{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:47:45Z","timestamp":1791726465118,"version":"4.3.4"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.neubiorev.2020.12.013","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T10:11:36Z","timestamp":1608459096000},"page":"250-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["A mu-opioid feedback model of human social behavior"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-1059","authenticated-orcid":false,"given":"Isabell M.","family":"Meier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"van Honk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-8734","authenticated-orcid":false,"given":"David","family":"Terburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2020.12.013_bib0005","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.neubiorev.2008.09.009","article-title":"Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse","volume":"33","author":"Andersen","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0010","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1073\/pnas.0710225105","article-title":"Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates","volume":"105","author":"Barr","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2013.00133","article-title":"Acute stress selectively reduces reward sensitivity","volume":"7","author":"Berghorst","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.physbeh.2009.02.044","article-title":"\u201cLiking\u201d and \u201cwanting\u201d food rewards: brain substrates and roles in eating disorders","volume":"97","author":"Berridge","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00213-008-1099-6","article-title":"Affective neuroscience of pleasure: reward in humans and animals","volume":"199","author":"Berridge","year":"2008","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0030","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.conb.2013.01.017","article-title":"Neuroscience of affect: brain mechanisms of pleasure and displeasure","volume":"23","author":"Berridge","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0035","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.neuron.2015.02.018","article-title":"Pleasure systems in the brain","volume":"86","author":"Berridge","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.psyneuen.2014.12.004","article-title":"Opioid partial agonist buprenorphine dampens responses to psychosocial stress in humans","volume":"52","author":"Bershad","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.psyneuen.2015.09.011","article-title":"Effects of buprenorphine on responses to social stimuli in healthy adults","volume":"63","author":"Bershad","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0050","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1017\/S0954579416000973","article-title":"The endocrinology of human caregiving and its intergenerational transmission","volume":"29","author":"Bos","year":"2017","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuroimage.2015.03.049","article-title":"Oxytocin reduces neural activity in the pain circuitry when seeing pain in others","volume":"113","author":"Bos","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.dcn.2018.05.002","article-title":"Parental touch reduces social vigilance in children","volume":"35","author":"Brummelman","year":"2018","journal-title":"Dev. Cogn. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.39648","article-title":"Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system","volume":"7","author":"Buchel","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0138-15.2016","article-title":"Touch perception altered by chronic pain and by opioid blockade","volume":"3","author":"Case","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0075","doi-asserted-by":"crossref","first-page":"E9125","DOI":"10.1073\/pnas.1705753114","article-title":"Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula","volume":"114","author":"Castro","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0080","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/mp.2014.1","article-title":"Rewards of beauty: the opioid system mediates social motivation in humans","volume":"19","author":"Chelnokova","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0085","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1467-9280.2006.01832.x","article-title":"Lending a hand: social regulation of the neural response to threat","volume":"17","author":"Coan","year":"2006","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0090","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0145-2134(82)90081-3","article-title":"A study of the relationship between child abuse and drug addiction in 178 patients: preliminary results","volume":"6","author":"Cohen","year":"1982","journal-title":"Child Abus. Negl."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0095","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1177\/0269881110367726","article-title":"Opioids and anxiety","volume":"25","author":"Colasanti","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1017\/S0140525X05000063","article-title":"A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation","volume":"28","author":"Depue","year":"2005","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0105","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0278-5846(01)00161-0","article-title":"Role of endogenous opioid system in the regulation of the stress response","volume":"25","author":"Drolet","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0110","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1007\/s00213-016-4403-x","article-title":"Sweet taste pleasantness is modulated by morphine and naltrexone","volume":"233","author":"Eikemo","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0115","first-page":"1","article-title":"Opioid modulation of value-based decision making in healthy humans","author":"Eikemo","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0120","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/s41386-019-0377-9","article-title":"Intact responses to non-drug rewards in long-term opioid maintenance treatment","volume":"44","author":"Eikemo","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0125","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1523\/JNEUROSCI.5336-07.2008","article-title":"Blockade of endogenous opioid neurotransmission enhances acquisition of conditioned fear in humans","volume":"28","author":"Eippert","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyg.2015.01986","article-title":"The neurobiology shaping affective touch: expectation, motivation, and meaning in the multisensory context","volume":"6","author":"Ellingsen","year":"2016","journal-title":"Front. Psychol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00213-010-1916-6","article-title":"The role of early life stress as a predictor for alcohol and drug dependence","volume":"214","author":"Enoch","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0140","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.dr.2011.01.001","article-title":"Touch for socioemotional and physical well-being: a review","volume":"30","author":"Field","year":"2010","journal-title":"Dev. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0145","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1431","article-title":"State-dependent opioid control of pain","volume":"5","author":"Fields","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0150","article-title":"A motivation-decision model of pain: the role of opioids","author":"Fields","year":"2006","journal-title":"Proceedings of the 11th World Congress on Pain"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0155","first-page":"1","article-title":"Understanding opioid reward","author":"Fields","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0160","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.biopsycho.2015.01.005","article-title":"Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence","volume":"105","author":"Garland","year":"2015","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0165","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00213-016-4494-4","article-title":"Deficits in autonomic indices of emotion regulation and reward processing associated with prescription opioid use and misuse","volume":"234","author":"Garland","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0170","first-page":"1","article-title":"Anhedonia in chronic pain and prescription opioid misuse","author":"Garland","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0175","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1037\/0735-7044.109.4.631","article-title":"Effects of a microinjection of morphine into the amygdala on the acquisition and expression of conditioned fear and hypoalgesia in rats","volume":"109","author":"Good","year":"1995","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/dev.10043","article-title":"Morphine administration selectively facilitates social play in common marmosets","volume":"41","author":"Guard","year":"2002","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.npep.2007.10.006","article-title":"The impact of postnatal environment on opioid peptides in young and adult male Wistar rats","volume":"42","author":"Gustafsson","year":"2008","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15495","article-title":"Endogenous opioids regulate social threat learning in humans","volume":"8","author":"Haaker","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0195","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neubiorev.2019.09.020","article-title":"Making translation work: harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning","volume":"107","author":"Haaker","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0200","first-page":"10000","volume":"27","author":"Harris","year":"2007"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0091-3057(78)90167-3","article-title":"Effects of morphine and naloxone on separation distress and approach attachment: evidence for opiate mediation of social affect","volume":"9","author":"Herman","year":"1978","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0210","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/mp.2013.96","article-title":"Response of the \u03bc-opioid system to social rejection and acceptance","volume":"18","author":"Hsu","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/mp.2014.185","article-title":"It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder","volume":"20","author":"Hsu","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0220","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1037\/emo0000088","article-title":"Blocking opioids attenuates physical warmth-induced feelings of social connection","volume":"15","author":"Inagaki","year":"2015","journal-title":"Emotion"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0225","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/scan\/nsw006","article-title":"Opioids and social bonding: naltrexone reduces feelings of social connection","volume":"11","author":"Inagaki","year":"2016","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0230","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.psyneuen.2012.05.002","article-title":"Reduced fear-recognition sensitivity following acute buprenorphine administration in healthy volunteers","volume":"38","author":"Ipser","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0235","doi-asserted-by":"crossref","first-page":"E9185","DOI":"10.1073\/pnas.1710880114","article-title":"Reported associations between receptor genes and human sociality are explained by methodological errors and do not replicate","volume":"114","author":"Jern","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0240","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-0270(88)90184-7","article-title":"Regional cerebral opioid receptor studies with [11C]diprenorphine in normal volunteers","volume":"23","author":"Jones","year":"1988","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0245","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1001\/archpsyc.63.11.1199","article-title":"Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women","volume":"63","author":"Kennedy","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0250","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0306-4530(89)90065-6","article-title":"Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships","volume":"14","author":"Keverne","year":"1989","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0255","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1212\/WNL.0b013e3181e7ca2e","article-title":"Central opioidergic neurotransmission in complex regional pain syndrome","author":"Klega","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.55797","article-title":"Dopaminergic and opioidergic regulation of implicit hedonic facial reactions during anticipation and consumption of social and nonsocial rewards","volume":"9","author":"Korb","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0265","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0091-3057(80)90157-4","article-title":"Pain modulating and reward systems: a single brain mechanism?","volume":"12","author":"Le Magnen","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0270","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nrn2333","article-title":"A common neurobiology for pain and pleasure","volume":"9","author":"Leknes","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0275","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.brat.2008.02.005","article-title":"Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance","volume":"46","author":"Lissek","year":"2008","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2014.00430","article-title":"State-dependent mu-opioid modulation of social motivation","volume":"8","author":"L\u00f8seth","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0285","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.psyneuen.2018.02.035","article-title":"Morphine reduced perceived anger from neutral and implicit emotional expressions","volume":"91","author":"L\u00f8seth","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0290","first-page":"1","article-title":"Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial","author":"L\u00f8seth","year":"2019","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0295","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1038\/npp.2015.101","article-title":"Cortisol stress response in men and women modulated differentially by the mu-opioid receptor gene polymorphism OPRM1 