{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:51:48Z","timestamp":1776815508331,"version":"3.51.2"},"reference-count":180,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","award":["242301420008"],"award-info":[{"award-number":["242301420008"]}],"id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016305","name":"The First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["QNCXTD2023022"],"award-info":[{"award-number":["QNCXTD2023022"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.neo.2026.101306","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:24:33Z","timestamp":1775665473000},"page":"101306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting tumor dormancy: the next frontier in gastrointestinal stromal tumor therapy"],"prefix":"10.1016","volume":"76","author":[{"given":"Sihan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-3354","authenticated-orcid":false,"given":"Yang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2026.101306_bib0001","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.hoc.2013.07.003","article-title":"Gastrointestinal stromal tumors molecular markers and genetic subtypes","volume":"27","author":"Barnett","year":"2013","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.neo.2026.101306_bib0002","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1016\/j.cgh.2023.01.037","article-title":"Epidemiology of gastric malignancies 2000-2018 according to histology: a population-based analysis of incidence and temporal trends","volume":"21","author":"Rustgi","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neo.2026.101306_bib0003","series-title":"AJCC Cancer Staging Manual","author":"Amin","year":"2017"},{"key":"10.1016\/j.neo.2026.101306_bib0004","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/01.pas.0000213307.05811.f0","article-title":"Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations","volume":"31","author":"Agaimy","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.neo.2026.101306_bib0005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.humpath.2006.07.002","article-title":"High incidence of microscopic gastrointestinal stromal tumors in the stomach","volume":"37","author":"Kawanowa","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.neo.2026.101306_bib0006","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1470-2045(11)70299-6","article-title":"Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts","volume":"13","author":"Joensuu","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0007","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1200\/JCO.2017.74.9705","article-title":"Gastrointestinal stromal tumors","volume":"36","author":"von Mehren","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0008","first-page":"577","article-title":"Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors","volume":"279","author":"Hirota","year":"1998","journal-title":"Science (1979)"},{"key":"10.1016\/j.neo.2026.101306_bib0009","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJM200104053441404","article-title":"Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor","volume":"344","author":"Joensuu","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/annonc\/mdy320","article-title":"Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up (vol 29, pg 68, 2018)","volume":"29","author":"Casali","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0011","doi-asserted-by":"crossref","first-page":"853","DOI":"10.6004\/jnccn.2014.0080","article-title":"Gastrointestinal stromal tumors, version 2.2014","volume":"12","author":"von Mehren","year":"2014","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.neo.2026.101306_bib0012","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","article-title":"Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors","volume":"347","author":"Demetri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0013","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S0959-8049(02)80603-7","article-title":"Identification and treatment of chemoresistant inoperable or metastatic GIST: experience with the selective tyrosine kinase inhibitor imatinib mesylate (ST1571)","volume":"38","author":"Demetri","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-021-00254-5","article-title":"Gastrointestinal stromal tumours","volume":"7","author":"Blay","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.neo.2026.101306_bib0015","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.4060","article-title":"Efficacy and tolerability of 5-year adjuvant imatinib treatment for patients with resected intermediate-or high-risk primary gastrointestinal stromal tumor the PERSIST-5 clinical trial","volume":"4","author":"Raut","year":"2018","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0016","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.annonc.2024.08.2343","article-title":"A randomized study of 6 versus 3 years of adjuvant imatinib in patients with localized GIST at high risk of relapse","volume":"35","author":"Blay","year":"2024","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0017","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S1470-2045(24)00318-8","article-title":"Discontinuation versus continuation of imatinib in patients with advanced gastrointestinal stromal tumours (BFR14): exploratory long-term follow-up of an open-label, multicentre, randomised, phase 3 trial","volume":"25","author":"Blay","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0018","doi-asserted-by":"crossref","first-page":"702","DOI":"10.5966\/sctm.2014-0298","article-title":"Targeting disease persistence in gastrointestinal stromal tumors","volume":"4","author":"Ordog","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0019","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/133743c0","article-title":"The spread of tumours in the Human