{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:15:58Z","timestamp":1791951358433,"version":"4.3.4"},"reference-count":150,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Instituto C\u00e9rebro e Mente and University of Southern Santa Catarina"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neubiorev.2020.01.035","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T18:02:21Z","timestamp":1580580141000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"special_numbering":"C","title":["Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications"],"prefix":"10.1016","volume":"112","author":[{"given":"Gabriel R.","family":"Fries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline J.","family":"Zamzow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Pink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselli","family":"Scaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2020.01.035_bib0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S2215-0366(15)00544-1","article-title":"Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis","volume":"3","author":"Agnew-Blais","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0010","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/em.22206","article-title":"Loss of DNA polymerase beta induces cellular senescence","volume":"59","author":"Ahmed","year":"2018","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0015","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.cpr.2005.06.006","article-title":"The psychosocial context of bipolar disorder: environmental, cognitive, and developmental risk factors","volume":"25","author":"Alloy","year":"2005","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pscychresns.2008.02.001","article-title":"Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety","volume":"171","author":"Almeida","year":"2009","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0025","first-page":"65","article-title":"Association of polygenic score for schizophrenia and HLA antigen and inflammation genes with response to Lithium in bipolar affective disorder: a genome-wide association study","volume":"75","author":"Amare","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jad.2008.04.013","article-title":"Oxidative stress markers in bipolar disorder: a meta-analysis","volume":"111","author":"Andreazza","year":"2008","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1139\/jpn.0935","article-title":"3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder","volume":"34","author":"Andreazza","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0040","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jagp.2014.05.008","article-title":"Oxidative stress in older patients with bipolar disorder","volume":"23","author":"Andreazza","year":"2015","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2017.06.004","article-title":"Similarities and distinctions of Cancer and immune metabolism in inflammation and tumors","volume":"26","author":"Andrejeva","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0050","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ebiom.2015.07.029","article-title":"Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians","volume":"2","author":"Arai","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1192\/bjp.bp.108.059717","article-title":"Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis","volume":"195","author":"Arnone","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.envres.2017.06.038","article-title":"Cigarette smoking and telomere length: a systematic review of 84 studies and meta-analysis","volume":"158","author":"Astuti","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0065","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jad.2017.09.002","article-title":"Hypertension risk and clinical care in patients with bipolar disorder or schizophrenia; a systematic review and meta-analysis","volume":"225","author":"Ayerbe","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0070","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/1516-4446-2016-1910","article-title":"Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease","volume":"38","author":"Barbe-Tuana","year":"2016","journal-title":"Braz J Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0075","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cmet.2016.05.011","article-title":"Metformin as a tool to target aging","volume":"23","author":"Barzilai","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0080","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.18m12200","article-title":"A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression","volume":"80","author":"Bauer","year":"2018","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0085","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","article-title":"Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors","volume":"35","author":"Berk","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0095","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2005.08.031","article-title":"Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study","volume":"59","author":"Blumberg","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0100","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/bdi.12490","article-title":"Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta-analyses","volume":"19","author":"Bortolato","year":"2017","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.psychres.2014.04.005","article-title":"An updated meta-analysis of oxidative stress markers in bipolar disorder","volume":"218","author":"Brown","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/07853890.2012.687835","article-title":"The relationship between bipolar disorder and type 2 diabetes: more than just co-morbid disorders","volume":"45","author":"Calkin","year":"2013","journal-title":"Ann. Med."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpsychires.2015.12.012","article-title":"Hippocampal volume and verbal memory performance in late-stage bipolar disorder","volume":"73","author":"Cao","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0120","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/mp.2016.262","article-title":"Hippocampal subfield volumes in mood disorders","volume":"22","author":"Cao","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/pcn.12163","article-title":"Mitochondrial DNA variation and increased oxidative damage in euthymic patients with bipolar disorder","volume":"68","author":"Chang","year":"2014","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40345-016-0054-4","article-title":"Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications","volume":"4","author":"Charles","year":"2016","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0135","first-page":"183","article-title":"Lamin-B in systemic inflammation, tissue homeostasis, and aging","volume":"6","author":"Chen","year":"2015","journal-title":"Nucleus (Austin, Tex.)"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2008.07.002","article-title":"Molecular inflammation: underpinnings of aging and age-related diseases","volume":"8","author":"Chung","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/0004867418815987","article-title":"Thirty-year cardiovascular risk score in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives","volume":"53","author":"Coello","year":"2019","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jad.2015.06.034","article-title":"Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies","volume":"186","author":"Colpo","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/14737175.2018.1407242","article-title":"Immune-based strategies for mood disorders: facts and challenges","volume":"18","author":"Colpo","year":"2018","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0160","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/646354","article-title":"Oxidative stress, mitochondrial dysfunction, and aging","volume":"2012","author":"Cui","year":"2012","journal-title":"J. Signal Transduct."