A118G","author":"Lovallo","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0300","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/archgenpsychiatry.2008.522","article-title":"Responsiveness to drug cues and natural rewards in opiate addiction: associations with later heroin use","volume":"66","author":"Lubman","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0305","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.conb.2013.02.005","article-title":"The multiple facets of opioid receptor function: Implications for addiction","volume":"23","author":"Lutz","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0310","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tins.2012.11.002","article-title":"Opioid receptors: distinct roles in mood disorders","volume":"36","author":"Lutz","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0315","first-page":"1","article-title":"The opioid system and the social brain: implications for depression and suicide","author":"Lutz","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0320","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1163\/000579511X596624","article-title":"The brain opioid theory of social attachment: a review of the evidence","volume":"148","author":"Machin","year":"2011","journal-title":"Behaviour"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0325","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15294145.2013.10799826","article-title":"Opioid function is dysregulated subsequent to early social trauma: healthy young adults\u2019 response to a buprenorphine challenge","volume":"15","author":"Malcolm-Smith","year":"2013","journal-title":"Neuropsychoanalysis"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0330","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0306-4530(93)90027-I","article-title":"Opioid receptor blockade reduces maternal affect and social grooming in rhesus monkeys","volume":"18","author":"Martel","year":"1993","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0335","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2014.05.001","article-title":"Discriminative and affective touch: sensing and feeling","volume":"82","author":"McGlone","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0340","doi-asserted-by":"crossref","first-page":"153","DOI":"10.46867\/IJCP.2009.22.03.02","article-title":"The roles of endogenous opioids in fear learning","volume":"22","author":"McNally","year":"2009","journal-title":"Int. J. Comp. Psychol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0345","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1037\/0735-7044.117.6.1292","article-title":"Opioid receptors regulate the extinction of pavlovian fear conditioning","volume":"117","author":"McNally","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0350","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1523\/JNEUROSCI.1828-04.2004","article-title":"Opioid receptors in the midbrain periaqueductal gray regulate extinction of Pavlovian fear conditioning","volume":"24","author":"McNally","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0355","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.psyneuen.2016.08.022","article-title":"Naltrexone increases negatively-valenced facial responses to happy faces in female participants","volume":"74","author":"Meier","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0360","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.00005.2009","article-title":"Reward processing by the opioid system in the brain","author":"Merrer","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0365","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.psyneuen.2014.04.022","article-title":"Cortisol administration induces global down-regulation of the brain\u2019s reward circuitry","volume":"47","author":"Montoya","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0370","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0163-6383(97)90045-X","article-title":"The effect of mother-infant skin-to-skin contact on plasma cortisol and \u03b2-endorphin concentrations in preterm newborns","volume":"20","author":"Mooncey","year":"1997","journal-title":"Infant Behav. Dev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0375","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s40750-016-0052-x","article-title":"Keep calm and cuddle on: social touch as a stress buffer","author":"Morrison","year":"2016","journal-title":"Adapt. Hum. Behav. Physiol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0380","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroimage.2016.05.063","article-title":"Social touch modulates endogenous \u03bc-opioid system activity in humans","volume":"138","author":"Nummenmaa","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0385","first-page":"607","article-title":"The biology of social attachments: opiates alleviate separation distress","author":"Panksepp","year":"1978","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0390","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0149-7634(80)90036-6","article-title":"Endogenous opioids and social behavior","volume":"4","author":"Panksepp","year":"1980","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0395","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.physbeh.2008.04.006","article-title":"Opioid reward \u2018liking\u2019 and \u2018wanting\u2019 in the nucleus accumbens","volume":"94","author":"Peci\u00f1a","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0400","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/1073858406293154","article-title":"Hedonic hot spots in the brain","volume":"12","author":"Peci\u00f1a","year":"2006","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0405","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1177\/0956797619849894","article-title":"Variation in the \u03bc-opioid receptor gene (OPRM1) does not moderate social-rejection sensitivity in humans","volume":"30","author":"Persson","year":"2019","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0410","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/cne.20956","article-title":"Enkephalinergic afferents of the Centromedial Amygdala in the rat","volume":"496","author":"Poulin","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0415","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00213-004-2045-x","article-title":"Effect of the blockade of mu1-opioid and 5HT2A-serotonergic\/alpha1-noradrenergic receptors on sweet-substance-induced analgesia","volume":"179","author":"Rebou\u00e7as","year":"2005","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0420","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.pnpbp.2005.08.011","article-title":"Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptors","volume":"29","author":"Ribeiro","year":"2005","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0425","doi-asserted-by":"crossref","first-page":"E5638","DOI":"10.1073\/pnas.1511269112","article-title":"Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain","volume":"112","author":"Rutgen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0430","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.infbeh.2011.06.006","article-title":"Risks and realities: dyadic interaction between 6-month-old infants and their mothers in opioid maintenance treatment","volume":"34","author":"Sarfi","year":"2011","journal-title":"Infant