body","volume":"133","year":"1934","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216899","article-title":"Unveiling cancer dormancy: intrinsic mechanisms and extrinsic forces","volume":"591","author":"Liu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0021","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037556","article-title":"Cancer cell dormancy in metastasis","volume":"10","author":"Summers","year":"2020","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0022","article-title":"Targeting immune-mediated dormancy: a promising treatment of cancer","volume":"9","author":"Wang","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0023","doi-asserted-by":"crossref","first-page":"9015","DOI":"10.1158\/0008-5472.CAN-08-1935","article-title":"Imatinib mesylate induces quiescence in gastrointestinal stromal tumor cells through the CDH1-SKP2-p27<SUP>Kip1<\/SUP>signaling axis","volume":"68","author":"Liu","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0024","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nrc3598","article-title":"The DREAM complex: master coordinator of cell cycle-dependent gene expression (vol 13, pg 585, 2013)","volume":"13","author":"Sadasivam","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215639","article-title":"The nerve-tumour regulatory axis GDNF-GFRA1 promotes tumour dormancy, imatinib resistance and local recurrence of gastrointestinal stromal tumours by achieving autophagic flux","volume":"535","author":"Ni","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0026","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1053\/j.gastro.2010.05.083","article-title":"Kit<SUP>low<\/SUP>stem cells cause resistance to Kit\/platelet-derived growth factor \u03b1 inhibitors in murine gastrointestinal stromal tumors","volume":"139","author":"Bardsley","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neo.2026.101306_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100959","article-title":"Genomic profiling in GIST: implications in clinical outcome and future challenges","volume":"48","author":"Calderillo-Ruiz","year":"2024","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2026.101306_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41416-024-02672-0","article-title":"Gastrointestinal stromal tumour (GIST): British Sarcoma Group clinical practice guidelines","volume":"132","author":"Judson","year":"2025","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0029","doi-asserted-by":"crossref","first-page":"7510","DOI":"10.1158\/1078-0432.CCR-09-0190","article-title":"Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors","volume":"15","author":"Gramza","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0030","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41416-019-0388-7","article-title":"Secondary KIT mutations: the GIST of drug resistance and sensitivity","volume":"120","author":"Napolitano","year":"2019","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0031","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41416-019-0389-6","article-title":"Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours","volume":"120","author":"Serrano","year":"2019","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0032","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41591-023-02734-5","article-title":"Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial","volume":"30","author":"Heinrich","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0033","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10120-025-01639-1","article-title":"Clinical impact of primary and secondary KIT mutations on the efficacy of molecular-targeted therapies in gastrointestinal stromal tumors","volume":"28","author":"Kawabata","year":"2025","journal-title":"Gastric. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0034","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s11864-024-01272-7","article-title":"Current drug resistance mechanisms and treatment options in gastrointestinal stromal tumors: summary and update","volume":"25","author":"He","year":"2024","journal-title":"Curr. Treat. Options. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0035","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0036","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.neo.7900038","article-title":"The role of the vascular phase in solid tumor growth: a historical review","volume":"1","author":"Ribatti","year":"1999","journal-title":"Neoplasia"},{"key":"10.1016\/j.neo.2026.101306_bib0037","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nrc2256","article-title":"Models, mechanisms and clinical evidence for cancer dormancy","volume":"7","author":"Aguirre-Ghiso","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0038","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0039","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-020-00858-6","article-title":"Vasculogenic mimicry in carcinogenesis and clinical applications","volume":"13","author":"Luo","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.965277","article-title":"Tumor vessel co-option: the past & the future","volume":"12","author":"Cuypers","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0041","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.1158\/0008-5472.CAN-06-1010","article-title":"Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor","volume":"66","author":"Bao","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0042","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.2174\/1381612819666131125153536","article-title":"Tumor dormancy and the angiogenic switch: possible implications of bone marrow-derived