{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:06:58Z","timestamp":1793066818811,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92059206"],"award-info":[{"award-number":["92059206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008837","name":"Shanghai Chest Hospital","doi-asserted-by":"publisher","award":["KS21002"],"award-info":[{"award-number":["KS21002"]}],"id":[{"id":"10.13039\/501100008837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.neo.2024.100979","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T12:35:31Z","timestamp":1708518931000},"page":"100979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3691-5251","authenticated-orcid":false,"given":"Meng-qi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-qiang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-jia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-ping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-5492","authenticated-orcid":false,"given":"Yu-chen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-3884","authenticated-orcid":false,"given":"Xiao-long","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neo.2024.100979_bib0001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jtho.2019.11.030","article-title":"Validation of the eighth edition TNM lung cancer staging system","volume":"15","author":"Hwang","year":"2020","journal-title":"J. Thoracic Oncol. : Off. Pub. Int. Assoc. Study Lung Cancer"},{"issue":"1","key":"10.1016\/j.neo.2024.100979_bib0007","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: Proposals for revision of the TNM Stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.neo.2024.100979_bib0002","article-title":"NCCN Guidelines Non-Small Cell Lung Cancer Version 3.2023","year":"2023","journal-title":"National Comprehensive Cancer Network"},{"issue":"25","key":"10.1016\/j.neo.2024.100979_bib0008","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1200\/JCO.2017.72.4401","article-title":"Adjuvant Systemic therapy and adjuvant radiation therapy for stage I to IIIA completely resected non-small-cell lung cancers: American society of clinical oncology\/cancer care ontario clinical practice guideline update","volume":"35","author":"Kris","year":"2017","journal-title":"J. Clin. Oncol."},{"issue":"21","key":"10.1016\/j.neo.2024.100979_bib0009","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE collaborative group","volume":"26","author":"Pignon","year":"2008","journal-title":"J. Clin. Oncol. : Off. J. Am. Soc. Clin. Oncol."},{"issue":"11","key":"10.1016\/j.neo.2024.100979_bib0010","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1001\/jamaoncol.2020.4232","article-title":"Association of survival with adjuvant chemotherapy among patients with early-stage non-small cell lung cancer with vs without high-risk clinicopathologic features","volume":"6","author":"Pathak","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.neo.2024.100979_bib0011","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.lungcan.2019.04.024","article-title":"Propensity-matched analysis of adjuvant chemotherapy for completely resected Stage IB non-small-cell lung cancer patients","volume":"133","author":"Li","year":"2019","journal-title":"Lung Cancer"},{"issue":"10","key":"10.1016\/j.neo.2024.100979_bib0012","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.jtho.2016.05.022","article-title":"Adjuvant Chemotherapy for Patients with T2N0M0 NSCLC","volume":"11","author":"Morgensztern","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.neo.2024.100979_bib0013","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jtcvs.2017.09.143","article-title":"Prognostic significance and adjuvant chemotherapy survival benefits of a solid or micropapillary pattern in patients with resected stage IB lung adenocarcinoma","volume":"155","author":"Qian","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"4","key":"10.1016\/j.neo.2024.100979_bib0014","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.athoracsur.2015.10.075","article-title":"Adjuvant chemotherapy improves the probability of freedom from recurrence in patients with resected stage IB lung adenocarcinoma","volume":"101","author":"Hung","year":"2016","journal-title":"Ann. Thorac. Surg."},{"issue":"8","key":"10.1016\/j.neo.2024.100979_bib0015","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.21037\/tlcr-22-183","article-title":"Open-label, multi-center, phase II study of adjuvant pemetrexed plus cisplatin for completely resected stage IB to IIIA adenocarcinoma of the lung: APICAL trial","volume":"11","author":"Park","year":"2022","journal-title":"Transl. Lung Cancer Res."