{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:38:37Z","timestamp":1785800317564,"version":"3.56.0"},"reference-count":289,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ASL-Roma 1"},{"name":"IBBC-CNR"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neubiorev.2020.08.018","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T16:57:13Z","timestamp":1600793833000},"page":"654-668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications"],"prefix":"10.1016","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-8787","authenticated-orcid":false,"given":"Stefania","family":"Ciafr\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Ferraguti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Polimeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Ralli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Maria","family":"Ceci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Ceccanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2020.08.018_bib0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1530-0277.1989.tb00373.x","article-title":"Paternal and maternal alcohol consumption: effects on offspring in two strains of rats","volume":"13","author":"Abel","year":"1989","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0741-8329(93)90042-M","article-title":"Rat offspring sired by males treated with alcohol","volume":"10","author":"Abel","year":"1993","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0015","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1210\/en.2013-2030","article-title":"Fetal alcohol exposure disrupts metabolic signaling in hypothalamic proopiomelanocortin neurons via a circadian mechanism in male mice","volume":"155","author":"Agapito","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.21139","article-title":"Mouse and ratBDNF gene structure and expression revisited","volume":"85","author":"Aid","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096200","article-title":"Prenatal alcohol exposure modifies glucocorticoid receptor subcellular distribution in the medial prefrontal cortex and impairs frontal cortex-dependent learning","volume":"9","author":"Allan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0030","first-page":"17","article-title":"Alcohol intake during prenatal life affects neuroimmune mediators and brain neurogenesis","volume":"42","author":"Aloe","year":"2006","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0741-8329(92)90070-Q","article-title":"The effect of long-term alcohol intake on brain ngf-target cells of aged rats","volume":"9","author":"Aloe","year":"1992","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0376-8716(93)90068-2","article-title":"Effect of chronic ethanol intake on brain NGF level and on NGF-target issues of adult mice","volume":"31","author":"Aloe","year":"1993","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067141","article-title":"Identification of a functionally distinct truncated BDNF mRNA splice variant and protein in Trachemys scripta elegans","volume":"8","author":"Ambigapathy","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0050","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm3611","article-title":"Diversifying microRNA sequence and function","volume":"14","author":"Ameres","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2008.05.045","article-title":"Distinct role of long 3\u2032 UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons","volume":"134","author":"An","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0060","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0892-0362(99)00005-7","article-title":"Prenatal ethanol effects on NGF level, NPY and ChAT immunoreactivity in mouse entorhinal cortex: a preliminary study","volume":"21","author":"Angelucci","year":"1999","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0065","first-page":"e178","article-title":"Neuropyschological and behavioral outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders","volume":"16","author":"Astley","year":"2009","journal-title":"Can. J. Clin. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0070","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1261\/rna.7119904","article-title":"Probing microRNAs with microarrays: tissue specificity and functional inference","volume":"10","author":"Babak","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0075","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s11745-013-3821-3","article-title":"Prenatal ethanol exposure increases brain cholesterol content in adult rats","volume":"48","author":"Barcel\u00f3-Coblijn","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/jpn.0421","article-title":"Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression","volume":"29","author":"Barden","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/h0077579","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0090","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0095","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0100","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/acer.12082","article-title":"Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in \u03b2-endorphin-producing POMC neurons of the hypothalamus","volume":"37","author":"Bekdash","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0105","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1111\/acer.12497","article-title":"Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress","volume":"38","author":"Bekdash","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1098-2396(199901)31:1<51::AID-SYN7>3.0.CO;2-O","article-title":"Ethanol exposure during the third trimester equivalent results in long- lasting decreased synaptic efficacy but not plasticity in the CA1 region of the rat hippocampus","volume":"31","author":"Bellinger","year":"1999","journal-title":"Synapse"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fncel.2014.00236","article-title":"MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?","volume":"8","author":"Bellini","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0120","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2174\/1381612043384664","article-title":"Oxygen, Reactive Oxygen Species and Tissue Damage","volume":"10","author":"Bergamini","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0125","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.1787609","article-title":"An operational definition of epigenetics","volume":"23","author":"Berger","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0130","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","article-title":"Role for a bidentate ribonuclease in the initiation step of RNA interference","volume":"409","author":"Bernstein","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1054\/mehy.1999.1044","article-title":"Data and hypotheses on the role of nerve growth factor and other neurotrophins in psychiatric disorders","volume":"55","author":"Bersani","year":"2000","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","article-title":"CpG-Rich islands and the function of DNA methylation","volume":"321","author":"Bird","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0741-8329(97)87950-5","article-title":"Ethanol teratogenesis in the C57BL\/ 6J, DBA\/2J, and A\/J inbred mouse strains","volume":"14","author":"Boehm","year":"1997","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1261\/rna.5167604","article-title":"Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs","volume":"10","author":"Bohnsack","year":"2004","journal-title":"RNA"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000469238","article-title":"Catalytic properties of human liver alcohol dehydrogenase isoenzymes","volume":"37","author":"Bosron","year":"1987","journal-title":"Enzyme"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016704","article-title":"Modulation of brain \u03b2-Endorphin concentration by the specific part of the Y chromosome in mice","volume":"6","author":"Botbol","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0165","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1530-0277.2009.00911.x","article-title":"Beta-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats","volume":"33","author":"Boyadjieva","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0170","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1073\/pnas.0406458102","article-title":"Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior","volume":"102","author":"Boyle","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrg3080","article-title":"Uncovering the role of 5-hydroxymethylcytosine in the epigenome","volume":"13","author":"Branco","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09915","article-title":"Modelling