cells","volume":"20","author":"Shaked","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neo.2026.101306_bib0043","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1172\/JCI58128","article-title":"Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice","volume":"122","author":"Panigrahy","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neo.2026.101306_bib0044","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/jnci\/djj068","article-title":"A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype","volume":"98","author":"Naumov","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.neo.2026.101306_bib0045","first-page":"364","article-title":"Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis","volume":"7","author":"Guo","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.neo.2026.101306_bib0046","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-06119-x","article-title":"Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications","volume":"14","author":"Fang","year":"2023","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.neo.2026.101306_bib0047","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041331","article-title":"Dormancy in breast cancer","volume":"13","author":"Dalla","year":"2023","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0048","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.canlet.2018.06.002","article-title":"Does metronomic chemotherapy induce tumor angiogenic dormancy? A review of available preclinical and clinical data","volume":"432","author":"Natale","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0049","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/modpathol.3800767","article-title":"Prognostic significance of angiogenesis in gastrointestinal stromal tumor","volume":"20","author":"Imamura","year":"2007","journal-title":"Modern Pathol."},{"key":"10.1016\/j.neo.2026.101306_bib0050","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1158\/1078-0432.CCR-07-0895","article-title":"Association of intratumoral vascular endothelial growth factor expression and clinical outcome for patients with gastrointestinal stromal tumors treated with imatinib mesylate","volume":"13","author":"McAuliffe","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/biom11020130","article-title":"Minimal residual disease, metastasis and immunity","volume":"11","author":"Badia-Ramentol","year":"2021","journal-title":"Biomolecules."},{"key":"10.1016\/j.neo.2026.101306_bib0052","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrc3793","article-title":"Mechanisms of disseminated cancer cell dormancy: an awakening field","volume":"14","author":"Sosa","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0053","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM200302063480620","article-title":"Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery","volume":"348","author":"MacKie","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2021.10092","article-title":"Donor-transmitted cancer in orthotopic solid organ transplant recipients: a systematic review","volume":"35","author":"Greenhall","year":"2022","journal-title":"Transpl. Int."},{"key":"10.1016\/j.neo.2026.101306_bib0055","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1111\/ajt.14766","article-title":"Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients","volume":"18","author":"Matser","year":"2018","journal-title":"Am. J. TransPlant"},{"key":"10.1016\/j.neo.2026.101306_bib0056","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41581-018-0022-6","article-title":"Cancer in kidney transplant recipients","volume":"14","author":"Au","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.neo.2026.101306_bib0057","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI42002","article-title":"Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma","volume":"120","author":"Eyles","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neo.2026.101306_bib0058","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.4049\/jimmunol.162.5.2842","article-title":"Cancer dormancy.: VII.: A regulatory role for CD8<SUP>+<\/SUP>T cells and IFN-\u03b3 in establishing and maintaining the tumor-dormant state","volume":"162","author":"Farrar","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.neo.2026.101306_bib0059","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-56347-2","article-title":"Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche","volume":"16","author":"Mondal","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101306_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21045-2","article-title":"CD39<SUP>+<\/SUP>PD-1<SUP>+<\/SUP>CD8<SUP>+<\/SUP>T cells mediate metastatic dormancy in breast cancer","volume":"12","author":"Tall\u00f3n de Lara","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101306_bib0061","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ccr.2008.04.001","article-title":"TNFR1 signaling and IFN-\u03b3 signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis","volume":"13","author":"M\u00fcller-Hermelink","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0062","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1158\/0008-5472.CAN-13-2084","article-title":"T lymphocytes restrain spontaneous metastases in permanent dormancy","volume":"74","author":"Romero","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0063","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2013.07.038","article-title":"Immune microenvironment profiles of tumor immune equilibrium and immune escape states of mouse sarcoma","volume":"340","author":"Wu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0064","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.ccell.2025.05.014","article-title":"Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models","volume":"43","author":"Vitiello","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0065","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-021-03614-z","article-title":"Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy","volume":"594","author":"Correia","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0066","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-025-03394-8","article-title":"Reprogramming