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Scand."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0580","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/hmg\/ddg239","article-title":"Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse","volume":"12","author":"Itier","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0585","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.parkreldis.2010.06.014","article-title":"Occurrence of depression and anxiety prior to Parkinson\u2019s disease","volume":"16","author":"Jacob","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0590","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.physbeh.2017.01.046","article-title":"Chronic mild stress augments MPTP induced neurotoxicity in a murine model of Parkinson\u2019s disease","volume":"173","author":"Janakiraman","year":"2017","journal-title":"Physiol. 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A."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0605","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbr.2010.07.023","article-title":"Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats","volume":"216","author":"Jungnickel","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0610","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1523\/JNEUROSCI.20-17-06365.2000","article-title":"Subcellular localization of wild-type and Parkinson\u2019s disease-associated mutant alpha -synuclein in human and transgenic mouse brain","volume":"20","author":"Kahle","year":"2000","journal-title":"J. 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Med."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0750","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neures.2015.01.006","article-title":"Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson\u2019s disease model rats","volume":"96","author":"Maegawa","year":"2015","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0755","first-page":"681","article-title":"The concept of prodromal Parkinson\u2019s disease","volume":"5","author":"Mahlknecht","year":"2015","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0760","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1074\/jbc.C100560200","article-title":"The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein","volume":"277","author":"Manning-Bog","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0765","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11910-013-0409-5","article-title":"Depression and Parkinson\u2019s disease: current knowledge","volume":"13","author":"Marsh","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0770","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.nbd.2013.07.004","article-title":"Glial A30\u2009P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice","volume":"59","author":"Marxreiter","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0775","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1126\/science.287.5456.1265","article-title":"Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders","volume":"287","author":"Masliah","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0780","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1007\/s12035-015-9330-z","article-title":"Temporal dissociation of striatum and prefrontal cortex uncouples anhedonia and defense behaviors relevant to depression in 6-OHDA-Lesioned rats","volume":"53","author":"Matheus","year":"2016","journal-title":"Mol. 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Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0795","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0006-8993(90)90072-J","article-title":"6-Hydroxydopamine lesions of the ventral tegmentum abolish D-amphetamine and morphine analgesia in the formalin test but not in the tail flick test","volume":"519","author":"Morgan","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0800","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jns.2011.06.056","article-title":"Increased dopamine transporter density in Parkinson\u2019s disease patients with social anxiety disorder","volume":"310","author":"Moriyama","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0805","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0810","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-018-9896-0","article-title":"Nociceptive response to L-DOPA-Induced dyskinesia in hemiparkinsonian rats","author":"Nascimento","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0815","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/mds.22142","article-title":"Chronic pain in Parkinson\u2019s disease: the cross-sectional French DoPaMiP survey","volume":"23","author":"N\u00e8gre-Pag\u00e8s","year":"2008","journal-title":"Mov. 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Genet."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0830","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nbd.2011.06.017","article-title":"Olfactory neuron-specific expression of A30P \u03b1-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson\u2019s disease stages","volume":"44","author":"Nuber","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0835","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1523\/JNEUROSCI.3040-07.2008","article-title":"Neurodegeneration and motor dysfunction in a conditional model of Parkinson\u2019s disease","volume":"28","author":"Nuber","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0840","doi-asserted-by":"crossref","first-page":"e60378","DOI":"10.1371\/journal.pone.0060378","article-title":"Age-dependent effects of A53\u2009T alpha-synuclein on behavior and dopaminergic function","volume":"8","author":"Oaks","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0845","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2015.01.002","article-title":"Characterization of nociceptive response to chemical, mechanical, and thermal stimuli in adolescent rats with neonatal dopamine depletion","volume":"289","author":"Ogata","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0850","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/mds.21813","article-title":"Nonmotor symptoms as presenting complaints in Parkinson\u2019s disease: a clinicopathological study","volume":"23","author":"O\u2019Sullivan","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0855","first-page":"85","article-title":"LRRK2: cause, risk, and mechanism","volume":"3","author":"Pais\u00e1n-Ruiz","year":"2013","journal-title":"J. Park. Dis."},{"issue":"Suppl. 3","key":"10.1016\/j.neubiorev.2018.10.004_bib0860","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00415-009-5240-1","article-title":"Non-motor symptoms in Parkinson\u2019s disease","volume":"256","author":"Park","year":"2009","journal-title":"J. Neurol."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0865","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12990-015-0026-1","article-title":"Pain perception in acute model mice of Parkinson\u2019s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)","volume":"11","author":"Park","year":"2015","journal-title":"Mol. 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Methods"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0885","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbr.2010.01.049","article-title":"Lack of involvement of alpha-synuclein in unconditioned anxiety in mice","volume":"209","author":"Pe\u00f1a-Oliver","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0890","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1073\/pnas.0409598102","article-title":"Parkin-deficient mice are not a robust model of parkinsonism","volume":"102","author":"Perez","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0895","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0900","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mds.26077","article-title":"The onset of nonmotor symptoms in Parkinson\u2019s disease (the ONSET PD study)","volume":"30","author":"Pont-Sunyer","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0905","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0910","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.pain.2011.03.002","article-title":"Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy","volume":"152","author":"Qu","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0915","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12868-017-0341-8","article-title":"Early start of progressive motor deficits in Line 61 \u03b1-synuclein transgenic mice","volume":"18","author":"Rabl","year":"2017","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0920","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/00207454.2014.994208","article-title":"Association of restless legs syndrome, pain, and mood disorders in Parkinson\u2019s disease","volume":"126","author":"Rana","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0925","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ana.24066","article-title":"Lewy body extracts from Parkinson disease brains trigger \u03b1-synuclein pathology and neurodegeneration in mice and monkeys","volume":"75","author":"Recasens","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0930","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12264-017-0159-5","article-title":"Premotor diagnosis of Parkinson\u2019s disease","volume":"33","author":"Reichmann","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0935","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/brain\/awh445","article-title":"Depression in Parkinson\u2019s disease: loss of dopamine and noradrenaline innervation in the limbic system","volume":"128","author":"Remy","year":"2005","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0940","first-page":"267","article-title":"Impact of mood and behavioral disorders on quality of life in Parkinson\u2019s disease","volume":"6","author":"Rieu","year":"2016","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0945","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jnr.10231","article-title":"Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters","volume":"68","author":"Rockenstein","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0950","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00335-009-9235-0","article-title":"Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 (416insG) mice","volume":"21","author":"Rosemann","year":"2010","journal-title":"Mamm. 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Dis."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0965","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(96)01164-X","article-title":"Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons","volume":"751","author":"Saad\u00e9","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2018.10.004_bib0970","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-2952(75)90304-4","article-title":"Mechanisms of action of 6-hydroxydopamine","volume":"24","author":"Sachs","year":"1975","journal-title":"Biochem. 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