{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:23:27Z","timestamp":1793388207787,"version":"4.5.0"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Foundation of Natural Science of China","doi-asserted-by":"crossref","award":["31471114"],"award-info":[{"award-number":["31471114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Foundation of Natural Science of China","doi-asserted-by":"crossref","award":["81430024"],"award-info":[{"award-number":["81430024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Foundation of Natural Science of China","doi-asserted-by":"crossref","award":["31500837"],"award-info":[{"award-number":["31500837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taishan Scholarship and Program for New Century Excellent Talents in University"},{"DOI":"10.13039\/100014103","name":"Key Research and Development Program of Shandong Province","doi-asserted-by":"crossref","award":["216GSF201053"],"award-info":[{"award-number":["216GSF201053"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["BS2015SW022"],"award-info":[{"award-number":["BS2015SW022"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shandong Province Special Foundation for Postdoctoral Innovation","award":["201401006"],"award-info":[{"award-number":["201401006"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.neubiorev.2016.12.010","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T23:37:04Z","timestamp":1481931424000},"page":"98-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["The neurological effects of ghrelin in brain diseases: Beyond metabolic functions"],"prefix":"10.1016","volume":"73","author":[{"given":"Qian","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2016.12.010_bib0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1677\/JOE-08-0495","article-title":"Peripheral administration of GH induces cell proliferation in the brain of adult hypophysectomized rats","volume":"201","author":"Aberg","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0010","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1172\/JCI29867","article-title":"Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite","volume":"116","author":"Abizaid","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0015","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1365-2826.2009.01896.x","article-title":"Ghrelin and dopamine: new insights on the peripheral regulation of appetite","volume":"21","author":"Abizaid","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cmet.2006.04.006","article-title":"Ghrelin\u2013a new player in glucose homeostasis?","volume":"3","author":"Ahima","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0025","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature07181","article-title":"UCP2 mediates ghrelin's action on NPY\/AgRP neurons by lowering free radicals","volume":"454","author":"Andrews","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0030","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1523\/JNEUROSCI.3890-09.2009","article-title":"Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism","volume":"29","author":"Andrews","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0035","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2174\/1871527313666140917110635","article-title":"Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease?a translational perspective","volume":"13","author":"Apetz","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0040","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1210\/jcem.86.10.7885","article-title":"Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans","volume":"86","author":"Ariyasu","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0045","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF03343763","article-title":"Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans","volume":"23","author":"Arvat","year":"2000","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0050","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/nmo.12193","article-title":"Ghrelin signaling in the gut, its physiological properties, and therapeutic potential","volume":"25","author":"Avau","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0055","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1212\/01.wnl.0000334276.09729.0e","article-title":"Weight loss in Huntington disease increases with higher CAG repeat number","volume":"71","author":"Aziz","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1468-1331.2009.02798.x","article-title":"Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease","volume":"17","author":"Aziz","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0065","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1468-1331.2009.02617.x","article-title":"Dopaminergic treatment is associated with decreased body weight in patients with Parkinson's disease and dyskinesias","volume":"16","author":"Bachmann","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0070","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.clinbiochem.2009.02.020","article-title":"Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment","volume":"42","author":"Barim","year":"2009","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2042018813479645","article-title":"Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection","volume":"4","author":"Bayliss","year":"2013","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.npep.2015.05.003","article-title":"Blocking the ghrelin receptor type 1a in the rat brain impairs memory encoding","volume":"52","author":"Beheshti","year":"2015","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0085","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jalz.2014.08.104","article-title":"Self-reported sleep disturbance is associated with Alzheimer's disease risk in men","volume":"11","author":"Benedict","year":"2015","journal-title":"Alzheimers Dementia"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-2094-10-40","article-title":"Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones","volume":"10","author":"Beynon","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1155\/2011\/143857","article-title":"Emotional dysfunction in Parkinson's disease","volume":"24","author":"Blonder","year":"2011","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2826.2005.01379.x","article-title":"Cell biology of the ghrelin receptor","volume":"18","author":"Camina","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0105","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0006-291X(02)02740-7","article-title":"Ghrelin increases anxiety-like behavior and memory retention in rats","volume":"299","author":"Carlini","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0110","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.1038\/srep08489","article-title":"Neuroinflammation and Abeta accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation","volume":"5","author":"Carret-Rebillat","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0115","first-page":"41","article-title":"Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS","volume":"9","author":"Carri","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0120","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1007\/s12035-015-9227-x","article-title":"Effects of ghrelin on the proteolytic pathways of alzheimer's disease neuronal cells","volume":"53","author":"Cecarini","year":"2015","journal-title":"Mol. Neurobiol."