{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:32:33Z","timestamp":1794007953414,"version":"4.8.0"},"reference-count":319,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013072","name":"Major Science and Technology Project of Hainan Province","doi-asserted-by":"publisher","award":["ZDYF2024SHFZ099"],"award-info":[{"award-number":["ZDYF2024SHFZ099"]}],"id":[{"id":"10.13039\/501100013072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007935","name":"Hainan Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["825RC765"],"award-info":[{"award-number":["825RC765"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.neo.2026.101290","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:59:44Z","timestamp":1772096384000},"page":"101290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Microbial crosstalk along the oral\u2013gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum"],"prefix":"10.1016","volume":"74","author":[{"given":"Shiwang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yage","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2026.101290_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41368-020-0082-x","article-title":"Oral microbiome: possible harbinger for children's health","author":"Xiao","year":"2020","journal-title":"Int J Oral Sci"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0002","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","article-title":"The oral microbiome: diversity, biogeography and human health","volume":"22","author":"Baker","year":"2024","journal-title":"Nature Rev. Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020882","article-title":"Armed to the teeth-the oral mucosa immunity system and microbiota","volume":"23","author":"Ptasiewicz","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6596","key":"10.1016\/j.neo.2026.101290_bib0004","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.abn1890","article-title":"The effects of oral microbiota on health","volume":"376","author":"Tuganbaev","year":"2022","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.neo.2026.101290_bib0006","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3389\/fmicb.2018.01136","article-title":"Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles","volume":"9","author":"Xun","year":"2018","journal-title":"Front Microbiol"},{"issue":"17","key":"10.1016\/j.neo.2026.101290_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174146","article-title":"Oral bacteria and intestinal dysbiosis in colorectal cancer","volume":"20","author":"Koliarakis","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0008","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1177\/0022034520924633","article-title":"The bacterial connection between the oral cavity and the gut diseases","volume":"99","author":"Kitamoto","year":"2020","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0009","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2019.1586422","article-title":"Can oral bacteria affect the microbiome of the gut?","volume":"11","author":"Olsen","year":"2019","journal-title":"J Oral Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/omi.12359","article-title":"Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4(+) T cells","volume":"37","author":"Sohn","year":"2022","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0011","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/prd.12424","article-title":"Periodontal connection with intestinal inflammation: microbiological and immunological mechanisms","volume":"89","author":"Kitamoto","year":"2022","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0012","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s40001-025-02508-4","article-title":"Association between periodontitis and gastrointestinal cancer risk and prognosis: evidence from a nested case-control study in Southwest China","volume":"30","author":"Luo","year":"2025","journal-title":"Eur J Med Res"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0013","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jcpe.13590","article-title":"Periodontitis, Helicobacter pylori infection, and gastrointestinal tract cancer mortality","volume":"49","author":"Sung","year":"2022","journal-title":"J Clin Periodontol"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0014","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/ijc.31254","article-title":"Periodontitis and cancer mortality: register-based cohort study of 68,273 adults in 10-year follow-up","volume":"142","author":"Heikkil\u00e4","year":"2018","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/gutjnl-2016-312580","article-title":"Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study","volume":"67","author":"Fan","year":"2018","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0016","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.3748\/wjg.v22.i11.3227","article-title":"Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients","volume":"22","author":"Li","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.neo.2026.101290_bib0017","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jdsr.2023.08.003","article-title":"Oral-gut axis as a novel biological mechanism linking periodontal disease and systemic diseases: A review","volume":"59","author":"Yamazaki","year":"2023","journal-title":"Jpn Dent Sci Rev"},{"key":"10.1016\/j.neo.2026.101290_bib0018","article-title":"The oral microbiota: community composition, influencing factors, pathogenesis, and interventions","volume":"13","author":"Li","year":"2022","journal-title":"Front Microbiol"},{"issue":"7500","key":"10.1016\/j.neo.2026.101290_bib0019","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nature13178","article-title":"Dynamics and associations of microbial community types across the human body","volume":"509","author":"Ding","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101290_bib0020","article-title":"Multifaceted impacts of periodontal pathogens in disorders of the intestinal barrier","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"issue":"6361","key":"10.1016\/j.neo.2026.101290_bib0021","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aan4526","article-title":"Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation","volume":"358","author":"Atarashi","year":"2017","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0022","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/s41564-022-01224-7","article-title":"Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium veillonella parvula in the intestine","volume":"7","author":"Rojas-Tapias","year":"2022","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.640309","article-title":"Salivary microbiota for gastric cancer prediction: an exploratory study","volume":"11","author":"Huang","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0024","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42693","article-title":"Extensive transmission of microbes along the gastrointestinal tract","volume":"8","author":"Schmidt","year":"2019","journal-title":"Elife"},{"issue":"18","key":"10.1016\/j.neo.2026.101290_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15184594","article-title":"The gum-gut axis: periodontitis and the risk of gastrointestinal cancers","volume":"15","author":"Baima","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.neo.2026.101290_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/nu16183206","article-title":"Balancing the oral-gut-brain axis with diet","volume":"16","author":"Kerstens","year":"2024","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0027","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41368-018-0043-9","article-title":"Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice","volume":"11","author":"Li","year":"2019","journal-title":"Int J Oral Sci"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0028","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2023.2186591","article-title":"Understanding the bacterial compositional network associations between oral and gut microbiome within healthy Koreans","volume":"15","author":"Jeong","year":"2023","journal-title":"J Oral Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0029","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2405547","article-title":"Comparative analysis of the duodenojejunal microbiome with the oral and fecal microbiomes reveals its stronger association with obesity and nutrition","volume":"16","author":"Steinbach","year":"2024","journal-title":"Gut Microbes"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071978","article-title":"Roles of oral infections in the pathomechanism of atherosclerosis","volume":"19","author":"Aarabi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neo.2026.101290_bib0031","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3389\/fimmu.2019.01403","article-title":"Distal consequences of oral inflammation","volume":"10","author":"Konkel","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuy035","article-title":"Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis","volume":"43","author":"du Teil Espina","year":"2019","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0033","doi-asserted-by":"crossref","DOI":"10.1186\/s43066-024-00340-9","article-title":"Oral microbiome dysbiosis and gastrointestinal diseases: a narrative review","volume":"14","author":"Elghannam","year":"2024","journal-title":"Egyptian Liver Journal"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0034","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1286-4579(00)00391-9","article-title":"The oral cavity as a reservoir of bacterial pathogens for focal infections","volume":"2","author":"Gendron","year":"2000","journal-title":"Microbes Infect"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0035","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/odi.14531","article-title":"Bacteremia following different oral procedures: systematic review and meta-analysis","volume":"30","author":"Martins","year":"2024","journal-title":"Oral Dis"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0036","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1128\/jcm.28.10.2205-2209.1990","article-title":"Detection and quantitation by lysis-filtration of bacteremia after different oral surgical procedures","volume":"28","author":"Heimdahl","year":"1990","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0037","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/154405910408300217","article-title":"Bacteremia following surgical dental extraction with an emphasis on anaerobic strains","volume":"83","author":"Rajasuo","year":"2004","journal-title":"J Dent Res"},{"issue":"13","key":"10.1016\/j.neo.2026.101290_bib0038","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1177\/0022034519877150","article-title":"Horizontal and vertical transfer of oral microbial dysbiosis and periodontal