schizophrenia using human induced pluripotent stem cells","volume":"473","author":"Brennand","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresrev.2011.02.001","article-title":"The role of oxidative stress in fetal alcohol Spectrum disorders","author":"Brocardo","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/acer.13266","article-title":"The effects of ethanol exposure during distinct periods of brain development on oxidative stress in the adult rat brain","volume":"41","author":"Brocardo","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0195","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0959-4388(00)00211-7","article-title":"Transcription-dependent and -independent control of neuronal survival by the PI3K\u2013Akt signaling pathway","volume":"11","author":"Brunet","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0200","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1210\/me.2006-0557","article-title":"Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence","volume":"21","author":"Bumaschny","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0205","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/IJDHD.2007.6.4.383","article-title":"Fetal alcohol spectrum disorders and mental illness","volume":"6","author":"Burd","year":"2007","journal-title":"Int. J. Disabil. Hum. Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/J157v02n01_06","article-title":"The use of a silymarin\/phospholipid compound as a fetoprotectant from ethanol-induced behavioral deficits","volume":"2","author":"Busby","year":"2002","journal-title":"J. Herb. Pharmacother."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0215","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1523\/JNEUROSCI.19-17-07568.1999","article-title":"Mechanisms of induction and expression of long-term depression at GABAergic synapses in the neonatal rat hippocampus","volume":"19","author":"Caillard","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0220","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.pbb.2008.05.004","article-title":"Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model","volume":"90","author":"Caldwell","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0225","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1080\/14786419.2014.918977","article-title":"Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75","volume":"28","author":"Carito","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0230","first-page":"382","article-title":"TNF-\u03b1 and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation","volume":"51","author":"Carito","year":"2015","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0235","first-page":"65","article-title":"Polyphenols, nerve growth factor, brain-derived neurotrophic factor, and the brain","author":"Carito","year":"2015","journal-title":"Bioact Nutraceuticals Diet Suppl Neurol Brain Dis Prev Ther"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0240","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.2174\/0929867323666160627104022","article-title":"Neurotrophins\u2019 modulation by olive polyphenols","volume":"23","author":"Carito","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0245","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.nut.2016.08.014","article-title":"Olive polyphenol effects in a mouse model of chronic ethanol addiction","volume":"33","author":"Carito","year":"2017","journal-title":"Nutrition"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0250","first-page":"17","article-title":"NGF and BDNF alterations by prenatal alcohol exposure","author":"Carito","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0255","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2174\/1570159X15666170825101308","article-title":"NGF and BDNF alterations by prenatal alcohol exposure","volume":"17","author":"Carito","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-4328(01)00452-1","article-title":"Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice","volume":"134","author":"Carola","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0265","first-page":"24","article-title":"Red wine consumption and cardiovascular health","author":"Castaldo","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0270","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/01.mcg.0000225570.04773.5d","article-title":"Acute alcoholic hepatitis","volume":"40","author":"Ceccanti","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0275","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.neurobiolaging.2010.03.005","article-title":"Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor","volume":"33","author":"Ceccanti","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0280","first-page":"383","article-title":"NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders","volume":"49","author":"Ceccanti","year":"2013","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0285","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.physbeh.2015.06.034","article-title":"Spatial learning in men undergoing alcohol detoxification","volume":"149","author":"Ceccanti","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0290","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/adb.12255","article-title":"Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol-elicited preference in male offspring","volume":"21","author":"Ceccanti","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0295","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1139\/cjpp-2017-0013","article-title":"Virtual Morris task responses in individuals in an abstinence phase from alcohol","volume":"96","author":"Ceccanti","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0300","doi-asserted-by":"crossref","DOI":"10.2174\/1570159X18666200429003239","article-title":"Nerve growth factor in alcohol use disorders","author":"Ceci","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0305","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrg2540","article-title":"Linking DNA methylation and histone modification: patterns and paradigms","volume":"10","author":"Cedar","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0310","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0315","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","article-title":"Role of oxidative stress in alcohol-induced liver injury","volume":"83","author":"Cederbaum","year":"2009","journal-title":"Arch. Toxicol."},{"issue":"80-","key":"10.1016\/j.neubiorev.2020.08.018_bib0320","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0325","first-page":"43","article-title":"Atherosclerotic lesions: possible interactive involvement of intima, adventitia and associated adipose tissue","volume":"7","author":"Chaldakov","year":"2000","journal-title":"Int Med J"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0330","first-page":"HY19","article-title":"Metabotrophic potential of neurotrophins: implication in obesity and related diseases?","volume":"9","author":"Chaldakov","year":"2003","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0335","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1042\/CBI20100509","article-title":"Neuroadipology: A novel component of neuroendocrinology","volume":"34","author":"Chaldakov","year":"2010","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0340","series-title":"Hippocampal Epigenetic Changes in a Mouse Model of Fetal Alcohol Spectrum disorders","author":"Chater-diehl","year":"2017"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0345","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.alcohol.2017.01.005","article-title":"Changes to histone modifications following prenatal alcohol exposure: an emerging picture","volume":"60","author":"Chater-Diehl","year":"2017","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0350","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0022-3565(24)39048-2","article-title":"Iron-mediated free radical injury in ethanol-exposed mouse neural crest cells","volume":"294","author":"Chen","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0355","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1124\/mol.105.017004","article-title":"Ethanol induces apoptotic death of developing beta-endorphin neurons via suppression of cyclic adenosine monophosphate production and activation of transforming growth factor-beta1-linked apoptotic signaling","volume":"69","author":"Chen","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0360","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Chen","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0365","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1523\/JNEUROSCI.19-03-00878.1999","article-title":"Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor","volume":"19","author":"Cho","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0370","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-007-0199-4","article-title":"Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons","volume":"113","author":"Chu","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0375","series-title":"Fetal Alcohol Syndrome and Fetal Alcohol Spectrum Disorder. Manag. Genet. Syndr","author":"Chudley","year":"2005"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0380","doi-asserted-by":"crossref","DOI":"10.1139\/bcb-2018-0248","article-title":"How alcohol drinking affects our genes: an epigenetic point of view","author":"Ciafre\u2019","year":"2019","journal-title":"Biochem. Cell Biol."