"137","article-title":"Vitronectin-Binding Integrins in Cancer","author":"Murphy","year":"2010"},{"issue":"11","key":"10.1016\/j.neo.2022.100803_bib0014","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.18632\/oncotarget.3351","article-title":"CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis","volume":"6","author":"Cerqueira","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.neo.2022.100803_bib0015","doi-asserted-by":"crossref","unstructured":"Lobba, A.R.M., et\u00a0al., High CD90 (THY-1) expression positively correlates with cell transformation and worse prognosis in basal-like breast cancer tumors. 2018. 13(6): p. e0199254.","DOI":"10.1371\/journal.pone.0199254"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0016","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1023\/B:HIJO.0000045943.26251.24","article-title":"Cellular protein and mRNA expression patterns of matrix metalloproteinases-2, -3 and -9 in human breast cancer: correlation with tumour growth","volume":"35","author":"Lebeau","year":"2004","journal-title":"J Mol Histol"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0017","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3393\/jksc.2011.27.3.133","article-title":"Matrix metalloproteinase-2 and -7 expression in colorectal cancer","volume":"27","author":"Hong","year":"2011","journal-title":"J Korean Soc Coloproctol"},{"issue":"11","key":"10.1016\/j.neo.2022.100803_bib0018","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/bjc.1998.714","article-title":"Tenascin-C expression in invasion border of early breast cancer: a predictor of local and distant recurrence","volume":"78","author":"Jahkola","year":"1998","journal-title":"Br J Cancer"},{"issue":"1-2","key":"10.1016\/j.neo.2022.100803_bib0019","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/19336918.2015.1008331","article-title":"Tenascin C in metastasis: a view from the invasive front","volume":"9","author":"Lowy","year":"2015","journal-title":"Cell Adh Migr"},{"key":"10.1016\/j.neo.2022.100803_bib0020","doi-asserted-by":"crossref","DOI":"10.5858\/arpa.2018-0902-SA","article-title":"Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists clinical practice guideline focused update","author":"Wolff","year":"2018","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0021","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molonc.2007.02.004","article-title":"The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression","volume":"1","author":"Kenny","year":"2007","journal-title":"Mol Oncol"},{"issue":"7","key":"10.1016\/j.neo.2022.100803_bib0022","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"4","key":"10.1016\/j.neo.2022.100803_bib0023","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/bcr3444","article-title":"BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome","volume":"15","author":"Madden","year":"2013","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.neo.2022.100803_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/420747","article-title":"Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes","author":"Hruz","year":"2008","journal-title":"Adv Bioinformatic"},{"issue":"9","key":"10.1016\/j.neo.2022.100803_bib0025","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/labinvest.2016.73","article-title":"Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement","volume":"96","author":"Zarrella","year":"2016","journal-title":"Lab Invest"},{"key":"10.1016\/j.neo.2022.100803_bib0026","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1472-6890-13-16","article-title":"Expression of integrin genes and proteins in progression and dissemination of colorectal adenocarcinoma","volume":"13","author":"Denadai","year":"2013","journal-title":"BMC Clin Pathol"},{"issue":"24 Supplement","key":"10.1016\/j.neo.2022.100803_bib0027","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1158\/0008-5472.SABCS-09-3049","article-title":"Tumor-Stroma Ratio within the Primary Tumor Is a Prognostic Factor in Early Breast Cancer Patients, Especially in Triple-Negative-Carcinoma Patients","volume":"69","author":"de Kruijf","year":"2009","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0028","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/NEN.0b013e3182851019","article-title":"Longitudinal expression analysis of alphav integrins in human gliomas reveals upregulation of integrin alphavbeta3 as a negative prognostic factor","volume":"72","author":"Schittenhelm","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0029","first-page":"5599","article-title":"Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer","volume":"34","author":"Waisberg","year":"2014","journal-title":"Anticancer Res"},{"issue":"4","key":"10.1016\/j.neo.2022.100803_bib0030","first-page":"787","article-title":"Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules","volume":"139","author":"Koukoulis","year":"1991","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0031","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physrev.1996.76.1.69","article-title":"Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction","volume":"76","author":"Ronnov-Jessen","year":"1996","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.neo.2022.100803_bib0032","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/bioinformatics\/18.4.585","article-title":"Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts","volume":"18","author":"Greenbaum","year":"2002","journal-title":"Bioinformatics"},{"issue":"5518","key":"10.1016\/j.neo.2022.100803_bib0033","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.292.5518.929","article-title":"Integrated genomic and proteomic analyses of a systematically perturbed metabolic network","volume":"292","author":"Ideker","year":"2001","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.neo.2022.100803_bib0034","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Genome Biol"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0035","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1074\/mcp.M400055-MCP200","article-title":"Integrated genomic and proteomic analyses of gene expression in mammalian cells","volume":"3","author":"Tian","year":"2004","journal-title":"Mol