{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:00:59Z","timestamp":1791666059718,"version":"4.3.4"},"reference-count":201,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Dupont, Nutrition, Cremo SA, Alkermes Inc."},{"name":"4D Pharma PLC"},{"DOI":"10.13039\/100006628","name":"Mead Johnson Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006628","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nutricia Danone"},{"DOI":"10.13039\/100014114","name":"GW Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Ministry of Health"},{"name":"Italian Medicine Agency"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.neubiorev.2019.10.002","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T11:38:23Z","timestamp":1571139503000},"page":"750-764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Can we \u2018seize\u2019 the gut microbiota to treat epilepsy?"],"prefix":"10.1016","volume":"107","author":[{"given":"Carmen","family":"De Caro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Francesco","family":"Iannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Citraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovambattista","family":"De Sarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Constanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-8123","authenticated-orcid":false,"given":"Emilio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2019.10.002_bib0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood\u2013brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0010","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1073\/pnas.1612177114","article-title":"Endocannabinoid system acts as a regulator of immune homeostasis in the gut","volume":"114","author":"Acharya","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0015","doi-asserted-by":"crossref","first-page":"26800","DOI":"10.1038\/srep26800","article-title":"Impaired gut-liver-brain axis in patients with cirrhosis","volume":"6","author":"Ahluwalia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/gut.46.4.493","article-title":"Butyrate and glucose metabolism by colonocytes in experimental colitis in mice","volume":"46","author":"Ahmad","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0025","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0030","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2014.01.058","article-title":"Diet and the intestinal microbiome: associations, functions, and implications for health and disease","volume":"146","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0035","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pneurobio.2005.09.006","article-title":"Cellular and molecular mechanisms of epilepsy in the human brain","volume":"77","author":"Avoli","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yebeh.2019.03.038","article-title":"Effect of probiotic supplementation on seizure activity and cognitive performance in PTZ-induced chemical kindling","volume":"95","author":"Bagheri","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","article-title":"Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation","volume":"25","author":"Bailey","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0050","first-page":"G675","article-title":"Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation","volume":"303","author":"Bajaj","year":"2012","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046231","article-title":"Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB\/c mouse","volume":"7","author":"Bangsgaard Bendtsen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13073-017-0428-y","article-title":"Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-na\u00efve Parkinson\u2019s disease patients","volume":"9","author":"Bedarf","year":"2017","journal-title":"Genome Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0070","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal \u03b3\u03b4 T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0075","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0080","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni.3780","article-title":"Regulation of inflammation by microbiota interactions with the host","volume":"18","author":"Blander","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrn2038","article-title":"Microglia-mediated neurotoxicity: uncovering the molecular mechanisms","volume":"8","author":"Block","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WCO.0000000000000432","article-title":"New insights into the mechanisms of the ketogenic diet","volume":"30","author":"Boison","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41589-019-0270-1","article-title":"Chemogenetics defines receptor-mediated functions of short chain free fatty acids","volume":"15","author":"Bolognini","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/mol.115.102301","article-title":"The pharmacology and function of receptors for short-chain fatty acids","volume":"89","author":"Bolognini","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0105","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.molmed.2014.05.002","article-title":"Microbiota and neurodevelopmental windows: implications for brain disorders","volume":"20","author":"Borre","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0110","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1007\/s00415-018-8943-3","article-title":"Can epilepsy be treated by antibiotics?","volume":"265","author":"Braakman","year":"2018","journal-title":"J. Neurol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0115","doi-asserted-by":"crossref","first-page":"29166","DOI":"10.1074\/jbc.M110.217463","article-title":"Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide","volume":"286","author":"Brailoiu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009759","article-title":"The gut microbiota influences blood-brain barrier permeability in mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0125","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.biopsych.2016.12.031","article-title":"Targeting the microbiota-gut-Brain Axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice","volume":"82","author":"Burokas","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0135","series-title":"Handbook of Experimental Pharmacology","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-319-20825-1_6","article-title":"Endocannabinoids and the immune system in health and disease","author":"Cabral","year":"2015"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0140","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0145","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.0451-15.2016","article-title":"The chemokine CCL2 mediates the seizure-enhancing effects of systemic inflammation","volume":"36","author":"Cerri","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0150","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs","author":"Chen","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0155","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fpsyt.2019.00034","article-title":"Systematic review of gut microbiota and major depression","volume":"10","author":"Cheung","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0160","doi-asserted-by":"crossref","DOI":"10.4103\/0976-500X.120975","article-title":"Corticosteroid-related central nervous system side effects","author":"Ciriaco","year":"2013","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0165","article-title":"Effects