},{"issue":"Suppl. 1","key":"10.1016\/j.neubiorev.2016.12.010_bib0125","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1038\/ijo.2009.17","article-title":"Ghrelin and the growth hormone secretagogue receptor in growth and development","volume":"33","author":"Chanoine","year":"2009","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0130","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1002\/jcb.23209","article-title":"Ghrelin induces cell migration through GHS-R, CaMKII, AMPK, and NF-kappaB signaling pathway in glioma cells","volume":"112","author":"Chen","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SHK.0b013e3181f48a37","article-title":"Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve","volume":"35","author":"Cheyuo","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0140","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/460549","article-title":"Ghrelin's roles in stress, mood, and anxiety regulation","volume":"2010","author":"Chuang","year":"2010","journal-title":"Int. J. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0145","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/en.2006-0991","article-title":"Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation","volume":"148","author":"Chung","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0150","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1677\/JOE-08-0160","article-title":"Phosphatidylinositol-3-kinase\/Akt\/glycogen synthase kinase-3 beta and ERK1\/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells","volume":"198","author":"Chung","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1507\/endocrj.K10E-396","article-title":"Ghrelin suppresses tunicamycin- or thapsigargin-triggered endoplasmic reticulum stress-mediated apoptosis in primary cultured rat cortical neuronal cells","volume":"58","author":"Chung","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/JOE-13-0045","article-title":"Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells","volume":"218","author":"Chung","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0165","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1523\/JNEUROSCI.4404-13.2014","article-title":"Ghrelin acts as an interface between physiological state and phasic dopamine signaling","volume":"34","author":"Cone","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0170","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1079\/BJN20051678","article-title":"Subthalamic nucleus stimulation in patients with Parkinson's disease does not increase serum ghrelin levels","volume":"95","author":"Corcuff","year":"2006","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0175","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0896-6273(03)00063-1","article-title":"The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis","volume":"37","author":"Cowley","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0180","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/archsurg.138.4.389","article-title":"Roles for ghrelin in the regulation of appetite and body weight","volume":"138","author":"Cummings","year":"2003","journal-title":"Arch. Surg."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0185","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","article-title":"A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans","volume":"50","author":"Cummings","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0190","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1210\/endo.141.11.7757","article-title":"Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans","volume":"141","author":"Date","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0195","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/gast.2002.35954","article-title":"The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats","volume":"123","author":"Date","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0200","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2337\/diabetes.51.1.124","article-title":"Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion","volume":"51","author":"Date","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000358345","article-title":"Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do?","volume":"42","author":"Delhanty","year":"2014","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0210","article-title":"Structure and physiological actions of ghrelin","volume":"2013","author":"Delporte","year":"2013","journal-title":"Scientifica (Cairo)"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0215","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nn1656","article-title":"Ghrelin controls hippocampal spine synapse density and memory performance","volume":"9","author":"Diano","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0220","doi-asserted-by":"crossref","first-page":"12057","DOI":"10.1073\/pnas.0710434105","article-title":"UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival","volume":"105","author":"Diao","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0225","doi-asserted-by":"crossref","first-page":"16681","DOI":"10.1074\/jbc.M600223200","article-title":"Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility","volume":"281","author":"Dixit","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10549-014-3060-1","article-title":"Ghrelin and des-acyl ghrelin inhibit aromatase expression and activity in human adipose stromal cells: suppression of cAMP as a possible mechanism","volume":"147","author":"Docanto","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0235","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12031-008-9162-7","article-title":"Ghrelin antagonized 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells","volume":"37","author":"Dong","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0240","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-0115(01)00243-9","article-title":"A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control","volume":"99","author":"Dornonville de la Cour","year":"2001","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0245","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1089\/neu.2009.1210","article-title":"The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats","volume":"27","author":"Ersahin","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0250","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12349","article-title":"Des-Acyl ghrelin directly targets the arcuate nucleus in a ghrelin-Receptor independent manner and impairs the orexigenic effect of ghrelin","volume":"28","author":"Fernandez","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0255","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/157015909787602779","article-title":"Ghrelin in central neurons","volume":"7","author":"Ferrini","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0260","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/610813","article-title":"Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0265","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0404.2009.01185.x","article-title":"Leptin and ghrelin concentrations and weight loss in