{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:48:00Z","timestamp":1790426880794,"version":"4.1.0"},"reference-count":258,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.neubiorev.2017.01.046","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T12:47:31Z","timestamp":1486385251000},"page":"148-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"special_numbering":"C","title":["Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?"],"prefix":"10.1016","volume":"77","author":[{"given":"Sami","family":"Piirainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan V.","family":"Kalueff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Landreth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarja","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2017.01.046_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2014.07.051","article-title":"Skeletal muscle PGC-1alpha1 modulates kynurenine metabolism and mediates resilience to stress-induced depression","volume":"159","author":"Agudelo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-2094-7-9","article-title":"Interleukin 18 in the CNS","volume":"7","author":"Alboni","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2741\/e371","article-title":"Chronic psychosocial stress exposes Alzheimer's disease phenotype in a novel at-risk model","volume":"4","author":"Alkadhi","year":"2012","journal-title":"Front Biosci. (Elite Ed)"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12035-014-8839-x","article-title":"Chronic stress decreases basal levels of memory-related signaling molecules in area CA1 of at-risk (subclinical) model of alzheimer's disease","volume":"52","author":"Alkadhi","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0025","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/glia.22503","article-title":"Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory \u201cBarrel\u201d cortex","volume":"61","author":"Arnoux","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0030","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0035","doi-asserted-by":"crossref","first-page":"e81744","DOI":"10.1371\/journal.pone.0081744","article-title":"Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice","volume":"8","author":"Ataka","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0040","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1523\/JNEUROSCI.1496-12.2012","article-title":"Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology","volume":"32","author":"Bachstetter","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb03132.x","article-title":"Hippocampal interleukin-1 beta gene expression during long-term potentiation decays with age","volume":"992","author":"Balschun","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0050","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1126\/science.1067859","article-title":"Control of synaptic strength by glial TNFalpha","volume":"295","author":"Beattie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.atherosclerosis.2011.11.041","article-title":"Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE-\/- mice","volume":"221","author":"Bernberg","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1474-4422(12)70259-4","article-title":"Genetic insights in Alzheimer's disease","volume":"12","author":"Bettens","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuron.2010.08.023","article-title":"Regulation of tau pathology by the microglial fractalkine receptor","volume":"68","author":"Bhaskar","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0070","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/nn.3560","article-title":"TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement","volume":"16","author":"Bialas","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0075","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/glia.22966","article-title":"Dark microglia: a new phenotype predominantly associated with pathological states","volume":"64","author":"Bisht","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0080","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbi.2009.04.013","article-title":"Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress","volume":"23","author":"Blandino","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer's disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0090","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.socscimed.2012.02.012","article-title":"Social disorder APOE-E4 genotype, and change in cognitive function among older adults living in Chicago","volume":"74","author":"Boardman","year":"2012","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pharep.2014.08.011","article-title":"Anti-interleukin-1beta antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex","volume":"67","author":"Bobula","year":"2015","journal-title":"Pharmacol. Rep.: PR"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/JAD-151020","article-title":"Clearing amyloid-beta through PPARgamma\/ApoE activation by genistein is a treatment of experimental Alzheimer's disease","volume":"51","author":"Bonet-Costa","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0105","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.194.8.1111","article-title":"A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells","volume":"194","author":"Bouchon","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0115","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nn.3435","article-title":"CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology","volume":"16","author":"Bradshaw","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jpsychires.2009.09.004","article-title":"Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c","volume":"44","author":"Brummett","year":"2010","journal-title":"J. Psychiatr Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0125","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0130","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nn1715","article-title":"Control of microglial neurotoxicity by the fractalkine receptor","volume":"9","author":"Cardona","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0135","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1161\/STROKEAHA.107.498212","article-title":"Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke","volume":"39","author":"Caso","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0140","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.mp.4002101","article-title":"The amyloidogenic potential and behavioral correlates of stress","volume":"14","author":"Catania","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0145","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1096\/fj.09-141754","article-title":"Massive gliosis induced by interleukin-6 suppresses A\u03b2 deposition in vivo: evidence against inflammation as a driving force for amyloid deposition","volume":"24","author":"Chakrabarty","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0150","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuron.2014.11.020","article-title":"IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior","volume":"85","author":"Chakrabarty","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1750-1326-7-36","article-title":"Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition","volume":"7","author":"Chakrabarty","year":"2012","journal-title":"Mol. Neurodegeneration"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0160","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/nn.4126","article-title":"CD33 