{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:39:46Z","timestamp":1793975986792,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008047","name":"Hebei University","doi-asserted-by":"publisher","award":["2022QB24"],"award-info":[{"award-number":["2022QB24"]}],"id":[{"id":"10.13039\/501100008047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.neo.2026.101281","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:01:06Z","timestamp":1770483666000},"page":"101281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA"],"prefix":"10.1016","volume":"73","author":[{"given":"Mengli","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8361-3310","authenticated-orcid":false,"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.neo.2026.101281_bib0001","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1001\/jamaoncol.2024.2212","article-title":"Bilateral mastectomy and breast cancer mortality","volume":"10","author":"Giannakeas","year":"2024","journal-title":"JAMA Oncol,"},{"issue":"11","key":"10.1016\/j.neo.2026.101281_bib0002","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.trecan.2017.09.001","article-title":"Breast cancer: multiple subtypes within a tumor?","volume":"3","author":"Yeo","year":"2017","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.neo.2026.101281_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"16","key":"10.1016\/j.neo.2026.101281_bib0004","doi-asserted-by":"crossref","first-page":"R921","DOI":"10.1016\/j.cub.2020.06.081","article-title":"The tumor microenvironment","volume":"30","author":"Anderson","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neo.2026.101281_bib0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101281_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1572764","article-title":"The impact of the tumor microenvironment on macrophages","volume":"16","author":"Xiao","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0007","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12943-025-02258-1","article-title":"Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment","volume":"24","author":"Wan","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0008","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12943-024-01990-4","article-title":"Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer","volume":"23","author":"Kundu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.neo.2026.101281_bib0009","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqae068","article-title":"Protein arginine methyltransferase CARM1 in human breast cancer","volume":"165","author":"Bacabac","year":"2024","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.neo.2026.101281_bib0010","doi-asserted-by":"crossref","first-page":"R223","DOI":"10.1530\/JME-18-0224","article-title":"Epigenetic arginine methylation in breast cancer: emerging therapeutic strategies","volume":"62","author":"Wang","year":"2019","journal-title":"J. Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.neo.2026.101281_bib0011","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cac2.12291","article-title":"Cancer-associated fibroblasts in breast cancer: challenges and opportunities","volume":"42","author":"Hu","year":"2022","journal-title":"Cancer Commun. (Lond)"},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188587","article-title":"Tumor microenvironment of human breast cancer, and feline mammary carcinoma as a potential study model","volume":"1876","author":"Nascimento","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0013","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13058-022-01516-0","article-title":"Radiomics predicts the prognosis of patients with locally advanced breast cancer by reflecting the heterogeneity of tumor cells and the tumor microenvironment","volume":"24","author":"Wang","year":"2022","journal-title":"Breast. Cancer Res."},{"issue":"13","key":"10.1016\/j.neo.2026.101281_bib0014","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1007\/s00018-021-03828-4","article-title":"Arginine-dependent immune responses","volume":"78","author":"Mart\u00ed","year":"2021","journal-title":"Cell Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.neo.2026.101281_bib0015","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","article-title":"L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity","volume":"167","author":"Geiger","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neo.2026.101281_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215616","article-title":"Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism","volume":"534","author":"Lyu","year":"2022","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.neo.2026.101281_bib0017","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.neo.2026.101281_bib0018","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.immuni.2024.11.016","article-title":"Beyond classical immunity: mast cells as signal converters between tissues and neurons","volume":"57","author":"Plum","year":"2024","journal-title":"Immunity."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0019","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0952-7915(94)90039-6","article-title":"Mast cells: function and contents","volume":"6","author":"Schwartz","year":"1994","journal-title":"Curr. Opin. Immunol."},{"issue":"3","key":"10.1016\/j.neo.2026.101281_bib0020","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.pharmthera.2014.01.004","article-title":"Targeting mast cells in inflammatory diseases","volume":"142","author":"Reber","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.neo.2026.101281_bib0021","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1158\/2326-6066.CIR-13-0119","article-title":"Mast cells: potential positive and negative roles in tumor biology","volume":"1","author":"Marichal","year":"2013","journal-title":"Cancer Immunol. Res."