Parkinson's disease","volume":"121","author":"Fiszer","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0270","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tins.2014.06.005","article-title":"Sleep, clocks, and synaptic plasticity","volume":"37","author":"Frank","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0275","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.1523\/JNEUROSCI.5809-11.2012","article-title":"Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain","volume":"32","author":"Friedman","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0280","doi-asserted-by":"crossref","first-page":"R485","DOI":"10.1152\/ajpregu.90555.2008","article-title":"Ghrelin modulates electrical activity of area postrema neurons","volume":"296","author":"Fry","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0285","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.2003.040600","article-title":"Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats","volume":"550","author":"Fujino","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0290","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/mp.2015.220","article-title":"Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1","volume":"21","author":"Fujitsuka","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0295","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3233\/JAD-2010-100873","article-title":"Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer's disease patients","volume":"22","author":"Gahete","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0300","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.peptides.2011.09.019","article-title":"Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease","volume":"32","author":"Gahete","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0305","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0005-2728(00)00175-4","article-title":"How do uncoupling proteins uncouple?","volume":"1459","author":"Garlid","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0310","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.molmet.2016.05.008","article-title":"PGC-1alpha expression in murine AgRP neurons regulates food intake and energy balance","volume":"5","author":"Gill","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0315","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans","volume":"87","author":"Gnanapavan","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0320","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(03)00965-7","article-title":"Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action","volume":"552","author":"Gualillo","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0325","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1073\/pnas.0800708105","article-title":"Ghrelin octanoylation mediated by an orphan lipid transferase","volume":"105","author":"Gutierrez","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0330","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.tips.2015.04.003","article-title":"Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell\u2013cell communication by chemokines","volume":"36","author":"Gyoneva","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0335","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1037\/a0023572","article-title":"Rat prefrontal dopamine and cognitive control: impaired and enhanced conflict performance","volume":"125","author":"Haddon","year":"2011","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0340","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0345","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0350","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0196-9781(02)00269-3","article-title":"Neuropeptides, food intake and body weight regulation: a hypothalamic focus","volume":"23","author":"Hillebrand","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0355","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.regpep.2006.02.005","article-title":"Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat","volume":"134","author":"Hou","year":"2006","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0360","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1507\/endocrj.K09E-072","article-title":"Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4","volume":"56","author":"Hwang","year":"2009","journal-title":"Endocr. J."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0365","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.expneurol.2008.05.006","article-title":"Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra","volume":"212","author":"Jiang","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0370","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrneurol.2013.269","article-title":"Sleep and Alzheimer disease pathology?a bidirectional relationship","volume":"10","author":"Ju","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0375","doi-asserted-by":"crossref","first-page":"R980","DOI":"10.1152\/ajpregu.00594.2012","article-title":"Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke?","volume":"304","author":"Kenny","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0380","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuron.2011.10.038","article-title":"Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism","volume":"73","author":"Kern","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0385","first-page":"LE01","article-title":"Ghrelin O acyl transferase (GOAT) as a novel metabolic regulatory enzyme","volume":"9","author":"Khatib","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0390","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bone.2005.04.020","article-title":"Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells","volume":"37","author":"Kim","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0395","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nm.1997","article-title":"GOAT links dietary lipids with the endocrine control of energy balance","volume":"15","author":"Kirchner","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0400","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000223731","article-title":"Ghrelin plasma levels are not altered in major depression","volume":"59","author":"Kluge","year":"2009","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0405","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpsychires.2010.09.002","article-title":"Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression","volume":"45","author":"Kluge","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0410","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2337\/diabetes.52.4.948","article-title":"Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin","volume":"52","author":"Kohno","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0415","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.bbrc.2007.11.166","article-title":"Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons","volume":"366","author":"Kohno","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0420","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncpendmet0080","article-title":"Drug insight: the functions of ghrelin and its potential as a multitherapeutic