Cell Proteomics"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0036","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.0030057","article-title":"Posttranscriptional expression regulation: what determines translation rates?","volume":"3","author":"Brockmann","year":"2007","journal-title":"PLoS Comput Biol"},{"issue":"9","key":"10.1016\/j.neo.2022.100803_bib0037","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tibs.2005.07.005","article-title":"Post-transcriptional control of gene expression: a genome-wide perspective","volume":"30","author":"Mata","year":"2005","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0038","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10911-005-9586-4","article-title":"Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia","volume":"10","author":"Gudjonsson","year":"2005","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0039","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.celrep.2017.05.050","article-title":"Laminin-111 and the level of nuclear actin regulate epithelial quiescence via exportin-6","volume":"19","author":"Fiore","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.neo.2022.100803_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2018.00059","article-title":"Sleeping beauty and the microenvironment enchantment: microenvironmental regulation of the proliferation-quiescence decision in normal tissues and in cancer development","volume":"6","author":"Fiore","year":"2018","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"10.1016\/j.neo.2022.100803_bib0041","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1073\/pnas.0610296104","article-title":"The EGF repeat and discoidin domain protein, SED1\/MFG-E8, is required for mammary gland branching morphogenesis","volume":"104","author":"Ensslin","year":"2007","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"10.1016\/j.neo.2022.100803_bib0042","first-page":"1949","article-title":"The human myoepithelial cell is a natural tumor suppressor","volume":"3","author":"Sternlicht","year":"1997","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11050615","article-title":"Integrins: moonlighting proteins in invadosome formation","volume":"11","author":"Pelaez","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.neo.2022.100803_bib0044","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1038\/oncsis.2013.27","article-title":"Binding of \u03b1v\u03b21 and \u03b1v\u03b26 integrins to tenascin-C induces epithelial\u2013mesenchymal transition-like change of breast cancer cells","volume":"2","author":"Katoh","year":"2013","journal-title":"Oncogenesis"},{"issue":"7","key":"10.1016\/j.neo.2022.100803_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9070084","article-title":"Integrin alphavbeta3 Signaling in Tumor-Induced Bone Disease","volume":"9","author":"Kwakwa","year":"2017","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0046","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/path.4490","article-title":"Tumour but not stromal expression of \u03b2 3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer","volume":"235","author":"Carter","year":"2015","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.neo.2022.100803_bib0047","first-page":"1421","article-title":"Expression of thrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast","volume":"53","author":"Clezardin","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2022.100803_bib0048","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1038\/onc.2014.280","article-title":"CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis","volume":"34","author":"Truesdell","year":"2014","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0049","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1023\/B:HIJO.0000045943.26251.24","article-title":"Cellular protein and mRNA expression patterns of matrix metalloproteinases-2,-3 and-9 in human breast cancer: correlation with tumour growth","volume":"35","author":"Lebeau","year":"2004","journal-title":"J Mol Histol"},{"issue":"6","key":"10.1016\/j.neo.2022.100803_bib0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/(SICI)1097-0215(19961220)69:6<445::AID-IJC4>3.0.CO;2-4","article-title":"Expression of tenascin in invasion border of early breast cancer correlates with higher risk of distant metastasis","volume":"69","author":"Jahkola","year":"1996","journal-title":"Int J Cancer"},{"issue":"9","key":"10.1016\/j.neo.2022.100803_bib0051","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/sj.bjc.6605655","article-title":"Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer","volume":"102","author":"Wong","year":"2010","journal-title":"Br J Cancer"},{"issue":"7","key":"10.1016\/j.neo.2022.100803_bib0052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131842","article-title":"Interactions between alphav-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain","volume":"10","author":"Lal","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0053","first-page":"13304","article-title":"Impact of the presence and quantity of ductal carcinoma in situ component on the outcome of invasive breast cancer","volume":"8","author":"Cedolini","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"8","key":"10.1016\/j.neo.2022.100803_bib0054","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1590\/S0100-879X2002000800008","article-title":"Presence of ductal carcinoma in situ confers an improved prognosis for patients with T1N0M0 invasive breast carcinoma","volume":"35","author":"Logullo","year":"2002","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1046-2023(03)00032-X","article-title":"Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures","volume":"30","author":"Debnath","year":"2003","journal-title":"Methods"},{"issue":"suppl 1","key":"10.1016\/j.neo.2022.100803_bib0056","doi-asserted-by":"crossref","first-page":"e479s","DOI":"10.6061\/clinics\/2018\/e479s","article-title":"Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer","volume":"73","author":"Strauss","year":"2018","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0057","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(02)01001-2","article-title":"The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini","volume":"111","author":"Debnath","year":"2002","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.neo.2022.100803_bib0058","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1089\/ten.tec.2011.0260","article-title":"MCF-7 