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0165","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.arr.2012.02.002","article-title":"N-glycomic biomarkers of biological aging and longevity: a link with inflammaging","volume":"12","author":"Dall\u2019Olio","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0170","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/PSY.0000000000000356","article-title":"The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons","volume":"78","author":"Darrow","year":"2016","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pnpbp.2013.09.002","article-title":"Leukocyte mitochondrial DNA copy number in bipolar disorder","volume":"48","author":"de Sousa","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0180","doi-asserted-by":"crossref","first-page":"290","DOI":"10.18632\/aging.100452","article-title":"ATM-dependent phosphorylation of SNEVhPrp19\/hPso4 is involved in extending cellular life span and suppression of apoptosis","volume":"4","author":"Dellago","year":"2012","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0185","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jagp.2016.11.014","article-title":"History of bipolar disorder and the risk of dementia: a systematic review and meta-analysis","volume":"25","author":"Diniz","year":"2017","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0190","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1474-9726.2007.00294.x","article-title":"Oxidative stress and aberrant signaling in aging and cognitive decline","volume":"6","author":"Droge","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0195","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/ijc.31189","article-title":"DNA methylation-based biological aging and cancer risk and survival: pooled analysis of seven prospective studies","volume":"142","author":"Dugue","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0200","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jad.2011.08.006","article-title":"The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder","volume":"135","author":"Elvsashagen","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0205","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13028","article-title":"Reversal of epigenetic aging and immunosenescent trends in humans","author":"Fahy","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0210","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/10408363.2018.1504274","article-title":"Telomere length measurement as a clinical biomarker of aging and disease","volume":"55","author":"Fasching","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0215","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0220","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12773","article-title":"Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice","volume":"17","author":"Foote","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0225","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.pnpbp.2006.06.011","article-title":"Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report","volume":"31","author":"Frey","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0230","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/s41398-017-0048-8","article-title":"Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder","volume":"7","author":"Fries","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0235","article-title":"Accelerated hippocampal biological aging in bipolar disorder","author":"Fries","year":"2019","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0240","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pbb.2018.12.006","article-title":"Revisiting inflammation in bipolar disorder","volume":"177","author":"Fries","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0245","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1017\/S1461145711000617","article-title":"Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia","volume":"14","author":"Gawryluk","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0250","series-title":"Brain Aging: Models, Methods, and Mechanisms","article-title":"Frontiers in neuroscience oxidative stress and the aging brain: from theory to prevention","author":"Gemma","year":"2007"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0255","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/ajcn\/nqy107","article-title":"Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies","volume":"108","author":"Gielen","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0260","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/JGP.0b013e31802dd367","article-title":"Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder","volume":"15","author":"Gildengers","year":"2007","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0265","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1399-5618.2009.00739.x","article-title":"The longitudinal course of cognition in older adults with bipolar disorder","volume":"11","author":"Gildengers","year":"2009","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0270","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.18632\/aging.101518","article-title":"A promising connection between BDNF and Alzheimer\u2019s disease","volume":"10","author":"Giuffrida","year":"2018","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0275","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1159\/000502257","article-title":"Metformin and aging: a review","volume":"65","author":"Glossmann","year":"2019","journal-title":"Gerontology"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0280","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1474-9728.2002.00015.x","article-title":"Oxidative stress and aging: beyond correlation","volume":"1","author":"Golden","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0285","doi-asserted-by":"crossref","first-page":"992","DOI":"10.18632\/aging.100710","article-title":"Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging","volume":"6","author":"Grammatikakis","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0290","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109720","article-title":"Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants","volume":"95","author":"Grigolon","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0300","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.biopsych.2010.08.029","article-title":"Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data","volume":"69","author":"Hallahan","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0305","first-page":"154","article-title":"Influence of age and physical fitness on miRNA-21, TGF-beta and its receptors in leukocytes of healthy women","volume":"21","author":"Halper","year":"2015","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0310","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.mad.2012.07.003","article-title":"Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations","volume":"133","author":"Harries","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0315","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/mp.2015.227","article-title":"Subcortical volumetric abnormalities in bipolar