disease","volume":"98","author":"Payne","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.neo.2026.101290_bib0039","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jare.2022.03.007","article-title":"Roles of oral microbiota and oral-gut microbial transmission in hypertension","volume":"43","author":"Chen","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.neo.2026.101290_bib0040","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3389\/fmicb.2018.01603","article-title":"Microbial similarity and preference for specific sites in healthy oral cavity and esophagus","volume":"9","author":"Dong","year":"2018","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0041","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1442-2050.2012.01328.x","article-title":"Bacterial flora of the human oral cavity, and the upper and lower esophagus","volume":"26","author":"Norder Grusell","year":"2013","journal-title":"Dis Esophagus"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0042","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.7150\/jca.67068","article-title":"Influence of oral intaking habit on tongue coating microbiota in patients with esophageal precancerous lesions","volume":"13","author":"Xiao","year":"2022","journal-title":"J Cancer"},{"key":"10.1016\/j.neo.2026.101290_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1057668","article-title":"Esophageal cancer and bacterial part of gut microbiota - A multidisciplinary point of view","volume":"12","author":"Muszy\u0144ski","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0044","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13127","article-title":"The esophageal microbiota in health and disease","volume":"1381","author":"Di Pilato","year":"2016","journal-title":"Ann N Y Acad Sci"},{"issue":"18","key":"10.1016\/j.neo.2026.101290_bib0045","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.3748\/wjg.v25.i18.2149","article-title":"Alteration of the esophageal microbiota in Barrett's esophagus and esophageal adenocarcinoma","volume":"25","author":"Lv","year":"2019","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0046","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01322-24","article-title":"The association between oral microbiome and gastric precancerous lesions","volume":"10","author":"Chen","year":"2025","journal-title":"mSystems"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0047","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1186\/s12967-024-05878-1","article-title":"Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms","volume":"22","author":"Chen","year":"2024","journal-title":"J Transl Med"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0048","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.14309\/ctg.0000000000000703","article-title":"Longitudinal microbiome changes in children exposed to proton pump inhibitors","volume":"15","author":"Zhang","year":"2024","journal-title":"Clin Transl Gastroenterol"},{"issue":"15","key":"10.1016\/j.neo.2026.101290_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/nu15153377","article-title":"Unraveling the impact of gut and oral microbiome on gut health in inflammatory bowel diseases","volume":"15","author":"Elzayat","year":"2023","journal-title":"Nutrients"},{"issue":"23","key":"10.1016\/j.neo.2026.101290_bib0050","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148543","article-title":"A potential pathogenic association between periodontal disease and Crohn's disease","volume":"6","author":"Imai","year":"2021","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0051","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/10409238.2016.1243654","article-title":"Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut","volume":"52","author":"Chairatana","year":"2017","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.neo.2026.101290_bib0052","article-title":"The effects of secretory IgA in the mucosal immune system","volume":"2020","author":"Li","year":"2020","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0053","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4161\/gmic.18604","article-title":"The continuum of intestinal CD4+ T cell adaptations in host-microbial mutualism","volume":"2","author":"Geuking","year":"2011","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0054","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2011.03.021","article-title":"Intestinal bacterial colonization induces mutualistic regulatory T cell responses","volume":"34","author":"Geuking","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.neo.2026.101290_bib0055","article-title":"The effect of the \"Oral-Gut\" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations","volume":"13","author":"Zhou","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0056","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/intimm\/dxac027","article-title":"Untangling the oral-gut axis in the pathogenesis of intestinal inflammation","volume":"34","author":"Kitamoto","year":"2022","journal-title":"Int Immunol"},{"key":"10.1016\/j.neo.2026.101290_bib0057","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2147\/JIR.S344321","article-title":"Oral-intestinal microbiota in colorectal cancer: inflammation and immunosuppression","volume":"15","author":"Mo","year":"2022","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.neo.2026.101290_bib0058","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1093967","article-title":"Regulatory effects of oral microbe on intestinal microbiota and the illness","volume":"13","author":"Lu","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0059","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12030685","article-title":"Linking periodontitis with inflammatory bowel disease through the oral-gut axis: the potential role of Porphyromonas gingivalis","volume":"12","author":"Huang","year":"2024","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0966-842X(96)10057-3","article-title":"The indigenous gastrointestinal microflora","volume":"4","author":"Berg","year":"1996","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1197838","article-title":"Temporal stability and community assembly mechanisms in healthy broiler cecum","volume":"14","author":"Ameer","year":"2023","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0062","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41559-017-0109","article-title":"Community structure follows simple assembly rules in microbial microcosms","volume":"1","author":"Friedman","year":"2017","journal-title":"Nat Ecol Evol"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112206","article-title":"Oral microbiota and tumor-A new perspective of tumor pathogenesis","volume":"10","author":"Li","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0064","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13099-023-00570-z","article-title":"Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction","volume":"15","author":"Zhu","year":"2023","journal-title":"Gut Pathog"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0065","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0066","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/ibd\/izac241","article-title":"The oral-gut axis: periodontal diseases and gastrointestinal disorders","volume":"29","author":"Lam","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0067","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8081135","article-title":"Periodontitis: A multifaceted disease of tooth-supporting tissues","volume":"8","author":"K\u00f6n\u00f6nen","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.neo.2026.101290_bib0068","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2020-0787","article-title":"The prevalence of novel periodontal pathogens and bacterial complexes in stage II generalized periodontitis based on 16S rRNA next generation sequencing","volume":"29","author":"Abu Fanas","year":"2021","journal-title":"J Appl Oral Sci"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0069","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0071","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/1040841X.2024.2339260","article-title":"Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms","volume":"51","author":"Mukherjee","year":"2025","journal-title":"Crit Rev Microbiol"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0072","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1002\/jcp.26479","article-title":"The multifaceted link between inflammation and human diseases","volume":"233","author":"Rajendran","year":"2018","journal-title":"J Cell Physiol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0073","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2012.07.009","article-title":"Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation","volume":"143","author":"Chiba","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0074","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/prd.12540","article-title":"Periodontitis and risk of cancer: mechanistic evidence","volume":"96","author":"Baima","year":"2024","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0075","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12199-018-0740-1","article-title":"Inflammation and cancer","volume":"23","author":"Murata","year":"2018","journal-title":"Environ Health Prev Med"},{"key":"10.1016\/j.neo.2026.101290_bib0076","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.apcsb.2019.09.004","article-title":"Interplay between inflammation and cancer","volume":"119","author":"Khandia","year":"2020","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0077","article-title":"Epithelial-mesenchymal transition (EMT) induced by TNF-\u03b1 requires AKT\/GSK-3\u03b2-mediated stabilization of snail in colorectal cancer","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0078","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1007\/s10620-023-07972-8","article-title":"Role of interleukins in inflammation-mediated tumor immune microenvironment modulation in colorectal cancer pathogenesis","volume":"68","author":"Jain","year":"2023","journal-title":"Dig Dis Sci"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0079","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.7150\/ijbs.61350","article-title":"TNF-\u03b1 augments CXCL10\/CXCR3 axis activity to induce epithelial-mesenchymal transition in colon cancer cell","volume":"17","author":"Wang","year":"2021","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.neo.2026.101290_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.760971","article-title":"IL-6\/STAT3 is a promising therapeutic target for hepatocellular carcinoma","volume":"11","author":"Xu","year":"2021","journal-title":"Front Oncol"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0081","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/jcmm.12164","article-title":"A systems biology view of blood vessel growth and