modulates TREM2: convergence of Alzheimer loci","volume":"18","author":"Chan","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0165","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1038\/ncomms5486","article-title":"Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0170","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk","volume":"109","author":"Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(02)00030-1","article-title":"Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease","volume":"112","author":"Combrinck","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0002-9440(10)64354-4","article-title":"CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils","volume":"160","author":"Coraci","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0185","doi-asserted-by":"crossref","first-page":"34722","DOI":"10.1074\/jbc.M111.280826","article-title":"Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation","volume":"286","author":"Costello","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0190","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bbi.2012.12.017","article-title":"Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia","volume":"29","author":"Couch","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0195","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3109\/15622975.2015.1054879","article-title":"Neuroinflammation in suicide: toward a comprehensive model","volume":"17","author":"Courtet","year":"2016","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0200","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.bbi.2011.10.004","article-title":"CD200 fusion protein decreases microglial activation in the hippocampus of aged rats","volume":"26","author":"Cox","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0205","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuron.2013.02.026","article-title":"GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease","volume":"78","author":"Cruchaga","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.biopsych.2008.07.024","article-title":"Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease","volume":"65","author":"Cunningham","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0215","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1523\/JNEUROSCI.2614-05.2005","article-title":"Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration","volume":"25","author":"Cunningham","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0220","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12974-015-0366-9","article-title":"Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice","volume":"12","author":"Dagher","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0225","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"ATP mediates rapid microglial response to local brain injury in vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0235","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1212\/WNL.38.11.1688","article-title":"A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques","volume":"38","author":"Davies","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0240","doi-asserted-by":"crossref","first-page":"e569","DOI":"10.1038\/tp.2015.60","article-title":"Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1","volume":"5","author":"Dawson","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0245","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s12035-007-0036-8","article-title":"Neuronal chemokines: versatile messengers in central nervous system cell interaction","volume":"36","author":"de Haas","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0250","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-2094-11-34","article-title":"Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation","volume":"11","author":"de Pablos","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0255","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbi.2013.05.011","article-title":"A cytokine network involving brain-borne IL-1beta, IL-1ra, IL-18, IL-6, and TNFalpha operates during long-term potentiation and learning","volume":"33","author":"del Rey","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0260","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuropharm.2014.12.034","article-title":"Microglia in neuronal plasticity: influence of stress","volume":"96","author":"Delpech","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0265","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1523\/JNEUROSCI.3028-14.2015","article-title":"Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission","volume":"35","author":"Delpech","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-015-1449-5","article-title":"Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities","volume":"130","author":"Dorostkar","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0275","doi-asserted-by":"crossref","first-page":"pyv089","DOI":"10.1093\/ijnp\/pyv089","article-title":"Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+\/- Mice: Interleukin-10 and Kynurenic Acid","volume":"19","author":"Dugan","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0280","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1084\/jem.20021546","article-title":"CD36 mediates the innate host response to beta-amyloid","volume":"197","author":"El Khoury","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0285","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biopsych.2005.06.017","article-title":"Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease","volume":"59","author":"Elgh","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0290","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1096\/fj.03-0364fje","article-title":"The LPS receptor (CD14) links innate immunity with Alzheimer's disease","volume":"18","author":"Fassbender","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0295","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1742-2094-9-62","article-title":"Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology","volume":"9","author":"Ferretti","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0300","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pneurobio.2015.05.003","article-title":"Alternatively activated microglia and macrophages in the central nervous system","volume":"131","author":"Franco","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0305","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbi.2006.03.005","article-title":"Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses","volume":"21","author":"Frank","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0310","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.psyneuen.2013.11.006","article-title":"Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus","volume":"40","author":"Frank","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0315","doi-asserted-by":"crossref","first-page":"E2705","DOI":"10.1073\/pnas.1604032113","article-title":"IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline","volume":"113","author":"Fu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0320","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/glia.22331","article-title":"Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia","volume":"60","author":"Fu","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0325","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbi.2015.12.020","article-title":"Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: both effects are reversed by inhibition of indoleamine 2,3-dioxygenase","volume":"54","author":"Fuertig","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0330","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00401-015-1484-2","article-title":"Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies","volume":"130","author":"Fuller","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0335","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2013.05.007","article-title":"Microglia as dynamic and essential components of the amyloid hypothesis","volume":"78","author":"Gandy","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0340","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nrneurol.2015.218","article-title":"Alzheimer disease: solanezumab-prospects for meaningful interventions in AD?","volume":"11","author":"Gandy","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0345","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biopsych.2012.07.005","article-title":"Stress-induced neuroinflammation: role of the Toll-like receptor-4 pathway","volume":"73","author":"Garate","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0350","series-title":"Brain Aging: Models, Methods, and Mechanisms, Boca Raton, FL","article-title":"Changes in cognitive function in human aging","author":"Glisky","year":"2007"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0355","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.mp.4002055","article-title":"Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression","volume":"13","author":"Goshen","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0360","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yfrne.2008.10.001","article-title":"Interleukin-1 (IL-1): a central regulator of stress responses","volume":"30","author":"Goshen","year":"2009","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0365","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jagp.2013.02.011","article-title":"Depression and incident Alzheimer disease: the impact of disease severity","volume":"23","author":"Gracia-Garcia","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0370","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nn.2432","article-title":"Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia","volume":"12","author":"Grathwohl","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0375","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1523\/JNEUROSCI.2797-06.2006","article-title":"Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease","volume":"26","author":"Green","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0380","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.60.5.753","article-title":"Depression as a risk factor for Alzheimer disease: the MIRAGE Study","volume":"60","author":"Green","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0385","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0390","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1007\/s00018-008-7578-4","article-title":"Molecular mechanisms of phagocytic uptake in mammalian cells","volume":"65","author":"Groves","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0395","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0400","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuron.2014.12.068","article-title":"Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology","volume":"85","author":"Guillot-Sestier","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0405","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12974-015-0416-3","article-title":"IL-4\/10 prevents stress vulnerability following imipramine discontinuation","volume":"12","author":"Han","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0410","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/CS20110164","article-title":"Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential","volume":"121","author":"Hanke","year":"2011","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0415","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.pharmthera.2013.04.013","article-title":"Microglia during development and aging","volume":"139","author":"Harry","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0420","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0197-4580(97)80309-0","article-title":"Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation","volume":"18","author":"Hartmann","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0425","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/nn1805","article-title":"The P2Y12 receptor regulates microglial activation by extracellular nucleotides","volume":"9","author":"Haynes","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0430","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2174\/1567205012666151020114607","article-title":"Aging in Down syndrome and the development of Alzheimer's disease neuropathology","volume":"13","author":"Head","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0435","first-page":"76","article-title":"Susceptibility to focal and global brain ischemia of Alzheimer mice displaying abeta deposits: effect of immunoglobulin","volume":"5","author":"Heikkinen","year":"2014","journal-title":"Aging Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0440","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbi.2015.11.008","article-title":"Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice","volume":"55","author":"Hellwig","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0445","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0450","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1073\/pnas.0909586107","article-title":"Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine","volume":"107","author":"Heneka","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0455","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrn3880","article-title":"Immune attack: the role of inflammation in Alzheimer disease","volume":"16","author":"Heppner","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0460","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0465","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nn.3554","article-title":"The microglial sensome revealed by direct RNA sequencing","volume":"16","author":"Hickman","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0470","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/cercor\/bhr229","article-title":"Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex","volume":"22","author":"Hinwood","year":"2012","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0475","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/cercor\/bhs151","article-title":"Chronic stress induced remodeling of the prefrontal cortex: structural re-organization of microglia and the inhibitory effect of