{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:12:09Z","timestamp":1787731929632,"version":"build-2784847793"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017453","name":"Institute for Prostate Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"DOD","doi-asserted-by":"publisher","award":["PC230420"],"award-info":[{"award-number":["PC230420"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA266452"],"award-info":[{"award-number":["R01CA266452"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA282005"],"award-info":[{"award-number":["R01CA282005"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["P01CA163227"],"award-info":[{"award-number":["P01CA163227"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["P01CA298991"],"award-info":[{"award-number":["P01CA298991"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA291986"],"award-info":[{"award-number":["R01CA291986"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R50CA274336"],"award-info":[{"award-number":["R50CA274336"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.neo.2026.101321","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:51:44Z","timestamp":1780109504000},"page":"101321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer"],"prefix":"10.1016","volume":"78","author":[{"given":"Lisha G.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilsa M.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8386-1785","authenticated-orcid":false,"given":"Tony L.H.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-5683","authenticated-orcid":false,"given":"Erolcan","family":"Sayar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-649X","authenticated-orcid":false,"given":"Brian","family":"Hanratty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-644X","authenticated-orcid":false,"given":"Mohamed","family":"Adil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-8089","authenticated-orcid":false,"given":"Holly M.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3810-4099","authenticated-orcid":false,"given":"Conner J.","family":"Sessions","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8421-6168","authenticated-orcid":false,"given":"Erin L.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-0166","authenticated-orcid":false,"given":"Joshi J.","family":"Alumkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui M. Gil","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-8591","authenticated-orcid":false,"given":"Yuzhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence D.","family":"True","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-6551","authenticated-orcid":false,"given":"Ruth","family":"Dumpit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Haffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-5333","authenticated-orcid":false,"given":"Colm","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2026.101321_bib0001","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1172\/JCI128212","article-title":"Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer","volume":"129","author":"Labrecque","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neo.2026.101321_bib0002","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1158\/0008-5472.CAN-21-0307","article-title":"RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate Cancer","volume":"81","author":"Labrecque","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101321_bib0003","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1038\/s41467-022-29963-5","article-title":"ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer","volume":"13","author":"Nouruzi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0004","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.eururo.2006.11.030","article-title":"NeuroD1 expression in human prostate cancer: can it contribute to neuroendocrine differentiation comprehension?","volume":"52","author":"Cindolo","year":"2007","journal-title":"Eur. Urol."},{"key":"10.1016\/j.neo.2026.101321_bib0005","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1038\/s41467-021-26042-z","article-title":"Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer","volume":"12","author":"Cejas","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0006","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/path.5781","article-title":"Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer","volume":"255","author":"Asrani","year":"2021","journal-title":"J. Pathol."},{"key":"10.1016\/j.neo.2026.101321_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10112834","article-title":"Emerging Role of YAP and the Hippo Pathway in Prostate Cancer","volume":"10","author":"Koinis","year":"2022","journal-title":"Biomedicines."},{"key":"10.1016\/j.neo.2026.101321_bib0008","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ydbio.2020.12.018","article-title":"YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance","volume":"475","author":"Szulzewsky","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neo.2026.101321_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2021.06.016","article-title":"Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP\/TEAD activity","volume":"39","author":"Pearson","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101321_bib0010","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1038\/s41467-021-23395-3","article-title":"Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues","volume":"12","author":"Kastan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0011","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41391-020-0229-z","article-title":"The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer","volume":"23","author":"Cheng","year":"2020","journal-title":"Prostate Cancer Prostatic. Dis."},{"key":"10.1016\/j.neo.2026.101321_bib0012","doi-asserted-by":"crossref","first-page":"8658","DOI":"10.1093\/nar\/gkac509","article-title":"RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling","volume":"50","author":"Choi","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.neo.2026.101321_bib0013","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.18632\/oncotarget.2809","article-title":"Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget."},{"key":"10.1016\/j.neo.2026.101321_bib0014","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1802354115","article-title":"Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.neo.2026.101321_bib0015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC. Bioinformatics."