},{"issue":"80-","key":"10.1016\/j.neubiorev.2020.08.018_bib0385","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.1075510","article-title":"The developing synapse: construction and modulation of synaptic structures and circuits","volume":"298","author":"Cohen-Cory","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0390","first-page":"359","article-title":"Fetal Alcohol Spectrum disorder (FASD): neurobehavioral profile, indications for diagnosis and treatment","volume":"48","author":"Coriale","year":"2013","journal-title":"Riv. Psichiatr."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0395","first-page":"131","article-title":"Behavioral responses in people affected by alcohol use disorder and psychiatric comorbidity: correlations with addiction severity","volume":"55","author":"Coriale","year":"2019","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0400","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0960-9822(03)00492-5","article-title":"Learning and memory deficits in notch mutant mice","volume":"13","author":"Costa","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0405","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.tins.2012.06.004","article-title":"Caspase-3 in the central nervous system: beyond apoptosis","volume":"35","author":"D\u2019Amelio","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0410","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neubiorev.2004.10.008","article-title":"Stress, genes and the mechanism of programming the brain for later life","volume":"29","author":"de Kloet","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0415","first-page":"e390","article-title":"Role of central nervous system insulin resistance in fetal alcohol spectrum disorders","volume":"17","author":"de la Monte","year":"2010","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0420","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.nut.2012.11.007","article-title":"Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain","volume":"29","author":"De Nicol\u00f3","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0425","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40474-014-0023-5","article-title":"Aberrant behavioral and neurobiologic profiles in rodents exposed to ethanol or red wine early in development","volume":"1","author":"De Nicol\u00f2","year":"2014","journal-title":"Curr Dev Disord Reports"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0430","first-page":"179","article-title":"Influence of ethanol consumption on brain nerve growth factor and its target cells in developing and adult rodents","volume":"29","author":"De Simone","year":"1993","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0435","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3240001","article-title":"Biochemistry and pathology of radical-mediated protein oxidation","volume":"324","author":"Dean","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0440","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0445","first-page":"273","article-title":"[Plasma concentrations of beta-endorphins in the children of alcoholic patients]","volume":"24","author":"Del Arbol","year":"2007","journal-title":"An. Med. Interna"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0450","series-title":"The Hypothalamus-pituitary-adrenal Axis","author":"Del Rey","year":"2008"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0455","first-page":"291","article-title":"Intrauterine ethanol exposure results in hypothalamic oxidative stress and neuroendocrine alterations in adult rat offspring","author":"Dembele","year":"2006","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0460","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ntt.2006.10.007","article-title":"Exposure in fetus of methylazoxymethanol in the rat alters brain neurotrophins\u2019 levels and brain cells\u2019 proliferation","volume":"29","author":"Di Fausto","year":"2007","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0465","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0470","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.toxlet.2009.12.012","article-title":"The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos","volume":"193","author":"Dong","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0475","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/acer.12639","article-title":"Pioglitazone blocks ethanol induction of microglial activation and immune responses in the Hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol Spectrum disorders","volume":"39","author":"Drew","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0480","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/alcalc\/34.6.894","article-title":"Gender differences in the relationship between alcohol consumption and drink problems are largely accounted for by body water","volume":"34","author":"Ely","year":"1999","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0485","series-title":"Long-Term Endocrine Consequences of Prenatal","first-page":"176","author":"Exposure","year":"2009"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0490","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1176\/ajp.155.4.552","article-title":"Mental illness in adults with fetal alcohol syndrome or fetal alcohol effects","volume":"155","author":"Famy","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0495","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/jnr.20404","article-title":"Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system","volume":"79","author":"Feng","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0500","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0505","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2174\/0929867321666141229103158","article-title":"Alcohol Addiction: A Molecular Biology Perspective","volume":"22","author":"Ferraguti","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0510","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.toxlet.2017.04.016","article-title":"Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: comparison with four alcohol screening questionnaires","volume":"275","author":"Ferraguti","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0515","article-title":"Fetus morphology changes by second-trimester ultrasound in pregnant women drinking alcohol","author":"Ferraguti","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0520","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0892-0362(98)00003-8","article-title":"Prenatal sulfur dioxide exposure induces changes in the behavior of adult male mice during agonistic encounters","volume":"20","author":"Fiore","year":"1998","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0525","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0031-9384(00)00310-3","article-title":"Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases","volume":"71","author":"Fiore","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0530","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3940(01)02045-6","article-title":"Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor","volume":"309","author":"Fiore","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0535","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1460-9568.2003.02573.x","article-title":"Agonistic encounters in aged male mouse potentiate the expression of endogenous brain NGF and BDNF: possible implication for brain progenitor cells\u2019 activation","volume":"17","author":"Fiore","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0540","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuro.2008.11.009","article-title":"Early exposure to ethanol but not red wine at the same alcohol concentration induces behavioral and brain neurotrophin alterations in young and adult