hormone","volume":"2","author":"Kojima","year":"2006","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0425","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0430","doi-asserted-by":"crossref","first-page":"19985","DOI":"10.1074\/jbc.M112.367854","article-title":"Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons","volume":"287","author":"Komori","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0435","first-page":"137","article-title":"Brain-gut axis and its role in the control of food intake","volume":"55","author":"Konturek","year":"2004","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0440","first-page":"881","article-title":"The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors","volume":"86","author":"Korbonits","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0445","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/JOE-15-0330","article-title":"Ghrelin O-acyltransferase knockout mice show resistance to obesity when fed high-sucrose diet","volume":"228","author":"Kouno","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0450","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.09.023","article-title":"Autophagy and the integrated stress response","volume":"40","author":"Kroemer","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0455","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/mp.2012.144","article-title":"Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression","volume":"18","author":"Lamers","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0460","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2012.05.046","article-title":"Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm","volume":"218","author":"Lamont","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0465","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuroscience.2014.09.061","article-title":"Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy","volume":"302","author":"Latta","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0470","doi-asserted-by":"crossref","first-page":"92","DOI":"10.14802\/jmd.15003","article-title":"Many faces of parkinson's disease: non-Motor symptoms of parkinson's disease","volume":"8","author":"Lee","year":"2015","journal-title":"J Mov Disord"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0475","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3803\/EnM.2014.29.3.371","article-title":"Ghrelin inhibits oligodendrocyte cell death by attenuating microglial activation","volume":"29","author":"Lee","year":"2014","journal-title":"Endocrinol. Metab. (Seoul)"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0480","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1677\/JOE-10-0040","article-title":"Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus","volume":"205","author":"Lee","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0485","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4196\/kjpp.2012.16.1.43","article-title":"Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation","volume":"16","author":"Lee","year":"2012","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0490","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/TA.0000000000000445","article-title":"Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy","volume":"77","author":"Lee","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0495","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1507\/endocrj.EJ13-0008","article-title":"Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory","volume":"60","author":"Li","year":"2013","journal-title":"Endocr. J."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0500","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1507\/endocrj.EJ13-0045","article-title":"Ghrelin-induced hippocampal neurogenesis and enhancement of cognitive function are mediated independently of GH\/IGF-1 axis: lessons from the spontaneous dwarf rats","volume":"60","author":"Li","year":"2013","journal-title":"Endocr. J."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0505","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2013.11.021","article-title":"Ghrelin stimulates proliferation, migration and differentiation of neural progenitors from the subventricular zone in the adult mice","volume":"252","author":"Li","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0510","first-page":"15993","article-title":"Effect of immobilization stress on the appetite and stomach ghrelin expression in maternal mice","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0515","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.expneurol.2011.04.003","article-title":"Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1\/2 and phosphatidylinositol-3-kinase\/Akt\/glycogen synthase kinase-3beta pathways","volume":"230","author":"Lim","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0520","first-page":"244","article-title":"Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia\/reperfusion","volume":"49","author":"Liu","year":"2006","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0525","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cmet.2008.03.006","article-title":"Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin","volume":"7","author":"Lopez","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0530","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2012.10.031","article-title":"Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a UCP-2 mechanism","volume":"1489","author":"Lopez","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0535","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn.2139","article-title":"The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress","volume":"11","author":"Lutter","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0540","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"Malenka","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0545","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1159\/000430377","article-title":"Ghrelin attenuated lipotoxicity via autophagy induction and nuclear factor-kappaB inhibition","volume":"37","author":"Mao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0550","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000335045","article-title":"The role of ghrelin, neuropeptide Y and leptin peptides in weight gain after deep brain stimulation for Parkinson's disease","volume":"90","author":"Markaki","year":"2012","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0555","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1566524013666131118103706","article-title":"Hypothalamic mTOR: the rookie energy sensor","volume":"14","author":"Martinez de Morentin","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0560","doi-asserted-by":"crossref","first-page":"e46923","DOI":"10.1371\/journal.pone.0046923","article-title":"Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin","volume":"7","author":"Martins","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0565","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2012.07.027","article-title":"Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder","volume":"1473","author":"Matsuo","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0570","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/mend.11.4.9908","article-title":"Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors","volume":"11","author":"McKee","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0575","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mito.2015.02.001","article-title":"Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders","volume":"21","author":"Mena","year":"2015","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0580","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0585","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.coph.2006.08.004","article-title":"Importance