of histone deacetylase inhibitors on the development of epilepsy and psychiatric comorbidity in WAG\/Rij rats","author":"Citraro","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0170","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.2174\/1381612823666171024130001","article-title":"Role of histone deacetylases (HDACs) in epilepsy and epileptogenesis","volume":"23","author":"Citraro","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eplepsyres.2011.02.013","article-title":"Preclinical activity profile of \u03b1-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy","volume":"95","author":"Citraro","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0185","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0190","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1124\/pr.118.015768","article-title":"Gut reactions: breaking down xenobiotic\u2013microbiome interactions","volume":"71","author":"Clarke","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0195","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1053\/j.gastro.2009.01.075","article-title":"The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease","volume":"136","author":"Collins","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0200","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41564-019-0422-9","article-title":"Talking about a microbiome revolution","volume":"4","author":"Cryan","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0205","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0210","article-title":"Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function","author":"Cussotto","year":"2018","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0215","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1523\/JNEUROSCI.3567-08.2009","article-title":"Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor signaling during peripheral organ inflammation","volume":"29","author":"D\u2019Mello","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0220","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ebiom.2019.05.024","article-title":"The gut microbiome and epilepsy","volume":"44","author":"Dahlin","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0225","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0230","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/14737175.2017.1373019","article-title":"The potential role of cannabinoids in epilepsy treatment","volume":"17","author":"De Caro","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0235","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0240","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.3390\/ijms150711678","article-title":"Mediterranean diet and health: food effects on gut microbiota and disease control","volume":"15","author":"Del Chierico","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0245","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0250","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/epi.13947","article-title":"The relation between cortisol and functional connectivity in people with and without stress-sensitive epilepsy","volume":"59","author":"den Heijer","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0255","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","article-title":"Glia and epilepsy: excitability and inflammation","volume":"36","author":"Devinsky","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","article-title":"The microbiome-gut-Brain Axis in health and disease","volume":"46","author":"Dinan","year":"2017","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0265","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.eplepsyres.2014.04.001","article-title":"Physiological bases of the K+ and the glutamate\/GABA hypotheses of epilepsy","volume":"108","author":"DiNuzzo","year":"2014","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0270","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.physbeh.2018.07.014","article-title":"Dietary interventions for autism spectrum disorder: new perspectives from the gut-brain axis","volume":"194","author":"Doenyas","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0275","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s11064-012-0766-5","article-title":"Roles of glutamine synthetase inhibition in epilepsy","volume":"37","author":"Eid","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0280","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","article-title":"Activation of the peripheral endocannabinoid system in human obesity","volume":"54","author":"Engeli","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0285","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0290","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0295","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jcpa.2014.04.010","article-title":"Loss of endothelial barrier antigen immunoreactivity as a marker of Clostridium perfringens type d epsilon toxin-induced microvascular damage in rat brain","volume":"151","author":"Finnie","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0300","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.molmed.2013.02.004","article-title":"Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis","volume":"19","author":"Fischer","year":"2013","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0305","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE Official Report: a practical clinical definition of epilepsy","volume":"55","author":"Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0310","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tins.2018.09.006","article-title":"Mast cells in neuroimmune interactions","volume":"42","author":"Forsythe","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0320","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.biopsych.2017.03.005","article-title":"Searching for cross-diagnostic convergence: neural mechanisms governing excitation and inhibition balance in schizophrenia and autism Spectrum disorders","volume":"81","author":"Foss-Feig","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0325","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0330","doi-asserted-by":"crossref","DOI":"10.3389\/neuro.02.005.2008","article-title":"Epilepsy, E\/I balance and GABAA receptor plasticity","volume":"1","author":"Fritschy","year":"2008","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0335","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/jne.12256","article-title":"\u0392-hydroxybutyric acid inhibits growth hormone-releasing hormone synthesis and secretion through the GPR109A\/Extracellular signal-regulated 1\/2 signalling pathway in the hypothalamus","volume":"27","author":"Fu","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0340","series-title":"The Enteric Nervous System","year":"2007"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0345","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.immuni.2011.03.021","article-title":"Intestinal bacterial colonization induces mutualistic regulatory t cell responses","volume":"34","author":"Geuking","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0350","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3920\/BM2018.0018","article-title":"The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study","volume":"9","author":"G\u00f3mez-Egu\u00edlaz","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0355","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.euroneuro.2017.11.001","article-title":"Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS\u00ae) ingestion","volume":"28","author":"Gronier","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0360","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.3748\/wjg.v23.i19.3565","article-title":"Fecal