remodelling","volume":"18","author":"Logsdon","year":"2014","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.neo.2026.101290_bib0082","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.apcsb.2019.12.001","article-title":"Roles of Porphyromonas gingivalis and its virulence factors in periodontitis","volume":"120","author":"Xu","year":"2020","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0083","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058496","article-title":"Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-\u03bab signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts","volume":"8","author":"Herath","year":"2013","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.neo.2026.101290_bib0084","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710011","article-title":"Lipopolysaccharide from Porphyromonas gingivalis, but not from Porphyromonas endodontalis, induces macrophage M1 profile","volume":"23","author":"Veloso","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"26","key":"10.1016\/j.neo.2026.101290_bib0085","doi-asserted-by":"crossref","first-page":"18902","DOI":"10.1016\/S0021-9258(19)37046-2","article-title":"Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) gingivalis","volume":"267","author":"Wingrove","year":"1992","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0086","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.bcp.2010.06.017","article-title":"Complement and periodontitis","volume":"80","author":"Hajishengallis","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0087","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1046\/j.1365-2567.1996.478594.x","article-title":"Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis. Prior oxidation of C5 augments proteinase digestion of C5","volume":"87","author":"Discipio","year":"1996","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0088","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1340085","article-title":"Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function","volume":"9","author":"Olsen","year":"2017","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0089","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fcimb.2019.00262","article-title":"Pathogenesis of important virulence factors of Porphyromonas gingivalis via toll-like receptors","volume":"9","author":"Jia","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0090","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.3389\/fimmu.2019.02286","article-title":"Disruption of immune homeostasis in Human dendritic cells via regulation of autophagy and apoptosis by Porphyromonas gingivalis","volume":"10","author":"Meghil","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0091","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004647","article-title":"Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk","volume":"10","author":"El-Awady","year":"2015","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0092","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/omi.12087","article-title":"Periodontal innate immune mechanisms relevant to atherosclerosis","volume":"30","author":"Amar","year":"2015","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0093","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0022034514557545","article-title":"TLR2 promoter hypermethylation creates innate immune dysbiosis","volume":"94","author":"Benakanakere","year":"2015","journal-title":"J Dent Res"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0094","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.4081\/ejh.2017.2826","article-title":"Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation","volume":"61","author":"Diomede","year":"2017","journal-title":"Eur J Histochem"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0095","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1902\/jop.2013.130335","article-title":"miR-584 expressed in human gingival epithelial cells is induced by Porphyromonas gingivalis stimulation and regulates interleukin-8 production via lactoferrin receptor","volume":"85","author":"Ouhara","year":"2014","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0096","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1333396","article-title":"Periodontitis, pathogenesis and progression: miRNA-mediated cellular responses to Porphyromonas gingivalis","volume":"9","author":"Olsen","year":"2017","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0097","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3389\/fmicb.2020.01881","article-title":"Porphyromonas gingivalis-induced NLRP3 inflammasome activation and its downstream interleukin-1\u03b2 release depend on caspase-4","volume":"11","author":"Ding","year":"2020","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0098","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1128\/IAI.00862-13","article-title":"Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection","volume":"82","author":"Park","year":"2014","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0099","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1128\/iai.64.6.1984-1991.1996","article-title":"Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis","volume":"64","author":"Jagels","year":"1996","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0100","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1177\/0022034515593465","article-title":"A dual role for P2\u00d77 receptor during Porphyromonas gingivalis infection","volume":"94","author":"Ramos-Junior","year":"2015","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070210","article-title":"P2\u00d74 assembles with P2\u00d77 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation","volume":"8","author":"Hung","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0102","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat Immunol"},{"issue":"21","key":"10.1016\/j.neo.2026.101290_bib0103","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.1003738107","article-title":"Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis","volume":"107","author":"Jones","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0104","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1128\/IAI.00519-06","article-title":"The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration","volume":"74","author":"d'Empaire","year":"2006","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0105","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9124004","article-title":"Porphyromonas gingivalis Mfa1 induces chemokine and cell adhesion molecules in mouse gingival fibroblasts via toll-like receptors","volume":"9","author":"Takayanagi","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.neo.2026.101290_bib0106","article-title":"Porphyromonas gingivalis outer membrane vesicles exacerbate retinal microvascular endothelial cell dysfunction in diabetic retinopathy","volume":"14","author":"Huang","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0107","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1103592","article-title":"Porphyromonas gingivalis regulates atherosclerosis through an immune pathway","volume":"14","author":"Ruan","year":"2023","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0108","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0109","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.molmed.2014.11.004","article-title":"Polymicrobial synergy and dysbiosis in inflammatory disease","volume":"21","author":"Lamont","year":"2015","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0110","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/imr.12451","article-title":"Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence","volume":"273","author":"Uriarte","year":"2016","journal-title":"Immunol Rev"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0111","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2073785","article-title":"Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils","volume":"14","author":"Tan","year":"2022","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0112","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/0022034520909312","article-title":"Porphyromonas gingivalis promotes oral squamous cell carcinoma progression in an immune microenvironment","volume":"99","author":"Wen","year":"2020","journal-title":"J Dent Res"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0113","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14030536","article-title":"The good, the bad, and the ugly: neutrophils, angiogenesis, and cancer","volume":"14","author":"Ozel","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.neo.2026.101290_bib0114","article-title":"Fusobacterium nucleatum acts as a pro-carcinogenic bacterium in colorectal cancer: from association to causality","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101592","article-title":"Targeting programmed Fusobacterium nucleatum Fap2 for colorectal cancer therapy","volume":"11","author":"Ganesan","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0116","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1186\/s12885-021-08903-4","article-title":"Fusobacterium nucleatum and oral cancer: a critical review","volume":"21","author":"McIlvanna","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neo.2026.101290_bib0117","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1274295","article-title":"From trash to treasure: the role of bacterial extracellular vesicles in gut health and disease","volume":"14","author":"Sun","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1902718","article-title":"Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier through targeting RIPK1-mediated cell death pathway","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0119","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12866-021-02130-4","article-title":"Oral microbiota and Helicobacter pylori in gastric carcinogenesis: what do we know and where next?","volume":"21","author":"Bakhti","year":"2021","journal-title":"BMC Microbiol"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0120","doi-asserted-by":"crossref","first-page":"e1356","DOI":"10.1002\/iid3.1356","article-title":"Interactions between toll-like receptors signaling pathway and gut microbiota in host homeostasis","volume":"12","author":"Chen","year":"2024","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.neo.2026.101290_bib0121","article-title":"Bacterial species associated with Human inflammatory bowel disease and their pathogenic mechanisms","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0122","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105724","article-title":"Autoinducer-2 of Fusobacterium nucleatum promotes macrophage M1 polarization via TNFSF9\/IL-1\u03b2 signaling","volume":"74","author":"Wu","year":"2019","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0123","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4049\/jimmunol.1302734","article-title":"IL-1\u03b2 promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1\/17 cells that are specific for pathogenic and commensal microbes","volume":"193","author":"Duhen","year":"2014","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0124","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/mi.2008.28","article-title":"IL-23 and Th17 cytokines in intestinal homeostasis","volume":"1","author":"Maloy","year":"2008","journal-title":"Mucosal Immunol"},{"issue":"22","key":"10.1016\/j.neo.2026.101290_bib0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223684","article-title":"The species of gut bacteria associated with antitumor immunity in cancer therapy","volume":"11","author":"Qi","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0126","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0127","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2149448","article-title":"Antagonistic interaction between two key endodontic pathogens Enterococcus faecalis and Fusobacterium nucleatum","volume":"15","author":"Xiang","year":"2023","journal-title":"J Oral Microbiol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0128","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/JPER.22-0205","article-title":"Fusobacterium nucleatum aggravates ulcerative colitis through promoting gut microbiota dysbiosis and dysmetabolism","volume":"94","author":"Lin","year":"2023","journal-title":"J Periodontol"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0129","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1016\/j.fct.2008.05.034","article-title":"The role of acetaldehyde outside ethanol metabolism in the carcinogenicity of alcoholic beverages: evidence from a large chemical survey","volume":"46","author":"Lachenmeier","year":"2008","journal-title":"Food Chem Toxicol"},{"issue":"Pt E","key":"10.1016\/j.neo.2026.101290_bib0130","first-page":"1","article-title":"Personal habits and indoor combustions","volume":"100","year":"2012","journal-title":"IARC Monogr Eval Carcinog Risks Hum"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0131","article-title":"Ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system","volume":"11","author":"Contreras-Zentella","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0132","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8030050","article-title":"Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in Alcohol-associated liver disease","volume":"8","author":"Jiang","year":"2020","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0133","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/odi.12341","article-title":"Acetaldehyde production by major oral microbes","volume":"21","author":"Moritani","year":"2015","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0134","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2018.1492316","article-title":"Characterization of oral microbiota and acetaldehyde production","volume":"10","author":"Yokoyama","year":"2018","journal-title":"J Oral Microbiol"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0135","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0136","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.alcohol.2005.03.009","article-title":"DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis","volume":"35","author":"Brooks","year":"2005","journal-title":"Alcohol"},{"issue":"13","key":"10.1016\/j.neo.2026.101290_bib0137","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1093\/nar\/gkac570","article-title":"Acetaldehyde makes a distinct mutation signature in single-stranded DNA","volume":"50","author":"Vijayraghavan","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0138","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091943","article-title":"Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium","volume":"18","author":"Mizumoto","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0139","doi-asserted-by":"crossref","first-page":"25","DOI":"10.35946\/arcr.v35.1.04","article-title":"Alcohol, DNA methylation, and cancer","volume":"35","author":"Varela-Rey","year":"2013","journal-title":"Alcohol Res"},{"key":"10.1016\/j.neo.2026.101290_bib0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.redox.2014.08.009","article-title":"The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts","volume":"3","author":"Linhart","year":"2014","journal-title":"Redox Biol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0141","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1368-8375(00)00076-2","article-title":"Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers","volume":"37","author":"Homann","year":"2001","journal-title":"Oral Oncol"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0142","article-title":"The impact of alcohol consumption and oral microbiota on upper aerodigestive tract carcinomas: A pilot study","volume":"12","author":"Fiore","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"15","key":"10.1016\/j.neo.2026.101290_bib0143","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13153846","article-title":"Ethanol-induced cell damage can result in the development of oral tumors","volume":"13","author":"Hoes","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0144","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10010011","article-title":"Local acetaldehyde-an essential role in alcohol-related upper gastrointestinal tract carcinogenesis","volume":"10","author":"Nieminen","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1751-2980.2011.00480.x","article-title":"Acetaldehyde and gastric cancer","volume":"12","author":"Salaspuro","year":"2011","journal-title":"J Dig Dis"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0146","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1158\/1055-9965.EPI-05-0196","article-title":"Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a mendelian randomization approach","volume":"14","author":"Lewis","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0147","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1902\/jop.2009.090012","article-title":"Hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria","volume":"80","author":"Yoshida","year":"2009","journal-title":"J Periodontol"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0148","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1002\/jcp.29761","article-title":"Protective mechanisms of hydrogen sulfide in myocardial ischemia","volume":"235","author":"Chen","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.neo.2026.101290_bib0149","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7570489","article-title":"Protective effects of hydrogen sulfide in the ageing kidney","volume":"2016","author":"Hou","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.neo.2026.101290_bib0150","article-title":"Hydrogen sulfide protects against paraquat-induced acute liver injury in rats by regulating oxidative stress, mitochondrial function, and inflammation","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0151","article-title":"Protective roles of hydrogen sulfide in Alzheimer's disease and traumatic brain injury","volume":"12","author":"Paul","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0152","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.freeradbiomed.2011.02.016","article-title":"Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis","volume":"50","author":"Xu","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neo.2026.101290_bib0153","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101772","article-title":"Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics","volume":"38","author":"Paul","year":"2021","journal-title":"Redox Biol"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0154","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/bph.12369","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms","volume":"171","author":"Szabo","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0155","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/tx300066z","article-title":"Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H(2)S","volume":"25","author":"Hoffman","year":"2012","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0156","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1038\/s41598-017-05457-z","article-title":"Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR\/ERK\/MMP-2 and PTEN\/AKT signaling pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.neo.2026.101290_bib0157","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113775","article-title":"Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1\u03b1 activation","volume":"172","author":"Wang","year":"2020","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0158","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.freeradbiomed.2011.08.007","article-title":"Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells","volume":"51","author":"Pupo","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0159","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1038\/s41598-023-29731-5","article-title":"Butyrate limits human natural killer cell effector function","volume":"13","author":"Zaiatz-Bittencourt","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.neo.2026.101290_bib0160","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.canlet.2019.11.019","article-title":"Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating wnt signaling and gut microbiota","volume":"469","author":"Chen","year":"2020","journal-title":"Cancer Lett"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0161","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/omi.12322","article-title":"A double-edged sword: role of butyrate in the oral cavity and the gut","volume":"36","author":"Guan","year":"2021","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0162","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.micpath.2015.10.006","article-title":"Re-discovering periodontal butyric acid: new insights on an old metabolite","volume":"94","author":"Cueno","year":"2016","journal-title":"Microb Pathog"},{"key":"10.1016\/j.neo.2026.101290_bib0163","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.12991","article-title":"Butyrate promotes oral squamous cell carcinoma cells migration, invasion and epithelial-mesenchymal transition","volume":"10","author":"Zang","year":"2022","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0164","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051679","article-title":"Butyrate decreases ICAM-1 expression in Human oral squamous cell carcinoma cells","volume":"21","author":"Magrin","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0165","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1177\/0022034515606045","article-title":"Oral microbiome metabolism: from \"who are they?