the breast tumor immune microenvironment: cold-to-hot transition for enhanced immunotherapy","volume":"44","author":"Imani","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.06.007","article-title":"Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps","author":"He","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0068","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nm.2438","article-title":"Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of ido","volume":"17","author":"Balachandran","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0069","article-title":"Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution","volume":"15","author":"Liu","year":"2024","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.neo.2026.101306_bib0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-023-01770-6","article-title":"Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers","volume":"22","author":"Li","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0071","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.trecan.2024.10.005","article-title":"Metabolic landscape of disseminated cancer dormancy","volume":"11","author":"Drapela","year":"2025","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0072","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.semcancer.2021.02.004","article-title":"Disseminated cancer cells in breast cancer: mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities","volume":"78","author":"Ramamoorthi","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0073","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-021-01883-2","article-title":"Fibroblasts in cancer dormancy: foe or friend?","volume":"21","author":"Dai","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.neo.2026.101306_bib0074","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094862","article-title":"Tumor dormancy: implications for invasion and metastasis","volume":"22","author":"Gomatou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neo.2026.101306_bib0075","first-page":"320","article-title":"Slow degrading Mg-based materials induce tumor cell dormancy on an osteosarcoma-fibroblast coculture model","volume":"16","author":"Globig","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.neo.2026.101306_bib0076","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1158\/0008-5472.CAN-08-3820","article-title":"Computational identification of a p38<SUP>SAPK<\/SUP>-regulated transcription factor network required for tumor cell quiescence","volume":"69","author":"Adam","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0077","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1158\/1078-0432.CCR-10-2574","article-title":"ERK1\/2 and p38\u03b1\/\u03b2 signaling in tumor cell quiescence: opportunities to control dormant residual disease","volume":"17","author":"Sosa","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0078","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125138","article-title":"Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells","volume":"4","author":"Shimizu","year":"2019","journal-title":"JCI. Insight."},{"key":"10.1016\/j.neo.2026.101306_bib0079","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s10120-019-00950-y","article-title":"The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors","volume":"22","author":"Koga","year":"2019","journal-title":"Gastric. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcancer.2019.07.027","article-title":"Cell-intrinsic survival signals. The role of autophagy in metastatic dissemination and tumor cell dormancy","volume":"60","author":"Vera-Ramirez","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0081","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-024-01878-7","article-title":"Autophagy is required for mammary tumor recurrence by promoting dormant tumor cell survival following therapy","volume":"26","author":"Dwyer","year":"2024","journal-title":"Breast. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0082","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04070-6","article-title":"Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence","volume":"9","author":"Vera-Ramirez","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101306_bib0083","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.semcancer.2021.06.004","article-title":"Cellular stress responses and metabolic reprogramming in cancer progression and dormancy","volume":"78","author":"Payne","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101868","article-title":"Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922\/DEC2 axis","volume":"40","author":"Dai","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-020-01285-4","article-title":"CSN8 is a key regulator in hypoxia-induced epithelial-mesenchymal transition and dormancy of colorectal cancer cells","volume":"19","author":"Ju","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0086","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.canlet.2020.06.004","article-title":"Hypoxia in bone metastasis and osteolysis","volume":"489","author":"Todd","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0087","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2020.05.026","article-title":"Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy","volume":"488","author":"Ferrer","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neo.2026.101306_bib0088","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jare.2024.05.031","article-title":"Unlocking the crucial role of cancer-associated fibroblasts in tumor metastasis: mechanisms and therapeutic prospects","volume":"71","author":"Liu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.neo.2026.101306_bib0089","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.cell.2023.03.016","article-title":"Fibroblasts