microbiota transplantation cured epilepsy in a case with Crohn\u2019s Disease: the first report","volume":"23","author":"He","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0365","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/nutrit\/nux062","article-title":"Interindividual variability in gut microbiota and host response to dietary interventions","volume":"75","author":"Healey","year":"2017","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0370","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0375","first-page":"2","article-title":"Epigenetics and epilepsy","volume":"5","author":"Henshall","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0380","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14737175.2018.1400909","article-title":"Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer\u2019s disease-type beta-amyloid neuropathological mechanisms","volume":"18","author":"Ho","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0385","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12929-015-0157-8","article-title":"Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus","volume":"22","author":"Ho","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0390","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1038\/tp.2016.42","article-title":"Regulation of prefrontal cortex myelination by the microbiota","volume":"6","author":"Hoban","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0395","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.irn.2016.08.005","article-title":"Neuropeptides, microbiota, and behavior","volume":"131","author":"Holzer","year":"2016","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0400","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41398-018-0155-1","article-title":"Glutamate and GABA in autism spectrum disorder\u2014a translational magnetic resonance spectroscopy study in man and rodent models","volume":"8","author":"Horder","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0405","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0410","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.chembiol.2007.05.009","article-title":"Benzodiazepine biosynthesis in Streptomyces refuineus","volume":"14","author":"Hu","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0415","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S1473-3099(15)00293-5","article-title":"A comprehensive repertoire of prokaryotic species identified in human beings","volume":"15","author":"Hugon","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0420","first-page":"1","article-title":"Microbiota-gut brain axis involvement in neuropsychiatric disorders","author":"Iannone","year":"2019","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0425","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous Bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0430","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1476-5381.2009.00183.x","article-title":"Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding","volume":"158","author":"Izzo","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0435","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4161\/gmic.28684","article-title":"The role of microbiota in hepatic encephalopathy","volume":"5","author":"Bajaj","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0440","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0445","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.neuroimage.2015.11.018","article-title":"Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate","volume":"125","author":"Janik","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0450","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1460-9568.1999.00495.x","article-title":"Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state","volume":"11","author":"Karst","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0455","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.2042-7158.1997.tb06790.x","article-title":"The role of mammalian intestinal Bacteria in the reductive metabolism of Zonisamide","volume":"49","author":"Kitamura","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0460","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1021\/acs.jproteome.5b01025","article-title":"Metabolomic modeling to monitor host responsiveness to gut microbiota manipulation in the BTBRT+tf\/j mouse","volume":"15","author":"Klein","year":"2016","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0465","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity","volume":"38","author":"Kowia\u0144ski","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0470","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.biopsych.2016.05.011","article-title":"Excitation\/Inhibition imbalance in animal models of autism spectrum disorders","volume":"81","author":"Lee","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0475","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.physbeh.2018.02.006","article-title":"A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder","volume":"188","author":"Lee","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0480","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1073\/pnas.1000082107","article-title":"Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis","volume":"108","author":"Lee","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0485","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainresbull.2017.09.014","article-title":"E ff ects of gut microbiota disturbance induced in early life on the expression of extrasynaptic GABA-A receptor \u03b1 5 and \u03b4 subunits in the hippocampus of adult rats","volume":"135","author":"Liang","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0490","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.1073\/pnas.1501305112","article-title":"Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock","volume":"112","author":"Liang","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0495","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41522-018-0073-2","article-title":"The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy","volume":"5","author":"Lindefeldt","year":"2019","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0500","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41398-019-0389-6","article-title":"Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review","volume":"9","author":"Liu","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0505","article-title":"Emerging roles for the intestinal microbiome in epilepsy","author":"Lum","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0510","series-title":"Advances in Pharmacology (San Diego, Calif.)","first-page":"97","article-title":"GABAergic control of depression-related brain States","author":"Luscher","year":"2015"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0515","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tins.2012.11.005","article-title":"The ketogenic diet: metabolic influences on brain excitability and