disorder","volume":"21","author":"Hibar","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0320","article-title":"Effectiveness of pharmacologic interventions in the management of weight gain in patients with severe mental illness: a systematic review and meta-analysis","volume":"21","author":"Hiluy","year":"2019","journal-title":"Prim. Care Companion CNS Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0325","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2990.2012.01307.x","article-title":"Review: systemic inflammation and Alzheimer\u2019s disease","volume":"39","author":"Holmes","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0330","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2013-10-532085","article-title":"Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort","volume":"124","author":"Hosnijeh","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0335","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.psychres.2018.09.035","article-title":"Leukocyte telomere length in patients with bipolar disorder: an updated meta-analysis and subgroup analysis by mood status","volume":"270","author":"Huang","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0340","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1177\/0269881117725711","article-title":"Anti-inflammatory treatments for mood disorders: systematic review and meta-analysis","volume":"31","author":"Husain","year":"2017","journal-title":"J. Psychopharmacol. (Oxford)"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0345","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S1461145713001569","article-title":"Decreased global methylation in patients with bipolar disorder who respond to lithium","volume":"17","author":"Huzayyin","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0350","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/bdi.12319","article-title":"A combined analysis of worldwide studies demonstrates an association between bipolar disorder and tobacco smoking behaviors in adults","volume":"17","author":"Jackson","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0355","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/rej.2012.1324","article-title":"The role of DNA methylation in aging, rejuvenation, and age-related disease","volume":"15","author":"Johnson","year":"2012","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0360","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jad.2013.02.011","article-title":"Systemic oxidatively generated DNA\/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy","volume":"149","author":"Jorgensen","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0365","doi-asserted-by":"crossref","first-page":"546","DOI":"10.5483\/BMBRep.2017.50.11.175","article-title":"DNA methylation-based age prediction from various tissues and body fluids","volume":"50","author":"Jung","year":"2017","journal-title":"BMB Rep."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0370","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jad.2017.06.001","article-title":"The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression","volume":"233","author":"Kageyama","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0375","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1017\/S1461145705005213","article-title":"Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia","volume":"8","author":"Kakiuchi","year":"2005","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0380","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpsychires.2010.05.015","article-title":"Peripheral biomarkers and illness activity in bipolar disorder","volume":"45","author":"Kapczinski","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0385","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1399-5618.2004.00180.x","article-title":"Gender differences in bipolar disorder: age of onset, course, comorbidity, and symptom presentation","volume":"7","author":"Kawa","year":"2005","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0390","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1196\/annals.1297.047","article-title":"Mechanism of telomere shortening by oxidative stress","volume":"1019","author":"Kawanishi","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0395","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/acps.12667","article-title":"Evidence for clinical progression of unipolar and bipolar disorders","volume":"135","author":"Kessing","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0400","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/bdi.12772","article-title":"New drug candidates for bipolar disorder-A nation-wide population-based study","volume":"21","author":"Kessing","year":"2019","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0405","article-title":"The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.psy.0000151489.36347.18","article-title":"Psychiatric and medical comorbidities of bipolar disorder","volume":"67","author":"Krishnan","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0415","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13353-014-0251-8","article-title":"Osteoarthritis and telomere shortening","volume":"56","author":"Kuszel","year":"2015","journal-title":"J. Appl. Genet."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0420","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2147\/COPD.S155952","article-title":"Role of accelerated aging in limb muscle wasting of patients with COPD","volume":"13","author":"Lakhdar","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0425","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pnpbp.2016.06.009","article-title":"Crack cocaine addiction, early life stress and accelerated cellular aging among women","volume":"71","author":"Levandowski","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0430","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpsychires.2017.06.002","article-title":"Association between childhood trauma and accelerated telomere erosion in adulthood: a meta-analytic study","volume":"93","author":"Li","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0435","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jad.2014.09.043","article-title":"Analysis of telomere attrition in bipolar disorder","volume":"172","author":"Lima","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0440","first-page":"260","article-title":"Telomere shortening in alzheimer\u2019s disease patients","volume":"46","author":"Liu","year":"2016","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0445","doi-asserted-by":"crossref","first-page":"e636","DOI":"10.1038\/tp.2015.134","article-title":"Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder","volume":"5","author":"Mamdani","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/HRP.0000000000000161","article-title":"Clinical and environmental risk factors for bipolar disorder: review of prospective studies","volume":"26","author":"Marangoni","year":"2018","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0455","first-page":"1319","article-title":"Circulating MicroRNA are predictive of aging and acute adaptive response to resistance exercise in men","volume":"72","author":"Margolis","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0460","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1038\/tp.2013.37","article-title":"Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres","volume":"3","author":"Martinsson","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0465","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbi.2016.02.002","article-title":"Perceived stress and telomere length: a systematic review, meta-analysis, and methodologic considerations