in cancer: unity in heterogeneity","volume":"186","author":"Chhabra","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0090","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.cell.2022.03.033","article-title":"Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche","volume":"185","author":"Baldominos","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0091","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/cam4.707","article-title":"Dermal fibroblasts induce cell cycle arrest and block epithelial-mesenchymal transition to inhibit the early stage melanoma development","volume":"5","author":"Zhou","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.neo.2026.101306_bib0092","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1038\/s41388-021-01685-w","article-title":"Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis","volume":"40","author":"Yoon","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101306_bib0093","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1158\/0008-5472.CAN-25-1404","article-title":"Cancer-associated fibroblasts promote imatinib resistance in gastrointestinal stromal tumors through PGK1-mediated metabolic reprogramming","volume":"86","author":"Li","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0094","article-title":"Cancer-associated fibroblasts-derived CXCL1 activates DEC2-mediated dormancy in oral squamous cell carcinoma","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon."},{"key":"10.1016\/j.neo.2026.101306_bib0095","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1158\/0008-5472.CAN-22-2034","article-title":"Collagens in cancer: structural regulators and guardians of cancer progression","volume":"83","author":"De Martino","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0096","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10555-023-10094-2","article-title":"Regulation of dormancy during tumor dissemination: the role of the ECM","volume":"42","author":"Mukherjee","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.neo.2026.101306_bib0097","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41568-024-00737-z","article-title":"Cancer drug-tolerant persister cells: from biological questions to clinical opportunities","volume":"24","author":"Russo","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0098","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrc3910","article-title":"Metastasis prevention by targeting the dormant niche","volume":"15","author":"Ghajar","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0099","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-022-01252-0","article-title":"Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcancer.2021.07.011","article-title":"Neutrophil extracellular traps in cancer","volume":"79","author":"Cristinziano","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0101","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41568-025-00888-7","article-title":"Neutrophil extracellular traps in cancer","volume":"26","author":"Shahzad","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0102","article-title":"Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling","volume":"8","author":"Li","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0103","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.trecan.2023.06.010","article-title":"Perivascular niches: critical hubs in cancer evolution","volume":"9","author":"Nowosad","year":"2023","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s43018-021-00297-3","article-title":"Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain","volume":"3","author":"Dai","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0105","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.trecan.2023.06.002","article-title":"Collagen architecture and signaling orchestrate cancer development","volume":"9","author":"Su","year":"2023","journal-title":"Trends. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108330","article-title":"Collagen remodeling-mediated signaling pathways and their impact on tumor therapy","volume":"301","author":"Yuan","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neo.2026.101306_bib0107","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature02330","article-title":"Control of the SCF<SUP>Skp2-Cks1<\/SUP>ubiquitin ligase by the APC\/C<SUP>Cdh1<\/SUP>ubiquitin ligase","volume":"428","author":"Bashir","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0108","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1535-6108(04)00091-1","article-title":"Crashing waves of destruction:: the cell cycle and APC<SUP>Cdh1<\/SUP>regulation of SCF<SUP>Skp2<\/SUP>","volume":"5","author":"Kurland","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0109","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ncb1847","article-title":"Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC-Cdh1-mediated Skp2 destruction","volume":"11","author":"Gao","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/12027","article-title":"p45<SUP>SKP2<\/SUP>promotes p27<SUP>Kip1<\/SUP>degradation and induces S phase in quiescent cells","volume":"1","author":"Sutterl\u00fcty","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0111","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.stem.2011.07.003","article-title":"p57<SUP>KiP2<\/SUP>and p27<SUP>Kip1<\/SUP>cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70","volume":"9","author":"Zou","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0112","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.stem.2011.06.014","article-title":"p57 Is required for quiescence and maintenance of adult hematopoietic stem cells","volume":"9","author":"Matsumoto","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0113","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1044-579X(02)00098-6","article-title":"Deregulated