{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:15:04Z","timestamp":1762899304188,"version":"3.40.5"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.neubiorev.2016.06.015","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T11:44:27Z","timestamp":1466855067000},"page":"342-355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"PB","title":["Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome"],"prefix":"10.1016","volume":"74","author":[{"given":"Abdul Waheed","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J.","family":"Corcoran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Esler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-9137","authenticated-orcid":false,"given":"Assam","family":"El-Osta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2016.06.015_bib0005","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fphys.2014.00230","article-title":"Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with the postural orthostatic tachycardia syndrome (POTS)","volume":"5","author":"Anderson","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jmcc.2000.1319","article-title":"The neuronal norepinephrine transporter in experimental heart failure: evidence for a posttranscriptional downregulation","volume":"33","author":"Backs","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0015","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.4161\/cc.9.22.13888","article-title":"Histone modifications regulate the norepinephrine transporter gene","volume":"9","author":"Bayles","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0020","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1161\/ATVBAHA.111.244343","article-title":"Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome","volume":"32","author":"Bayles","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0025","doi-asserted-by":"crossref","first-page":"e83223","DOI":"10.1371\/journal.pone.0083223","article-title":"Methylation of the SLC6a2 gene promoter in major depression and panic disorder","volume":"8","author":"Bayles","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0030","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pneurobio.2004.09.001","article-title":"Norepinephrine and acetylcholine mediation of the components of reflexive attention: implications for attention deficit disorders","volume":"74","author":"Beane","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0035","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.mayocp.2012.08.013","article-title":"Postural tachycardia syndrome: a heterogeneous and multifactorial disorder","volume":"87","author":"Benarroch","year":"2012","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0040","first-page":"285","article-title":"The molecular mechanism of HDAC inhibitors in anticancer effects","volume":"3","author":"Bi","year":"2006","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0045","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.HYP.32.5.831","article-title":"Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy","volume":"32","author":"Bohm","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0050","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/cphy.c130037","article-title":"Regulation of aldosterone synthesis and secretion","volume":"4","author":"Bollag","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/BF00218272","article-title":"Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter","volume":"91","author":"Bruss","year":"1993","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0060","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neulet.2005.04.099","article-title":"Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients","volume":"384","author":"Caetano","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0065","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbagrm.2012.02.014","article-title":"CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression","volume":"1819","author":"Chatterjee","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/3-540-37633-X_2","article-title":"Nucleosome structure and function","author":"Chodaparambil","year":"2006","journal-title":"Ernst Schering Res Found Workshop"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0080","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0085","doi-asserted-by":"crossref","first-page":"e1000179","DOI":"10.1371\/journal.pgen.1000179","article-title":"Genetic modifiers of MeCP2 function in Drosophila","volume":"4","author":"Cukier","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0090","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature16462","article-title":"Competition between DNA methylation and transcription factors determines binding of NRF1","volume":"528","author":"Domcke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0095","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","article-title":"Epigenetics in human disease and prospects for epigenetic therapy","volume":"429","author":"Egger","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0100","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.84.3.1354","article-title":"Neuronal reuptake of norepinephrine and production of dihydroxyphenylglycol by cardiac sympathetic nerves in the anesthetized dog","volume":"84","author":"Eisenhofer","year":"1991","journal-title":"Circulation"},{"issue":"1656","key":"10.1016\/j.neubiorev.2016.06.015_bib0105","first-page":"1657","article-title":"On the use of DNA methylation inhibitors and the reversal of transcriptional silencing","volume":"101","author":"El-Osta","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/A:1009889922985","article-title":"Measurement of sympathetic nervous system activity in heart failure: the role of norepinephrine kinetics","volume":"5","author":"Esler","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.HYP.3.2.149","article-title":"Norepinephrine kinetics in essential hypertension: defective neuronal uptake of norepinephrine in some patients","volume":"3","author":"Esler","year":"1981","journal-title":"Hypertension"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0120","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1152\/physrev.1990.70.4.963","article-title":"Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions","volume":"70","author":"Esler","year":"1990","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/1359786806066055","article-title":"The neuronal noradrenaline transporter, anxiety and cardiovascular disease","volume":"20","author":"Esler","year":"2006","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1196\/annals.1410.064","article-title":"Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder","volume":"1148","author":"Esler","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin. Auton. Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/HYPERTENSIONAHA.111.172262","article-title":"Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome","volume":"58","author":"Fu","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0145","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1074\/jbc.M210256200","article-title":"The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation","volume":"278","author":"Fuks","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0150","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1161\/01.CIR.98.20.2154","article-title":"Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control","volume":"98","author":"Furlan","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0155","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1093\/nar\/gki971","article-title":"Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain","volume":"33","author":"Galvao","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0160","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1212\/01.wnl.0000267663.05398.40","article-title":"The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome","volume":"69","author":"Garland","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0165","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s40265-015-0388-8","article-title":"Panobinostat: first global approval","volume":"75","author":"Garnock-Jones","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.CIR.78.1.41","article-title":"In vivo measurement of neuronal uptake of norepinephrine in the human heart","volume":"78","author":"Goldstein","year":"1988","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0175","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1161\/01.CIR.0000036015.54619.B6","article-title":"Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes","volume":"106","author":"Goldstein","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0180","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1128\/MCB.06728-11","article-title":"Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation","volume":"32","author":"Gonzales","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0185","doi-asserted-by":"crossref","first-page":"e000395","DOI":"10.1161\/JAHA.113.000395","article-title":"Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome","volume":"2","author":"Green","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0190","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1161\/CIRCULATIONAHA.107.761643","article-title":"Postural tachycardia syndrome","volume":"117","author":"Grubb","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0195","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/jnnp.2008.168484","article-title":"Cardiac neurotransmission imaging with 123I-meta-iodobenzylguanidine in postural tachycardia syndrome","volume":"81","author":"Haensch","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0200","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/mus.24245","article-title":"Small-fiber neuropathy with cardiac denervation in postural tachycardia syndrome","volume":"50","author":"Haensch","year":"2014","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0205","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1523\/JNEUROSCI.23-11-04470.2003","article-title":"A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters","volume":"23","author":"Hahn","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0210","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/mol.105.011270","article-title":"Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation","volume":"68","author":"Hahn","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0215","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/10297","article-title":"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis","volume":"22","author":"Halushka","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0220","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1523\/JNEUROSCI.4675-09.2010","article-title":"Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons","volume":"30","author":"Harikrishnan","year":"2010","journal-title":"J. Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.neubiorev.2016.06.015_bib0225","first-page":"5","article-title":"The history of valproate in clinical neuroscience","volume":"37","author":"Henry","year":"2003","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0230","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng1162","article-title":"Trans allele methylation and paramutation-like effects in mice","volume":"34","author":"Herman","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0235","doi-asserted-by":"crossref","first-page":"e00726","DOI":"10.7554\/eLife.00726","article-title":"DNA methylation presents distinct binding sites for human transcription factors","volume":"2","author":"Hu","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0240","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1101\/gad.3.5.612","article-title":"CpG methylation of the cAMP-responsive enhancer\/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation","volume":"3","author":"Iguchi-Ariga","year":"1989","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0245","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00000441-200302000-00002","article-title":"Orthostatic intolerance is not necessarily related to a specific mutation (Ala457Pro) in the human norepinephrine transporter gene","volume":"325","author":"Ivancsits","year":"2003","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0250","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/01.CIR.99.13.1706","article-title":"Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance","volume":"99","author":"Jacob","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0255","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1056\/NEJM200010053431404","article-title":"The neuropathic postural tachycardia syndrome","volume":"343","author":"Jacob","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"Suppl","key":"10.1016\/j.neubiorev.2016.06.015_bib0260","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0265","doi-asserted-by":"crossref","first-page":"23326","DOI":"10.1074\/jbc.M601156200","article-title":"Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization","volume":"281","author":"Jayanthi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0270","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0275","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.1063852","article-title":"The role of DNA methylation in mammalian epigenetics","volume":"293","author":"Jones","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0280","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0333102410382792","article-title":"Orthostatic