for advancing the field","volume":"54","author":"Mathur","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0470","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/JCP.0000000000000938","article-title":"Evaluating the effect of coenzyme Q10 augmentation on treatment of bipolar depression: a double-blind controlled clinical trial","volume":"38","author":"Mehrpooya","year":"2018","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0475","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s00439-014-1458-9","article-title":"Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly","volume":"133","author":"Mengel-From","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0480","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3233\/JAD-171163","article-title":"Circulating, cell-free Micro-RNA profiles reflect discordant development of dementia in monozygotic twins","volume":"63","author":"Mengel-From","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0485","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0490","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jpsychires.2017.03.025","article-title":"Metabolic syndrome in subjects with bipolar disorder and major depressive disorder in a current depressive episode: population-based study: metabolic syndrome in current depressive episode","volume":"92","author":"Moreira","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0495","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1590\/1516-4446-2017-2328","article-title":"Metabolic syndrome and psychiatric disorders: a population-based study","volume":"41","author":"Moreira","year":"2019","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0500","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/obr.12126","article-title":"Body mass index and leukocyte telomere length in adults: a systematic review and meta-analysis","volume":"15","author":"Muezzinler","year":"2014","journal-title":"Obes. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0505","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/bdi.12245","article-title":"Elevated levels of urinary markers of oxidatively generated DNA and RNA damage in bipolar disorder","volume":"17","author":"Munkholm","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0510","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpsychires.2018.01.013","article-title":"Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder","volume":"99","author":"Nguyen","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0515","doi-asserted-by":"crossref","first-page":"725","DOI":"10.18632\/aging.100603","article-title":"Age-related changes in microRNA levels in serum","volume":"5","author":"Noren Hooten","year":"2013","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0520","first-page":"1","article-title":"Epigenetic alterations associated with childhood trauma and adult mental health outcomes: a systematic review","author":"Nothling","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0525","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1038\/npp.2016.126","article-title":"The role of BDNF in age-dependent changes of excitatory and inhibitory synaptic markers in the human prefrontal cortex","volume":"41","author":"Oh","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0530","series-title":"Chronic Inflammation","author":"Pahwa","year":"2019"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0535","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3389\/fgene.2018.00468","article-title":"Genetic risk for psychiatric disorders and telomere length","volume":"9","author":"Palmos","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0540","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jad.2014.12.010","article-title":"Increased serum levels of eotaxin\/CCL11 in late-stage patients with bipolar disorder: An accelerated aging biomarker?","volume":"182","author":"Panizzutti","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0545","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1038\/ncomms9570","article-title":"The transcriptional landscape of age in human peripheral blood","volume":"6","author":"Peters","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0550","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12916-017-0974-6","article-title":"Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals","volume":"15","author":"Pietzner","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0555","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/956792","article-title":"Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants","volume":"2013","author":"Poljsak","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0560","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13148-016-0302-6","article-title":"Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study","volume":"9","author":"Raina","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0565","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s13679-018-0322-y","article-title":"Bipolar disorder and obesity: contributing factors, impact on clinical course, and the role of bariatric surgery","volume":"7","author":"Reilly-Harrington","year":"2018","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0570","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/jc.2017-01625","article-title":"Associations between cellular aging markers and metabolic syndrome: findings from the CARDIA study","volume":"103","author":"Revesz","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0575","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/bdi.12121","article-title":"Immunosenescence is associated with human cytomegalovirus and shortened telomeres in type I bipolar disorder","volume":"15","author":"Rizzo","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0580","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neubiorev.2014.02.004","article-title":"The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research","volume":"42","author":"Rizzo","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0585","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1590\/2237-6089-2014-0002","article-title":"Biomarkers and staging of bipolar disorder: a systematic review","volume":"37","author":"Roda","year":"2015","journal-title":"Trends Psychiatry Psychother."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0590","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/bdi.12373","article-title":"Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis","volume":"18","author":"Rosenblat","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0595","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1871530315666150316124019","article-title":"Metformin and inflammation: its potential beyond glucose-lowering effect","volume":"15","author":"Saisho","year":"2015","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0600","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jpsychires.2017.03.018","article-title":"A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients","volume":"92","author":"Sayana","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0605","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.1038\/tp.2017.83","article-title":"Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients","volume":"7","author":"Scaini","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0610","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jad.2018.12.076","article-title":"Steeper aging-related declines in cognitive control processes among adults with bipolar