degradation of the cdk inhibitor p27 and malignant transformation","volume":"13","author":"Bloom","year":"2003","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0114","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1182\/blood.V100.8.2950","article-title":"Expression of Skp2, a p27<SUP>Kip1<\/SUP>ubliquitin ligase, in malignant lymphoma: correlation with p27<SUP>Kip1<\/SUP>and proliferation index","volume":"100","author":"Lim","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.neo.2026.101306_bib0115","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1182\/blood-2007-09-112904","article-title":"Targeting the p27 E3 ligase SCF<SUP>Skp2<\/SUP>results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy","volume":"111","author":"Chen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.neo.2026.101306_bib0116","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ccr.2013.09.021","article-title":"Skp2Deletion Unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors","volume":"24","author":"Zhao","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0117","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccell.2017.04.004","article-title":"Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2","volume":"31","author":"Zhang","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0118","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1158\/0008-5472.CAN-13-0579","article-title":"The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis","volume":"73","author":"Boichuk","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0119","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: i have a DREAM","volume":"25","author":"Engeland","year":"2018","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.neo.2026.101306_bib0120","series-title":"DREAM On: Cell Cycle Control in Development and Disease","first-page":"309","volume":"55","author":"Walston","year":"2021"},{"key":"10.1016\/j.neo.2026.101306_bib0121","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.tibs.2022.06.007","article-title":"Coordinating gene expression during the cell cycle","volume":"47","author":"Fischer","year":"2022","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/j.neo.2026.101306_bib0122","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41422-020-0372-z","article-title":"Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle","volume":"31","author":"Liu","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.neo.2026.101306_bib0123","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tcb.2023.05.012","article-title":"The bidirectional relationship between metabolism and cell cycle control","volume":"34","author":"Diehl","year":"2024","journal-title":"Trends. Cell Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0124","series-title":"Proc Natl Acad Sci U S A","first-page":"6706","article-title":"Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase","volume":"100","author":"Sommer","year":"2003"},{"key":"10.1016\/j.neo.2026.101306_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101226","article-title":"Targeting TRAP1-dependent metabolic reprogramming to overcome doxorubicin resistance in quiescent breast cancer","volume":"81","author":"Saleem","year":"2025","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.neo.2026.101306_bib0126","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1038\/onc.2015.370","article-title":"Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics","volume":"35","author":"Wang","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101306_bib0127","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nature09409","article-title":"ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours","volume":"467","author":"Chi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0128","article-title":"Stem-cell states converge in multistage cutaneous squamous cell carcinoma development","volume":"384","author":"Taylor","year":"2024","journal-title":"Science (1979)"},{"key":"10.1016\/j.neo.2026.101306_bib0129","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.semcancer.2010.05.006","article-title":"The stem cell niche in health and malignancy","volume":"20","author":"Burness","year":"2010","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0130","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0131","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1158\/0008-5472.CAN-06-3126","article-title":"Cancer stem cells\u2013perspectives on current status and future directions: AACR Workshop on cancer stem cells","volume":"66","author":"Clarke","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0132","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0133","series-title":"Proc Natl Acad Sci U S A","first-page":"6890","article-title":"Prospective identification of tumorigenic breast cancer cells (vol 100, pg 3983, 2003)","volume":"100","author":"Al-Hajj","year":"2003"},{"key":"10.1016\/j.neo.2026.101306_bib0134","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcancer.2021.03.008","article-title":"Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity","volume":"82","author":"Zhang","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0135","doi-asserted-by":"crossref","first-page":"10946","DOI":"10.1158\/0008-5472.CAN-05-2018","article-title":"Prospective identification of tumorigenic prostate cancer stem cells","volume":"65","author":"Collins","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0136","doi-asserted-by":"crossref","first-page":"67","DOI":"10.7150\/thno.16752","article-title":"CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer","volume":"7","author":"Li","year":"2017","journal-title":"Theranostics."