Behav. Dev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0435","doi-asserted-by":"crossref","first-page":"e1054","DOI":"10.1038\/tp.2017.34","article-title":"Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery","volume":"7","author":"Savulich","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0440","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.psyneuen.2011.03.002","article-title":"OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques","volume":"36","author":"Schwandt","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0445","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/scan\/nst152","article-title":"Opioid receptor blockade and warmth-liking: effects on interpersonal trust and frontal asymmetry","volume":"9","author":"Schweiger","year":"2013","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0450","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/da.20914","article-title":"Attention biases, anxiety, and development: toward or away from threats or rewards?","volume":"29","author":"Shechner","year":"2012","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0455","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1526-4637.2010.00881.x","article-title":"Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain","volume":"11","author":"Shurman","year":"2010","journal-title":"Pain Med."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0460","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.psyneuen.2014.11.009","article-title":"Improved memory for reward cues following acute buprenorphine administration in humans","volume":"53","author":"Syal","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0465","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0014-2999(81)90161-8","article-title":"Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats","volume":"70","author":"Szechtman","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0470","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/1754073913477510","article-title":"Approach\u2013avoidance versus dominance\u2013submissiveness: a multilevel neural framework on how testosterone promotes social status","volume":"5","author":"Terburg","year":"2013","journal-title":"Emot. Rev."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0475","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/0956797611398492","article-title":"Eye tracking unconscious face-to-face confrontations: dominance motives prolong gaze to masked angry faces","volume":"22","author":"Terburg","year":"2011","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0480","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0956797611433336","article-title":"Testosterone affects gaze aversion from angry faces outside of conscious awareness","volume":"23","author":"Terburg","year":"2012","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0485","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tips.2010.06.008","article-title":"The pleasures of play: pharmacological insights into social reward mechanisms","volume":"31","author":"Trezza","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0490","article-title":"Assessment of anhedonia in adults with and without mental illness: a systematic review and meta-analysis","volume":"3","author":"Tr\u00f8stheim","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0495","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/17470919.2010.482786","article-title":"Social hedonic capacity is associated with the A118G polymorphism of the mu-opioid receptor gene (OPRM1) in adult healthy volunteers and psychiatric patients","volume":"6","author":"Troisi","year":"2011","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0500","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ynstr.2014.09.006","article-title":"Endogenous opioids: the downside of opposing stress","volume":"1","author":"Valentino","year":"2015","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0505","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0006-3223(85)90061-7","article-title":"Inescapable shock, neurotransmitters, and addiction to trauma: toward a psychobiology of post traumatic stress","volume":"20","author":"van der Kolk","year":"1985","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0510","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-2999(95)00040-R","article-title":"Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats","volume":"276","author":"Vanderschuren","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0515","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/ADM.0b013e31817e6105","article-title":"The opioid dependent mother and newborn dyad: nonpharmacologic care","volume":"2","author":"Velez","year":"2008","journal-title":"J. Addict. Med."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0520","article-title":"Naltrexone alters the processing of social and emotional stimuli in healthy adults","volume":"0919","author":"Wardle","year":"2015","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0525","doi-asserted-by":"crossref","first-page":"15079","DOI":"10.1073\/pnas.0812612106","article-title":"Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection","volume":"106","author":"Way","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0530","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0196-9781(03)00118-9","article-title":"Emotion regulation and touch in infants: the role of cholecystokinin and opioids","volume":"24","author":"Weller","year":"2003","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0535","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1037\/0097-7403.17.3.219","article-title":"Aversive conditioning in the rat: effects of a benzodiazepine and of an opioid agonist and antagonist on conditioned hypoalgesia and fear","volume":"17","author":"Westbrook","year":"1991","journal-title":"J. Exp. Psychol. Anim. Behav. Process."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0540","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1037\/0735-7044.117.2.202","article-title":"Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat","volume":"117","author":"Zhang","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0545","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1126\/science.1060952","article-title":"Regional mu opioid receptor regulation of sensory and affective dimensions of pain","volume":"293","author":"Zubieta","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2020.12.013_bib0550","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archpsyc.60.11.1145","article-title":"Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission","volume":"60","author":"Zubieta","year":"2003","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763420306898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763420306898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:51:46Z","timestamp":1758966706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763420306898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":110,"alternative-id":["S0149763420306898"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.12.013","relation":{"has-preprint":[{"id-type":"doi","id":"10.31234\/osf.io\/mhjyw","asserted-by":"object"}]},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A mu-opioid feedback model of human social behavior","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2020.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}