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J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0500","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.0711278105","article-title":"GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current","volume":"105","author":"Lauckner","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0505","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.eplepsyres.2019.03.015","article-title":"Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome\u202f: expanded access program results","volume":"154","author":"Laux","year":"2019","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0510","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000137588","article-title":"Anticonvulsant effects of the (\u2013) and (+)Isomers of cannabidiol and their dimethylheptyl homologs","volume":"24","author":"Leite","year":"1982","journal-title":"Pharmacology"},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0515","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-017-2222-z","article-title":"Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs","author":"L\u00f6scher","year":"2017","journal-title":"Neurochem. 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Clin. Exp. 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Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0575","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/BF00450585","article-title":"Toward drugs derived from cannabis","volume":"65","author":"Mechoulam","year":"1978","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-3084(00)00184-5","article-title":"A historical overview of chemical research on cannabinoids","volume":"108","author":"Mechoulam","year":"2000","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0585","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0040-4020(63)85022-X","article-title":"Hashish\u2014I. The structure of cannabidiol","volume":"19","author":"Mechoulam","year":"1963","journal-title":"Tetrahedron"},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0590","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6904-5-3","article-title":"Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)","volume":"5","author":"Mencher","year":"2005","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0595","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2471\/BLT.09.064147","article-title":"Global disparities in the epilepsy treatment gap: a systematic review","volume":"88","author":"Meyer","year":"2010","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0600","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00497858","article-title":"Hypnoticlike effects of cannabidiol in the rat","volume":"55","author":"Monti","year":"1977","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0605","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0920-1211(00)00107-8","article-title":"Audiogenic kindling in the Wistar rat: A potential model for recruitment of limbic structures","volume":"39","author":"Moraes","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neubiorev.2020.01.014_bib0610","first-page":"103","article-title":"Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature","volume":"4","author":"Mortati","year":"2007","journal-title":"Rev. Neurol. 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