{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:50:24Z","timestamp":1781189424950,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.neubiorev.2009.11.003","type":"journal-article","created":{"date-parts":[[2009,11,7]],"date-time":"2009-11-07T10:50:06Z","timestamp":1257591006000},"page":"555-558","source":"Crossref","is-referenced-by-count":29,"title":["The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature"],"prefix":"10.1016","volume":"34","author":[{"given":"Bernard A.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Boggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2009.11.003_bib1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2337\/diacare.27.2.596","article-title":"Consensus development conference on antipsychotic drugs and obesity and diabetes","volume":"27","author":"ADA","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/0269216308094337","article-title":"The misuse\/abuse of antihistamine antiemetic medication (cyclizine) by cancer patients","volume":"22","author":"Bailey","year":"2008","journal-title":"Palliat. Med."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0022-3565(25)23894-0","article-title":"Some behavioral effects of histamine H1 antagonists in squirrel monkeys","volume":"239","author":"Bergman","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.schres.2008.01.013","article-title":"Quetiapine at high doses for the treatment of refractory schizophrenia","volume":"101","author":"Boggs","year":"2008","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib5","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1176\/appi.ps.51.7.928","article-title":"Misuse of anticholinergic drugs by people with serious mental illness","volume":"51","author":"Buhrich","year":"2000","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1440-1819.2009.01953.x","article-title":"Dependence on quetiapine in combination with zolpidem and clonazepam in bipolar depression","volume":"63","author":"Chen","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/PL00005274","article-title":"Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade","volume":"358","author":"Dringenberg","year":"1998","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0022-3565(25)22797-5","article-title":"Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital","volume":"250","author":"Evans","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4088\/PCC.v07n0602","article-title":"Atypicality of atypical antipsychotics","volume":"7","author":"Farah","year":"2005","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib10","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4088\/JCP.v61n0914g","article-title":"Clarification of anticholinergic effects of quetiapine","volume":"61","author":"Goldstein","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0149-7634(01)00038-0","article-title":"Mechanisms and abuse liability of the anti-histamine dimenhydrinate","volume":"26","author":"Halpert","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib12","first-page":"40","article-title":"Anticholinergic drug abuse","volume":"24","author":"Hidalgo","year":"1990","journal-title":"DICP"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib13","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1176\/appi.ajp.162.9.1755-a","article-title":"Intravenous quetiapine abuse","volume":"162","author":"Hussain","year":"2005","journal-title":"Am. J. Psychiatry"},{"issue":"Suppl. 5","key":"10.1016\/j.neubiorev.2009.11.003_bib14","first-page":"43","article-title":"Tardive dyskinesia in affective disorders","volume":"60","author":"Kane","year":"1999","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib15","first-page":"161","article-title":"Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action","volume":"25","author":"Kapur","year":"2000","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","article-title":"H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs","volume":"28","author":"Kroeze","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib17","first-page":"580","article-title":"Abuse and misuse of anticholinergic medications","volume":"42","author":"Land","year":"1991","journal-title":"Hosp. Community Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib18","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1176\/appi.ajp.164.4.630","article-title":"Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia","volume":"164","author":"Mizrahi","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2146\/ajhp060226","article-title":"Possible intranasal quetiapine misuse","volume":"64","author":"Morin","year":"2007","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib20","doi-asserted-by":"crossref","DOI":"10.1037\/1064-1297.4.4.421","article-title":"Reinforcing, subjective, and performance effects of lorazepam and diphenhydramine in humans","author":"Mumford","year":"1996","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib21","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1176\/appi.ajp.2008.08020277","article-title":"Addictive potential of quetiapine","volume":"165","author":"Murphy","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4088\/JCP.v69n0122a","article-title":"Quetiapine: another drug with potential for misuse? A case report","volume":"69","author":"Paparrigopoulos","year":"2008","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib23","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1176\/appi.ajp.161.9.1718","article-title":"Intranasal quetiapine abuse","volume":"161","author":"Pierre","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.schres.2004.07.014","article-title":"High-dose quetiapine in treatment refractory schizophrenia","volume":"73","author":"Pierre","year":"2005","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1176\/appi.ajp.164.1.174","article-title":"Quetiapine addiction?","volume":"164","author":"Pinta","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-3565(25)10815-X","article-title":"Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability","volume":"262","author":"Preston","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/bmj.289.6445.612","article-title":"Anticholinergic drug abuse: a common problem?","volume":"289","author":"Pullen","year":"1984","journal-title":"Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib28","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/SMJ.0b013e3180f62d53","article-title":"Additional evidence of the abuse potential of quetiapine","volume":"100","author":"Reeves","year":"2007","journal-title":"South Med. J."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib29","first-page":"1","article-title":"Tardive dyskinesia in a patient treated with quetiapine","author":"Rizos","year":"2007","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0896-6273(03)00021-7","article-title":"Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons","volume":"37","author":"Saal","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1037\/1064-1297.3.1.26","article-title":"Maintenance of H1 antagonists self-injection in baboons","volume":"3","author":"Sannerud","year":"1995","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF02247122","article-title":"Drug interactions in the reinforcing effects of over-the-counter cough syrups","volume":"102","author":"Suzuki","year":"1990","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02316857","article-title":"Potentiation of pentazocine conditioned place preference by tripelennamine in rats","volume":"105","author":"Suzuki","year":"1991","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib34","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1176\/appi.ajp.161.9.1620","article-title":"Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics","volume":"161","author":"Tauscher","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2009.11.003_bib35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1517\/14740330802496883","article-title":"Is quetiapine a drug of abuse? Reexamining the issue of addiction","volume":"7","author":"Tcheremissine","year":"2008","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/0269881107083809","article-title":"Diphenhydramine abuse and detoxification: a brief review and case report","volume":"23","author":"Thomas","year":"2009","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0006-8993(93)90908-6","article-title":"The tuberomammillary nucleus region as a reinforcement inhibiting substrate: facilitation of ipsihypothalamic self-stimulation by unilateral ibotenic acid lesions","volume":"613","author":"Wagner","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2009.11.003_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1176\/appi.ajp.164.1.173-a","article-title":"Intravenous quetiapine-cocaine use (\u201cQ-ball\u201d)","volume":"164","author":"Waters","year":"2007","journal-title":"Am. J. Psychiatry"}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763409001699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763409001699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T03:53:49Z","timestamp":1739418829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763409001699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0149763409001699"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2009.11.003","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}