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Res."},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0450","first-page":"S4","article-title":"Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts","volume":"54","author":"Lobo","year":"2000","journal-title":"Neurol. Dis. Elderly Res. Group Neurol."},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0455","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/NEN.0000000000000037","article-title":"Gender differences in multiple sclerosis: induction of estrogen signaling in male and progesterone signaling in female lesions","volume":"73","author":"Luchetti","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0460","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. 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Endocrinol."},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0590","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/endo-65-3-369","article-title":"Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig","volume":"65","author":"Phoenix","year":"1959","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0595","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1155\/2013\/705373","article-title":"The pathophysiology and pharmacological treatment of Huntington disease","volume":"26","author":"Pidgeon","year":"2013","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.neubiorev.2019.04.003_bib0600","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31887\/DCNS.2016.18.4\/cepperson","article-title":"Considering sex and gender in Alzheimer disease and other dementias","volume":"18","author":"Podcasy","year":"2016","journal-title":"Dialogues Clin. 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