epilepsy","volume":"36","author":"Lutas","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0520","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12974-019-1434-3","article-title":"Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis","volume":"16","author":"Ma","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0525","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.yebeh.2012.09.040","article-title":"Stress, seizures, and hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy","volume":"26","author":"Maguire","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0530","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0535","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1528-1167.2007.00988.x","article-title":"Seizure-promoting effect of Blood? Brain barrier disruption","volume":"48","author":"Marchi","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0540","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ni0111-5","article-title":"Diet, gut microbiota and immune responses","volume":"12","author":"Maslowski","year":"2011","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.neubiorev.2019.10.002_bib0545","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut-brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0550","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.47.6.861","article-title":"The neurobiology of stress and gastrointestinal disease","volume":"47","author":"Mayer","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0555","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0560","doi-asserted-by":"crossref","first-page":"15645","DOI":"10.1038\/s41598-017-15154-6","article-title":"Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity","volume":"7","author":"Mehrpouya-Bahrami","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0565","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neulet.2018.01.052","article-title":"Feeding the developing brain: juvenile rats fed diet rich in prebiotics and bioactive milk fractions exhibit reduced anxiety-related behavior and modified gene expression in emotion circuits","volume":"677","author":"Mika","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0570","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/jcp.25518","article-title":"Neurotransmitters: the critical modulators regulating gut-brain Axis","volume":"232","author":"Mittal","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0575","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/liv.13200","article-title":"Lactulose reduces bacterial DNA translocation, which worsens neurocognitive shape in cirrhotic patients with minimal hepatic encephalopathy","volume":"37","author":"Moratalla","year":"2017","journal-title":"Liver Int."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0580","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0585","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/msb.2010.46","article-title":"The endocannabinoid system links gut microbiota to adipogenesis","volume":"6","author":"Muccioli","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0590","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molmed.2014.12.002","article-title":"The infant microbiome development: mom matters","volume":"21","author":"Mueller","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0595","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jneuroim.2014.11.023","article-title":"Chronic systemic IL-1\u03b2 exacerbates central neuroinflammation independently of the blood-brain barrier integrity","volume":"278","author":"Murta","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0600","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1523\/JNEUROSCI.2006-14.2016","article-title":"Histone deacetylase inhibitors protect against pyruvate dehydrogenase dysfunction in Huntington\u2019s disease","volume":"37","author":"Naia","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0605","doi-asserted-by":"crossref","DOI":"10.1186\/s13229-016-0099-3","article-title":"Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder","volume":"7","author":"Newell","year":"2016","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0610","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.celrep.2016.08.092","article-title":"Rapid and efficient generation of regulatory t cells to commensal antigens in the periphery","volume":"17","author":"Nutsch","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0615","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","article-title":"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses","volume":"65","author":"O\u2019Mahony","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0620","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0625","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/j.1528-1167.2006.00817.x","article-title":"The Blood? Brain barrier and epilepsy","volume":"47","author":"Oby","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0630","first-page":"G807","article-title":"Probiotic bacteria and intestinal epithelial barrier function","volume":"298","author":"Ohland","year":"2010","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0635","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cell.2018.04.027","article-title":"The gut microbiota mediates the anti-seizure effects of the ketogenic diet","volume":"173","author":"Olson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0640","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.eplepsyres.2018.09.013","article-title":"Altered composition of the gut microbiome in patients with drug-resistant epilepsy","volume":"147","author":"Peng","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0645","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1038\/sj.ijo.0803272","article-title":"The pharmacology of cannabinoid receptors and their ligands: an overview","volume":"30","author":"Pertwee","year":"2006","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0650","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022822","article-title":"Epileptogenesis","volume":"5","author":"Pitk\u00e4nen","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0655","first-page":"135","article-title":"The role of dietary fibre in inflammatory bowel disease","volume":"10","author":"Pituch-Zdanowska","year":"2015","journal-title":"Prz. Gastroenterol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0660","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tins.2014.11.001","article-title":"Adding fuel to the fire: the impact of stress on the ageing brain","volume":"38","author":"Prenderville","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0665","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/ana.410180115","article-title":"Serum prolactin and cortisol levels in evaluation of pseudoepileptic seizures","volume":"18","author":"Pritchard","year":"1985","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0670","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0675","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12035-008-8026-z","article-title":"Immune-to-brain signaling: how important are the blood-brain barrier-independent pathways? Why does CNS Need to sense immunological activity?","volume":"37","author":"Quan","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0680","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nbd.2010.02.005","article-title":"Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis","volume":"39","author":"Qureshi","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0685","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrgastro.2016.107","article-title":"The