of the gut-brain axis in the control of glucose homeostasis","volume":"6","author":"Migrenne","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0590","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.regpep.2004.08.038","article-title":"Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus","volume":"126","author":"Mondal","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0595","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s12640-009-9037-x","article-title":"Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation","volume":"15","author":"Moon","year":"2009","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0600","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2010-101263","article-title":"Ghrelin ameliorates cognitive dysfunction and neurodegeneration in intrahippocampal amyloid-beta1-42 oligomer-injected mice","volume":"23","author":"Moon","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0605","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/and.12183","article-title":"Immunolocalisation of ghrelin and obestatin in human testis, seminal vesicles, prostate and spermatozoa","volume":"46","author":"Moretti","year":"2014","journal-title":"Andrologia"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0610","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molmet.2015.03.005","volume":"4","author":"Muller","year":"2015","journal-title":"Ghrelin. Mol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0615","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrendo.2014.91","article-title":"Hormonal and neural mechanisms of food reward, eating behaviour and obesity","volume":"10","author":"Murray","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0620","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-pathol-020712-163918","article-title":"Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease","volume":"8","author":"Murrow","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0625","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0630","first-page":"437","article-title":"Hormonal regulators of food intake and weight gain in Parkinson's disease after subthalamic nucleus stimulation","volume":"32","author":"Novakova","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0635","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0196-9781(03)00105-0","article-title":"Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus","volume":"24","author":"Olszewski","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0640","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4306\/pi.2014.11.2.167","article-title":"Serum ghrelin and leptin levels in patients with depression and the effects of treatment","volume":"11","author":"Ozsoy","year":"2014","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0645","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1007\/s00213-014-3640-0","article-title":"The role of ghrelin in addiction: a review","volume":"231","author":"Panagopoulos","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0650","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1210\/jc.2004-1641","article-title":"Characterization of ghrelin-like immunoreactivity in human plasma","volume":"90","author":"Patterson","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0655","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/jne.12236","article-title":"Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system","volume":"27","author":"Perello","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0660","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/00365513.2013.862848","article-title":"Urinary tract infection during pregnancy affects the level of leptin, ghrelin and insulin in maternal and placental blood","volume":"74","author":"Piatek","year":"2014","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0665","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2174\/156720511796391908","article-title":"Nutritional approaches to modulate oxidative stress in Alzheimer's disease","volume":"8","author":"Pocernich","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0670","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10284150400027107","article-title":"Brain somatic cross-talk: ghrelin, leptin and ultimate challengers of obesity","volume":"8","author":"Popovic","year":"2005","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0675","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2119\/molmed.2011.00390","article-title":"Ghrelin attenuates brain injury after traumatic brain injury and uncontrolled hemorrhagic shock in rats","volume":"18","author":"Qi","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0680","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/SLA.0000000000000328","article-title":"Ghrelin protects rats against traumatic brain injury and hemorrhagic shock through upregulation of UCP2","volume":"260","author":"Qi","year":"2014","journal-title":"Ann. Surg."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0685","doi-asserted-by":"crossref","first-page":"E149","DOI":"10.1073\/pnas.1313798111","article-title":"Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus","volume":"111","author":"Ribeiro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0690","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.175R001","article-title":"Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients","volume":"175","author":"Rigamonti","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0695","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuint.2014.12.012","article-title":"Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders","volume":"88","author":"Ruszkiewicz","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0700","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-3940(03)00294-5","article-title":"Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion","volume":"342","author":"Sakata","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0705","doi-asserted-by":"crossref","first-page":"e0141043","DOI":"10.1371\/journal.pone.0141043","article-title":"In situ localization and rhythmic expression of ghrelin and ghs-r1 ghrelin receptor in the brain and gastrointestinal tract of goldfish (Carassius auratus)","volume":"10","author":"Sanchez-Bretano","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0710","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/AN20120066","article-title":"Neuroimmunological processes in Parkinson's disease and their relation to alpha-synuclein: microglia as the referee between neuronal processes and peripheral