\" to \"what are they doing?","volume":"94","author":"Takahashi","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.neo.2026.101290_bib0166","article-title":"Periodontal pathogens: A crucial link between Periodontal diseases and oral cancer","volume":"13","author":"Li","year":"2022","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0167","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41522-025-00669-y","article-title":"Regulation of tryptophan-indole metabolic pathway in Porphyromonas gingivalis virulence and microbiota dysbiosis in periodontitis","volume":"11","author":"Ding","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0168","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1859812","article-title":"The aryl hydrocarbon receptor as a mediator of host-microbiota interplay","volume":"12","author":"Dong","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neo.2026.101290_bib0169","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.903526","article-title":"Dual role of indoles derived from intestinal microbiota on Human health","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"issue":"584","key":"10.1016\/j.neo.2026.101290_bib0170","article-title":"Toxicology studies of indole-3-carbinol in F344\/N rats and B6C3F1\/N mice and toxicology and carcinogenesis studies of indole-3-carbinol in Harlan Sprague Dawley rats and B6C3F1\/N mice (gavage studies)","year":"2017","journal-title":"Natl Toxicol Program Tech Rep Ser"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0171","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4162\/nrp.2023.17.4.616","article-title":"IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells","volume":"17","author":"Ismael","year":"2023","journal-title":"Nutr Res Pract"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0172","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s00726-021-03122-4","article-title":"Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate","volume":"54","author":"Armand","year":"2022","journal-title":"Amino Acids"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0173","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1021\/acs.joc.0c02774","article-title":"An organic chemist's guide to N-nitrosamines: their structure, reactivity, and role as contaminants","volume":"86","author":"Beard","year":"2021","journal-title":"J Org Chem"},{"key":"10.1016\/j.neo.2026.101290_bib0174","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2023.100470","article-title":"Nitrite and nitrate in meat processing: functions and alternatives","volume":"6","author":"Zhang","year":"2023","journal-title":"Curr Res Food Sci"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094559","article-title":"Metabolic activation and DNA interactions of carcinogenic N-nitrosamines to which humans are commonly exposed","volume":"23","author":"Li","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0176","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2741\/3739","article-title":"Mechanisms of oxidative DNA damage induced by carcinogenic arylamines","volume":"16","author":"Murata","year":"2011","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0177","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/toxsci\/kfq121","article-title":"Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells","volume":"116","author":"Hebels","year":"2010","journal-title":"Toxicol Sci"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0178","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/jat.4332","article-title":"Reactive oxygen species-mediated activation of NLRP3 inflammasome associated with pyroptosis in Het-1A cells induced by the co-exposure of nitrosamines","volume":"42","author":"Liu","year":"2022","journal-title":"J Appl Toxicol"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0179","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/0022034518755697","article-title":"Diabetes activates periodontal ligament fibroblasts via NF-\u03bab In Vivo","volume":"97","author":"Zheng","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.neo.2026.101290_bib0180","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1681972","article-title":"Fusobacterium nucleatum facilitates apoptosis, ROS generation, and inflammatory cytokine production by activating AKT\/MAPK and NF-\u03bab signaling pathways in Human gingival fibroblasts","volume":"2019","author":"Kang","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"33","key":"10.1016\/j.neo.2026.101290_bib0181","doi-asserted-by":"crossref","first-page":"20147","DOI":"10.1074\/jbc.M115.655787","article-title":"Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (Receptor Activator of NF-\u03baB Ligand) through activation of toll-like receptor 2 in osteoblasts","volume":"290","author":"Kassem","year":"2015","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0182","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00247-22","article-title":"Treponema denticola induces interleukin-36\u03b3 expression in Human oral gingival keratinocytes via the parallel activation of NF-\u03bab and mitogen-activated protein kinase pathways","volume":"90","author":"Hinson","year":"2022","journal-title":"Infect Immun"},{"issue":"19","key":"10.1016\/j.neo.2026.101290_bib0183","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16193305","article-title":"Mechanistic insights on microbiota-mediated development and progression of esophageal cancer","volume":"16","author":"Moe","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0184","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1007\/s11912-024-01591-w","article-title":"Unveiling the hidden links: periodontal disease, Fusobacterium Nucleatum, and cancers","volume":"26","author":"Akbari","year":"2024","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.neo.2026.101290_bib0185","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1023177","article-title":"The role of IL-6\/JAK2\/STAT3 signaling pathway in cancers","volume":"12","author":"Huang","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0186","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13046-022-02376-4","article-title":"Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2\/STAT3\/Sox4\/NLRP3 signaling pathway","volume":"41","author":"Xiao","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0187","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03448-22","article-title":"Oral microbiota alteration and roles in Epstein-Barr Virus reactivation in nasopharyngeal carcinoma","volume":"11","author":"Liao","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.neo.2026.101290_bib0188","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6282635","article-title":"Quercetin inhibits inflammatory response induced by LPS from Porphyromonas gingivalis in Human gingival fibroblasts via suppressing NF-\u03bab signaling pathway","volume":"2019","author":"Xiong","year":"2019","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0189","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41564-024-01695-w","article-title":"Peptostreptococcus anaerobius mediates anti-PD1 therapy resistance and exacerbates colorectal cancer via myeloid-derived suppressor cells in mice","volume":"9","author":"Liu","year":"2024","journal-title":"Nat Microbiol"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0190","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1158\/0008-5472.CAN-24-2580","article-title":"Intratumoral Fusobacterium nucleatum recruits tumor-associated neutrophils to promote gastric cancer progression and immune evasion","volume":"85","author":"Zhang","year":"2025","journal-title":"Cancer Res"},{"key":"10.1016\/j.neo.2026.101290_bib0191","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101042","article-title":"Inhibition of NF-\u03bab signaling unveils novel strategies to overcome drug resistance in cancers","volume":"73","author":"Li","year":"2024","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.neo.2026.101290_bib0192","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106398","article-title":"A renewed concept on the MAPK signaling pathway in cancers: polyphenols as a choice of therapeutics","volume":"184","author":"Anjum","year":"2022","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12865-016-0185-5","article-title":"Porphyromonas gingivalis activates NF\u03baB and MAPK pathways in human oral epithelial cells","volume":"18","author":"Groeger","year":"2017","journal-title":"BMC Immunol"},{"key":"10.1016\/j.neo.2026.101290_bib0194","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.823685","article-title":"TLR2 Activation by Porphyromonas gingivalis requires both PPAD activity and Fimbriae","volume":"13","author":"Wielento","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.neo.2026.101290_bib0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.584798","article-title":"Intracellular Porphyromonas gingivalis promotes the proliferation of colorectal cancer cells via the MAPK\/ERK signaling pathway","volume":"10","author":"Mu","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0196","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2017.12.002","article-title":"Overexpression of ELF3 facilitates cell growth and metastasis through PI3K\/Akt and ERK signaling pathways in non-small cell lung cancer","volume":"94","author":"Wang","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0197","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbrc.2015.06.092","article-title":"PI3K\/Akt signaling mediated hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma","volume":"464","author":"Zhuo","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"13","key":"10.1016\/j.neo.2026.101290_bib0198","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111019","article-title":"BAFFR activates PI3K\/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors","volume":"39","author":"Sevdali","year":"2022","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0199","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.2041-1014.2010.00569.x","article-title":"Porphyromonas gingivalis infection sequesters pro-apoptotic bad through Akt in primary gingival epithelial cells","volume":"25","author":"Yao","year":"2010","journal-title":"Mol Oral Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0200","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13045-024-01563-4","article-title":"Wnt\/\u03b2-catenin signaling pathway in carcinogenesis and cancer therapy","volume":"17","author":"Song","year":"2024","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.neo.2026.101290_bib0201","article-title":"Fusobacterium nucleatum promotes the progression of colorectal cancer through Cdk5-activated wnt\/\u03b2-catenin signaling","volume":"11","author":"Li","year":"2020","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0202","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0203","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15112898","article-title":"Exploring connections