bowel and beyond: the enteric nervous system in neurological disorders","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0690","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1001\/jama.1916.02580470017009","article-title":"The Bacillus epilepticus","volume":"LXVI","author":"Reed","year":"1916","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0695","doi-asserted-by":"crossref","first-page":"17151","DOI":"10.1073\/pnas.0806682105","article-title":"Microglial activation and TNF production mediate altered CNS excitability following peripheral inflammation","volume":"105","author":"Riazi","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0700","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.eplepsyres.2009.09.004","article-title":"Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability","volume":"89","author":"Riazi","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0705","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1440-1746.2003.03284.x","article-title":"Intestinal inflammation alters the susceptibility to pentylenetetrazole-induced seizure in mice","volume":"19","author":"Riazi","year":"2004","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0710","first-page":"331","article-title":"The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases","volume":"16","author":"Richard","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0715","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0022-3565(25)22410-7","article-title":"Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice","volume":"270","author":"Roberts","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0720","first-page":"26050","article-title":"The composition of the gut microbiota throughout life, with an emphasis on early life","volume":"26","author":"Rodr\u00edguez","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0725","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0730","unstructured":"Roshchina, V.V, n.d. 2.2 Occurrence of Neurotransmitters in Living Organisms 2.2.1 Discoveries."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0735","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"Round","year":"2011","journal-title":"Science (80-.)"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0740","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0745","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm1521","article-title":"Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors","volume":"13","author":"Rousseaux","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0750","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3945\/ajcn.110.002188","article-title":"High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health","volume":"93","author":"Russell","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0755","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.phrs.2015.11.026","article-title":"Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice","volume":"103","author":"Russo","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0760","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0765","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1017\/S1368980007668578","article-title":"Mediterranean diet and depression","volume":"9","author":"S\u00e1nchez-Villegas","year":"2006","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0770","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S2215-0366(14)00051-0","article-title":"Nutritional medicine as mainstream in psychiatry","volume":"2","author":"Sarris","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0775","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/mp.2013.129","article-title":"HPA axis genetic variation, cortisol and psychosis in major depression","volume":"19","author":"Schatzberg","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0780","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pbb.2004.04.012","article-title":"Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG\/Rij rats","volume":"78","author":"Schridde","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0785","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fimmu.2019.00205","article-title":"Germ-free mice exhibit mast cells with impaired functionality and gut homing and do not develop food allergy","volume":"10","author":"Schwarzer","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0790","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and Bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0795","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","article-title":"The central nervous system and the gut microbiome","volume":"167","author":"Sharon","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0800","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13416","article-title":"Recent developments in understanding the role of the gut microbiota in brain health and disease","volume":"1420","author":"Sherwin","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0805","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.cub.2012.02.022","article-title":"Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions","volume":"22","author":"Shifrin","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0810","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/bph.13637","article-title":"An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis","volume":"174","author":"Simeoli","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0815","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0820","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.smim.2006.10.002","article-title":"Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota","volume":"19","author":"Smith","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0825","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science (80-.)"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0830","article-title":"Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders","volume":"1","author":"Sohal","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0835","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1528-1167.2005.59504.x","article-title":"Epileptogenesis due to peripheral injury as a cause of focal epilepsy","volume":"46","author":"Spiller","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0840","first-page":"223","article-title":"Feeding the microbiota-gut-brain axis\u202f: diet, microbiome, and neuropsychiatry","volume":"179","author":"Stanton","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0845","doi-asserted-by":"crossref","first-page":"N44","DOI":"10.1093\/neuros\/nyx450","article-title":"Gut microbiome and endothelial TLR4 activation provoke cerebral cavernous malformations","volume":"81","author":"Starke","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0850","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0855","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03574","article-title":"Discovery of a small molecule that inhibits bacterial ribosome biogenesis","volume":"3","author":"Stokes","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0860","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0865","doi-asserted-by":"crossref","first-page":"509","DOI":"10.5009\/gnl15419","article-title":"Evaluation and management of hepatic encephalopathy: current status and future