{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:24:26Z","timestamp":1786994666885,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.neo.2026.101331","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:29:41Z","timestamp":1782404981000},"page":"101331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Heterogeneous SPP1-expressing esophageal cancer cells license immunotherapy resistance by organizing an immunosuppressive niche"],"prefix":"10.1016","volume":"79","author":[{"given":"Jiakang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1475-9483","authenticated-orcid":false,"given":"Jie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-3377","authenticated-orcid":false,"given":"Yusheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neo.2026.101331_bib0001","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41388-021-02122-8","article-title":"GTF2E2 is a novel biomarker for recurrence after surgery and promotes progression of esophageal squamous cell carcinoma via miR-139-5p\/GTF2E2\/FUS axis","volume":"41","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101331_bib0002","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.neo.2026.101331_bib0003","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70604","article-title":"Macrophage infiltration and ITGB2 expression in ESCC: a novel correlation","volume":"14","author":"Huang","year":"2025","journal-title":"Cancer Med."},{"key":"10.1016\/j.neo.2026.101331_bib0004","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40164-024-00587-3","article-title":"Identification of a novel subtype of SPP1 + macrophages expressing SIRPalpha: implications for tumor immune evasion and treatment response prediction","volume":"13","author":"Chen","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.neo.2026.101331_bib0005","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41420-024-02019-x","article-title":"Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy","volume":"10","author":"Shi","year":"2024","journal-title":"Cell Death. Discov."},{"key":"10.1016\/j.neo.2026.101331_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204890","article-title":"Triple-combination immunogenic nanovesicles reshape the tumor microenvironment to potentiate chemo-immunotherapy in preclinical cancer models","volume":"10","author":"Shi","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.neo.2026.101331_bib0007","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13073-024-01320-9","article-title":"Single-cell profiling of response to neoadjuvant chemo-immunotherapy in surgically resectable esophageal squamous cell carcinoma","volume":"16","author":"Ji","year":"2024","journal-title":"Genom. Med."},{"key":"10.1016\/j.neo.2026.101331_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104281","article-title":"Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in esophageal squamous cell carcinoma","volume":"84","author":"Guo","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neo.2026.101331_bib0009","doi-asserted-by":"crossref","first-page":"9097","DOI":"10.1038\/s41467-024-52977-0","article-title":"Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101331_bib0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40164-024-00539-x","article-title":"Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside","volume":"13","author":"Yin","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.neo.2026.101331_bib0011","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12943-023-01898-5","article-title":"Extracellular vesicles remodel tumor environment for cancer immunotherapy","volume":"22","author":"Yue","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0012","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41568-024-00761-z","article-title":"Convergent inducers and effectors of T cell paralysis in the tumour microenvironment","volume":"25","author":"Hanahan","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0013","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1097\/CM9.0000000000002525","article-title":"Tumor immune microenvironment-modulated nanostrategy for the treatment of lung cancer metastasis","volume":"136","author":"Zhu","year":"2023","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.neo.2026.101331_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202309094","article-title":"A PD-L1-targeting regulator for metabolic reprogramming to enhance glutamine inhibition-mediated synergistic antitumor metabolic and immune therapy","volume":"36","author":"Jin","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.neo.2026.101331_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-025-01678-2","article-title":"Anti-TGF-beta\/PD-L1 bispecific antibody synergizes with radiotherapy to enhance antitumor immunity and mitigate radiation-induced pulmonary fibrosis","volume":"18","author":"Wu","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.neo.2026.101331_bib0016","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccell.2023.01.009","article-title":"Metabolic programming and immune suppression in the tumor microenvironment","volume":"41","author":"Arner","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0017","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41586-024-08290-3","article-title":"Evolution of myeloid-mediated immunotherapy resistance in prostate cancer","volume":"637","author":"Lyu","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101331_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-011319","article-title":"Malevolent alliance of MYBL2(hi) cancer stem cell and SPP1+ macrophage confers resistance to neoadjuvant immunotherapy in bladder cancer","volume":"13","author":"Chen","year":"2025","journal-title":"J. ImmunOther Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0019","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1158\/0008-5472.CAN-22-2593","article-title":"Intratumoral microbiota composition regulates chemoimmunotherapy response in esophageal squamous cell carcinoma","volume":"83","author":"Wu","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.neo.2026.101331_bib0020","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12885-015-1065-8","article-title":"The role of HGF\/MET and FGF\/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma","volume":"15","author":"Saito","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0021","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004832","article-title":"Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance","volume":"10","author":"Cheng","year":"2022","journal-title":"J. ImmunOther Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0022","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1136\/gutjnl-2013-305806","article-title":"LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma","volume":"63","author":"Li","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.neo.2026.101331_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103510","article-title":"Transcriptomics based multi-dimensional characterization and drug screen in esophageal squamous cell carcinoma","volume":"70","author":"Li","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neo.2026.101331_bib0024","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.ccell.2023.09.011","article-title":"Progenitor-like exhausted SPRY1(+)CD8(+) T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma","volume":"41","author":"Liu","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0025","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0026","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neo.2026.101331_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2023.06.005","article-title":"Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression","volume":"41","author":"Wang","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0028","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.neo.2026.101331_bib0029","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13059-023-02988-9","article-title":"scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics","volume":"24","author":"Li","year":"2023","journal-title":"Genom. Biol."