between oral microbiota, short-chain fatty acids, and specific cancer types: A study of oral cancer, head and neck cancer, pancreatic cancer, and gastric cancer","volume":"15","author":"Nouri","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0204","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41579-024-01075-5","article-title":"The oral-gut microbiome axis in health and disease","volume":"22","author":"Kunath","year":"2024","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12944-021-01440-w","article-title":"Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and meta-analysis","volume":"20","author":"Li","year":"2021","journal-title":"Lipids Health Dis"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0206","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04327-22","article-title":"Characteristics of the salivary microbiota in periodontal diseases and potential roles of individual bacterial species to predict the severity of periodontal disease","volume":"11","author":"Ji","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0207","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095142","article-title":"Impact of oral microbiome in periodontal health and periodontitis: A critical review on prevention and treatment","volume":"23","author":"Di Stefano","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.neo.2026.101290_bib0208","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1010853","article-title":"The oral-gut axis: salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease","volume":"12","author":"Abdelbary","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0209","article-title":"The interactions between oral-gut axis microbiota and Helicobacter pylori","volume":"12","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12929-018-0469-6","article-title":"H. pylori infection and extra-gastroduodenal diseases","volume":"25","author":"Tsay","year":"2018","journal-title":"J Biomed Sci"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0211","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.identj.2024.10.025","article-title":"Association of 41 inflammatory cytokines with common oral diseases","volume":"75","author":"Liu","year":"2025","journal-title":"Int Dent J"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0212","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.neo.2026.101290_bib0213","article-title":"Effect of three oral pathogens on the TMA-TMAO metabolic pathway","volume":"14","author":"Wang","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.neo.2026.101290_bib0214","article-title":"Gut microbiota-dependent trimethylamine n-oxide pathway contributes to the bidirectional relationship between intestinal inflammation and periodontitis","volume":"12","author":"Wang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0215","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/hep.27819","article-title":"Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy","volume":"62","author":"Bajaj","year":"2015","journal-title":"Hepatology"},{"issue":"7516","key":"10.1016\/j.neo.2026.101290_bib0216","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature13568","article-title":"Alterations of the human gut microbiome in liver cirrhosis","volume":"513","author":"Qin","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0217","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1186\/s12967-023-04559-9","article-title":"Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample mendelian randomization study","volume":"21","author":"Ye","year":"2023","journal-title":"J Transl Med"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0218","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092124","article-title":"Oral-gut microbiome axis in gastrointestinal disease and cancer","volume":"13","author":"Park","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0219","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1177\/00220345231160747","article-title":"High-resolution detection of translocation of oral bacteria to the gut","volume":"102","author":"Kageyama","year":"2023","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0220","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mucimm.2023.11.006","article-title":"Exploring the oral-gut linkage: interrelationship between oral and systemic diseases","volume":"17","author":"Yamazaki","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0221","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0022034520926126","article-title":"Inflammatory networks linking oral microbiome with systemic health and disease","volume":"99","author":"Kleinstein","year":"2020","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0222","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2023.2213112","article-title":"The interplay between oral microbiota, gut microbiota and systematic diseases","volume":"15","author":"Tan","year":"2023","journal-title":"J Oral Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0223","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2110194","article-title":"Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice","volume":"14","author":"Yamazaki","year":"2022","journal-title":"J Oral Microbiol"},{"issue":"6369","key":"10.1016\/j.neo.2026.101290_bib0224","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neo.2026.101290_bib0225","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3389\/fmicb.2018.00774","article-title":"Oral bacterial and fungal microbiome impacts colorectal carcinogenesis","volume":"9","author":"Klimesova","year":"2018","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0226","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1574-6941.2008.00525.x","article-title":"Coaggregation between and among human intestinal and oral bacteria","volume":"66","author":"Ledder","year":"2008","journal-title":"FEMS Microbiol Ecol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0227","doi-asserted-by":"crossref","first-page":"348","DOI":"10.21037\/jtd-22-856","article-title":"Global trends in the burden of esophageal cancer, 1990-2019: results from the Global Burden of Disease Study 2019","volume":"15","author":"Jiang","year":"2023","journal-title":"J Thorac Dis"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0228","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1053\/j.gastro.2022.05.054","article-title":"The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020","volume":"163","author":"Morgan","year":"2022","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0229","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/dote.12147","article-title":"Age and sex differences in the incidence of esophageal adenocarcinoma: results from the Surveillance, Epidemiology, and End Results (SEER) Registry (1973-2008)","volume":"27","author":"Mathieu","year":"2014","journal-title":"Dis Esophagus"},{"issue":"6556","key":"10.1016\/j.neo.2026.101290_bib0230","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.abd1449","article-title":"Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition","volume":"373","author":"Nowicki-Osuch","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0231","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13010141","article-title":"Global burden, risk factors, and trends of esophageal cancer: an analysis of cancer registries from 48 countries","volume":"13","author":"Huang","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0232","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ijc.29688","article-title":"Age-specific risk factor profiles of adenocarcinomas of the esophagus: A pooled analysis from the international BEACON consortium","volume":"138","author":"Drahos","year":"2016","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0233","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1053\/j.gastro.2017.07.046","article-title":"The epidemiology of esophageal adenocarcinoma","volume":"154","author":"Coleman","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0234","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1586\/17446651.2015.1077696","article-title":"Obesity and increased risk of esophageal adenocarcinoma","volume":"10","author":"Elliott","year":"2015","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0235","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0236","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1053\/j.gastro.2017.08.023","article-title":"Epidemiology of esophageal squamous cell carcinoma","volume":"154","author":"Abnet","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0237","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1053\/j.gastro.2016.01.035","article-title":"Genomic landscape of esophageal squamous cell carcinoma in a Japanese population","volume":"150","author":"Sawada","year":"2016","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0238","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13051009","article-title":"Risk factors of esophageal squamous cell carcinoma beyond alcohol and smoking","volume":"13","author":"Tarazi","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"23","key":"10.1016\/j.neo.2026.101290_bib0239","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15235604","article-title":"Overview of risk factors for esophageal squamous cell carcinoma in China","volume":"15","author":"Conway","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0240","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.apsb.2021.03.008","article-title":"Advances and challenges in the treatment of esophageal cancer","volume":"11","author":"He","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0241","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1177\/00220345241263768","article-title":"Association between periodontal diseases and the risk of site-specific gastrointestinal cancers: A systematic review and meta-analysis","volume":"103","author":"Wang","year":"2024","journal-title":"J Dent Res"},{"key":"10.1016\/j.neo.2026.101290_bib0242","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13027-019-0220-2","article-title":"The role of Tannerella forsythia and Porphyromonas gingivalis in pathogenesis of esophageal cancer","volume":"14","author":"Malinowski","year":"2019","journal-title":"Infect Agent Cancer"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0243","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s13402-020-00573-x","article-title":"Porphyromonas gingivalis promotes tumor progression in esophageal squamous cell carcinoma","volume":"44","author":"Chen","year":"2021","journal-title":"Cell Oncol (Dordr)"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0244","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/acsinfecdis.0c00007","article-title":"Porphyromonas gingivalis promotes the proliferation and migration of esophageal Squamous cell carcinoma through the miR-194\/GRHL3\/PTEN\/Akt