immunity","volume":"5","author":"Sanchez-Guajardo","year":"2013","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0715","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbrc.2006.09.088","article-title":"Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord","volume":"350","author":"Sato","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0720","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/sj.npp.1300670","article-title":"Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls","volume":"30","author":"Schmid","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0725","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.conb.2012.11.012","article-title":"Updating dopamine reward signals","volume":"23","author":"Schultz","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0730","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2174\/138161212799277806","article-title":"Ghrelin and the brain-gut axis as a pharmacological target for appetite control","volume":"18","author":"Seim","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0735","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3390\/biom5021000","article-title":"Role of alpha- and beta-Synucleins in the Axonal Pathology of Parkinson's Disease and Related Synucleinopathies","volume":"5","author":"Sekigawa","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0740","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/npp.2015.287","article-title":"Daily exposure to sucrose impairs subsequent learning about food cues: a role for alterations in ghrelin signaling and dopamine D2 receptors","volume":"41","author":"Sharpe","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2014.07.010","article-title":"Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma","volume":"60","author":"Sheriff","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0750","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/ncomms2439","article-title":"Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7\/KCNQ channels","volume":"4","author":"Shi","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0755","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-016-9729-1","article-title":"Ghrelin and neurodegenerative disorders-a review","author":"Shi","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0760","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000333075","article-title":"Genetic association between ghrelin polymorphisms and Alzheimer's disease in a Japanese population","volume":"32","author":"Shibata","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0765","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.peptides.2009.03.013","article-title":"Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance","volume":"30","author":"Shrestha","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0770","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI0213300","article-title":"Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity","volume":"109","author":"Shuto","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0775","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.4155\/bio.14.108","article-title":"Quantification of ghrelin and des-acyl ghrelin in human plasma by using cubic-selected reaction-monitoring LCMS","volume":"6","author":"Sidibe","year":"2014","journal-title":"Bioanalysis"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0780","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/brainsci3010344","article-title":"The role of ghrelin in neuroprotection after ischemic brain injury","volume":"3","author":"Spencer","year":"2013","journal-title":"Brain Sci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0785","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mce.2011.02.013","article-title":"Ghrelin in mental health, sleep, memory","volume":"340","author":"Steiger","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0790","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.mce.2013.08.009","article-title":"Ghrelin-induced food intake and adiposity depend on central mTORC1\/S6K1 signaling","volume":"381","author":"Stevanovic","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0795","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2202-15-49","article-title":"Ghrelin accelerates synapse formation and activity development in cultured cortical networks","volume":"15","author":"Stoyanova","year":"2014","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0800","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.regpep.2013.07.004","article-title":"Ghrelin stimulates synaptic formation in cultured cortical networks in a dose-dependent manner","volume":"186","author":"Stoyanova","year":"2013","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0805","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1128\/MCB.23.22.7973-7981.2003","article-title":"Deletion of ghrelin impairs neither growth nor appetite","volume":"23","author":"Sun","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0810","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1073\/pnas.0305930101","article-title":"Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor","volume":"101","author":"Sun","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0815","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1210\/en.2007-0271","article-title":"Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance","volume":"149","author":"Sun","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0820","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/adb.12025","article-title":"Ethanol affects acylated and total ghrelin levels in peripheral blood of alcohol-dependent rats","volume":"18","author":"Szulc","year":"2013","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0825","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1038\/ncomms3685","article-title":"Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans","volume":"4","author":"Takagi","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0830","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1210\/jcem.85.12.7167","article-title":"Ghrelin strongly stimulates growth hormone release in humans","volume":"85","author":"Takaya","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0835","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1210\/jc.2004-0835","article-title":"Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader-Willi syndrome","volume":"89","author":"Tan","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0840","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.regpep.2004.06.015","article-title":"Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa","volume":"122","author":"Tanaka","year":"2004","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0845","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1365-2826.2005.01340.x","article-title":"Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1- and corticotrophin-releasing factor 1 receptor activation","volume":"17","author":"Tebbe","year":"2005","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0850","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12603-012-0058-4","article-title":"Ghrelin and leptin secretion in patients with moderate Alzheimer's disease","volume":"16","author":"Theodoropoulou","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0855","doi-asserted-by":"crossref","first-page":"1309502","DOI":"10.1155\/2016\/1309502","article-title":"Exenatide treatment causes suppression of serum ghrelin levels following mixed meal test in obese