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Tucker, D., Wellesley, D., Yevtushok, L., Dolk, H., 2013. Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening. Eur. J. Hum. Genet. 21, 27\u201333.","DOI":"10.1038\/ejhg.2012.94"},{"key":"10.1016\/j.neubiorev.2014.01.012_bib0730","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0306-9877(98)90270-5","article-title":"Autism: a mitochondrial disorder?","volume":"50","author":"Lombard","year":"1998","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neubiorev.2014.01.012_bib0735","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-444-54299-1.00006-6","article-title":"Neurological phenotypes for Down syndrome across the life span","volume":"197","author":"Lott","year":"2012","journal-title":"Prog. 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