axis","volume":"6","author":"Liang","year":"2020","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.neo.2026.101290_bib0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2022.01.014","article-title":"Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1\/RIPK2\/NF-\u03bab pathway","volume":"530","author":"Nomoto","year":"2022","journal-title":"Cancer Lett"},{"key":"10.1016\/j.neo.2026.101290_bib0246","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jare.2023.08.014","article-title":"Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma","volume":"61","author":"Guo","year":"2024","journal-title":"J Adv Res"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0247","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/febs.16619","article-title":"Fusobacterium nucleatum promotes proliferation in oesophageal squamous cell carcinoma via AHR\/CYP1A1 signalling","volume":"290","author":"Yin","year":"2023","journal-title":"Febs j"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0248","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1111\/cas.15787","article-title":"Fusobacterium nucleatum promotes the early occurrence of esophageal cancer through upregulation of IL-32\/PRTN3 expression","volume":"114","author":"Lei","year":"2023","journal-title":"Cancer Sci"},{"key":"10.1016\/j.neo.2026.101290_bib0249","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101404","article-title":"The current and future incidence and mortality of gastric cancer in 185 countries, 2020-40: A population-based modelling study","volume":"47","author":"Morgan","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0250","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01869-15","article-title":"Helicobacter pylori diversity and gastric cancer risk","volume":"7","author":"Cover","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.neo.2026.101290_bib0251","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1403089","article-title":"Porphyromonas gingivalis, a bridge between oral health and immune evasion in gastric cancer","volume":"14","author":"Mu\u00f1oz-Medel","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.neo.2026.101290_bib0252","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-0716-0939-2_21","article-title":"Invasion of gingival epithelial cells by Porphyromonas gingivalis","volume":"2210","author":"Takeuchi","year":"2021","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.neo.2026.101290_bib0253","series-title":"Helicobacter pylori - From First Isolation to 2020","article-title":"Effect of Helicobacter pylori on tight junctions in gastric epithelia","author":"Rend\u00f3n-Huerta","year":"2021"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0254","doi-asserted-by":"crossref","DOI":"10.3390\/cells12020243","article-title":"Tight junction protein signaling and cancer biology","volume":"12","author":"Nehme","year":"2023","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0255","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12825","article-title":"A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27","volume":"20","author":"Lee","year":"2018","journal-title":"Cell Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0256","doi-asserted-by":"crossref","DOI":"10.3390\/biom9020050","article-title":"Heat shock protein 27 phosphorylation regulates tumor cell migration under shear stress","volume":"9","author":"Zhang","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.neo.2026.101290_bib0257","article-title":"Clinicopathological significance of heat shock protein (HSP) 27 expression in gastric cancer: A updated meta-analysis","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.neo.2026.101290_bib0258","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jdsr.2021.09.003","article-title":"Porphyromonas gingivalis FimA and Mfa1 fimbriae: current insights on localization, function, biogenesis, and genotype","volume":"57","author":"Hasegawa","year":"2021","journal-title":"Jpn Dent Sci Rev"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0259","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/cmi.12211","article-title":"Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation","volume":"16","author":"Inaba","year":"2014","journal-title":"Cell Microbiol"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0260","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13254","article-title":"Porphyromonas gulae lipopolysaccharide elicits inflammatory responses through toll-like receptor 2 and 4 in human gingivalis epithelial cells","volume":"22","author":"Inaba","year":"2020","journal-title":"Cell Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0261","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1038\/s41598-023-31740-3","article-title":"Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer","volume":"13","author":"Lehr","year":"2023","journal-title":"Sci Rep"},{"issue":"30","key":"10.1016\/j.neo.2026.101290_bib0262","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3748\/wjg.v28.i30.4120","article-title":"Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer","volume":"28","author":"Chen","year":"2022","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0263","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15010269","article-title":"Fusobacterium Nucleatum-induced tumor mutation burden predicts poor survival of gastric cancer patients","volume":"15","author":"Hsieh","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0264","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/15384101.2024.2324587","article-title":"Extracellular vesicles from Fusobacterium nucleatum: roles in the malignant phenotypes of gastric cancer","volume":"23","author":"Meng","year":"2024","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0265","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1111\/cas.15781","article-title":"Fusobacterium nucleatum-induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p\/EphB2 axis","volume":"114","author":"Xin","year":"2023","journal-title":"Cancer Sci"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0266","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41416-024-02753-0","article-title":"Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers","volume":"131","author":"Hara","year":"2024","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0267","first-page":"1207","article-title":"Meta-analyses of colorectal cancer risk factors","volume":"24","author":"Johnson","year":"2013","journal-title":"Cancer Causes Control"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0268","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2388801","article-title":"Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion","volume":"16","author":"D\u00edaz-Basabe","year":"2024","journal-title":"Gut Microbes"},{"issue":"10","key":"10.1016\/j.neo.2026.101290_bib0269","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1158\/0008-5472.CAN-20-3827","article-title":"Porphyromonas gingivalis promotes colorectal carcinoma by activating the hematopoietic NLRP3 inflammasome","volume":"81","author":"Wang","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0270","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/omi.12332","article-title":"Porphyromonas gingivalis induced up-regulation of PD-L1 in colon carcinoma cells","volume":"36","author":"Adel-Khattab","year":"2021","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0271","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.micinf.2007.10.011","article-title":"P. gingivalis accelerates gingival epithelial cell progression through the cell cycle","volume":"10","author":"Kuboniwa","year":"2008","journal-title":"Microbes Infect"},{"issue":"12","key":"10.1016\/j.neo.2026.101290_bib0272","first-page":"5981","article-title":"Porphyromonas gingivalis induced UCHL3 to promote colon cancer progression","volume":"13","author":"Lu","year":"2023","journal-title":"Am J Cancer Res"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0273","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1128\/IAI.72.7.3743-3751.2004","article-title":"Activation of the phosphatidylinositol 3-kinase\/akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis","volume":"72","author":"Yilmaz","year":"2004","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0274","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1462-5822.2007.00931.x","article-title":"Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis","volume":"9","author":"Mao","year":"2007","journal-title":"Cell Microbiol"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0275","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1462-5822.2007.01089.x","article-title":"ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2\u00d77-mediated host-cell apoptosis","volume":"10","author":"Yilmaz","year":"2008","journal-title":"Cell Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0276","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1038\/s41467-021-25965-x","article-title":"Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion","volume":"12","author":"Okumura","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0277","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.gastro.2016.11.018","article-title":"Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-\u03bab, and up-regulating expression of MicroRNA-21","volume":"152","author":"Yang","year":"2017","journal-title":"Gastroenterology"},{"issue":"19","key":"10.1016\/j.neo.2026.101290_bib0278","doi-asserted-by":"crossref","first-page":"31802","DOI":"10.18632\/oncotarget.15992","article-title":"Invasive Fusobacterium nucleatum activates beta-catenin signaling in colorectal cancer via a TLR4\/P-PAK1 cascade","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0279","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2458203","article-title":"Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1","volume":"17","author":"Duizer","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neo.2026.101290_bib0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140196","article-title":"Fusobacterium nucleatum modulates the wnt\/\u03b2-catenin pathway in colorectal cancer development","volume":"299","author":"Mondal","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.neo.2026.101290_bib0281","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2024.04.226","article-title":"Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin\/\u03b2-catenin\/GPX4 axis in colorectal cancer","volume":"220","author":"Li","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0282","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/s41467-024-45572-w","article-title":"Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15","volume":"15","author":"Zhu","year":"2024","journal-title":"Nat Commun"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0283","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1038\/s41564-024-01784-w","article-title":"The adhesin RadD