{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:17:47Z","timestamp":1770340667625,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.neo.2024.100999","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T16:27:53Z","timestamp":1713284873000},"page":"100999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-5909","authenticated-orcid":false,"given":"Carmen","family":"Degitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Reime","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-3877","authenticated-orcid":false,"given":"Christina-Marie","family":"Baumbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Rauschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-0384","authenticated-orcid":false,"given":"Oliver","family":"Thews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2024.100999_bib0001","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2024.100999_bib0002","first-page":"1029","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science (1979)"},{"key":"10.1016\/j.neo.2024.100999_bib0003","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.2174\/0929867322666150514095910","article-title":"Regulation of mitochondrial function and its impact in metabolic stress","volume":"22","author":"Duarte","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neo.2024.100999_bib0004","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3390\/biom11071012","article-title":"Mitostasis, calcium and free radicals in health, aging and neurodegeneration","volume":"11","author":"Godoy","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.neo.2024.100999_bib0005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.trecan.2020.04.009","article-title":"Mitochondrial stress response and cancer","volume":"6","author":"O'Malley","year":"2020","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.neo.2024.100999_bib0006","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/cells8030237","article-title":"Adaptations in mitochondrial enzymatic activity occurs independent of genomic dosage in response to aerobic exercise training and deconditioning in human skeletal muscle","volume":"8","author":"Fritzen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.neo.2024.100999_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010017","article-title":"Mitochondrial gene expression and beyond-novel aspects of cellular physiology","volume":"9","author":"Kotrys","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.neo.2024.100999_bib0008","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13578-016-0089-3","article-title":"Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation","volume":"6","author":"Lim","year":"2016","journal-title":"Cell Biosci."},{"key":"10.1016\/j.neo.2024.100999_bib0009","doi-asserted-by":"crossref","first-page":"18406","DOI":"10.1074\/jbc.REV120.011202","article-title":"Structure, mechanism, and regulation of mitochondrial DNA transcription initiation","volume":"295","author":"Basu","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neo.2024.100999_bib0010","first-page":"1062","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science (1979)"},{"key":"10.1016\/j.neo.2024.100999_bib0011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2016.07.003","article-title":"Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation","volume":"24","author":"Corbet","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.neo.2024.100999_bib0012","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2019.01.014","article-title":"Hypercapnic tumor microenvironment confers chemoresistance to lung cancer cells by reprogramming mitochondrial metabolism in vitro","volume":"134","author":"Kikuchi","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neo.2024.100999_bib0013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41419-018-1242-1","article-title":"Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D","volume":"10","author":"Hu","year":"2019","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.neo.2024.100999_bib0014","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1038\/ncomms4550","article-title":"Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival","volume":"5","author":"Khacho","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2024.100999_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000293","article-title":"The genomic analysis of lactic acidosis and acidosis response in human cancers","volume":"4","author":"Chen","year":"2008","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.neo.2024.100999_bib0016","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1469-7793.1999.00709.x","article-title":"Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum","volume":"520","author":"Gekle","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.neo.2024.100999_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.635063","article-title":"Gain-of-function STIM1 L96V mutation causes myogenesis alteration in muscle cells from a patient affected by tubular aggregate myopathy","volume":"9","author":"Conte","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neo.2024.100999_bib0018","doi-asserted-by":"crossref","first-page":"e21549","DOI":"10.1371\/journal.pone.0021549","article-title":"Regulation of mTORC1 signaling by pH","volume":"6","author":"Balgi","year":"2011","journal-title":"PLoS. One"},{"key":"10.1016\/j.neo.2024.100999_bib0019","doi-asserted-by":"crossref","first-page":"e22445","DOI":"10.1371\/journal.pone.0022445","article-title":"Acidic environment leads to ROS-induced MAPK signaling in cancer cells","volume":"6","author":"Riemann","year":"2011","journal-title":"PLoS. One"},{"key":"10.1016\/j.neo.2024.100999_bib0020","doi-asserted-by":"crossref","first-page":"e7541","DOI":"10.1371\/journal.pone.0007541","article-title":"A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells","volume":"4","author":"Galli","year":"2009","journal-title":"PLoS. One"},{"key":"10.1016\/j.neo.2024.100999_bib0021","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1947601911407328","article-title":"The ERK cascade: distinct functions within various subcellular organelles","volume":"2","author":"Wortzel","year":"2011","journal-title":"Genes. Cancer"},{"key":"10.1016\/j.neo.2024.100999_bib0022","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1593\/neo.05697","article-title":"Impact of extracellular acidity on the activity of p-glycoprotein and the cytotoxicity of chemotherapeutic