},{"issue":"10","key":"10.1016\/j.neo.2026.101281_bib0022","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230570","article-title":"Landscape of mast cell populations across organs in mice and humans","volume":"220","author":"Tauber","year":"2023","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.neo.2026.101281_bib0023","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ajh.26962","article-title":"Systemic mastocytosis in adults: 2023 update on diagnosis, risk stratification and management","volume":"98","author":"Pardanani","year":"2023","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.neo.2026.101281_bib0024","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12016-017-8646-z","article-title":"Role of mast cells in regulation of T Cell responses in experimental and clinical settings","volume":"54","author":"Elieh Ali Komi","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"12","key":"10.1016\/j.neo.2026.101281_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122713","article-title":"Harnessing the power of mast cells in unconventional immunotherapy strategies and vaccine adjuvants","volume":"9","author":"Willows","year":"2020","journal-title":"Cells,"},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0026","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.semarthrit.2006.03.004","article-title":"The role of mast cells in osteoporosis","volume":"36","author":"Chiappetta","year":"2006","journal-title":"Semin. Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.neo.2026.101281_bib0027","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.neo.2026.101281_bib0028","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1399-3038.2008.00798.x","article-title":"The role of mast cells in eosinophilic esophagitis","volume":"20","author":"Lucendo","year":"2009","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.neo.2026.101281_bib0029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.aambs.2022.11.002","article-title":"Metabolic engineering of Escherichia coli for efficient production of l-arginine","volume":"122","author":"Hai-De","year":"2023","journal-title":"Adv. Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0030","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41467-024-46776-w","article-title":"Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer","volume":"15","author":"Bi","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0031","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s43018-020-00148-7","article-title":"Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer","volume":"2","author":"Mehta","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.neo.2026.101281_bib0032","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1016\/j.csbj.2021.08.019","article-title":"The molecular feature of macrophages in tumor immune microenvironment of glioma patients","volume":"19","author":"Zhang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0033","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s13046-025-03545-x","article-title":"Peripheral nerve injury-induced remodeling of the tumor-associated macrophages promotes immune evasion in breast cancer","volume":"44","author":"Jiang","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0034","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12672-025-02161-7","article-title":"Applying integrated transcriptome and single-cell sequencing analysis to develop a prognostic signature based on M2-like tumor-associated macrophages for breast cancer","volume":"16","author":"Xu","year":"2025","journal-title":"Discov. Oncol."},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.168056","article-title":"M1 macrophages enhance breast cancer chemoresistance via JAK-STAT3 signaling","volume":"1872","author":"Feng","year":"2026","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.neo.2026.101281_bib0036","article-title":"Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis","volume":"31","author":"Edwards","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"issue":"1-2","key":"10.1016\/j.neo.2026.101281_bib0037","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-2999(94)90698-X","article-title":"Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro","volume":"257","author":"Giraldelo","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neo.2026.101281_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107008","article-title":"The role of LSM1 in breast cancer: Shaping metabolism and tumor-associated macrophage infiltration","volume":"198","author":"Tzeng","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.neo.2026.101281_bib0039","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ccell.2025.03.015","article-title":"Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion","volume":"43","author":"Zhu","year":"2025","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.neo.2026.101281_bib0040","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1186\/s12967-024-05652-3","article-title":"Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment","volume":"22","author":"Wang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.neo.2026.101281_bib0041","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jare.2024.02.006","article-title":"Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction","volume":"68","author":"Li","year":"2025","journal-title":"J. Adv. Res."}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:54:56Z","timestamp":1774032896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558626000102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"alternative-id":["S1476558626000102"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2026.101281","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating single-cell and spatial transcriptomics to dissect mast-cell heterogeneity and arginine-metabolism-associated markers in BRCA","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2026.101281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101281"}}