enhances Fusobacterium nucleatum tumour colonization and colorectal carcinogenesis","volume":"9","author":"Zhang","year":"2024","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0284","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1980347","article-title":"Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322\/CCL20 axis and M2 polarization","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"issue":"15","key":"10.1016\/j.neo.2026.101290_bib0285","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2418155122","article-title":"Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF","volume":"122","author":"Marongiu","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0286","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03732-24","article-title":"Virulence factor discovery identifies associations between the fic gene family and Fap2(+) fusobacteria in colorectal cancer microbiomes","volume":"16","author":"Nakatsu","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.neo.2026.101290_bib0287","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.658681","article-title":"Fusobacterium nucleatum facilitates M2 macrophage polarization and colorectal carcinoma progression by activating TLR4\/NF-\u03baB\/S100A9 cascade","volume":"12","author":"Hu","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0288","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1186\/s12967-023-04527-3","article-title":"Fusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis","volume":"21","author":"Ou","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0289","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13046-023-02817-8","article-title":"Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression","volume":"42","author":"Kong","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0290","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1136\/gutjnl-2020-322780","article-title":"F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer","volume":"70","author":"Hong","year":"2021","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0291","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091256","article-title":"Proinflammatory and cancer-promoting pathobiont Fusobacterium nucleatum directly targets colorectal cancer stem cells","volume":"12","author":"Cavallucci","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0292","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181595","article-title":"Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells","volume":"135","author":"Wang","year":"2025","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.neo.2026.101290_bib0293","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847638","article-title":"Fusobacterium nucleatum promotes colorectal cancer by inducing wnt\/\u03b2-catenin modulator Annexin A1","volume":"20","author":"Rubinstein","year":"2019","journal-title":"EMBO Rep"},{"issue":"18","key":"10.1016\/j.neo.2026.101290_bib0294","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3748\/wjg.v28.i18.1981","article-title":"Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model","volume":"28","author":"Wu","year":"2022","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.neo.2026.101290_bib0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011096","article-title":"Fn-Dps, a novel virulence factor of Fusobacterium nucleatum, disrupts erythrocytes and promotes metastasis in colorectal cancer","volume":"19","author":"Wu","year":"2023","journal-title":"PLoS Pathog"},{"issue":"10242","key":"10.1016\/j.neo.2026.101290_bib0296","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.neo.2026.101290_bib0297","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1245\/s10434-023-14366-7","article-title":"Does oral microbiota have a close relationship with pancreatic cancer? A systematic review and meta-analysis","volume":"30","author":"Ma","year":"2023","journal-title":"Ann Surg Oncol"},{"issue":"19","key":"10.1016\/j.neo.2026.101290_bib0298","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197351","article-title":"P. gingivalis lipopolysaccharide stimulates the upregulated expression of the pancreatic cancer-related genes regenerating islet-derived 3 A\/G in mouse pancreas","volume":"21","author":"Hiraki","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0299","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1111\/cas.15901","article-title":"Intratumor Fusobacterium nucleatum promotes the progression of pancreatic cancer via the CXCL1-CXCR2 axis","volume":"114","author":"Hayashi","year":"2023","journal-title":"Cancer Sci"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0300","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/gutjnl-2023-330941","article-title":"Oral bacteria accelerate pancreatic cancer development in mice","volume":"73","author":"Saba","year":"2024","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.neo.2026.101290_bib0301","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12082331","article-title":"Intracellular Porphyromonas gingivalis promotes the tumorigenic behavior of pancreatic carcinoma cells","volume":"12","author":"Gnanasekaran","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"756","key":"10.1016\/j.neo.2026.101290_bib0302","doi-asserted-by":"crossref","first-page":"eabn4948","DOI":"10.1126\/scisignal.abn4948","article-title":"Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling","volume":"15","author":"Udayasuryan","year":"2022","journal-title":"Sci Signal"},{"issue":"13","key":"10.1016\/j.neo.2026.101290_bib0303","first-page":"184","article-title":"Paradigms lost-an emerging role for over-expression of tight junction adhesion proteins in cancer pathogenesis","volume":"3","author":"Leech","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.neo.2026.101290_bib0304","article-title":"Recent advances in the diagnosis, staging, treatment, and prognosis of advanced gastric cancer: A literature review","volume":"8","author":"Chen","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"24","key":"10.1016\/j.neo.2026.101290_bib0305","article-title":"Landscape of innovative methods for early diagnosis of gastric cancer: A systematic review","volume":"13","author":"Or\u0103\u0219eanu","year":"2023","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"10.1016\/j.neo.2026.101290_bib0306","first-page":"2217","article-title":"A screening method for gastric cancer by oral microbiome detection","volume":"39","author":"Sun","year":"2018","journal-title":"Oncol Rep"},{"issue":"9","key":"10.1016\/j.neo.2026.101290_bib0307","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.7150\/jca.83395","article-title":"Porphyromonas gingivalis in Colorectal cancer and its Association to Patient Prognosis","volume":"14","author":"Kerdreux","year":"2023","journal-title":"J Cancer"},{"issue":"3","key":"10.1016\/j.neo.2026.101290_bib0308","first-page":"e165","article-title":"Fusobacterium nucleatum and clinicopathologic features of colorectal cancer: results from the ColoCare study","volume":"20","author":"Eisele","year":"2021","journal-title":"Clin Colorectal Cancer"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0309","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.3168\/jds.2019-18003","article-title":"Probiotics, prebiotics, and synbiotics regulate the intestinal microbiota differentially and restore the relative abundance of specific gut microorganisms","volume":"103","author":"Li","year":"2020","journal-title":"J Dairy Sci"},{"issue":"2","key":"10.1016\/j.neo.2026.101290_bib0310","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12020368","article-title":"Immune responses raised in an experimental colon carcinoma model following oral administration of Lactobacillus casei","volume":"12","author":"Aindelis","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.neo.2026.101290_bib0311","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112871","article-title":"Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation","volume":"149","author":"Srikham","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.neo.2026.101290_bib0312","article-title":"Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials","volume":"14","author":"Zheng","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.neo.2026.101290_bib0313","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4092472","article-title":"Probiotics can boost the antitumor immunity of CD8(+)T cells in BALB\/c mice and patients with colorectal carcinoma","volume":"2020","author":"Mao","year":"2020","journal-title":"J Immunol Res"},{"key":"10.1016\/j.neo.2026.101290_bib0314","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104533","article-title":"Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolites","volume":"91","author":"Gao","year":"2023","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0315","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/jcpe.13304","article-title":"Oral health and gastrointestinal cancer: A nationwide cohort study","volume":"47","author":"Lee","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"7","key":"10.1016\/j.neo.2026.101290_bib0316","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/1940-6207.CAPR-20-0577","article-title":"Oral health and risk of upper gastrointestinal cancers in a large prospective study from a high-risk region: Golestan cohort study","volume":"14","author":"Yano","year":"2021","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.neo.2026.101290_bib0317","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101330","article-title":"Poor oral health and risks of total and site-specific cancers in China: A prospective cohort study of 0.5 million adults","volume":"45","author":"Zhang","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"6","key":"10.1016\/j.neo.2026.101290_bib0318","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/jcpe.13274","article-title":"Treatment of periodontitis reduces systemic inflammation in type 2 diabetes","volume":"47","author":"Preshaw","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"11","key":"10.1016\/j.neo.2026.101290_bib0319","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000520","article-title":"Periodontal treatment and usual care for nonalcoholic fatty liver disease: A multicenter, randomized controlled trial","volume":"13","author":"Kamata","year":"2022","journal-title":"Clin Transl Gastroenterol"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:08:40Z","timestamp":1773842920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558626000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":319,"alternative-id":["S1476558626000199"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2026.101290","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbial crosstalk along the oral\u2013gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2026.101290","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101290"}}