},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0016","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.athoracsur.2021.04.108","article-title":"Adjuvant chemotherapy for high-risk pathologic stage I non-small cell lung cancer","volume":"113","author":"Tsutani","year":"2022","journal-title":"Ann. Thorac. Surg"},{"key":"10.1016\/j.neo.2024.100979_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2022.01.025","article-title":"The impact of epidermal growth factor receptor mutation status on adjuvant chemotherapy for patients with high-risk stage I lung adenocarcinoma","author":"Tsutani","year":"2022","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"2","key":"10.1016\/j.neo.2024.100979_bib0018","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/JTO.0b013e318206a221","article-title":"International association for the study of lung cancer\/american thoracic society\/european respiratory society international multidisciplinary classification of lung adenocarcinoma","volume":"6","author":"Travis","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.neo.2024.100979_bib0003","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jtho.2020.06.001","article-title":"A Grading system for invasive pulmonary adenocarcinoma: a proposal from the international association for the study of lung cancer pathology committee","volume":"15","author":"Moreira","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.neo.2024.100979_bib0019","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.jtho.2021.04.008","article-title":"Validation study of the international association for the study of lung cancer histologic grading system of invasive lung adenocarcinoma","volume":"16","author":"Rokutan-Kurata","year":"2021","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.neo.2024.100979_bib0020","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.jtho.2021.07.006","article-title":"Validation of the novel international association for the study of lung cancer grading system for invasive pulmonary adenocarcinoma and association with common driver mutations","volume":"16","author":"Deng","year":"2021","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.neo.2024.100979_bib0021","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jso.27091","article-title":"The new IASLC grading system for invasive non-mucinous lung adenocarcinoma is a more useful indicator of patient survival compared with previous grading systems","volume":"127","author":"Yanagawa","year":"2023","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.neo.2024.100979_bib0022","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.lungcan.2022.07.003","article-title":"Clinicopathologic and genomic features of high-grade pattern and their subclasses in lung adenocarcinoma","volume":"170","author":"Ahn","year":"2022","journal-title":"Lung Cancer"},{"issue":"6","key":"10.1016\/j.neo.2024.100979_bib0023","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41379-021-00994-5","article-title":"Prognostic and predictive value of the newly proposed grading system of invasive pulmonary adenocarcinoma in Chinese patients: a retrospective multicohort study","volume":"35","author":"Hou","year":"2022","journal-title":"Mod. Pathol. : Off. J. U. S. Canad. Acad. Pathol., Inc"},{"issue":"12","key":"10.1016\/j.neo.2024.100979_bib0024","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jtho.2018.08.2022","article-title":"Implications of the eighth edition of the TNM Proposal: Invasive versus total tumor size for the t descriptor in pathologic stage I-IIA lung adenocarcinoma","volume":"13","author":"Kameda","year":"2018","journal-title":"J. Thorac. Oncol. : Off. Pub. Int. Assoc. Stud. Lung Cancer"},{"issue":"1","key":"10.1016\/j.neo.2024.100979_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12890-023-02305-x","article-title":"Postoperative survival of pulmonary invasive mucinous adenocarcinoma versus non-mucinous invasive adenocarcinoma","volume":"23","author":"Cui","year":"2023","journal-title":"BMC Pulmonary Med."},{"issue":"7","key":"10.1016\/j.neo.2024.100979_bib0026","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jtho.2016.03.011","article-title":"Prognosis in resected invasive mucinous adenocarcinomas of the lung: related factors and comparison with resected nonmucinous adenocarcinomas","volume":"11","author":"Lee","year":"2016","journal-title":"J. Thorac. Oncol. : Off. Pub. Int. Assoc. Stud. Lung Cancer"},{"issue":"23","key":"10.1016\/j.neo.2024.100979_bib0027","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1111\/1759-7714.14687","article-title":"Prognosis of resected invasive mucinous adenocarcinoma compared with the IASLC histologic grading system for invasive nonmucinous adenocarcinoma: Surgical database study in the TKIs era in Korea","volume":"13","author":"Woo","year":"2022","journal-title":"Thorac Cancer"},{"issue":"8","key":"10.1016\/j.neo.2024.100979_bib0028","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s00432-016-2201-9","article-title":"Analysis of the clinicopathologic characteristics and prognostic of stage I invasive mucinous adenocarcinoma","volume":"142","author":"Luo","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0029","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/modpathol.2010.232","article-title":"Impact of proposed IASLC\/ATS\/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases","volume":"24","author":"Yoshizawa","year":"2011","journal-title":"Modern Pathol."