diabetic women","volume":"2016","author":"Topyildiz","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0860","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tschop","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0865","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity","volume":"50","author":"Tschop","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0870","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00415-010-5864-1","article-title":"Postprandial ghrelin response is reduced in patients with Parkinson's disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson's disease","volume":"258","author":"Unger","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0875","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2337\/db10-0802","article-title":"The central Sirtuin 1\/p53 pathway is essential for the orexigenic action of ghrelin","volume":"60","author":"Velasquez","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0880","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/MPG.0000000000000223","article-title":"Ghrelin and obestatin levels in children with failure to thrive and obesity","volume":"58","author":"Wali","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0885","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington's disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0890","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fphys.2014.00231","article-title":"Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0895","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ncpendmet0625","article-title":"Ghrelin, obesity and diabetes","volume":"3","author":"Wiedmer","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0900","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1210\/en.2003-1059","article-title":"Vagotomy dissociates short- and long-term controls of circulating ghrelin","volume":"144","author":"Williams","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0905","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.smrv.2015.11.003","article-title":"Synaptic plasticity model of therapeutic sleep deprivation in major depression","volume":"30","author":"Wolf","year":"2015","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0910","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1172\/JCI26003","article-title":"Absence of ghrelin protects against early-onset obesity","volume":"115","author":"Wortley","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0915","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1210\/jcem.86.12.8111","article-title":"Ghrelin enhances appetite and increases food intake in humans","volume":"86","author":"Wren","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0920","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1046\/j.0007-1331.2001.00757.x","article-title":"Regulational effect of ghrelin on growth hormone secretion from perifused rat anterior pituitary cells","volume":"14","author":"Yamazaki","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0925","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2008.01.017","article-title":"Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone","volume":"132","author":"Yang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0930","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1073\/pnas.0805353105","article-title":"Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides","volume":"105","author":"Yang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0935","first-page":"1061","article-title":"Down-regulation of ghrelin receptors in the small intestine delays small intestinal transit in vagotomized rats","volume":"4","author":"Yang","year":"2011","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0940","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.cell.2011.07.039","article-title":"Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop","volume":"146","author":"Yang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0945","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3892\/mmr.2012.1157","article-title":"Gastric motility in ghrelin receptor knockout mice","volume":"7","author":"Yang","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0950","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5493\/wjem.v5.i2.103","article-title":"Mood disorders: a potential link between ghrelin and leptin on human body?","volume":"5","author":"Zarouna","year":"2015","journal-title":"World J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0955","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1113\/jphysiol.2004.064121","article-title":"Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus","volume":"559","author":"Zhang","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0960","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.peptides.2005.04.023","article-title":"Stimulation of neurogenesis in rat nucleus of the solitary tract by ghrelin","volume":"26","author":"Zhang","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0965","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.3390\/ijms13089864","article-title":"Acute effect of ghrelin on ischemia\/reperfusion injury in the rat spinal cord","volume":"13","author":"Zhang","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0970","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.peptides.2013.08.015","article-title":"Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase","volume":"48","author":"Zhang","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0975","first-page":"1770","article-title":"AMPK activity is down-regulated in endothelial cells of GHS-R(-\/-) mice","volume":"6","author":"Zhang","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0980","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mce.2013.02.008","article-title":"Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro","volume":"370","author":"Zhang","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0985","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.1002271107","article-title":"Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0990","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1172\/JCI26002","article-title":"Mice lacking ghrelin receptors resist the development of diet-induced obesity","volume":"115","author":"Zigman","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2016.12.010_bib0995","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cne.20823","article-title":"Expression of ghrelin receptor mRNA in the rat and the mouse brain","volume":"494","author":"Zigman","year":"2006","journal-title":"J. Comp. Neurol."}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976341630241X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976341630241X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T11:38:04Z","timestamp":1589715484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014976341630241X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":199,"alternative-id":["S014976341630241X"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2016.12.010","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neurological effects of ghrelin in brain diseases: Beyond metabolic functions","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2016.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}