minocycline","volume":"23","author":"Hinwood","year":"2013","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0480","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0485","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0490","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.conb.2015.12.004","article-title":"New insights on the role of microglia in synaptic pruning in health and disease","volume":"36","author":"Hong","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0495","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1742-2094-8-171","article-title":"Neuroinflammation in Alzheimer's disease wanes with age","volume":"8","author":"Hoozemans","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0500","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization-new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0505","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pneurobio.2014.06.002","article-title":"Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles","volume":"119-120","author":"Hu","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0510","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biopsych.2015.11.026","article-title":"Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor","volume":"80","author":"Iwata","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0515","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0520","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2174\/156720511795745366","article-title":"The mechanism of memory impairment induced by Abeta chronic administration involves imbalance between cytokines and neurotrophins in the rat hippocampus","volume":"8","author":"Ji","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0525","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1016\/j.neurobiolaging.2015.08.019","article-title":"Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice","volume":"36","author":"Jiang","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0530","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s12035-013-8536-1","article-title":"CD33 in Alzheimer's disease","volume":"49","author":"Jiang","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0535","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.neuroscience.2005.06.090","article-title":"Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines","volume":"135","author":"Johnson","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0540","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2012.08.007","article-title":"Beta-adrenergic receptor activation primes microglia cytokine production","volume":"254","author":"Johnson","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0545","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbi.2015.02.014","article-title":"Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse","volume":"48","author":"Jones","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0550","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0555","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-2012-120328","article-title":"Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease","volume":"31","author":"Joshi","year":"2012","journal-title":"J. Alzheimers Dis"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0560","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1523\/JNEUROSCI.3333-14.2015","article-title":"Posttraumatic stress disorder-like induction elevates beta-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses","volume":"35","author":"Justice","year":"2015","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0565","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2014.05.041","article-title":"Alzheimer's disease genetics: from the bench to the clinic","volume":"83","author":"Karch","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0570","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer's disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0575","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0580","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molimm.2008.09.026","article-title":"Complement Receptor 1: disease associations and therapeutic implications","volume":"46","author":"Khera","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0585","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The role of apolipoprotein E in Alzheimer's disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0590","doi-asserted-by":"crossref","first-page":"767","DOI":"10.14348\/molcells.2014.0248","article-title":"Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms","volume":"37","author":"Kim","year":"2014","journal-title":"Mol Cells"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0595","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/ni1411","article-title":"The TREM receptor family and signal integration","volume":"7","author":"Klesney-Tait","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0600","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","article-title":"Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis","volume":"19","author":"Kreisel","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0605","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2012.236","article-title":"Deciphering the mechanism underlying late-onset Alzheimer disease","volume":"9","author":"Krstic","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0610","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fnbeh.2014.00257","article-title":"Mixed housing with DBA\/2 mice induces stress in C57BL\/6 mice: implications for interventions based on social enrichment","volume":"8","author":"Kulesskaya","year":"2014","journal-title":"Front Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0615","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0620","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2014.07.024","article-title":"Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis","volume":"36","author":"Lee","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0625","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/1871527315666160202125914","article-title":"Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system","volume":"15","author":"Leszek","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0630","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1096\/fj.14-262683","article-title":"Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia","volume":"29","author":"Li","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0635","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bbi.2014.02.008","article-title":"Microglia are polarized to M1 type in high-anxiety inbred mice in response to lipopolysaccharide challenge","volume":"38","author":"Li","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0640","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jalz.2014.12.009","article-title":"The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease","volume":"11","author":"Lill","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0645","doi-asserted-by":"crossref","first-page":"e81218","DOI":"10.1371\/journal.pone.0081218","article-title":"Neuronal synapse formation induced by microglia and interleukin 10","volume":"8","author":"Lim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0650","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/glia.22359","article-title":"Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx","volume":"61","author":"Linnartz","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0655","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1212\/WNL.0000000000001877","article-title":"Amyloid-beta 