{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:32:09Z","timestamp":1761647529520,"version":"3.38.0"},"reference-count":61,"publisher":"JLE","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N\u00e9phrologie &amp; Th\u00e9rapeutique"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.nephro.2007.07.006","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T09:58:56Z","timestamp":1193392736000},"page":"34-40","source":"Crossref","is-referenced-by-count":7,"title":["Syndrome h\u00e9molytique et ur\u00e9mique chez l\u2019enfant"],"prefix":"10.1684","volume":"4","author":[{"given":"Patrick","family":"Niaudet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18929","reference":[{"key":"10.1016\/j.nephro.2007.07.006_bib1","series-title":"Hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura","first-page":"213","article-title":"Hemolytic-uremic syndrome in families","author":"Kaplan","year":"1992"},{"key":"10.1016\/j.nephro.2007.07.006_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00858960","article-title":"Haemolytic-uraemic syndrome: prognostic features in children over three years of age","volume":"9","author":"Renaud","year":"1995","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib3","first-page":"495","article-title":"Haemolytic-uremic syndrome with recurrent episodes: an important subset","volume":"8","author":"Kaplan","year":"1977","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib4","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1038\/ki.1997.508","article-title":"Epidemic hemolytic-uremic syndrome in children","volume":"52","author":"Repetto","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.nephro.2007.07.006_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00467-001-0783-0","article-title":"Hemolytic-uremic syndrome: epidemiology, pathophysiology, and therapy","volume":"17","author":"Andreoli","year":"2002","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/j.spid.2004.07.007","article-title":"The role of Shiga toxin-producing Escherichia\u00a0coli in hemorrhagic colitis and haemolytic-uremic syndrome","volume":"15","author":"Cleary","year":"2004","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.nephro.2007.07.006_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMra020528","article-title":"Thrombotic microangiopathies","volume":"347","author":"Moake","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004670050018","article-title":"Enterohemorrhagic Escherichia\u00a0coli infections: following transmission routes","volume":"14","author":"Vermelen","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa020524","article-title":"An outbreak of Escherichia\u00a0coli O157: H7 infections among visitors to a dairy farm","volume":"347","author":"Crump","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1017\/S0950268899003623","article-title":"Haemolytic-uraemic syndrome and Shiga toxin-producing Escherichia coli infection in children in France. The Soci\u00e9t\u00e9 de nephrologie pediatrique","volume":"124","author":"Decludt","year":"2000","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.nephro.2007.07.006_bib11","first-page":"141","article-title":"Hemolytic-uremic syndrome in the child","volume":"22","author":"Loirat","year":"1993","journal-title":"Adv Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0022-3476(94)70001-X","article-title":"Spectrum of extrarenal involvement in postdiarrheal hemolytic-uremic syndrome","volume":"125","author":"Siegler","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.nephro.2007.07.006_bib13","series-title":"Pediatric Nephrology","first-page":"887","article-title":"Hemolytic-uremic syndromes","author":"Loirat","year":"2003"},{"key":"10.1016\/j.nephro.2007.07.006_bib14","series-title":"Hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura","first-page":"315","article-title":"Pathology of the hemolytic and uremic syndrome","author":"Habib","year":"1992"},{"key":"10.1016\/j.nephro.2007.07.006_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1086\/341940","article-title":"Clinical course and the role of shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997\u20132000, in Germany and Austria: a prospective study","volume":"186","author":"Gerber","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nephro.2007.07.006_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1651-2227.1984.tb09962.x","article-title":"Hemolytic-uremic syndrome: an analysis of the natural history and prognostic features","volume":"73","author":"Loirat","year":"1984","journal-title":"Acta Paediatr Scand"},{"key":"10.1016\/j.nephro.2007.07.006_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s004670050248","article-title":"Childhood haemolytic-uremic syndrome in Argentina: long-term follow-up and prognostic features","volume":"11","author":"Spizzirri","year":"1997","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000188221","article-title":"Outcome and prognostic determinants in the haemolytic-uremic syndrome of children","volume":"68","author":"T\u00f6nshoff","year":"1994","journal-title":"Nephron"},{"key":"10.1016\/j.nephro.2007.07.006_bib19","first-page":"39","article-title":"Long-term (15\u201325 years) outcome of childhood hemolytic-uremic syndrome","volume":"46","author":"Gagnadoux","year":"1996","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib20","first-page":"99","article-title":"Prognosis of the hemolyric-uremic syndrome in children","volume":"11","author":"Habib","year":"1982","journal-title":"Adv Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/BF02000785","article-title":"Childhood haemolytic uraemic syndrome: long-term outcome and prognostic features","volume":"153","author":"Kelles","year":"1994","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.nephro.2007.07.006_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/adc.58.2.101","article-title":"Haemolytic-uraemic syndrome: an analysis of prognostic features","volume":"58","author":"Trompeter","year":"1983","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.nephro.2007.07.006_bib23","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1056\/NEJM200006293422601","article-title":"The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli 0157: H7 infections","volume":"342","author":"Wong","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib24","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1016\/j.vaccine.2006.02.035","article-title":"Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2","volume":"24","author":"Smith","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.nephro.2007.07.006_bib25","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s004670050338","article-title":"Postdysenteric haemolytic-uremic syndrome in children during an epidemic of Shigella dysentery in Kwazulu\/Natal","volume":"11","author":"Bhimma","year":"1997","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib26","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1542\/peds.110.2.371","article-title":"Invasive pneumococcal disease and haemolytic-uremic syndrome","volume":"110","author":"Brandt","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.nephro.2007.07.006_bib27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s004670100564","article-title":"Prognosis of Streptococcus pneumoniae-induced haemolytic-uremic syndrome","volume":"16","author":"Nathanson","year":"2001","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0022-3476(05)83531-0","article-title":"Atypical (non-diarrhea-associated) hemolytic-uremic syndrome in childhood","volume":"122","author":"Fitzpatrick","year":"1993","journal-title":"J Pediatr"},{"key":"10.1016\/j.nephro.2007.07.006_bib29","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/adc.76.6.518","article-title":"Heterogeneity of atypical haemolytic-uremic syndromes","volume":"76","author":"Neuhaus","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.nephro.2007.07.006_bib30","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","article-title":"International registry of recurrent and familial HUS\/TTP. Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome","volume":"108","author":"Caprioli","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.nephro.2007.07.006_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00281-005-0003-2","article-title":"Atypical haemolytic-uraemic syndrome and mutations in complement regulator genes","volume":"27","author":"Dragon-Durey","year":"2005","journal-title":"Springer Semin Immunopathol"},{"key":"10.1016\/j.nephro.2007.07.006_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/humu.20435","article-title":"The interactive factor H-atypical haemolytic-uremic syndrome mutation database and website: update and integration of membrane cofactor protein and factor I mutations with structural models","volume":"28","author":"Saunders","year":"2007","journal-title":"Hum Mutat"},{"key":"10.1016\/j.nephro.2007.07.006_bib33","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J med"},{"key":"10.1016\/j.nephro.2007.07.006_bib34","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1523-1755.1998.00824.x","article-title":"Genetic studies into haemolytic-uraemic syndrome","volume":"53","author":"Warwicker","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.nephro.2007.07.006_bib35","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/ndt\/14.5.1229","article-title":"Familial relapsing haemolytic-uraemic syndrome and complement factor H deficiency","volume":"14","author":"Warwicker","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nephro.2007.07.006_bib36","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1086\/302877","article-title":"Complement factor H gene mutation associated with autosomal recessive atypical haemolytic-uremic syndrome","volume":"66","author":"Buddles","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nephro.2007.07.006_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1681\/ASN.V122297","article-title":"Italian registry of familial and recurrent HUS\/TTP. The molecular basis of familial haemolytic-uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20","volume":"12","author":"Caprioli","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s004670050515","article-title":"Hypocomplementemic autosomal recessive haemolytic-uremic syndrome with decreased factor H","volume":"12","author":"Ohali","year":"1998","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib39","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/302673","article-title":"Complement factor H gene mutation associated with autosomal recessive atypical haemolytic-uremic syndrome","volume":"65","author":"Ying","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nephro.2007.07.006_bib40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/jmg.40.9.676","article-title":"Haemolytic-uraemic syndrome and mutations of the factor H gene: a registry-based study of German speaking countries","volume":"40","author":"Neumann","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.nephro.2007.07.006_bib41","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1681\/ASN.2005010103","article-title":"Mutations in complement factor I predispose to development of atypical haemolytic-uremic syndrome","volume":"16","author":"Kavanagh","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib42","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0140-6736(03)14742-3","article-title":"International registry of recurrent and familial HUS\/TTP. Familial haemolytic-uraemic syndrome and an MCP mutation","volume":"362","author":"Noris","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.nephro.2007.07.006_bib43","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1681\/ASN.2005101051","article-title":"Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical haemolytic-uremic syndrome","volume":"17","author":"Fremeaux-Bacchi","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib44","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1073\/pnas.0603420103","article-title":"Gain-of-function mutations in complement factor B are associated with atypical haemolytic-uremic syndrome","volume":"104","author":"Goicoechea de Jorge","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nephro.2007.07.006_bib45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1681\/ASN.2004050380","article-title":"Anti-factor H autoantibodies associated with atypical haemolytic-uremic syndrome","volume":"16","author":"Dragon-Durey","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib46","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJM199811263392202","article-title":"von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome","volume":"339","author":"Furlan","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib47","doi-asserted-by":"crossref","first-page":"11902","DOI":"10.1073\/pnas.172277399","article-title":"Mutations and common polymorphisms in ADAMTS 13 gene responsible for von Willebrand factor-cleaving protease activity","volume":"99","author":"Kokame","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.nephro.2007.07.006_bib48","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/35097008","article-title":"Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura","volume":"413","author":"Levy","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.nephro.2007.07.006_bib49","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJM199811263392203","article-title":"Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura","volume":"339","author":"Tsai","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib50","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1067\/mpd.2003.79","article-title":"Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical haemolytic-uremic syndrome","volume":"142","author":"Veyradier","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.nephro.2007.07.006_bib51","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00467-002-0944-9","article-title":"Plasma therapy in von Willebrand factor-protease deficiency","volume":"17","author":"Deschenes","year":"2002","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib52","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1681\/ASN.2005010086","article-title":"Complement factor H mutation","volume":"16","author":"Noris","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00043426-200205000-00023","article-title":"Cobalamin C disease presenting as hemolytic-uremic syndrome in the neonatal period","volume":"24","author":"Kind","year":"2002","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.nephro.2007.07.006_bib54","first-page":"261","article-title":"Hemolytic-uremic syndrome: hereditary forms and forms associated with hereditary diseases","volume":"30","author":"Niaudet","year":"2000","journal-title":"Adv Nephrol Necker Hosp"},{"key":"10.1016\/j.nephro.2007.07.006_bib55","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s004670050793","article-title":"Autosomal dominant haemolytic-uremic syndrome: variable phenotypes and transplant results","volume":"14","author":"Kaplan","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib56","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.7326\/0003-4819-135-12-200112180-00008","article-title":"Quinine-associated thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome: frequency, clinical features, and long-term outcomes","volume":"135","author":"Kojouri","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.nephro.2007.07.006_bib57","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00467-002-0936-9","article-title":"Shiga toxin-associated haemolytic-uremic syndrome: absence of recurrence after renal transplantation","volume":"17","author":"Ferraris","year":"2002","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib58","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/00007890-199805270-00023","article-title":"Recurrence of haemolytic-uremic syndrome in renal transplant recipients","volume":"65","author":"Ducloux","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.nephro.2007.07.006_bib59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2215\/CJN.00050505","article-title":"Outcome of renal transplantation in patients with non Shiga toxin-associated haemolytic-uremic syndrome: prognostic significance of genetic backgroung","volume":"1","author":"Bresin","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.nephro.2007.07.006_bib60","first-page":"148","article-title":"R\u00e9cidive du syndrome h\u00e9molytique et ur\u00e9mique apr\u00e8s transplantation r\u00e9nale: facteurs de risque, incidence et prognostic","volume":"3","author":"Loirat","year":"2006","journal-title":"Courrier de la Transplantation"},{"key":"10.1016\/j.nephro.2007.07.006_bib61","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00467-003-1289-8","article-title":"The risk of recurrence of haemolytic-uremic syndrome after renal transplantation in children","volume":"18","author":"Loirat","year":"2003","journal-title":"Pediatr Nephrol"}],"container-title":["N\u00e9phrologie &amp; Th\u00e9rapeutique"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769725507002027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1769725507002027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jle.com\/10.1016\/j.nephro.2007.07.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T13:56:33Z","timestamp":1741182993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1769725507002027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S1769725507002027"],"URL":"https:\/\/doi.org\/10.1016\/j.nephro.2007.07.006","relation":{},"ISSN":["1769-7255"],"issn-type":[{"type":"print","value":"1769-7255"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}