},{"issue":"12","key":"10.1016\/j.neo.2024.100979_bib0004","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1245\/s10434-021-10122-x","article-title":"Blood vessel invasion predicts postoperative survival outcomes and systemic recurrence regardless of location or blood vessel type in patients with lung adenocarcinoma","volume":"28","author":"Lee","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.neo.2024.100979_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.lungcan.2021.12.013","article-title":"Prognostic implication of tumor spread through air spaces in patients with pathologic N0 lung adenocarcinoma","volume":"164","author":"Chen","year":"2022","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0006","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.athoracsur.2019.05.080","article-title":"High-Risk Factors for Recurrence of Stage I Lung Adenocarcinoma: Follow-up Data From JCOG0201","volume":"108","author":"Tsutani","year":"2019","journal-title":"Ann. Thorac. Surg."},{"issue":"12","key":"10.1016\/j.neo.2024.100979_bib0031","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.jtho.2017.07.009","article-title":"Prognostic factors in completely resected node-negative lung adenocarcinoma of 3 cm or smaller","volume":"12","author":"Hung","year":"2017","journal-title":"J. Thorac. Oncol. : Off. Pub. Int. Assoc. Stud. Lung Cancer"},{"key":"10.1016\/j.neo.2024.100979_bib0032","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.lungcan.2019.09.022","article-title":"Prognostic significance of blood and lymphatic vessel invasion in pathological stage IA lung adenocarcinoma in the 8th edition of the TNM classification","volume":"137","author":"Samejima","year":"2019","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0033","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/PAS.0000000000000399","article-title":"Clinical impact of minimal micropapillary pattern in invasive lung adenocarcinoma: prognostic significance and survival outcomes","volume":"39","author":"Lee","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0034","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00408-022-00561-y","article-title":"Impact of high-grade patterns in early-stage lung adenocarcinoma: A multicentric analysis","volume":"200","author":"Bertoglio","year":"2022","journal-title":"Lung"},{"issue":"2","key":"10.1016\/j.neo.2024.100979_bib0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.humpath.2013.10.011","article-title":"Cribriform and fused glands are patterns of high-grade pulmonary adenocarcinoma","volume":"45","author":"Moreira","year":"2014","journal-title":"Human Pathol."},{"issue":"4","key":"10.1016\/j.neo.2024.100979_bib0036","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/JTO.0000000000000490","article-title":"Prognostic impact and clinicopathological correlations of the cribriform pattern in pulmonary adenocarcinoma","volume":"10","author":"Warth","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"5","key":"10.1016\/j.neo.2024.100979_bib0037","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/modpathol.2013.188","article-title":"The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype","volume":"27","author":"Kadota","year":"2014","journal-title":"Mod. Pathol. : Off. J. U. S. Canad. Acad. Pathol., Inc"},{"issue":"2","key":"10.1016\/j.neo.2024.100979_bib0038","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jtho.2018.09.028","article-title":"Cribriform subtype is an independent predictor of recurrence and survival after adjustment for the eighth edition of TNM staging system in patients with resected lung adenocarcinoma","volume":"14","author":"Kadota","year":"2019","journal-title":"J. Thorac. Oncol."}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558624000162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558624000162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:14:32Z","timestamp":1761484472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558624000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":37,"alternative-id":["S1476558624000162"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2024.100979","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Who benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-dimensional model for candidate selection","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2024.100979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100979"}}