},{"key":"10.1016\/j.neo.2026.101306_bib0137","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating cells","volume":"445","author":"Ricci-Vitiani","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0138","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1158\/0008-5472.CAN-08-0364","article-title":"Identification and characterization of ovarian cancer-initiating cells from primary human tumors","volume":"68","author":"Zhang","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0139","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","article-title":"Identification of pancreatic cancer stem cells","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0140","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/sj.cdd.4402283","article-title":"Identification and expansion of the tumorigenic lung cancer stem cell population","volume":"15","author":"Eramo","year":"2008","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.neo.2026.101306_bib0141","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107985","article-title":"Cell plasticity, senescence, and quiescence in cancer stem cells: biological and therapeutic implications","volume":"231","author":"Paul","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0142","article-title":"Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer","volume":"5","author":"Liu","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0143","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.01.018","article-title":"Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.neo.2026.101306_bib0144","article-title":"HDAC6 and USP9X control glutamine metabolism by stabilizing GS to promote glioblastoma tumorigenesis","volume":"12","author":"Kim","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.neo.2026.101306_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111903","article-title":"Cancer stem cells amino acid metabolism: roles, mechanisms, and intervention strategies","volume":"134","author":"Gong","year":"2025","journal-title":"Cell Signal."},{"key":"10.1016\/j.neo.2026.101306_bib0146","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/ijc.34967","article-title":"Metabolic characterization of sphere-derived prostate cancer stem cells reveals aberrant urea cycle in stemness maintenance","volume":"155","author":"Luo","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0147","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.semcancer.2019.09.002","article-title":"Dormant disseminated tumor cells and cancer stem\/progenitor-like cells: similarities and opportunities semin","volume":"60","author":"Hen","year":"2020","journal-title":"Cancer Biol."},{"key":"10.1016\/j.neo.2026.101306_bib0148","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41586-022-05043-y","article-title":"Cell-matrix interface regulates dormancy in human colon cancer stem cells","volume":"608","author":"Ohta","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101306_bib0149","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.stem.2024.01.003","article-title":"Metabolic regulation of the hallmarks of stem cell biology","volume":"31","author":"Jackson","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2024.12.006","article-title":"Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding","volume":"43","author":"Gao","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0151","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-024-00747-z","article-title":"Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma","volume":"11","author":"Cheng","year":"2025","journal-title":"Cell Discov."},{"key":"10.1016\/j.neo.2026.101306_bib0152","article-title":"Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression","volume":"9","author":"Peng","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0153","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gcc.20942","article-title":"CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers","volume":"51","author":"Chen","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0154","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/ajcp\/aqx028","article-title":"Epigenetic regulation of CD133in gastrointestinal stromal tumors","volume":"147","author":"Geddert","year":"2017","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.neo.2026.101306_bib0155","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1158\/1535-7163.MCT-20-0973","article-title":"KIT<SUP>low<\/SUP>cells mediate imatinib resistance in gastrointestinal stromal tumor","volume":"20","author":"Banerjee","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0156","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1158\/0008-5472.CAN-23-0082","article-title":"Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of Imatinib","volume":"83","author":"Zeng","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0157","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10120-025-01657-z","article-title":"Targeting yes-associated protein to overcome imatinib resistance in gastrointestinal stromal tumor drug-tolerant persister cells","volume":"28","author":"Yokouchi","year":"2025","journal-title":"Gastric. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0158","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tips.2018.12.004","article-title":"Targeting cancer cell dormancy","volume":"40","author":"Recasens","year":"2019","journal-title":"Trends. Pharmacol. Sci."