{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:29:57Z","timestamp":1791142197377,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.neubiorev.2011.08.004","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T03:36:50Z","timestamp":1313638610000},"page":"1902-1915","source":"Crossref","is-referenced-by-count":36,"title":["Toward affective circuit-based preclinical models of depression: Sensitizing dorsal PAG arousal leads to sustained suppression of positive affect in rats"],"prefix":"10.1016","volume":"35","author":[{"given":"Jason S.","family":"Wright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaak","family":"Panksepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2011.08.004_bib0005","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.neubiorev.2008.05.005","article-title":"Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD","volume":"32","author":"Adamec","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0010","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.neubiorev.2009.11.023","article-title":"Is subcortical\u2013cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach","volume":"34","author":"Alcaro","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0015","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.neubiorev.2011.03.002","article-title":"The SEEKING mind: primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression","volume":"35","author":"Alcaro","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0025","series-title":"The Truth About the Drug Companies: How They Deceive Us and What to do About it","author":"Angell","year":"2004"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2005.03.007","article-title":"Stress, depression, and anhedonia: caveats concerning animal models","volume":"29","author":"Anisman","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0525","doi-asserted-by":"crossref","unstructured":"Arakawa, H., Cruz, S., Deak. T. 2011. From models to mechanisms: Odorant communication as a key determinant of social behavior in rodents during illness-associated states. Neurosci Biobehav Rev. this issue, in press.","DOI":"10.1016\/j.neubiorev.2011.03.007"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neubiorev.2007.04.019","article-title":"Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake","volume":"32","author":"Avena","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0040","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(94)90047-7","article-title":"Columnar organization in the midbrain periaqueductal gray\u2014modules for emotional expression?","volume":"17","author":"Bandler","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0045","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0361-9230(96)00332-2","article-title":"Central C-Fos expression following 20kHz\/ultrasound induced defense behavior in the rat","volume":"42","author":"Beckett","year":"1997","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0301-0082(95)00009-K","article-title":"Functional-characteristics of the midbrain periaqueductal gray","volume":"46","author":"Behbehani","year":"1995","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0055","unstructured":"Bishop, P., 1984. Brain and opiate modulation of avian affective vocalizations. Unpublished Ph.D. Dissertation, Bowling Green State Univ., Bowling Green, OH."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0060","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/cne.902370403","article-title":"The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivision","volume":"237","author":"Beitz","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1037\/0033-295X.108.1.83","article-title":"Do infant rats cry?","volume":"108","author":"Blumberg","year":"2001","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0006-3223(02)01355-0","article-title":"rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest","volume":"52","author":"Boshuisen","year":"2002","journal-title":"Biol. Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0075","series-title":"A Secure Base: Parent Child Attachment and Healthy Human Development","author":"Bowlby","year":"1988"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0080","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neubiorev.2005.04.013","article-title":"Gabaergic regulation of the neural organization of fear in the midbrain tectum","volume":"29","author":"Brand\u00e3o","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2007.10.018","article-title":"Different patterns of freezing behavior organized in the periaqueductal gray of rats: association with different types of anxiety","volume":"188","author":"Brand\u00e3o","year":"2008","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neuropharm.2011.04.012","article-title":"Positive affective vocalizations during cocaine and sucrose self-administration: a model for spontaneous drug desire in rats","volume":"61","author":"Browning","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2010.10.006","article-title":"Effects of intraaccumbens amphetamine on production of 50kHz vocalizations in three lines of selectively bred Long-Evans rats","volume":"217","author":"Brudzynski","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0100","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1037\/0735-7044.114.2.320","article-title":"Anticipation of rewarding electrical brain stimulation evokes ultrasonic vocalization in rats","volume":"114","author":"Burgdorf","year":"2000","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0105","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1037\/0735-7044.115.4.940","article-title":"Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultra sonic vocalizations in rats","volume":"115","author":"Burgdorf","year":"2001","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s002130100685","article-title":"Evaluation of rat ultra-sonic vocalizations as predictors of the conditioned aversive effects of