disorders","volume":"246","author":"Seelye","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0615","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biopsych.2006.02.004","article-title":"Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging","volume":"60","author":"Simon","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0620","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5498\/wjp.v9.i1.7","article-title":"Comorbidity of bipolar and anxiety disorders: an overview of trends in research","volume":"9","author":"Spoorthy","year":"2019","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0625","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.euroneuro.2016.03.020","article-title":"Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients","volume":"26","author":"Squassina","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0630","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.mad.2008.09.020","article-title":"Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey","volume":"129","author":"Starr","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0635","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s11064-010-0195-2","article-title":"Role of oxidative stress in the pathophysiology of bipolar disorder","volume":"35","author":"Steckert","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0640","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.exger.2017.08.024","article-title":"Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles","volume":"98","author":"Suire","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0645","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fpsyt.2019.00008","article-title":"Elevated familial cardiovascular burden among adolescents with familial bipolar disorder","volume":"10","author":"Toma","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0650","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2014.12.025","article-title":"Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology","volume":"79","author":"Tyrka","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0655","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1038\/tp.2012.77","article-title":"Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress","volume":"2","author":"Unternaehrer","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0660","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fpsyt.2018.00250","article-title":"Markers of inflammation and monoamine metabolism indicate accelerated aging in bipolar disorder","volume":"9","author":"van den Ameele","year":"2018","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0665","article-title":"Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy","author":"Van den Bergh","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0670","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/ijnp\/pyx001","article-title":"Telomere length, oxidative stress, inflammation and BDNF levels in siblings of patients with bipolar disorder: implications for accelerated cellular aging","volume":"20","author":"Vasconcelos-Moreno","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0675","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/mp.2017.48","article-title":"Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study","volume":"23","author":"Verhoeven","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0680","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/mp.2012.188","article-title":"Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder","volume":"19","author":"Versace","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0685","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1038\/nrdp.2018.8","article-title":"Bipolar disorders","volume":"4","author":"Vieta","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0690","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12888-018-1717-8","article-title":"Differential mitochondrial DNA copy number in three mood states of bipolar disorder","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0695","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv002","article-title":"Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium","volume":"18","author":"Wei","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0700","doi-asserted-by":"crossref","first-page":"860","DOI":"10.12688\/f1000research.10692.1","article-title":"Molecular and phenotypic biomarkers of aging","volume":"6","author":"Xia","year":"2017","journal-title":"F1000Research"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0705","first-page":"192","article-title":"Differential impact of obesity on CD69 expression in individuals with bipolar disorder and healthy controls","volume":"3","author":"Yamagata","year":"2018","journal-title":"Mol. Neuropsychiatry"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0710","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6813016","article-title":"Endothelial dysfunction and inflammation: immunity in rheumatoid arthritis","volume":"2016","author":"Yang","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0715","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1515\/tnsci-2018-0004","article-title":"Further evidence of accelerated aging in bipolar disorder: focus on GDF-15","volume":"9","author":"Yang","year":"2018","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0720","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/gerona\/glu145","article-title":"Investigation of microRNA expression in human serum during the aging process","volume":"70","author":"Zhang","year":"2015","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0725","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1186\/s12864-017-4287-0","article-title":"Independent impacts of aging on mitochondrial DNA quantity and quality in humans","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0730","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1039\/C6MB00240D","article-title":"Molecular and genetic inflammation networks in major human diseases","volume":"12","author":"Zhao","year":"2016","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0735","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2016.05.059","article-title":"The potential association between obesity and bipolar disorder: a meta-analysis","volume":"202","author":"Zhao","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0740","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1159\/000366358","article-title":"MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3","volume":"34","author":"Zheng","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0745","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.archger.2019.04.007","article-title":"Mitochondrial DNA copy number and telomere length in peripheral blood mononuclear cells in comparison with whole blood in three different age groups","volume":"83","author":"Zole","year":"2019","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.neubiorev.2020.01.035_bib0750","first-page":"431","article-title":"Linkage between mitochondrial genome alterations, telomere length and aging population","volume":"29","author":"Zole","year":"2018","journal-title":"Mitochondrial DNA A. DNA Mapp. Seq. Anal."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763419309935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763419309935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:36:57Z","timestamp":1758965817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763419309935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":150,"alternative-id":["S0149763419309935"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.01.035","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.01.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}