},{"key":"10.1016\/j.neo.2026.101321_bib0016","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.neo.2026.101321_bib0017","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.90","article-title":"Gene Set Knowledge Discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.neo.2026.101321_bib0018","first-page":"25","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"The Gene Ontology Consortium. Nat Genet"},{"key":"10.1016\/j.neo.2026.101321_bib0019","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Aleksander","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.neo.2026.101321_bib0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/path.6216","article-title":"Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer","volume":"262","author":"Patel","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.neo.2026.101321_bib0021","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics."},{"key":"10.1016\/j.neo.2026.101321_bib0022","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41588-020-0648-8","article-title":"The DNA methylation landscape of advanced prostate cancer","volume":"52","author":"Zhao","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neo.2026.101321_bib0023","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.neo.2026.101321_bib0024","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1186\/gb-2012-13-6-r44","article-title":"SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips","volume":"13","author":"Maksimovic","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.neo.2026.101321_bib0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neo.2026.101321_bib0026","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1038\/s41467-018-04619-5","article-title":"A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes","volume":"9","author":"Papachristou","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0027","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nprot.2016.020","article-title":"Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes","volume":"11","author":"Mohammed","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neo.2026.101321_bib0028","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1073\/pnas.0602567103","article-title":"Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor","volume":"103","author":"Xin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. u S. a"},{"key":"10.1016\/j.neo.2026.101321_bib0029","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ccell.2015.05.005","article-title":"ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors","volume":"27","author":"Nguyen","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101321_bib0030","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.celrep.2015.07.012","article-title":"The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer","volume":"12","author":"Akamatsu","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.neo.2026.101321_bib0031","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13148-015-0074-4","article-title":"Polycomb-mediated silencing in neuroendocrine prostate cancer","volume":"7","author":"Clermont","year":"2015","journal-title":"Clin. Epigenetics."},{"key":"10.1016\/j.neo.2026.101321_bib0032","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1172\/JCI127961","article-title":"N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer","volume":"129","author":"Berger","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neo.2026.101321_bib0033","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167440","article-title":"LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function","volume":"8","author":"Kumaraswamy","year":"2023","journal-title":"JCI. Insight."},{"key":"10.1016\/j.neo.2026.101321_bib0034","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41588-024-01826-3","article-title":"Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer","volume":"56","author":"Zhao","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neo.2026.101321_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.01.020","article-title":"Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly","volume":"97","author":"Jacko","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neo.2026.101321_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154646","article-title":"SLC7A11 promotes the progression of gastric cancer and regulates ferroptosis through PI3K\/AKT pathway","volume":"248","author":"Jiang","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.neo.2026.101321_bib0037","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/CEJ.0000000000000789","article-title":"RBFOX2 confers tumor growth by PI3K\/AKT and MAPK signaling in gastric cancer","volume":"32","author":"Xie","year":"2023","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.neo.2026.101321_bib0038","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/pmic.201000419","article-title":"Landscape of the SOX2 protein-protein interactome","volume":"11","author":"Fang","year":"2011","journal-title":"Proteomics."},{"key":"10.1016\/j.neo.2026.101321_bib0039","first-page":"84","article-title":"SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer","volume":"355","author":"Mu","year":"2017","journal-title":"Science (1979)"},{"key":"10.1016\/j.neo.2026.101321_bib0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/pcan.2014.29","article-title":"SOX2 expression in the developing, adult, as well as, diseased prostate","volume":"17","author":"Yu","year":"2014","journal-title":"Prostate Cancer Prostatic. Dis."},{"key":"10.1016\/j.neo.2026.101321_bib0041","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1093\/nar\/gkab595","article-title":"RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners","volume":"49","author":"Zhou","year":"2021","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.neo.2026.101321_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2017.09.003","article-title":"Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling","volume":"32","author":"Bluemn","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101321_bib0043","article-title":"Extracellular matrix regulates lineage plasticity in prostate cancer through YAP\/TEAD","author":"Han","year":"2025","journal-title":"bioRxiv."