drugs","volume":"155","author":"Burgdorf","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0530","doi-asserted-by":"crossref","unstructured":"Burgdorf, J., Panksepp, J., Moskal., J.R. 2011. Frequency-modulated 50kHz ultrasonic vocalizations a tool for uncovering the molecular substrates of positive affect. Neurosci Biobehav Rev. this issue, in press.","DOI":"10.1016\/j.neubiorev.2010.11.011"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0031-9384(00)00411-X","article-title":"Tickling induces reward in adolescent rats","volume":"72","author":"Burgdorf","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0120","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbr.2007.03.010","article-title":"Neurobiology of 50-kHz ultrasonic vocalizations in rats: electrode mapping, lesion, and pharmacology studies","volume":"182","author":"Burgdorf","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1037\/a0012889","article-title":"Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: behavioral concomitants, relationship to reward and self-administration of playback","volume":"122","author":"Burgdorf","year":"2008","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00001756-199902050-00037","article-title":"Fos-like immunoreactivity in the periaqueductal gray of rats exposed to a natural predator","volume":"10","author":"Canteras","year":"1999","journal-title":"NeuroReport"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2010.12.009","article-title":"Cross-species affective functions of the medial forebrain bundle-Implications for the treatment of affective pain and depression in humans","author":"Coenen","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0140","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.neubiorev.2011.03.014","article-title":"Octodon degus. A useful animal model for social-affective neuroscience research: basic description of separation distress, social attachments and play","volume":"35","author":"Colonnello","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(03)01558-9","article-title":"Vocalizations during withdrawal from opiates and cocaine: possible expressions of affective distress","volume":"467","author":"Covington","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0150","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/79871","article-title":"Subcortical and cortical brain activity during the feeling of self-generated emotions","volume":"3","author":"Damasio","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/ajplegacy.1954.179.3.587","article-title":"Learning motivated by electrical stimulation of the brain stem","volume":"179","author":"Delgado","year":"1954","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0160","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00227243","article-title":"Longitudinal neuronal organization of defensive reactions in the midbrain periaqueductal gray region of the rat","volume":"90","author":"Depaulis","year":"1992","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neubiorev.2003.12.004","article-title":"Serotonin, the periaqueductal gray and panic","volume":"28","author":"Graeff","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0170","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1097\/01.wnr.0000183904.15773.47","article-title":"Deep brain stimulation can regulate arterial blood pressure in awake humans","volume":"16","author":"Green","year":"2005","journal-title":"NeuroReport"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0535","doi-asserted-by":"crossref","unstructured":"Harro, J., Kanarik, M., Matrov, D., Panksepp, J. 2011. Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: Relevance of animal affective systems to human disorders, with a focus on resilience to adverse events. Neurosci Biobehav Rev. this issue, in press.","DOI":"10.1016\/j.neubiorev.2011.02.016"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1467-8721.2009.01641.x","article-title":"Separation, sickness, and depression: a new perspective on an old animal model","volume":"18","author":"Hennessy","year":"2009","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0180","unstructured":"Herman, B.H., 1979. An exploration of brain social attachment substrates in guinea pigs. Unpublished Ph.D. Dissertation, Bowling Green State Univ., Bowling Green, OH."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0540","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0091-3057(78)90167-3","article-title":"Effects of morphine and naloxone on separation distress and approach attachment: Evidence for opiate mediation of social affect","volume":"9","author":"Herman","year":"1978","journal-title":"Pharmacol Biochem Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0185","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1126\/science.7466377","article-title":"Ascending endorphin inhibition of distress vocalization","volume":"211","author":"Herman","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0190","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0031-9384(88)90324-1","article-title":"Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens","volume":"44","author":"Hernandez","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2010.02.001","article-title":"Brain reward circuitry beyond the mesolimbic dopamine theory: a neurobiological theory","author":"Ikemoto","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0200","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0166-4328(94)90155-4","article-title":"The relationship between self-stimulation and sniffing in rats: does a common brain system mediate these behaviors?","volume":"61","author":"Ikemoto","year":"1994","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0165-1781(95)02673-K","article-title":"Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity","volume":"57","author":"Jenck","year":"1995","journal-title":"Psychiat. Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvoice.2007.07.005","article-title":"The neural control of vocalization in mammals: a review","volume":"23","author":"J\u00fcrgens","year":"2009","journal-title":"J. Voice"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/h0027657","article-title":"Exploratory behavior and spontaneous alternation in blind and anosmic rats","volume":"68","author":"Klein","year":"1969","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1037\/0735-7036.112.1.65","article-title":"Anticipation of play elicits high-frequency ultrasonic vocalizations in young rats","volume":"112","author":"Knutson","year":"1998","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0225","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0031-9384(98)00337-0","article-title":"High-frequency ultrasonic vocalizations index conditioned pharmacological reward in rats","volume":"66","author":"Knutson","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0230","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1037\/0033-2909.128.6.961","article-title":"Ultrasonic vocalizations as indices of affective states in rats","volume":"128","author":"Knutson","year":"2002","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0235","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2007.03.022","article-title":"Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray","volume":"182","author":"Kroes","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0306-4530(88)90011-X","article-title":"Psychoendocrine aspects of mother\u2013infant relationships in nonhuman primates","volume":"13","author":"Levine","year":"1988","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0245","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/107385840000600113","article-title":"Panic disorder\u2014a malfunction of multiple transmitter control systems within the midbrain periaqueductal gray matter?","volume":"6","author":"Lovick","year":"2000","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0250","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neubiorev.2005.03.014","article-title":"Dominant-submissive behavior as models of mania and depression","volume":"29","author":"Malatynska","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0255","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neubiorev.2005.03.004","volume":"29","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0545","doi-asserted-by":"crossref","unstructured":"Moskal, J. R., Burgdorf, J., Kroes, R.A., Brudzynski, S.M., Panksepp, J. 2011. A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism. Neurosci Biobehav Rev. this issue, in press.","DOI":"10.1016\/j.neubiorev.2011.06.006"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0260","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.1144298","article-title":"When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans","volume":"317","author":"Mobbs","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0265","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biopsych.2010.09.014","article-title":"Exposure to cocaine alters dynorphin-mediated regulation of excitatory synaptic transmission in nucleus accumbens neurons","volume":"69","author":"Mu","year":"2011","journal-title":"Biol. Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3171\/jns.1969.30.1.0014","article-title":"Sensations evoked by stimulation in the midbrain of man","volume":"30","author":"Nashold","year":"1967","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0275","series-title":"The Physiological Control of Mammalian Vocalizations","year":"1988"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0280","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.biopsych.2005.09.018","article-title":"The mesolimbic dopamine reward circuit in depression","volume":"59","author":"Nestler","year":"2006","journal-title":"Biol. Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0550","doi-asserted-by":"crossref","unstructured":"Normansell, L., Panksepp, J. 2011. Glutamatergic modulation of separation distress: Profound emotional effects of excitatory amino acids in chicks. Neurosci Biobehav Rev. this issue, in press.","DOI":"10.1016\/j.neubiorev.2011.06.004"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2010.12.007","article-title":"The \u2018resting-state hypothesis\u2019 of major depressive disorder\u2014a translational subcortical\u2013cortical framework for a system disorder","author":"Northoff","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0290","series-title":"Handbook of the Hypothalamus, vol. 3. Part A. Behavioral Studies of the Hypothalamus","first-page":"289","article-title":"Hypothalamic integration of behavior: rewards, punishments, and related psychobiological process","author":"Panksepp","year":"1981"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0295","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1017\/S0140525X00012759","article-title":"Toward a general psychobiological theory of emotions","volume":"5","author":"Panksepp","year":"1982","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0300","series-title":"Affective Neuroscience: The Foundations of Human and Animal Emotions","author":"Panksepp","year":"1998"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0305","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1037\/0033-295X.110.2.376","article-title":"Can anthropomorphic analyses of \u201cseparation cries\u201d in other animals inform us about the emotional nature of social loss in humans?","volume":"110","author":"Panksepp","year":"2003","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0310","first-page":"245","article-title":"Trennungsschmerz als mogliche ursache f\u00fcr panikattacken\u2014neuropsychologische Uberlegungen und Befunde","volume":"7","author":"Panksepp","year":"2003","journal-title":"Personlichkeitsstorung: Theorie und therapie"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0555","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.pnpbp.2006.01.004","article-title":"Emotional endophenotypes in evolutionary psychiatry","volume":"30","author":"Panksepp","year":"2006","journal-title":"Prog Neuro-Psychopharm Biol Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0320","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2007.02.015","article-title":"Neuroevolutionary