{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:48:28Z","timestamp":1791478108845,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.neubiorev.2021.01.019","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:59:49Z","timestamp":1612587589000},"page":"358-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Molecular genetics of substance use disorders: An umbrella review"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7504-3441","authenticated-orcid":false,"given":"Sandra","family":"Lopez-Leon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-218X","authenticated-orcid":false,"given":"Yeimy","family":"Gonz\u00e1lez-Giraldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-6697","authenticated-orcid":false,"given":"Talia","family":"Wegman-Ostrosky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Forero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neubiorev.2021.01.019_bib0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1017\/thg.2015.36","article-title":"Genome-wide meta-analysis of longitudinal alcohol consumption across youth and early adulthood","volume":"18","author":"Adkins","year":"2015","journal-title":"Twin Res. Hum. Genet."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0010","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1038\/tp.2012.54","article-title":"The genetics of addiction-a translational perspective","volume":"2","author":"Agrawal","year":"2012","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.neubiorev.2021.01.019_bib0015","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/mp.2017.200","article-title":"Genome-wide association study identifies a novel locus for cannabis dependence","volume":"23","author":"Agrawal","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0020","series-title":"Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gep.2009.11.005","article-title":"Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology","volume":"10","author":"Bedogni","year":"2010","journal-title":"Gene Expr. Patterns"},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1474-4422(14)70267-4","article-title":"Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses","volume":"14","author":"Belbasis","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/gbb.12265","article-title":"In search of predictive endophenotypes in addiction: insights from preclinical research","volume":"15","author":"Belin","year":"2016","journal-title":"Genes Brain Behav."},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.31887\/DCNS.2017.19.3\/wberrettini","article-title":"A brief review of the genetics and pharmacogenetics of opioid use disorders","volume":"19","author":"Berrettini","year":"2017","journal-title":"Dialogues Clin. Neurosci."},{"issue":"11","key":"10.1016\/j.neubiorev.2021.01.019_bib0045","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.biopsych.2018.11.024","article-title":"Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use","volume":"85","author":"Brazel","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0050","doi-asserted-by":"crossref","first-page":"109667","DOI":"10.1016\/j.pnpbp.2019.109667","article-title":"Genome-wide association meta-analysis of cocaine dependence: shared genetics with comorbid conditions","volume":"94","author":"Cabana-Dom\u00ednguez","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/dar.12580","volume":"37","author":"Day","year":"2018","journal-title":"Drug Alcohol Rev."},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.psc.2012.03.010","article-title":"The genetic basis of addictive disorders","volume":"35","author":"Ducci","year":"2012","journal-title":"Psychiatr. Clin. North Am."},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ajmg.a.37454","article-title":"Exonic deletions of AUTS2 in Chinese patients with developmental delay and intellectual disability","volume":"170A","author":"Fan","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/00952990.2019.1636384","article-title":"Convergent functional genomics of cocaine misuse in humans and animal models","volume":"46","author":"Forero","year":"2020","journal-title":"Am. J. Drug Alcohol Abuse"},{"issue":"7","key":"10.1016\/j.neubiorev.2021.01.019_bib0080","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/jmedgenet-2015-103631","article-title":"Current needs for human and medical genomics research infrastructure in low and middle income countries","volume":"53","author":"Forero","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0085","series-title":"Genome Plasticity in Health and Disease","first-page":"191","article-title":"Chapter 12 - genome plasticity and neuropsychiatric disorders","author":"Forero","year":"2020"},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/ebmental-2018-300014","article-title":"Ten simple rules for conducting umbrella reviews","volume":"21","author":"Fusar-Poli","year":"2018","journal-title":"Evid. Ment. Health"},{"issue":"12","key":"10.1016\/j.neubiorev.2021.01.019_bib0095","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S2215-0366(18)30337-7","article-title":"The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"5","author":"GBD Alcohol Drug Use, & Collaborators","year":"2018","journal-title":"Lancet Psychiatry"},{"issue":"7","key":"10.1016\/j.neubiorev.2021.01.019_bib0100","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrg1635","article-title":"The genetics of addictions: uncovering the genes","volume":"6","author":"Goldman","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0105","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jad.2018.08.041","article-title":"A review of the neurobiological underpinning of comorbid substance use and