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials","volume":"85","author":"Liu","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0660","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3109\/10253890.2014.995085","article-title":"Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction","volume":"18","author":"Liu","year":"2015","journal-title":"Stress (Amsterdam, Netherlands)"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0665","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1093\/brain\/awh531","article-title":"LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide","volume":"128","author":"Liu","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0670","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1471-4159.2006.04370.x","article-title":"IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro","volume":"101","author":"Lyons","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0675","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psychres.2015.01.001","article-title":"Differential expression of brain immune genes and schizophrenia-related behavior in C57BL\/6N and DBA\/2J female mice","volume":"226","author":"Ma","year":"2015","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0680","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-015-0297-5","article-title":"Association of brain immune genes with social behavior of inbred mouse strains","volume":"12","author":"Ma","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0685","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fncel.2011.00022","article-title":"CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment","volume":"5","author":"Maggi","year":"2011","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0690","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neurobiolaging.2004.07.002","article-title":"Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat","volume":"26","author":"Maher","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0695","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.0829-08.2008","article-title":"Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia\/macrophage phenotype in amyloid precursor protein transgenic mice","volume":"28","author":"Maier","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0700","doi-asserted-by":"crossref","first-page":"13320","DOI":"10.1523\/JNEUROSCI.1224-13.2013","article-title":"CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing","volume":"33","author":"Malik","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0705","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/glia.20973","article-title":"The role and therapeutic potential of monocytic cells in Alzheimer's disease","volume":"58","author":"Malm","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0710","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nbd.2004.09.009","article-title":"Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP\/PS1 double transgenic Alzheimer mice","volume":"18","author":"Malm","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0715","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1523\/JNEUROSCI.5268-11.2012","article-title":"Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease","volume":"32","author":"Mandrekar-Colucci","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0720","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3233\/JAD-2011-101863","article-title":"Socioeconomic status during lifetime and cognitive impairment no-dementia in late life: the population-based aging in the Chianti Area (InCHIANTI) Study","volume":"24","author":"Marengoni","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0725","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neubiorev.2008.10.005","article-title":"Evidence for a cytokine model of cognitive function","volume":"33","author":"McAfoose","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0730","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopsych.2013.10.003","article-title":"Major histocompatibility complex I in brain development and schizophrenia","volume":"75","author":"McAllister","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0735","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.1073\/pnas.0902018106","article-title":"H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning","volume":"106","author":"McConnell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0740","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/hipo.20966","article-title":"Social instability stress in adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in adulthood","volume":"22","author":"McCormick","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0745","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-013-1177-7","article-title":"The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy","volume":"126","author":"McGeer","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0750","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3233\/JAD-160488","article-title":"Inflammation Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years","volume":"54","author":"McGeer","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0755","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.biopsych.2015.07.010","article-title":"Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat","volume":"79","author":"McKim","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0760","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/j.ajpath.2013.01.051","article-title":"Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice","volume":"182","author":"Medeiros","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0765","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/1567205013666151116125714","article-title":"Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?","volume":"13","author":"Merino","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0770","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.celrep.2013.10.010","article-title":"Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta","volume":"5","author":"Michaud","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0775","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.neuron.2015.01.021","article-title":"Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology","volume":"85","author":"Michaud","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0780","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1523\/JNEUROSCI.6209-10.2011","article-title":"Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease","volume":"31","author":"Mildner","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0785","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbi.2015.07.024","article-title":"Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress","volume":"55","author":"Milior","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0790","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/mp.2014.111","article-title":"Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis","volume":"19","author":"Miller","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0795","doi-asserted-by":"crossref","first-page":"27971","DOI":"10.1074\/jbc.M302530200","article-title":"Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?","volume":"278","author":"Minogue","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0800","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0805","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cellimm.2011.04.003","article-title":"Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients","volume":"270","author":"Mundy-Bosse","year":"2011","journal-title":"Cell Immunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0810","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1460-9568.2004.03560.x","article-title":"TNF-\u03b1 accounts for short-term persistence of oxidative status in rat brain after two weeks of repeated stress","volume":"20","author":"Munhoz","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0815","doi-asserted-by":"crossref","first-page":"13690","DOI":"10.1523\/JNEUROSCI.0303-09.2010","article-title":"Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner","volume":"30","author":"Munhoz","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0820","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0825","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2119\/molmed.2011.00306","article-title":"Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease","volume":"18","author":"Naert","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0830","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0835","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1248\/bpb.25.945","article-title":"Regulating factors for microglial activation","volume":"25","author":"Nakamura","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0840","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0845","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for primary prevention of Alzheimer's disease: an analysis of population-based data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0850","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neuropharm.2015.12.004","article-title":"Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders","volume":"112","author":"O\u2019Farrell","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0855","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neurobiolaging.2007.06.006","article-title":"Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients","volume":"30","author":"Ojala","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0860","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fncel.2015.00102","article-title":"Restraint stress increases hemichannel activity in hippocampal glial cells and neurons","volume":"9","author":"Orellana","year":"2015","journal-title":"Front Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0865","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0870","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1176\/ajp.2006.163.9.1630","article-title":"Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress","volume":"163","author":"Pace","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0875","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0880","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3233\/JAD-2010-100204","article-title":"Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation","volume":"21","author":"Parachikova","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0885","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0890","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nn.2741","article-title":"Dendritic spine pathology in neuropsychiatric disorders","volume":"14","author":"Penzes","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0895","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0900","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrn2394","article-title":"C1q: the perfect complement for a synaptic feast?","volume":"9","author":"Perry","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0905","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0910","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1073\/pnas.1310655110","article-title":"Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via beta-adrenergic induction of myelopoiesis","volume":"110","author":"Powell","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0915","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tins.2014.11.001","article-title":"Adding fuel to the fire: the impact of stress on the ageing brain","volume":"38","author":"Prenderville","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0920","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1084\/jem.20150479","article-title":"Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice","volume":"212","author":"Prokop","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0925","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/1074-7613(94)90093-0","article-title":"CD14 is a pattern recognition receptor","volume":"1","author":"Pugin","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0930","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer's disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0935","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/j.1532-5415.2010.02977.x","article-title":"Greater prevalence and incidence of dementia in older veterans with posttraumatic stress disorder","volume":"58","author":"Qureshi","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0940","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/hmg\/ddt666","article-title":"CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility","volume":"23","author":"Raj","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0945","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1093\/brain\/awv231","article-title":"GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP","volume":"138","author":"Ramanan","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0950","doi-asserted-by":"crossref","first-page":"a020560","DOI":"10.1101\/cshperspect.a020560","article-title":"Microglia in Health and Disease","volume":"8","author":"Ransohoff","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0955","doi-asserted-by":"crossref","first-page":"15369","DOI":"10.1523\/JNEUROSCI.2637-10.2010","article-title":"Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu","volume":"30","author":"Reed-Geaghan","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0960","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1375\/twin.10.2.241","article-title":"Genotype-environment interactions: cognitive aging and social factors","volume":"10","author":"Reynolds","year":"2007","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0965","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nbd.2014.05.018","article-title":"Interleukin-1beta mediated amyloid plaque clearance is independent of CCR2 signaling in the APP\/PS1 mouse model of Alzheimer's disease","volume":"69","author":"Rivera-Escalera","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0970","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10571-014-0074-5","article-title":"Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability","volume":"34","author":"Rodrigues","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0975","doi-asserted-by":"crossref","first-page":"16241","DOI":"10.1523\/JNEUROSCI.3667-11.2011","article-title":"CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity","volume":"31","author":"Rogers","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0980","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2015.10.022","article-title":"Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention","volume":"103","author":"Rossetti","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0985","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jagp.2015.03.006","article-title":"Chronic