sources of laughter and social joy: modeling primal human laughter in laboratory rats","volume":"182","author":"Panksepp","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0560","doi-asserted-by":"crossref","first-page":"533","DOI":"10.31887\/DCNS.2010.12.4\/jpanksepp","article-title":"Affective neuroscience of the emotional BrainMind: evolutionary perspectives and implications for understanding depression","volume":"12","author":"Panksepp","year":"2010","journal-title":"Dialog Clin Neurosci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0325","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ajp.20929","article-title":"Toward a cross-species neuroscientific understanding of the affective mind: do animals have emotional feelings?","volume":"73","author":"Panksepp","year":"2011","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0335","series-title":"The Archaeology of Mind: Neuroevolutionary Origins of Human Emotion","author":"Panksepp","year":"2011"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.applanim.2010.09.014","article-title":"The basic neuroscience of emotional experiences in mammals: The Case of subcortical FEAR circuitry and implications for clinical anxiety","volume":"129","author":"Panksepp","year":"2011","journal-title":"App Animal Behav Sci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0340","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-4328(00)00238-2","article-title":"50k-Hz chirping (laughter?) in response to conditioned and unconditioned tickle-induced reward in rats: effects of social housing and genetic variables","volume":"115","author":"Panksepp","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0345","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0031-9384(03)00159-8","article-title":"\u201cLaughing\u201d rats and the evolutionary antecedents of human joy?","volume":"79","author":"Panksepp","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0570","first-page":"607","article-title":"The biology of social attachments: Opiates alleviate separation distress","volume":"13","author":"Panksepp","year":"1978","journal-title":"Biol Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0350","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1360-0443.2002.00025.x","article-title":"The role of emotional brain systems in addictions: a neuro-evolutionary perspective","volume":"97","author":"Panksepp","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0355","first-page":"51","article-title":"Critical conceptual issues in the analysis of separation distress systems of the brain","volume":"vol. 2","author":"Panksepp","year":"1992"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0360","series-title":"50th Nebraska Symposium on Motivation: Motivational Factors in the Etiology of Drug Abuse","first-page":"85","article-title":"The role of emotional systems in addiction: a neuroethological perspective","author":"Panksepp","year":"2004"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0365","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0091-3057(80)90050-7","article-title":"The neurochemical control of crying","volume":"12","author":"Panksepp","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0370","series-title":"Brain Stimulation Reward","first-page":"118","article-title":"Reversible CNS lesions and disruption of self-stimulation by inhibition of axoplasmic flow","author":"Panksepp","year":"1976"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0575","unstructured":"Panksepp, J., Moskal, J. 2008. Dopamine and SEEKING: Subcortical reward systems and appetitive urges. In: A. Elliot, A. (Ed.) Handbook of approach and avoidance motivation, Taylor & Francis Group, LLC, New York, pp. 67-87."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0375","series-title":"The Physiological Control of Mammalian Vocalizations","first-page":"263","article-title":"Neural and neurochemical control of the separation distress call","author":"Panksepp","year":"1988"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0380","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1521\/psyc.2011.74.1.5","article-title":"Why does depression hurt? Ancestral primary-process separation-distress (PANIC) and diminished brain reward (SEEKING) processes in the genesis of depressive affect","volume":"74","author":"Panksepp","year":"2011","journal-title":"Psychiatry"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0385","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/dev.420120109","article-title":"Attachment and separation distress in the guinea pig","volume":"12","author":"Pettijohn","year":"1979","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0390","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000318293","article-title":"Efficacy and effectiveness of antidepressants: current status of research","volume":"79","author":"Pigott","year":"2010","journal-title":"Psychother. Psychosomat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0395","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1517\/14656561003614781","article-title":"Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era","volume":"11","author":"Philip","year":"2010","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0400","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.wnr.0000203354.80438.1","article-title":"Increased brainstem volume in panic disorder: a voxel-based morphometric study","volume":"17","author":"Protopopescu","year":"2006","journal-title":"NeuroReport"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0405","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3758\/BF03333106","article-title":"Active avoidance conditioning with dorsal central gray stimulation in a place preference paradigm","volume":"15","author":"Roberts","year":"1987","journal-title":"Psychobiology"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0410","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0031-9384(92)90119-M","article-title":"Analysis