},{"key":"10.1016\/j.neo.2026.101321_bib0044","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/ncb3160","article-title":"TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors","volume":"17","author":"Cebola","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neo.2026.101321_bib0045","doi-asserted-by":"crossref","first-page":"12723","DOI":"10.1093\/nar\/gkac1063","article-title":"TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism","volume":"50","author":"Li","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.neo.2026.101321_bib0046","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/cdd.2017.99","article-title":"The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway","volume":"24","author":"Furth","year":"2017","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.neo.2026.101321_bib0047","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1038\/onc.2009.270","article-title":"Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation","volume":"28","author":"Aylon","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101321_bib0048","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1101\/gad.1447006","article-title":"A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization","volume":"20","author":"Aylon","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.neo.2026.101321_bib0049","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1158\/1078-0432.CCR-18-0729","article-title":"Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer","volume":"25","author":"Flores-Morales","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101321_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107669","article-title":"Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress","volume":"31","author":"Nyquist","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neo.2026.101321_bib0051","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yexcr.2004.04.031","article-title":"Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)","volume":"298","author":"Ke","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.neo.2026.101321_bib0052","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1158\/1078-0432.CCR-19-0775","article-title":"Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer","volume":"26","author":"Corella","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101321_bib0053","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/5960","article-title":"Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity","volume":"21","author":"Tao","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neo.2026.101321_bib0054","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/sj.onc.1205174","article-title":"LATS1 tumor suppressor regulates G2\/M transition and apoptosis","volume":"21","author":"Xia","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101321_bib0055","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102230","article-title":"TAZ Represses the Neuronal Commitment of Neural Stem Cells","volume":"9","author":"Robledinos-Ant\u00f3n","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neo.2026.101321_bib0056","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.neo.2026.101321_bib0057","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ncb3216","article-title":"Genome-wide association between YAP\/TAZ\/TEAD and AP-1 at enhancers drives oncogenic growth","volume":"17","author":"Zanconato","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neo.2026.101321_bib0058","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1038\/s41467-018-06258-2","article-title":"Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma","volume":"9","author":"Tome-Garcia","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0059","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1038\/ncomms7683","article-title":"Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state","volume":"6","author":"Verfaillie","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101321_bib0060","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biopha.2017.08.091","article-title":"YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis","volume":"95","author":"Lin","year":"2017","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.neo.2026.101321_bib0061","doi-asserted-by":"crossref","DOI":"10.1530\/EC-24-0097","article-title":"SLC7A11 promotes EMT and metastasis in invasive pituitary neuroendocrine tumors by activating the PI3K\/AKT signaling pathway","volume":"13","author":"Gui","year":"2024","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.neo.2026.101321_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165747","article-title":"MiR-139-5p\/SLC7A11 inhibits the proliferation, invasion and metastasis of pancreatic carcinoma via PI3K\/Akt signaling pathway","volume":"1866","author":"Zhu","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"10.1016\/j.neo.2026.101321_bib0063","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s12964-025-02447-x","article-title":"SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment","volume":"23","author":"Qiu","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.neo.2026.101321_bib0064","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-025-07809-4","article-title":"SLC7A11 upregulation via AR and NEDD4L ubiquitination contributes to ferroptosis inhibition and enzalutamide resistance in castration-resistant prostate cancer","volume":"16","author":"Tang","year":"2025","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.neo.2026.101321_bib0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/0113816128289372240105041038","article-title":"Artesunate inhibits the growth of insulinoma cells","volume":"30","author":"Chen","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neo.2026.101321_bib0066","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1038\/s41598-017-06227-7","article-title":"VGLL4 selectively represses YAP-dependent gene induction and tumorigenic phenotypes in breast cancer","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neo.2026.101321_bib0067","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00401-025-02845-y","article-title":"Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription","volume":"149","author":"Pagani","year":"2025","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neo.2026.101321_bib0068","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1158\/1541-7786.MCR-09-0229","article-title":"Emerging roles of the EBF family of transcription factors in tumor suppression","volume":"7","author":"Liao","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.neo.2026.101321_bib0069","article-title":"LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer","author":"Mandl","year":"2024","journal-title":"bioRxiv."},{"key":"10.1016\/j.neo.2026.101321_bib0070","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1038\/s41467-025-57478-2","article-title":"Structural insights into a highly flexible zinc finger module unravel INSM1 function in transcription regulation","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat. Commun."}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:57:27Z","timestamp":1783195047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558626000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":70,"alternative-id":["S1476558626000515"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2026.101321","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2026.101321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101321"}}