mood disorders","volume":"241","author":"Gomez-Coronado","year":"2018","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.neubiorev.2021.01.019_bib0110","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jamapsychiatry.2015.2132","article-title":"Epidemiology of DSM-5 drug use disorder: results from the national epidemiologic survey on alcohol and related conditions-III","volume":"73","author":"Grant","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"8","key":"10.1016\/j.neubiorev.2021.01.019_bib0120","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1176\/appi.ajp.2013.12060782","article-title":"DSM-5 criteria for substance use disorders: recommendations and rationale","volume":"170","author":"Hasin","year":"2013","journal-title":"Am. J. Psychiatry"},{"issue":"23","key":"10.1016\/j.neubiorev.2021.01.019_bib0125","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.neubiorev.2021.01.019_bib0130","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.mp.4001622","article-title":"Genetic susceptibility to substance dependence","volume":"10","author":"Hiroi","year":"2005","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neubiorev.2021.01.019_bib0135","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1503\/cmaj.081086","article-title":"Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses","volume":"181","author":"Ioannidis","year":"2009","journal-title":"CMAJ"},{"issue":"12","key":"10.1016\/j.neubiorev.2021.01.019_bib0140","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S2215-0366(20)30339-4","article-title":"A large-scale genome-wide association study meta-analysis of cannabis use disorder","volume":"7","author":"Johnson","year":"2020","journal-title":"Lancet Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archpsyc.57.3.261","article-title":"Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins","volume":"57","author":"Kendler","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"issue":"6","key":"10.1016\/j.neubiorev.2021.01.019_bib0150","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/archpsyc.65.6.674","article-title":"Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood","volume":"65","author":"Kendler","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1071","article-title":"Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease","volume":"33","author":"Lohmueller","year":"2003","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.neubiorev.2021.01.019_bib0160","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/sj.mp.4002088","article-title":"Meta-analyses of genetic studies on major depressive disorder","volume":"13","author":"Lopez-Leon","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mrrev.2018.06.002","article-title":"DNA methylation signatures: biomarkers of drug and alcohol abuse","volume":"777","author":"Mahna","year":"2018","journal-title":"Mutat. Res."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0170","series-title":"U. D. o. H. a. H. S.","author":"McCance-Katz","year":"2019"},{"issue":"7","key":"10.1016\/j.neubiorev.2021.01.019_bib0175","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-030-21737-2_7","article-title":"Genetic factors in cannabinoid use and dependence","volume":"1162","author":"Mulligan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"11","key":"10.1016\/j.neubiorev.2021.01.019_bib0185","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0090-9556(25)08453-3","article-title":"Role of human cytochrome P4502A6 in C-oxidation of nicotine","volume":"24","author":"Nakajima","year":"1996","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.neubiorev.2021.01.019_bib0190","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/mp.2015.102","article-title":"Evidence of CNIH3 involvement in opioid dependence","volume":"21","author":"Nelson","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.neubiorev.2021.01.019_bib0195","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/add.14234","article-title":"Global statistics on alcohol, tobacco and illicit drug use: 2017 status report","volume":"113","author":"Peacock","year":"2018","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41398-019-0397-6","article-title":"Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the \u201cdark side\u201d of addiction","volume":"9","author":"Peng","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0205","first-page":"e12877","article-title":"Common genetic substrates of alcohol and substance use disorder severity revealed by pleiotropy detection against GWAS catalog in two populations","author":"Peng","year":"2020","journal-title":"Addict. Biol."},{"issue":"7","key":"10.1016\/j.neubiorev.2021.01.019_bib0210","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/s41386-018-0008-x","article-title":"Environmental, genetic and epigenetic contributions to cocaine addiction","volume":"43","author":"Pierce","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.drugalcdep.2017.06.040","article-title":"The genetic epidemiology of substance use disorder: a review","volume":"180","author":"Prom-Wormley","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0220","series-title":"2017 National Survey on Drug Use and Health: Detailed Tables","author":"Quality","year":"2018"},{"issue":"4","key":"10.1016\/j.neubiorev.2021.01.019_bib0225","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41593-020-0609-7","article-title":"Emerging phenotyping strategies will advance our understanding of psychiatric genetics","volume":"23","author":"Sanchez-Roige","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.neubiorev.2021.01.019_bib0230","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/YCO.0000000000000332","article-title":"Substance