and non-orthostatic headache in postural tachycardia syndrome","volume":"31","author":"Khurana","year":"2011","journal-title":"Cephalalgia"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0285","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1074\/jbc.274.10.6507","article-title":"A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0290","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2003.08.057","article-title":"Norepinephrine transporter splice variants and their interaction with substrates and blockers","volume":"479","author":"Kitayama","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0295","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0300","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0955-0674(02)00335-6","article-title":"The many faces of histone lysine methylation","volume":"14","author":"Lachner","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0305","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/CIRCEP.107.750471","article-title":"Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome","volume":"1","author":"Lambert","year":"2008","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0310","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1468-1331.2010.03023.x","volume":"17","author":"Lauria","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0315","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0320","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/med.20024","article-title":"Histone deacetylation in epigenetics: an attractive target for anticancer therapy","volume":"25","author":"Mai","year":"2005","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0325","doi-asserted-by":"crossref","first-page":"20239","DOI":"10.1074\/jbc.M111.226811","article-title":"Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase","volume":"286","author":"Mannangatti","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0330","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1074\/jbc.M114.612192","article-title":"A role for p38 mitogen-activated protein kinase-mediated threonine 30-dependent norepinephrine transporter regulation in cocaine sensitization and conditioned place preference","volume":"290","author":"Mannangatti","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0335","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt1272","article-title":"Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug","volume":"25","author":"Marks","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0340","article-title":"A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism","author":"Marques","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0345","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/nar\/20.19.5085","article-title":"Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA","volume":"20","author":"Meehan","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0350","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00005344-199201000-00002","article-title":"Myocardial beta-adrenergic desensitization and neuronal norepinephrine uptake function in idiopathic dilated cardiomyopathy","volume":"19","author":"Merlet","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0355","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.autneu.2005.05.001","article-title":"A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome","volume":"120","author":"Nickander","year":"2005","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0360","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1285","article-title":"Complete sequencing and characterization of 21,243 full-length human cDNAs","volume":"36","author":"Ota","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0365","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/350350a0","article-title":"Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter","volume":"350","author":"Pacholczyk","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0370","doi-asserted-by":"crossref","first-page":"408","DOI":"10.18632\/genesandcancer.84","article-title":"A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1","volume":"6","author":"Pandey","year":"2015","journal-title":"Genes Cancer"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0375","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/eurheartj\/ehs041","article-title":"The human sympathetic nervous system: its relevance in hypertension and heart failure","volume":"33","author":"Parati","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0380","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.293.5532.1064","article-title":"Behind the scenes of gene expression","volume":"293","author":"Pennisi","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0385","doi-asserted-by":"crossref","first-page":"R546","DOI":"10.1016\/j.cub.2004.07.007","article-title":"Histones and histone modifications","volume":"14","author":"Peterson","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0390","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1006\/bbrc.1995.2582","article-title":"Molecular cloning and organization of the coding region of the human norepinephrine transporter gene","volume":"215","author":"Porzgen","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0395","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0167-4781(98)00072-4","article-title":"The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons","volume":"1398","author":"Porzgen","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0400","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gr.168781.113","article-title":"Vascular histone deacetylation by pharmacological HDAC inhibition","volume":"24","author":"Rafehi","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0405","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1161\/01.CIR.0000160356.97313.5D","article-title":"Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome","volume":"111","author":"Raj","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0410","first-page":"84","article-title":"The postural tachycardia syndrome (POTS): pathophysiology, diagnosis & management","volume":"6","author":"Raj","year":"2006","journal-title":"Indian Pacing Electrophysiol. J."