mice","volume":"30","author":"Fiore","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0545","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.toxlet.2009.04.013","article-title":"Hepatocyte growth factor, vascular endothelial growth factor, glial cell-derived neurotrophic factor and nerve growth factor are differentially affected by early chronic ethanol or red wine intake","volume":"188","author":"Fiore","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0550","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1515\/REVNEURO.2009.20.2.133","article-title":"Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems","volume":"20","author":"Fiore","year":"2009","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0555","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1002\/ana.410320706","article-title":"Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress","volume":"32","author":"Floyd","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0560","doi-asserted-by":"crossref","first-page":"18515","DOI":"10.1074\/jbc.272.30.18515","article-title":"Superoxide anion radical (O2\/-\u00b7), superoxide dismutases, and related matters","volume":"272","author":"Fridovich","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0565","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.4161\/cc.9.19.13193","article-title":"Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5\u2032-flanking region: A priming effect on the spreading of active demethylation?","volume":"9","author":"Fuso","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113228","article-title":"Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus e113228","volume":"9","author":"Gangisetty","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0575","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1096\/fj.03-0109fje","article-title":"Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson\u2019s disease","volume":"17","author":"Gao","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0580","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1530-0277.1991.tb00536.x","article-title":"Ethanol consumption inhibits fetal DNA methylation in mice: implications for the fetal alcohol syndrome","volume":"15","author":"Garro","year":"1991","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0585","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/mrd.21118","article-title":"DNA methylation in early development","volume":"77","author":"Geiman","year":"2010","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0590","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.brainresrev.2010.04.011","article-title":"Hippocampal cell loss and neurogenesis after fetal alcohol exposure: insights from different rodent models","volume":"64","author":"Gil-Mohapel","year":"2010","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0595","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF02698017","article-title":"Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats","volume":"116","author":"Gonzalez","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0600","first-page":"175","article-title":"Mechanisms of alcohol-induced damage to the developing nervous system","volume":"25","author":"Goodlett","year":"2001","journal-title":"Alcohol Res. Health"},{"issue":"November-December (6)","key":"10.1016\/j.neubiorev.2020.08.018_bib0605","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0892-0362(97)00062-7","article-title":"Neonatal binge ethanol exposure using intubation: timing and dose effects on place learning. - PubMed - NCBI","volume":"19","author":"Goodlett CR1","year":"1997","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0610","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1432-0436.1994.56120039.x","article-title":"Expression of DNA methyltransferase gene in mature and immature neurons as well as proliferating cells in mice","volume":"56","author":"Goto","year":"1994","journal-title":"Differentiation"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0615","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0620","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.biopsych.2012.04.006","article-title":"Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations","volume":"72","author":"Govorko","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0625","doi-asserted-by":"crossref","first-page":"945","DOI":"10.15288\/jsad.2017.78.945","article-title":"Utility of commercial ethyl glucuronide (EtG) and ethyl sulfate (EtS) testing for detection of lighter drinking among women of childbearing years","volume":"78","author":"Graham","year":"2017","journal-title":"J. Stud. Alcohol Drugs"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0630","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/alcalc\/agn105","article-title":"Foetal Alcohol Spectrum disorders and alterations in brain and behaviour","volume":"44","author":"Guerri","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0635","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0640","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1007\/s12035-016-9950-y","article-title":"Protective role of quercetin in cadmium-induced cholinergic dysfunctions in rat brain by modulating mitochondrial integrity and MAP kinase signaling","volume":"54","author":"Gupta","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0645","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0650","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1111\/j.1530-0277.2006.00251.x","article-title":"Infant stress reactivity and prenatal alcohol exposure","volume":"30","author":"Haley","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0655","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1002\/ana.410320704","article-title":"Oxygen radicals as key mediators in neurological disease: Fact or fiction?","volume":"32","author":"Halliwell","year":"1992","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0660","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0665","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0891-5849(95)91457-3","article-title":"The definition and measurement of antioxidants in biological systems","volume":"18","author":"Halliwell","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0670","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0741-8329(02)00225-2","article-title":"Folate deficiency, methionine metabolism, and alcoholic liver disease","volume":"27","author":"Halsted","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0675","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.alcohol.2007.05.002","article-title":"Long-term alcohol ingestion alters the folate-binding kinetics in intestinal brush border membrane in experimental alcoholism","volume":"41","author":"Hamid","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0680","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1101\/gad.1262504","article-title":"The Drosha-DGCR8 complex in primary microRNA processing","volume":"18","author":"Han","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0685","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2006.03.043","article-title":"Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex","volume":"125","author":"Han","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0690","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physiolgenomics.00181.2013","article-title":"Intergenerational effects of prenatal ethanol on glucose tolerance and insulin response","volume":"46","author":"Harper","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0695","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)01123-0","article-title":"Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum","volume":"334","author":"Heaton","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0700","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.devbrainres.2003.08.005","article-title":"Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods","volume":"145","author":"Heaton","year":"2003","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0705","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1196\/annals.1418.016","article-title":"Prenatal alcohol exposure increases vulnerability to stress and anxiety-like disorders in adulthood","volume":"1144","author":"Hellemans","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0710","article-title":"Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders","author":"Hellemans","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0715","first-page":"D541","article-title":"Ethanol, oxidative stress, reactive aldehydes, and the fetus","volume":"4","author":"Henderson","year":"1999","journal-title":"Front