cells as a three-dimensional model for the study of human breast cancer","volume":"17","author":"do Amaral","year":"2011","journal-title":"Tissue Eng Part C Methods"},{"issue":"26","key":"10.1016\/j.neo.2022.100803_bib0059","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","article-title":"Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing","volume":"315","author":"Dvorak","year":"1986","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2326-6066.CIR-14-0209","article-title":"Tumors: wounds that do not heal-redux","volume":"3","author":"Dvorak","year":"2015","journal-title":"Cancer Immunol Res"},{"issue":"6","key":"10.1016\/j.neo.2022.100803_bib0061","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41568-018-0006-7","article-title":"A history of exploring cancer in context","volume":"18","author":"Maman","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"10.1016\/j.neo.2022.100803_bib0062","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.yexcr.2010.02.045","article-title":"Hallmarks of cancer: interactions with the tumor stroma","volume":"316","author":"Pietras","year":"2010","journal-title":"Exp Cell Res"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0063","first-page":"69","article-title":"Integrin \u03b111\u03b21 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes","volume":"6","author":"Smeland","year":"2020","journal-title":"J Pathol"},{"key":"10.1016\/j.neo.2022.100803_bib0064","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1471-2407-12-306","article-title":"The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients","volume":"12","author":"Medrek","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neo.2022.100803_bib0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-3-030-34025-4_18","article-title":"Ovarian cancer biomarkers: moving forward in early detection","volume":"1219","author":"Bonif\u00e1cio","year":"2020","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.neo.2022.100803_bib0066","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s13402-016-0268-6","article-title":"PSA and beyond: alternative prostate cancer biomarkers","volume":"39","author":"Saini","year":"2016","journal-title":"Cell Oncol (Dordr)"},{"issue":"5","key":"10.1016\/j.neo.2022.100803_bib0067","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nm1764","article-title":"Stromal gene expression predicts clinical outcome in breast cancer","volume":"14","author":"Finak","year":"2008","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0068","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1007\/s11033-020-05826-4","article-title":"Do tumor exosome integrins alone determine organotropic metastasis?","volume":"47","author":"Grigoryeva","year":"2020","journal-title":"Mol Biol Rep"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0069","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13046-019-1317-6","article-title":"Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation","volume":"38","author":"Ciardiello","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2006.06.023","article-title":"Alternative splicing: new insights from global analyses","volume":"126","author":"Blencowe","year":"2006","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neo.2022.100803_bib0071","doi-asserted-by":"crossref","first-page":"e98936","DOI":"10.1371\/journal.pone.0098936","article-title":"Secreted \u03b23-integrin enhances natural killer cell activity against acute myeloid leukemia cells","volume":"9","author":"Skaik","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neo.2022.100803_bib0072","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1074\/jbc.M111.269811","article-title":"Engagement of \u03b1IIb\u03b23 (GPIIb\/IIIa) with \u03b1\u03bd\u03b23 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis","volume":"287","author":"Lonsdorf","year":"2012","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.neo.2022.100803_bib0073","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4161\/cbt.6.10.4710","article-title":"A naturally occurring truncated beta3 integrin in tumor cells: native anti-integrin involved in tumor cell motility","volume":"6","author":"Jin","year":"2007","journal-title":"Cancer Biol Ther"},{"issue":"Pt 1","key":"10.1016\/j.neo.2022.100803_bib0074","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj3000069","article-title":"A new alternative transcript encodes a 60 kDa truncated form of integrin beta 3","volume":"300","author":"Djaffar","year":"1994","journal-title":"Biochem J"},{"issue":"9","key":"10.1016\/j.neo.2022.100803_bib0075","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat Rev Cancer"},{"issue":"17","key":"10.1016\/j.neo.2022.100803_bib0076","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1158\/1078-0432.CCR-04-1223","article-title":"Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy","volume":"11","author":"Abdollahi","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.neo.2022.100803_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00262-007-0365-5","article-title":"Anti-cancer therapies targeting the tumor stroma","volume":"57","author":"Hofmeister","year":"2008","journal-title":"Cancer Immunol Immunother,"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558622000306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558622000306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:11:46Z","timestamp":1761484306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558622000306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":77,"alternative-id":["S1476558622000306"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2022.100803","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of integrin \u03b1V expression and localization pattern in invasive breast carcinomas","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2022.100803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100803"}}