use and addictive disorders in DSM-5 and ICD 10 and the draft ICD 11","volume":"30","author":"Saunders","year":"2017","journal-title":"Curr. Opin. Psychiatry"},{"issue":"17","key":"10.1016\/j.neubiorev.2021.01.019_bib0235","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1073\/pnas.1017288108","article-title":"Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption","volume":"108","author":"Schumann","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"50","key":"10.1016\/j.neubiorev.2021.01.019_bib0240","doi-asserted-by":"crossref","first-page":"14372","DOI":"10.1073\/pnas.1611243113","article-title":"KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference","volume":"113","author":"Schumann","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10519-015-9737-3","article-title":"Association of the OPRM1 variant rs1799971 (A118G) with non-specific liability to substance dependence in a collaborative de novo meta-analysis of European-Ancestry Cohorts","volume":"46","author":"Schwantes-An","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0250","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0255","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1111\/ejn.14171","article-title":"Neurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco","volume":"50","author":"Sharp","year":"2019","journal-title":"Eur. J. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2021.01.019_bib0260","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1001\/jamapsychiatry.2016.0036","article-title":"Genome-wide association study of cannabis dependence severity, novel risk variants, and shared genetic risks","volume":"73","author":"Sherva","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.neubiorev.2021.01.019_bib0265","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1097\/JAN.0000000000000162","article-title":"Neurobiology of comorbid substance use disorders and psychiatric disorders: current state of evidence","volume":"28","author":"Singh Balhara","year":"2017","journal-title":"J. Addict. Nurs."},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0270","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41380-017-0010-4","article-title":"Psychiatric genetics and the structure of psychopathology","volume":"24","author":"Smoller","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0275","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/tpj.2017.35","article-title":"Genome-wide meta-analysis of copy number variations with alcohol dependence","volume":"18","author":"Sulovari","year":"2018","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0280","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.copsyc.2018.08.008","article-title":"The complex genetic and psychosocial influences on polysubstance misuse","volume":"27","author":"Vaughn","year":"2019","journal-title":"Curr. Opin. Psychol."},{"issue":"5","key":"10.1016\/j.neubiorev.2021.01.019_bib0285","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1017\/S0033291714002165","article-title":"The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies","volume":"45","author":"Verhulst","year":"2015","journal-title":"Psychol. Med."},{"issue":"5","key":"10.1016\/j.neubiorev.2021.01.019_bib0290","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1369-1600.2012.00478.x","article-title":"The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation","volume":"18","author":"Verweij","year":"2013","journal-title":"Addict. Biol."},{"issue":"3","key":"10.1016\/j.neubiorev.2021.01.019_bib0295","first-page":"1423","article-title":"Pain polymorphisms and opioids: an evidence based review","volume":"19","author":"Vieira","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.neubiorev.2021.01.019_bib0300","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/ntr\/ntr118","article-title":"Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis","volume":"13","author":"Ware","year":"2011","journal-title":"Nicotine Tob. Res."},{"issue":"2","key":"10.1016\/j.neubiorev.2021.01.019_bib0305","doi-asserted-by":"crossref","first-page":"e0116820","DOI":"10.1371\/journal.pone.0116820","article-title":"The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010","volume":"10","author":"Whiteford","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.neubiorev.2021.01.019_bib0310","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/jamapsychiatry.2020.1206","article-title":"Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study","volume":"77","author":"Zhou","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"10.1016\/j.neubiorev.2021.01.019_bib0315","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41593-020-0643-5","article-title":"Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits","volume":"23","author":"Zhou","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.01.019_bib0320","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-981-10-5562-1_2","article-title":"Definition of substance and non-substance addiction","volume":"1010","author":"Zou","year":"2017","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763421000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763421000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T09:59:50Z","timestamp":1758967190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763421000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":64,"alternative-id":["S0149763421000336"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.01.019","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular genetics of substance use disorders: An umbrella review","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}