Biosci"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0720","first-page":"541","article-title":"ETHANOL, OXIDATIVE STRESS, REACTIVE ALDEHYDES, AND THE FETUS George I. Henderson, JuanJuan Chen and steven schenker","volume":"1972","author":"Henderson","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0725","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fendo.2016.00137","article-title":"Paraventricular hypothalamic mechanisms of chronic stress adaptation","volume":"7","author":"Herman","year":"2016","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0730","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0741-8329(02)00215-X","article-title":"Ethanol, oxidative stress, and cytokine-induced liver cell injury","volume":"27","author":"Hoek JB, Pastorino JG","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0735","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12020-007-0017-8","article-title":"Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta)","volume":"31","author":"Hoffman","year":"2007","journal-title":"Endocrine"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0740","first-page":"368","article-title":"Epigenetic inheritance mediated by histone lysine methylation: Maintaining transcriptional states without the precise restoration of marks?","author":"Huang","year":"2013","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0745","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.220412197","article-title":"Neuronal death enhanced by N-methyl-D-aspartate antagonists","volume":"97","author":"Ikonomidou","year":"2000","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0750","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12035-011-8186-0","article-title":"The role of notch signaling in adult neurogenesis","volume":"44","author":"Imayoshi","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0755","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2006.8.1583","article-title":"NADPH oxidases of the brain: distribution, regulation, and function","volume":"8","author":"Infanger","year":"2006","journal-title":"Antioxidants Redox Signal"},{"issue":"80-","key":"10.1016\/j.neubiorev.2020.08.018_bib0760","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0765","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devbrainres.2003.12.010","article-title":"Neurobehavioral effects in rat pups whose sires were exposed to alcohol","volume":"149","author":"Jamerson","year":"2004","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0770","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1203\/00006450-198106000-00005","article-title":"Immune deficiency in fetal alcohol syndrome","volume":"15","author":"Johnson","year":"1981","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0775","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0780","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0785","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(73)91291-9","article-title":"Pattern of malformation in offspring of chronic alcoholic mothers","volume":"301","author":"Jones","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0790","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.bbi.2010.12.013","article-title":"Alcoholism and inflammation: Neuroimmunology of behavioral and mood disorders","volume":"25","author":"Kelley","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0795","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/alcalc\/agp061","article-title":"Sexually dimorphic effects of alcohol exposure during development on the processing of social cues","volume":"44","author":"Kelly","year":"2009","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0800","first-page":"2","article-title":"The antioxidant role of glutathione and N-Acetyl-Cysteine supplements and exercise-induced oxidative stress","author":"Kerksick","year":"2005","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0805","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/nsmb.2372","article-title":"5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary","volume":"19","author":"Khare","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0810","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/hmg\/ddt453","article-title":"Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage","volume":"23","author":"Kim","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0815","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000365549","article-title":"Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice","volume":"36","author":"Kleiber","year":"2014","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0820","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2014.00161","article-title":"Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders","volume":"5","author":"Kleiber","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0825","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.neuron.2015.05.036","article-title":"Epigenetics of stress-related psychiatric disorders and gene \u00d7 environment interactions","volume":"86","author":"Klengel","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0830","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2014.01.013","article-title":"The role of DNA methylation in stress-related psychiatric disorders","volume":"80","author":"Klengel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0835","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1152\/ajpregu.00223.2003","article-title":"Prenatal exposure to ethanol causes partial diabetes insipidus in adult rats","volume":"287","author":"Knee","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0840","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature12750","article-title":"TET enzymes, TDG and the dynamics of DNA demethylation","volume":"502","author":"Kohli","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0845","first-page":"274","article-title":"Alcohol metabolism\u2019s damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1","volume":"29","author":"Koop","year":"2006","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0850","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.psyneuen.2018.06.018","article-title":"Interactive effects of prenatal alcohol exposure and chronic stress in adulthood on anxiety-like behavior and central stress-related receptor mRNA expression: sex- and time-dependent effects","volume":"97","author":"Lam","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0855","doi-asserted-by":"crossref","first-page":"15945","DOI":"10.1073\/pnas.1002929107","article-title":"Distinct 3\u2019UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)","volume":"107","author":"Lau","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0860","first-page":"977","article-title":"Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice","volume":"6","author":"Laufer","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0865","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2217\/epi.15.60","article-title":"Associative DNA methylation changes in children with prenatal alcohol exposure","volume":"7","author":"Laufer","year":"2015","journal-title":"Epigenomics"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0870","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0028-3908(94)90122-8","article-title":"Prenatal cocaine potentiates the effects of morphine in adult mice","volume":"33","author":"Laviola","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0875","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.physbeh.2018.10.009","article-title":"Drop-out, relapse and abstinence in a cohort of alcoholic people under detoxification","volume":"198","author":"Ledda","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0880","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0885","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1196\/annals.1418.015","article-title":"Role of various neurotransmitters in mediating the long-term endocrine consequences of prenatal alcohol exposure","volume":"1144","author":"Lee","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0890","first-page":"476","article-title":"Les enfants des parents alcoholiques: anomolies observ\u00e9es a propos de 127 cas","volume":"8","author":"Lemoine","year":"1968","journal-title":"Ouest. Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0895","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4103\/1008-682X.160267","article-title":"Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring","volume":"17","author":"Liang","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0900","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4161\/epi.4.7.9925","article-title":"Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation","volume":"4","author":"Liu","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0905","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1726","article-title":"The yin and yang of neurotrophin action","volume":"6","author":"Lu","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0910","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1101\/gad.248005.114","article-title":"Role of Tet proteins in enhancer activity and telomere elongation","volume":"28","author":"Lu","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0915","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1523\/JNEUROSCI.1786-08.2008","article-title":"Epigenetic regulation of bdnf gene transcription in the consolidation of fear memory","volume":"28","author":"Lubin","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0920","first-page":"20","article-title":"Active demethylation of Non-CpG moieties in animals: a neglected research area","author":"Lucarelli","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0925","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1749-6632.2003.tb03172.x","article-title":"New insights into the functions of \u03b1-MSH and related peptides in the immune system","volume":"994","author":"Luger","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0930","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/acer.12622","article-title":"Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain","volume":"39","author":"Lussier","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0935","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/13767","article-title":"Absence of genome-wide changes in DNA methylation during development of the zebrafish [1]","volume":"23","author":"Macleod","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0940","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1523\/JNEUROSCI.2434-05.2005","article-title":"Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission","volume":"25","author":"Mameli","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0945","first-page":"65","article-title":"Blood thiamine, zinc, selenium, lead and oxidative stress in a population of male and female alcoholics: clinical evidence and gender differences","volume":"49","author":"Mancinelli","year":"2013","journal-title":"Ann. Ist. Super. Sanita"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0950","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.physbeh.2009.08.011","article-title":"Changes in cognition induced by social isolation in the mouse are restored by electro-acupuncture","volume":"98","author":"Manni","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0955","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4236\/jbbs.2013.31009","article-title":"Neurodevelopmental timing of ethanol exposure may contribute to observed heterogeneity of behavioral deficits in a mouse model of fetal alcohol Spectrum disorder (FASD)","volume":"03","author":"Mantha","year":"2013","journal-title":"J. Behav. Brain Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0960","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0965","first-page":"15","article-title":"Effects of cytosine methylation on transcription factor binding sites","author":"Medvedeva","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0970","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/jcs.1992.Supplement_16.2","article-title":"Transcriptional repression by methylation of CpG","volume":"16","author":"Meehan","year":"1992","journal-title":"J. Cell Sci. Suppl."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0975","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.234294.113","article-title":"DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos","volume":"28","author":"Messerschmidt","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0980","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00232-005-0839-3","article-title":"The role of TRP channels in oxidative stress-induced cell death","volume":"209","author":"Miller","year":"2006","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0985","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/j.1530-0277.2006.00177.x","article-title":"The alcoholism generator","volume":"30","author":"Miller","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0990","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2007.02.022","article-title":"Covalent modification of DNA regulates memory formation","volume":"53","author":"Miller","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib0995","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2158","article-title":"Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation","volume":"30","author":"Modarresi","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1000","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neuroscience.2007.08.012","article-title":"Nerve growth factor neuroprotection of ethanol-induced neuronal death in rat cerebral cortex is age dependent","volume":"149","author":"Mooney","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/neu.20009","article-title":"Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: effects of prenatal exposure","volume":"60","author":"Moore","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1010","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.2436","article-title":"Dynamic DNA methylation programs persistent adverse effects of early-life stress","volume":"12","author":"Murgatroyd","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1015","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/acer.12171","article-title":"Alcohol exposure in utero increases susceptibility to prostate tumorigenesis in rat offspring","volume":"37","author":"Murugan","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6882-4-4","article-title":"The effects of ethanol and silymarin treatment during gestation on spatial working memory","author":"Neese","year":"2004","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tem.2006.03.002","article-title":"Reduced glucocorticoid receptors: consequence or cause of depression?","volume":"17","author":"Neigh","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1035","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1040","series-title":"Molecular Neuropharmacology : a Foundation for Clinical Neuroscience","author":"Nestler","year":"2009"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1045","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jnen\/64.6.490","article-title":"Molecular regulation of acute ethanol-induced neuron apoptosis","volume":"64","author":"Nowoslawski","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1050","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1055","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1081\/ADA-120015880","article-title":"Psychiatric illness in a clinical sample of children with prenatal alcohol exposure","volume":"28","author":"O\u2019Connor","year":"2002","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1060","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1093\/nar\/26.11.2536","article-title":"Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells","volume":"26","author":"Okano","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/1029842021000010875","article-title":"Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome","volume":"4","author":"Olney","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/10826084.2015.1073324","article-title":"Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) testing is not vulnerable to incidental alcohol exposure in pregnant women","volume":"51","author":"Ondersma","year":"2016","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1075","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.lfs.2007.07.030","article-title":"Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes","volume":"81","author":"Pal-Bhadra","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2012.02.004","article-title":"Hypothalamic neuropeptides and the regulation of appetite","volume":"63","author":"Parker","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1090","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/j.1440-1681.2009.05342.x","article-title":"Prenatal alcohol exposure: implications for cardiovascular function in the fetus and beyond","volume":"37","author":"Parkington","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fped.2014.00093","article-title":"A comparison of the different animal models of fetal alcohol Spectrum disorders and their use in studying complex behaviors","volume":"2","author":"Patten","year":"2014","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1100","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1139\/o84-129","article-title":"Catalase: an old enzyme with a new role?","volume":"62","author":"Percy","year":"1984","journal-title":"Can. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1105","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF00783755","article-title":"[Lipid peroxidation changes in the brain in fetal alcohol syndrome]","volume":"113","author":"Petkov","year":"1992","journal-title":"Biull. Eksp. Biol. Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1110","doi-asserted-by":"crossref","first-page":"110783","DOI":"10.1016\/j.nut.2020.110783","article-title":"Oxidative Stress Inhibition by Resveratrol in Alcohol Dependent Mice","volume":"79-80","author":"Petrella","year":"2020","journal-title":"Nutrition"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1115","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1530-0277.2010.01276.x","article-title":"Fetal alcohol exposure increases mammary tumor susceptibility and alters tumor phenotype in rats","volume":"34","author":"Polanco","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13072-016-0074-4","article-title":"DNA methylation signature of human fetal alcohol spectrum disorder","volume":"9","author":"Portales-Casamar","year":"2016","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0076-6879(84)05035-7","article-title":"[32] chemistry of lipid peroxidation","volume":"105","author":"Porter","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1130","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","article-title":"Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters","volume":"90","author":"Pruunsild","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1135","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1530-0277.2009.01128.x","article-title":"Ethanol acutely inhibits ionotropic glutamate receptor-mediated responses and long-term potentiation in the developing CA1 Hippocampus","volume":"34","author":"Puglia","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ecl.2013.05.008","article-title":"Effects of alcohol on the endocrine system","volume":"42","author":"Rachdaoui","year":"2013","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1145","first-page":"862","article-title":"In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal","volume":"25","author":"Ramachandran","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/gm148","article-title":"Genetic and epigenetic insights into fetal alcohol spectrum disorders","volume":"2","author":"Ramsay","year":"2010","journal-title":"Genome Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1155","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1515\/BC.2000.118","article-title":"Molecular genetic analysis of glucocorticoid signaling using the Cre\/loxP system","volume":"381","author":"Reichardt","year":"2000","journal-title":"Biol. Chem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1160","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1055\/s-1999-14085","article-title":"Prevention by a silymarin\/phospholipid compound of ethanol-induced social learning deficits in rats","volume":"65","author":"Reid","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1165","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1530-0277.1993.tb00857.x","article-title":"Effects of in utero administration of alcohol on glutathione levels in brain and liver","volume":"17","author":"Reyes","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1170","first-page":"511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1175","first-page":"1768","article-title":"Journal of neuroscience","volume":"15","author":"Ridder","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1180","article-title":"Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders","volume":"4","author":"Roberts","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0010-440X(66)80007-X","article-title":"Research activities related to treatment of alcoholism","volume":"7","author":"Rodgers","year":"1966","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1190","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/acer.13007","article-title":"Meta-analysis of gene expression patterns in animal models of prenatal alcohol exposure suggests role for protein synthesis inhibition and chromatin remodeling","volume":"40","author":"Rogic","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","article-title":"NF-\u03baB is a target of AKT in anti-apoptotic PDGF signalling","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.alcohol.2016.03.006","article-title":"Paternal preconception ethanol exposure blunts hypothalamic-pituitary-adrenal axis responsivity and stress-induced excessive fluid intake in male mice","volume":"53","author":"Rompala","year":"2016","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1205","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1095\/biolreprod.109.080952","article-title":"Animal models to study environmental Epigenetics1","volume":"82","author":"Rosenfeld","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1210","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.conb.2009.05.011","article-title":"Regulation of chromatin structure in memory formation","volume":"19","author":"Roth","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2011.12.059","article-title":"Lithium prevents long-term neural and behavioral pathology induced by early alcohol exposure","volume":"206","author":"Sadrian","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1220","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/adb.12186","article-title":"Male germline transmits fetal alcohol epigenetic marks for multiple generations: a review","volume":"21","author":"Sarkar","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1225","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1210\/en.2006-1606","article-title":"Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function","volume":"148","author":"Sarkar","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1230","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.neuron.2009.11.019","article-title":"Control of cognition and adaptive behavior by the GLP\/G9a epigenetic suppressor complex","volume":"64","author":"Schaefer","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1235","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1101\/gad.973302","article-title":"SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins","volume":"16","author":"Schultz","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1240","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molcel.2012.11.001","article-title":"The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells","volume":"48","author":"Seisenberger","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1245","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1530-0277.2008.00729.x","article-title":"Emerging role of epigenetics in the actions of alcohol","volume":"32","author":"Shukla","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.phrs.2015.12.033","article-title":"Long-term effects of early life stress exposure: role of epigenetic mechanisms","volume":"109","author":"Silberman","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1255","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devbrainres.2005.09.004","article-title":"Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum","volume":"160","author":"Smith","year":"2005","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1260","first-page":"179","article-title":"Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress and diabetes","volume":"28","author":"Sornelli","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1265","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1046\/j.1471-4159.1998.71052112.x","article-title":"Conjugates of catecholamines with cysteine and GSH in parkinson\u2019s disease: possible mechanisms of formation involving reactive oxygen species","volume":"71","author":"Spencer","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1270","series-title":"Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment","author":"Stratton","year":"1996"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1275","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1749-6632.1986.tb40322.x","article-title":"Studying alcohol teratogenesis from the perspective of the fetal alcohol syndrome: methodological and statistical issues","volume":"477","author":"Streissguth","year":"1986","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1280","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004703-200408000-00002","article-title":"Risk factors for adverse life outcomes in fetal alcohol sydnrome and fetal alcohol effects","volume":"25","author":"Streissguth","year":"2004","journal-title":"J. Dev. Behav. Pediatr."