},{"key":"10.1016\/j.neo.2026.101306_bib0159","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1607","article-title":"Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML","volume":"28","author":"Saito","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neo.2026.101306_bib0160","first-page":"904","article-title":"IFN\u03b1 activates dormant haematopoietic stem cells","volume":"458","author":"Essers","year":"2009","journal-title":"in vivoNature"},{"key":"10.1016\/j.neo.2026.101306_bib0161","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccr.2013.01.026","article-title":"Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence","volume":"23","author":"Takeishi","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0162","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1111\/jcmm.13126","article-title":"Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells","volume":"21","author":"Zhao","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0163","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/cdd.2016.39","article-title":"Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer","volume":"23","author":"Matassa","year":"2016","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.neo.2026.101306_bib0164","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1158\/0008-5472.CAN-18-3985","article-title":"Acquired resistance to HER2-targeted therapies creates vulnerability to ATP synthase inhibition","volume":"80","author":"Gale","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/jamaoncol.2017.3510","article-title":"Rethinking extended adjuvant antiestrogen therapy to increase survivorship in breast cancer","volume":"4","author":"Abderrahman","year":"2018","journal-title":"JAMa Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0166","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1200\/JCO.23.00455","article-title":"Endocrine therapy for primary and secondary prevention after diagnosis of high-risk breast lesions or preinvasive breast cancer","volume":"41","author":"Laws","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0167","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrclinonc.2016.26","article-title":"Treating cancer with selective CDK4\/6 inhibitors","volume":"13","author":"O'Leary","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0168","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/jamaoncol.2023.2000","article-title":"Cyclin-dependent kinase 4\/6 inhibitors for treatment of hormone receptor-positive, ERBB2-negative breast cancer A review","volume":"9","author":"O'Sullivan","year":"2023","journal-title":"JAMa Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0169","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1158\/1078-0432.CCR-18-3127","article-title":"Activity and safety of Palbociclib in patients with advanced gastrointestinal stromal tumors refractory to Imatinib and Sunitinib: a biomarker-driven phase II study","volume":"25","author":"Toulmonde","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0170","article-title":"An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy","volume":"219","author":"Khalil","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0171","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00262-014-1592-1","article-title":"Cancer stem cells: perspectives for therapeutic targeting","volume":"64","author":"Maccalli","year":"2015","journal-title":"Cancer Immunol. Immunther."},{"key":"10.1016\/j.neo.2026.101306_bib0172","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ejca.2013.11.014","article-title":"Immunology of cancer stem cells in solid tumours","volume":"50","author":"Maccalli","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.neo.2026.101306_bib0173","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s13238-017-0394-6","article-title":"Targeting cancer stem cells by using chimeric antigen receptor-modified T cells: a potential and curable approach for cancer treatment","volume":"9","author":"Guo","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.neo.2026.101306_bib0174","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.immuni.2023.09.010","article-title":"Synthetic manipulation of the cancer- immunity cycle: CAR-T cell therapy","volume":"56","author":"Singh","year":"2023","journal-title":"Immunity."},{"key":"10.1016\/j.neo.2026.101306_bib0175","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/mt.2014.164","article-title":"Treatment of CD33-directed chimeric antigen receptor-modified T cells in one patient with relapsed and refractory acute myeloid leukemia","volume":"23","author":"Wang","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.neo.2026.101306_bib0176","article-title":"A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma","volume":"9","author":"O'Rourke","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0177","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/JTO.0000000000000563","article-title":"Combination treatment with all-trans retinoic acid prevents cisplatin-induced enrichment of CD133<SUP>+<\/SUP>tumor-initiating cells and reveals heterogeneity of cancer stem cell compartment in lung cancer","volume":"10","author":"Moro","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.neo.2026.101306_bib0178","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-016-1088-y","article-title":"All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy","volume":"16","author":"Yan","year":"2016","journal-title":"BMC. Complement. Altern. Med."},{"key":"10.1016\/j.neo.2026.101306_bib0179","doi-asserted-by":"crossref","DOI":"10.1186\/1756-9966-29-113","article-title":"Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells","volume":"29","author":"Niu","year":"2010","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101306_bib0180","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-023-01877-w","article-title":"Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer","volume":"22","author":"Zeng","year":"2023","journal-title":"Mol. Cancer"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:31:06Z","timestamp":1776814266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558626000357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":180,"alternative-id":["S1476558626000357"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2026.101306","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting tumor dormancy: the next frontier in gastrointestinal stromal tumor therapy","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2026.101306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101306"}}