},{"key":"10.1016\/j.neo.2026.101331_bib0030","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neo.2026.101331_bib0031","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101331_bib0032","article-title":"hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data","volume":"3","author":"Morabito","year":"2023","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.neo.2026.101331_bib0033","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.neo.2026.101331_bib0034","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.csbj.2022.11.055","article-title":"scDrug: from single-cell RNA-seq to drug response prediction","volume":"21","author":"Hsieh","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.neo.2026.101331_bib0035","doi-asserted-by":"crossref","first-page":"W159-W164","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.neo.2026.101331_bib0036","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2023.01.011","article-title":"Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy","volume":"78","author":"Liu","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.neo.2026.101331_bib0037","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1038\/s41467-021-25202-5","article-title":"Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neo.2026.101331_bib0038","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.21037\/atm-21-4544","article-title":"Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy","volume":"9","author":"Shen","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.neo.2026.101331_bib0039","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.immuni.2019.08.004","article-title":"The Immune Landscape of cancer","volume":"51","author":"Thorsson","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.neo.2026.101331_bib0040","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.231","article-title":"TCellSI: a novel method for T cell state assessment and its applications in immune environment prediction","volume":"3","author":"Yang","year":"2024","journal-title":"Imeta"},{"key":"10.1016\/j.neo.2026.101331_bib0041","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1186\/s12967-024-06018-5","article-title":"Single-cell and spatial transcriptomics reveal SPP1-CD44 signaling drives primary resistance to immune checkpoint inhibitors in RCC","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.neo.2026.101331_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114906","article-title":"Targeting SPP1(+) macrophages via the SPP1-CD44 axis reveals a key mechanism of immune suppression and tumor progression in ovarian cancer","volume":"160","author":"Hou","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neo.2026.101331_bib0043","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005020","article-title":"Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy","volume":"10","author":"Liu","year":"2022","journal-title":"J. ImmunOther Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0044","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2018.05.060","article-title":"Single-cell map of diverse immune phenotypes in the breast tumor microenvironment","volume":"174","author":"Azizi","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0045","article-title":"SPP1 (+) macrophages in colorectal cancer: markers of malignancy and promising therapeutic targets","volume":"12","author":"Xie","year":"2025","journal-title":"Genes. Dis."},{"key":"10.1016\/j.neo.2026.101331_bib0046","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-025-09574-y","article-title":"SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer","volume":"648","author":"Li","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101331_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.01.007","article-title":"Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer","volume":"43","author":"Zhang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neo.2026.101331_bib0048","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41421-023-00563-x","article-title":"Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma","volume":"9","author":"He","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.neo.2026.101331_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120012","article-title":"Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K\/Akt1\/mTOR axis","volume":"246","author":"Duan","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.neo.2026.101331_bib0050","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/s41388-025-03359-3","article-title":"Fibroblast Activation protein (FAP)(+) cancer-associated fibroblasts induce macrophage M2-like polarization via the Fibronectin 1-integrin alpha5beta1 axis in breast cancer","volume":"44","author":"Chen","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.neo.2026.101331_bib0051","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/cac2.70016","article-title":"Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages","volume":"45","author":"Zhao","year":"2025","journal-title":"Cancer Commun."},{"key":"10.1016\/j.neo.2026.101331_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113944","article-title":"SPP1-mediated M2 macrophage polarization shapes the tumor microenvironment and enhances prognosis and immunotherapy guidance in nasopharyngeal carcinoma","volume":"147","author":"Huang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neo.2026.101331_bib0053","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.3390\/cancers12113379","article-title":"Osteopontin: a key regulator of tumor progression and immunomodulation","volume":"12","author":"Moorman","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.neo.2026.101331_bib0054","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41419-018-0391-6","article-title":"The role of osteopontin in the progression of solid organ tumour","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.neo.2026.101331_bib0055","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12964-023-01264-4","article-title":"Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.neo.2026.101331_bib0056","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1158\/1078-0432.CCR-18-4085","article-title":"The immune subtypes and landscape of squamous cell carcinoma","volume":"25","author":"Li","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neo.2026.101331_bib0057","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neo.2026.101331_bib0058","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41416-024-02683-x","article-title":"SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration","volume":"130","author":"Wang","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.neo.2026.101331_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.114127","article-title":"CCL19-armed recombinant influenza virus inhibited colorectal cancer growth by remodeling tumor microenvironment","volume":"28","author":"Ou","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.neo.2026.101331_bib0060","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ctrv.2010.02.015","article-title":"Dasatinib: a potent SRC inhibitor in clinical development for the treatment of solid tumors","volume":"36","author":"Araujo","year":"2010","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.neo.2026.101331_bib0061","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303513121","article-title":"Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts","volume":"121","author":"Nelson","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neo.2026.101331_bib0062","article-title":"A bilayer feature fusion framework for pan-cancer survival prediction based on multihead attention and adaptive differential privacy: model development and validation study","volume":"14","author":"Chen","year":"2026","journal-title":"JMIR Med. Inf."}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558626000618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:10:05Z","timestamp":1785222605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558626000618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":62,"alternative-id":["S1476558626000618"],"URL":"https:\/\/doi.org\/10.1016\/j.neo.2026.101331","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heterogeneous SPP1-expressing esophageal cancer cells license immunotherapy resistance by organizing an immunosuppressive niche","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neo.2026.101331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101331"}}