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0415","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/CIRCULATIONAHA.112.144501","article-title":"Postural tachycardia syndrome (POTS)","volume":"127","author":"Raj","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0420","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/carcin\/21.3.461","article-title":"DNA methylation: past, present and future directions","volume":"21","author":"Robertson","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0425","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0430","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00008571-200007000-00003","article-title":"Pharmacological properties of naturally occurring variants of the human norepinephrine transporter","volume":"10","author":"Runkel","year":"2000","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0435","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2337\/diab.45.6.801","article-title":"Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients","volume":"45","author":"Schnell","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0440","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/hc0302.102597","article-title":"Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance","volume":"105","author":"Schroeder","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0445","first-page":"180","article-title":"HDAC inhibitors in cancer care","volume":"24","author":"Shabason","year":"2010","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0450","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1056\/NEJM200002243420803","article-title":"Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency","volume":"342","author":"Shannon","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0455","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.hrthm.2015.03.029","article-title":"2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome inappropriate sinus tachycardia, and vasovagal syncope","volume":"12","author":"Sheldon","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0460","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1242\/dmm.012203","article-title":"Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome","volume":"6","author":"Shirey-Rice","year":"2013","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0465","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.brainres.2014.10.055","article-title":"Norepinephrine transporter knock-out alters expression of the genes connected with antidepressant drugs action","volume":"1594","author":"Solich","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0470","doi-asserted-by":"crossref","first-page":"H2749","DOI":"10.1152\/ajpheart.00429.2003","article-title":"Local vascular responses affecting blood flow in postural tachycardia syndrome","volume":"285","author":"Stewart","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0475","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/CS20050254","article-title":"Increased plasma angiotensin II in postural tachycardia syndrome (POTS) is related to reduced blood flow and blood volume","volume":"110","author":"Stewart","year":"2006","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0480","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fgene.2015.00287","article-title":"Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER","volume":"6","author":"Suchiman","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0485","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0959-437X(93)90027-M","article-title":"Effects of DNA methylation on DNA-binding proteins and gene expression","volume":"3","author":"Tate","year":"1993","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399401003878","article-title":"Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications","volume":"2001","author":"Tellioglu","year":"2001","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0495","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0025-6196(11)61027-6","article-title":"Postural orthostatic tachycardia syndrome: the Mayo clinic experience","volume":"82","author":"Thieben","year":"2007","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0500","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"UniProt","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0505","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1161\/01.CIR.0000130847.18666.39","article-title":"Clinical assessment of norepinephrine transporter blockade through biochemical and pharmacological profiles","volume":"109","author":"Vincent","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0510","doi-asserted-by":"crossref","first-page":"675851","DOI":"10.1155\/2013\/675851","article-title":"Prediction of deleterious nonsynonymous single-nucleotide polymorphism for human diseases","volume":"2013","author":"Wu","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0515","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/74839","article-title":"Mice lacking the norepinephrine transporter are supersensitive to psychostimulants","volume":"3","author":"Xu","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0520","doi-asserted-by":"crossref","first-page":"19416","DOI":"10.1073\/pnas.0707442104","article-title":"Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes","volume":"104","author":"Yasui","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0525","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2040-2392-4-3","article-title":"MeCP2 modulates gene expression pathways in astrocytes","volume":"4","author":"Yasui","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0530","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2982.2009.01421.x","article-title":"Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link?","volume":"22","author":"Zarate","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0535","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1101\/gad.13.15.1924","article-title":"Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation","volume":"13","author":"Zhang","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0540","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature12433","article-title":"Charting a dynamic DNA methylation landscape of the human genome","volume":"500","author":"Ziller","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.06.015_bib0545","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4161\/epi.20733","article-title":"SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression","volume":"7","author":"Zocchi","year":"2012","journal-title":"Epigenetics"}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763415303547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763415303547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T22:18:41Z","timestamp":1600813121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763415303547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":109,"alternative-id":["S0149763415303547"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2016.06.015","relation":{},"ISSN":["0149-7634"],"issn-type":[{"type":"print","value":"0149-7634"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2016.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}