depressive symptomatology in mild cognitive impairment is associated with frontal atrophy rate which hastens conversion to Alzheimer dementia","volume":"24","author":"Sacuiu","year":"2016","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib0990","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bbrc.2008.04.148","article-title":"ROCK, PAK, and Toll of synapses in Alzheimer's disease","volume":"371","author":"Salminen","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl 1","key":"10.1016\/j.neubiorev.2017.01.046_bib0995","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1023\/B:VERC.0000014178.16764.01","article-title":"Isolation stress in sheep: effects on neutrophil gene expression of CD18, IL8 and C5a receptors","volume":"27","author":"Sartorelli","year":"2003","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1000","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1523\/JNEUROSCI.4586-14.2015","article-title":"Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease","volume":"35","author":"Savage","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1005","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1010","doi-asserted-by":"crossref","first-page":"a020545","DOI":"10.1101\/cshperspect.a020545","article-title":"Microglia function in central nervous system development and plasticity","volume":"7","author":"Schafer","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1015","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1073\/pnas.95.13.7778","article-title":"A neuromodulatory role of interleukin-1beta in the hippocampus","volume":"95","author":"Schneider","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1025","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ana.24125","article-title":"Mild to moderate Alzheimer dementia with insufficient neuropathological changes","volume":"75","author":"Serrano-Pozo","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1030","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1172\/JCI31450","article-title":"Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology","volume":"117","author":"Shaftel","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1035","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/mp.2014.100","article-title":"DISC1 regulates trafficking and processing of APP and Abeta generation","volume":"20","author":"Shahani","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1040","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1045","doi-asserted-by":"crossref","first-page":"13029","DOI":"10.1523\/JNEUROSCI.1698-15.2015","article-title":"Complement C3-deficient mice fail to display age-related hippocampal decline","volume":"35","author":"Shi","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1050","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.4049\/jimmunol.181.9.6503","article-title":"IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia","volume":"181","author":"Shimizu","year":"2008","journal-title":"J. Immunol. (Baltimore Md.: 1950)"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1055","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jalz.2015.06.1893","article-title":"Phase 3 solanezumab trials: secondary outcomes in mild Alzheimer's disease patients","volume":"12","author":"Siemers","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1060","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","article-title":"Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease","volume":"49","author":"Simard","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1065","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1038\/ncomms10905","article-title":"Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex","volume":"7","author":"Sipe","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1070","doi-asserted-by":"crossref","first-page":"e47740","DOI":"10.1371\/journal.pone.0047740","article-title":"CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2","volume":"7","author":"Soberman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1075","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plipres.2015.12.003","article-title":"The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: acting separately or synergistically?","volume":"62","author":"Song","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1080","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1523\/JNEUROSCI.4705-12.2013","article-title":"Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation","volume":"33","author":"Sorrells","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2009.09.032","article-title":"The stressed CNS: when glucocorticoids aggravate inflammation","volume":"64","author":"Sorrells","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1090","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-4159.2008.05613.x","article-title":"Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau","volume":"107","author":"Sotiropoulos","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1095","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer's disease","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1100","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.biopsych.2008.08.021","article-title":"Chronic psychosocial stress exacerbates impairment of cognition and long-term potentiation in beta-amyloid rat model of Alzheimer's disease","volume":"65","author":"Srivareerat","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1105","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1110","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1115","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbr.2014.08.037","article-title":"Cytokine and endocrine parameters in mouse chronic social defeat: implications for translational \u2018cross-domain\u2019 modeling of stress-related brain disorders","volume":"276","author":"Stewart","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbi.2015.10.010","article-title":"Microglial toll-like receptors and Alzheimer's disease","volume":"52","author":"Su","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1125","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.neuroscience.2007.02.043","article-title":"Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18","volume":"146","author":"Sugama","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1742-2094-9-199","article-title":"Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-beta production in human neuron-like cells","volume":"9","author":"Sutinen","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1135","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/jnc.13072","article-title":"APOE-modulated Abeta-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective","volume":"133","author":"Tai","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1140","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.it.2008.11.002","article-title":"Neuronal