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1285","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.nbd.2013.01.022","article-title":"G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain","volume":"54","author":"Subbanna","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1290","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuroscience.2013.11.043","article-title":"Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice","volume":"258","author":"Subbanna","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1295","doi-asserted-by":"crossref","first-page":"237S","DOI":"10.1111\/j.1530-0277.2001.tb02402.x","article-title":"Ethanol and oxidative stress","volume":"25","author":"Sun","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1300","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1530-0277.1995.tb01608.x","article-title":"Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system","volume":"19","author":"Swanson","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1305","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2008.09.002","article-title":"Experience-dependent epigenetic modifications in the central nervous system","volume":"65","author":"Sweatt","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1310","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1101\/gad.989402","article-title":"G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis","volume":"16","author":"Tachibana","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0387-7604(82)80094-6","article-title":"Experimental studies on the influence of male alcoholism on fetal development","volume":"4","author":"Tanaka","year":"1982","journal-title":"Brain Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1320","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/1097-4547(20010115)63:2<200::AID-JNR1012>3.0.CO;2-Q","article-title":"Effects of alcohol on brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus","volume":"63","author":"Tapia-Arancibia","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1325","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14748\/bmr.v29.5848","article-title":"Clinical and genetic approach to the dysmorphic child","volume":"29","author":"Tarani","year":"2018","journal-title":"Biomed Rev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1330","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2174\/092986707780597961","article-title":"Microglial activation and its implications in the brain diseases","volume":"14","author":"Thameem Dheen","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1335","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1474-9726.2010.00577.x","article-title":"Tissue-specific dysregulation of DNA methylation in aging","volume":"9","author":"Thompson","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1340","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.cell.2014.07.012","article-title":"Single-cell identity generated by combinatorial homophilic interactions between \u03b1, \u03b2, and \u03b3 protocadherins","volume":"158","author":"Thu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1345","first-page":"9","article-title":"Dynamic DNA methylation in the brain: a new epigenetic mark for experience-dependent plasticity","author":"Tognini","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1350","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.biochi.2013.09.009","article-title":"Brain peroxisomes","volume":"98","author":"Trompier","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1355","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","article-title":"Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action","volume":"9","author":"Tsankova","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1360","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/cvr\/cvn156","article-title":"Role of microRNAs in vascular diseases, inflammation, and angiogenesis","volume":"79","author":"Urbich","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1365","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ajog.2005.02.101","article-title":"Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome","volume":"193","author":"Vink","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1370","article-title":"Comparing the MicroRNA Spectrum between serum and plasma","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1375","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neuroscience.2013.09.018","article-title":"Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques","volume":"264","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1380","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J Neuroendocr"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1385","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/j.1471-4159.2004.02433.x","article-title":"Alterations in hippocampal phospholipid profile by prenatal exposure to ethanol","volume":"89","author":"Wen","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1390","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0006-8993(91)90489-I","article-title":"Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study","volume":"540","author":"Wozniak","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1395","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.nbd.2004.08.006","article-title":"Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning\/memory deficits in juveniles followed by progressive functional recovery in adults","volume":"17","author":"Wozniak","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1400","first-page":"277","article-title":"Alcohol, oxidative stress, and free radical damage","volume":"27","author":"Wu","year":"2003","journal-title":"Alcohol Res. Health"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1405","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.toxlet.2014.01.023","article-title":"Prenatal ethanol exposure enhances the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming","volume":"226","author":"Xia","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1410","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/bdra.20110","article-title":"Impaired development of mitochondria plays a role in the central nervous system defects of fetal alcohol syndrome","volume":"73","author":"Xu","year":"2005","journal-title":"Birth Defects Res Part A - Clin Mol Teratol"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1415","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1101\/gad.1158803","article-title":"Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs","volume":"17","author":"Yi","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1420","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1523\/JNEUROSCI.5539-08.2009","article-title":"Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory","volume":"29","author":"Yu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1425","first-page":"365","article-title":"Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high\u2011fat diet by affecting BDNF\u2011associated pathway","volume":"45","author":"Yu","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1430","first-page":"58","article-title":"Antioxidants and vitamins in clinical conditions","author":"Zad\u00e1k","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1435","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1440","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-4328(05)80039-7","article-title":"Spatial learning of adult rats with fetal alcohol exposure: deficits are sex-dependent","volume":"42","author":"Zimmerberg","year":"1991","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2020.08.018_bib1445","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1523\/JNEUROSCI.5405-09.2010","article-title":"Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons","volume":"30","author":"Zucca","year":"2010","journal-title":"J Neurosci Off J Soc Neurosci"}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763420305546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763420305546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:55:22Z","timestamp":1758966922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763420305546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":289,"alternative-id":["S0149763420305546"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.08.018","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}