drugs","volume":"8","author":"Thews","year":"2006","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2024.100999_bib0023","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1002\/ijc.23818","article-title":"Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38","volume":"123","author":"Sauvant","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neo.2024.100999_bib0024","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1038\/ncomms11124","article-title":"Early ERK1\/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming","volume":"7","author":"Prieto","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2024.100999_bib0025","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.bbamcr.2013.02.002","article-title":"New insights into the function and regulation of mitochondrial fission","volume":"1833","author":"Otera","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neo.2024.100999_bib0026","first-page":"795","article-title":"O2 extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues","volume":"22","author":"Vaupel","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.neo.2024.100999_bib0027","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fonc.2016.00066","article-title":"Pathophysiological basis for the formation of the tumor microenvironment","volume":"6","author":"Horsman","year":"2016","journal-title":"Front. Oncol."},{"key":"10.1016\/j.neo.2024.100999_bib0028","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1038\/srep04927","article-title":"Beyond Warburg effect\u2013dual metabolic nature of cancer cells","volume":"4","author":"Xie","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neo.2024.100999_bib0029","doi-asserted-by":"crossref","first-page":"F840","DOI":"10.1152\/ajprenal.00219.2005","article-title":"Activation of ERK1\/2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells","volume":"291","author":"Nowak","year":"2006","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.neo.2024.100999_bib0030","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1073\/pnas.0912742107","article-title":"Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition","volume":"107","author":"Rasola","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.neo.2024.100999_bib0031","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1750-3639.2003.tb00478.x","article-title":"Localization of phosphorylated ERK\/MAP kinases to mitochondria and autophagosomes in Lewy body diseases","volume":"13","author":"Zhu","year":"2003","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neo.2024.100999_bib0032","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.bbamcr.2007.10.001","article-title":"Regulation of mitochondrial oxidative phosphorylation through cell signaling","volume":"1773","author":"H\u00fcttemann","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neo.2024.100999_bib0033","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1074\/jbc.M112.430082","article-title":"Acute mitochondrial inhibition by mitogen-activated protein kinase\/extracellular signal-regulated kinase kinase (MEK) 1\/2 inhibitors regulates proliferation","volume":"288","author":"Ripple","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neo.2024.100999_bib0034","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1476-5381.2010.01105.x","article-title":"Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression","volume":"162","author":"Gao","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neo.2024.100999_bib0035","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.4049\/jimmunol.180.11.7485","article-title":"Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity","volume":"180","author":"Monick","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.neo.2024.100999_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101478","article-title":"An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise","volume":"35","author":"Calbet","year":"2020","journal-title":"Redox. Biol."},{"key":"10.1016\/j.neo.2024.100999_bib0037","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.neo.2024.100999_bib0038","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2010.05629.x","article-title":"Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1","volume":"1201","author":"Chang","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neo.2024.100999_bib0039","doi-asserted-by":"crossref","first-page":"e3257","DOI":"10.1371\/journal.pone.0003257","article-title":"Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA","volume":"3","author":"Parone","year":"2008","journal-title":"PLoS. One"},{"key":"10.1016\/j.neo.2024.100999_bib0040","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1242\/jcs.171017","article-title":"Mitochondrial dynamics in neuronal injury, development and plasticity","volume":"130","author":"Flippo","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neo.2024.100999_bib0041","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.molcel.2015.01.002","article-title":"Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth","volume":"57","author":"Kashatus","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neo.2024.100999_bib0042","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3390\/genes9020115","article-title":"Dynamin-related protein 1 at the crossroads of cancer","volume":"9","author":"Lima","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.neo.2024.100999_bib0043","doi-asserted-by":"crossref","first-page":"e925","DOI":"10.1016\/j.molcel.2017.08.013","article-title":"mTOR controls mitochondrial dynamics and cell survival via MTFP1","volume":"67","author":"Morita","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neo.2024.100999_bib0044","doi-asserted-by":"crossref","first-page":"14","DOI":"10.20892\/j.issn.2095-3941.2017.0107","article-title":"Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer","volume":"15","author":"Ahmad","year":"2018","journal-title":"Cancer Biol. Med."}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147655862400040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147655862400040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T10:40:06Z","timestamp":1731753606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147655862400040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":44,"alternative-id":["S147655862400040X"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2024.100999","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2024.100999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100999"}}