regulation of immune responses in the central nervous system","volume":"30","author":"Tian","year":"2009","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1150","first-page":"25","article-title":"TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study","volume":"8","author":"Tobinick","year":"2006","journal-title":"MedGenMed"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1155","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2014.05.007","article-title":"Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides","volume":"42","author":"Torres-Platas","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1160","doi-asserted-by":"crossref","first-page":"e1000527","DOI":"10.1371\/journal.pbio.1000527","article-title":"Microglial interactions with synapses are modulated by visual experience","volume":"8","author":"Tremblay","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1165","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-9-106","article-title":"Tumor necrosis factor-alpha synthesis inhibitor 3,6\u2019-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease","volume":"9","author":"Tweedie","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1170","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.neurobiolaging.2015.07.027","article-title":"The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease","volume":"36","author":"Varnum","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1175","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1084\/jem.20150478","article-title":"Replacement of brain-resident myeloid cells does not alter cerebral amyloid-beta deposition in mouse models of Alzheimer's disease","volume":"212","author":"Varvel","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1180","doi-asserted-by":"crossref","first-page":"7215684","DOI":"10.1155\/2016\/7215684","article-title":"Acute psychological stress modulates the expression of enzymes involved in the Kynurenine pathway throughout corticolimbic circuits in adult male rats","volume":"2016","author":"Vecchiarelli","year":"2016","journal-title":"Neural. Plast"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1185","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.conb.2015.10.004","article-title":"Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease","volume":"36","author":"Villegas-Llerena","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1190","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrneurol.2014.44","article-title":"Alzheimer disease: lessons from immunotherapy for Alzheimer disease","volume":"10","author":"Wang","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1195","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbi.2013.03.004","article-title":"Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge","volume":"32","author":"Weber","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1200","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biopsych.2013.06.009","article-title":"Regulation of N-methyl-D-aspartate receptors by disrupted-in-schizophrenia-1","volume":"75","author":"Wei","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1205","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/npp.2011.239","article-title":"Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus","volume":"37","author":"Wei","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1210","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/glia.22866","article-title":"Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease","volume":"64","author":"Wes","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1215","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1212\/01.WNL.0000149525.53525.E7","article-title":"Proneness to psychological distress and risk of Alzheimer disease in a biracial community","volume":"64","author":"Wilson","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1220","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1225","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1230","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.biopsych.2013.11.029","article-title":"Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain","volume":"75","author":"Wohleb","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1235","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","article-title":"Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior","volume":"33","author":"Wohleb","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1240","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.neurobiolaging.2013.06.003","article-title":"Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency","volume":"34","author":"Wu","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1245","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.it.2015.08.008","article-title":"Microglia: dynamic mediators of synapse development and plasticity","volume":"36","author":"Wu","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1250","doi-asserted-by":"crossref","first-page":"10837","DOI":"10.1073\/pnas.162350199","article-title":"Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice","volume":"99","author":"Wyss-Coray","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1255","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1001\/archgenpsychiatry.2010.61","article-title":"Posttraumatic stress disorder and risk of dementia among US veterans","volume":"67","author":"Yaffe","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1260","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1265","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior","volume":"17","author":"Zhan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1270","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1136\/jech.2007.063917","article-title":"Apolipoprotein E polymorphism, life stress and self-reported health among older adults","volume":"62","author":"Zhang","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1275","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuron.2014.01.043","article-title":"Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase","volume":"82","author":"Zhang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1280","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbr.2015.11.027","article-title":"Behavioral characterization of CD36 knockout mice with SHIRPA primary screen","volume":"299","author":"Zhang","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1285","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2017.01.046_bib1290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-015-1527-8","article-title":"Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease","volume":"131","author":"Zou","year":"2016","journal-title":"Acta Neuropathol."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763416304857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763416304857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:37:12Z","timestamp":1719034632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763416304857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":258,"alternative-id":["S0149763416304857"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2017.01.046","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2017.01.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}