directions","volume":"10","author":"Suraweera","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0870","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1212\/WNL.0000000000002023","article-title":"Seizures as adverse events of antibiotic drugs","volume":"85","author":"Sutter","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0875","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.clnesp.2016.11.003","article-title":"Short-term impact of a classical ketogenic diet on gut microbiota in GLUT1 Deficiency Syndrome: a 3-month prospective observational study","volume":"17","author":"Tagliabue","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0880","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/sj.npp.1300709","article-title":"Chronic low-dose corticosterone supplementation enhances acquired epileptogenesis in the rat amygdala kindling model of TLE","volume":"30","author":"Taher","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0885","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/00004647-200110000-00012","article-title":"GAT2\/BGT-1 as a system responsible for the transport of \u03b3-Aminobutyric acid at the mouse blood\u2013brain barrier","volume":"21","author":"Takanaga","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0890","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature22075","article-title":"Endothelial TLR4 and the microbiome drive cerebral cavernous malformations","volume":"545","author":"Tang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0895","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1080\/14737175.2016.1204233","article-title":"The comorbidity of epilepsy and depression: diagnosis and treatment","volume":"16","author":"Tao","year":"2016","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0900","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.phrs.2016.05.009","article-title":"Preventing epileptogenesis: a realistic goal?","volume":"110","author":"Terrone","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0905","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short chain fatty acids and gut microbiota differ between patients with Parkinson\u2019s disease and age-matched controls","volume":"32","author":"Unger","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0910","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0915","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations","volume":"596","author":"van de Wouw","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0920","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3389\/fimmu.2017.01081","article-title":"Modulation of multiple sclerosis and its animal model experimental autoimmune encephalomyelitis by food and gut microbiota","volume":"8","author":"van den Hoogen","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0925","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.bbi.2008.03.009","article-title":"The role of cytokines in the pathophysiology of epilepsy","volume":"22","author":"Vezzani","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0930","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbi.2015.11.016","article-title":"Peripheral leukocyte profile in people with temporal lobe epilepsy reflects the associated proinflammatory state","volume":"53","author":"Vieira","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"Part B","key":"10.1016\/j.neubiorev.2019.10.002_bib0935","first-page":"124","article-title":"Review: classical neurotransmitters and neuropeptides involved in generalized epilepsy in a multi-neurotransmitter system: how to improve the antiepileptic effect?","volume":"71","author":"Werner","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0940","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1167.2008.01821.x","article-title":"History of the ketogenic diet","volume":"49","author":"Wheless","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0945","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/j.gastro.2015.12.034","article-title":"Histamine receptor H1\u2013Mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome","volume":"150","author":"Wouters","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0950","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/gmic.19320","article-title":"The role of gut microbiota in immune homeostasis and autoimmunity","volume":"3","author":"Wu","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0955","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.3748\/wjg.v23.i33.6164","article-title":"Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy","volume":"23","author":"Xie","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0960","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-\u03b2 promoter in the toll-like receptor signaling","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0965","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/NNR.0000000000000133","article-title":"The infant microbiome: implications for infant health and neurocognitive development","volume":"65","author":"Yang","year":"2016","journal-title":"Nurs. Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0970","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0975","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"Yizhar","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0980","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0006-8993(95)00241-H","article-title":"Gut bacteria provide precursors of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy","volume":"679","author":"Yurdaydin","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0985","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cmet.2014.11.008","article-title":"Diet and feeding pattern affect the diurnal dynamics of the gut microbiome","volume":"20","author":"Zarrinpar","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0990","doi-asserted-by":"crossref","first-page":"e1138","DOI":"10.1038\/tp.2017.112","article-title":"Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut-microbiota-brain axis","volume":"7","author":"Zhang","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2019.10.002_bib0995","first-page":"66","article-title":"The anticonvulsant effects of ketogenic diet on epileptic seizures and potential mechanisms","volume":"16","author":"Zhang","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib1000","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.eplepsyres.2018.06.015","article-title":"Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet","volume":"145","author":"Zhang","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2019.10.002_bib1005","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau8317","article-title":"The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice","volume":"5","author":"Zheng","year":"2019","journal-title":"Sci. Adv."}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763419306517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763419306517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:49:09Z","timestamp":1758966549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763419306517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":201,"alternative-id":["S0149763419306517"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2019.10.002","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can we \u2018seize\u2019 the gut microbiota to treat epilepsy?","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2019.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}