of the relationships between self-stimulation sniffing and brain-stimulation sniffing","volume":"51","author":"Rossi","year":"1992","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0420","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2008.02.002","article-title":"Playback of 22-kHz and 50-kHz ultrasonic vocalizations induce differential c-fos expression in rat brain","volume":"435","author":"Sadananda","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0425","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00001756-200506210-00010","article-title":"Cerebral glucose metabolism associated with a fear network in panic disorder","volume":"16","author":"Sakai","year":"2005","journal-title":"NeuroReport"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0430","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0149-7634(01)00060-4","article-title":"Modeling panic attacks","volume":"25","author":"Schenberg","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0435","series-title":"Modulation of Sensorimotor Activity During Alterations in Behavioral States","article-title":"Periventricular structures, elaboration of aversive effects and processing of sensory information","author":"Schmitt","year":"1984"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0166-4328(81)90038-3","article-title":"Escape and approach induced by brain stimulation: a parametric analysis","volume":"2","author":"Schmitt","year":"1981","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0445","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbr.2007.01.029","article-title":"Situational factors, conditions and individual variables which can determine ultrasonic vocalizations in male adult Wistar rats","volume":"182","author":"Schwarting","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0450","series-title":"Proceedings of the Collegium International Neuropsychopharmacologicum","first-page":"735","article-title":"Effects of psychotropic drugs on separation distress in dogs","author":"Scott","year":"1974"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0455","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainresrev.2004.04.009","article-title":"Regulation of affect by the lateral septum: implications for neuropsychiatry","volume":"46","author":"Sheehan","year":"2004","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0460","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neubiorev.2006.02.003","article-title":"Altered brain activity processing in high-anxiety rodents revealed by challenge paradigms and functional mapping","volume":"31","author":"Singewald","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0465","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/070674371005500303","article-title":"The sequenced treatment alternatives to relieve depression (STAR*D) trial: a review","volume":"55","author":"Sinyor","year":"2010","journal-title":"Can. J. Psychiat."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0470","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.neubiorev.2011.03.006","article-title":"In search of the physiological substrates for social playfulness in mammalian brains","volume":"35","author":"Siviy","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/brbi.1996.0001","article-title":"The effects of central administration of neuropeptide Y on behavior, neurotransmitter, and immune functions in the olfactory bulbectomized rat model of depression","volume":"10","author":"Song","year":"1996","journal-title":"Brain Behav. Immunol."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0480","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.neubiorev.2005.03.010","article-title":"The olfactory bulbectomised rat as a model of depression","volume":"29","author":"Song","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0485","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1196\/annals.1376.006","article-title":"Risk, resilience, and gene\u00d7environment interactions in rhesus monkeys","volume":"1094","author":"Suomi","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0490","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0039285","article-title":"The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions","volume":"69","author":"Teitelbaum","year":"1962","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0500","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/15294145.2009.10773593","article-title":"Depression: an evolutionarily conserved mechanism to terminate separation-distress? A review of aminergic, peptidergic, and neural network perspectives","volume":"11","author":"Watt","year":"2009","journal-title":"Neuropsychoanalysis"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0505","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0510","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.physbeh.2007.11.031","article-title":"Effects of experience and context on 50-kHz vocalizations in rats","volume":"93","author":"W\u00f6hr","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0515","series-title":"Neurosurgical Management of Pain","first-page":"288","article-title":"Brain stimulation","author":"Young","year":"1997"},{"key":"10.1016\/j.neubiorev.2011.08.004_bib0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2011.01.003","article-title":"Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: why depression feels so bad and what addicts really want","author":"Zellner","year":"2011","journal-title":"Neurosci. Biobehav. Rev."}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763411001503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763411001503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T21:30:34Z","timestamp":1686259834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763411001503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":110,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0149763411001503"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2011.08.004","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}