{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:07:45Z","timestamp":1792678065533,"version":"4.5.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA225590"],"award-info":[{"award-number":["T32 CA225590"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.neubiorev.2021.07.033","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T05:25:13Z","timestamp":1627968313000},"page":"206-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of chemotherapy for acute lymphoblastic leukemia on cognitive function in animal models of contemporary protocols: A systematic literature review"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-582X","authenticated-orcid":false,"given":"Tyler C.","family":"Alexander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Krull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2021.07.033_bib0005","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tips.2006.10.005","article-title":"Bioenergetics and the formation of mitochondrial reactive oxygen species","volume":"27","author":"Adam-Vizi","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrc2073","article-title":"Candidate mechanisms for chemotherapy-induced cognitive changes","volume":"7","author":"Ahles","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0015","series-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbr.2017.12.008","article-title":"Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model","volume":"346","author":"Alexander","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0025","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx085","article-title":"Changes in brain structural networks and cognitive functions in testicular cancer patients receiving cisplatin-based chemotherapy","volume":"109","author":"Amidi","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0035","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1177\/0883073808321065","article-title":"o. c. n. III Preventing neurocognitive late effects in childhood cancer survivors","volume":"23","author":"Askins","year":"2008","journal-title":"J Child Neurol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0040","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0161-813X(03)00043-3","article-title":"A new animal model of vincristine-induced nociceptive peripheral neuropathy","volume":"24","author":"Authier","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fnmol.2017.00199","article-title":"Distinct features of Doublecortin as a marker of neuronal migration and its implications in cancer cell mobility","volume":"10","author":"Ayanlaja","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124521","article-title":"Using the Morris water maze to assess spatial learning and memory in weanling mice","volume":"10","author":"Barnhart","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0055","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1158\/1078-0432.CCR-12-3764","article-title":"Effects of early chemotherapeutic treatment on learning in adolescent mice: implications for cognitive impairment and remediation in childhood cancer survivors","volume":"19","author":"Bisen-Hersh","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnagi.2012.00019","article-title":"Characterizing cognitive aging of working memory and executive function in animal models","volume":"4","author":"Bizon","year":"2012","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0065","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S2352-4642(18)30236-0","article-title":"Peripheral neuropathy in children and adolescents treated for cancer","volume":"2","author":"Bjornard","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-010-9177-4","article-title":"Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects","volume":"34","author":"Blom","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0080","article-title":"Adolescence and socioeconomic factors: key factors in the long-term impact of leukemia on scholastic performance-A LEA study","author":"Bonneau","year":"2018","journal-title":"J. Pediatr."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1471-2202-12-124","article-title":"Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications","volume":"12","author":"Briones","year":"2011","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbi.2013.07.175","article-title":"Dysregulation in myelination mediated by persistent neuroinflammation: possible mechanisms in chemotherapy-related cognitive impairment","volume":"35","author":"Briones","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0095","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/neuonc\/not114","article-title":"Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Brown","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0049-3848(01)00363-2","article-title":"Effects of homocysteine on proliferation, necrosis, and apoptosis of vascular smooth muscle cells in culture and influence of folic acid","volume":"104","author":"Buemi","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0105","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/toxics3020198","article-title":"Mitochondrial dysfunction in chemotherapy-induced peripheral neuropathy (CIPN)","volume":"3","author":"Canta","year":"2015","journal-title":"Toxics"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0110","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2506","article-title":"Assessment of thermal pain sensation in rats and mice using the hargreaves test","volume":"7","author":"Cheah","year":"2017","journal-title":"Bio Protoc"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0115","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neubiorev.2015.03.016","article-title":"Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: a systematic review","volume":"53","author":"Cheung","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0120","doi-asserted-by":"crossref","first-page":"e456","DOI":"10.1016\/S2352-3026(16)30110-7","article-title":"Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis","volume":"3","author":"Cheung","year":"2016","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0125","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.0089","article-title":"Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia","volume":"4","author":"Cheung","year":"2018","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193298","article-title":"The role of the folate pathway in pancreatic cancer risk","volume":"13","author":"Chittiboyina","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1037\/a0023766","article-title":"Animal models of prefrontal-executive function","volume":"125","author":"Chudasama","year":"2011","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0140","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1158\/1078-0432.CCR-13-1179","article-title":"Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits","volume":"19","author":"Cole","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0145","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1200\/JCO.2014.59.0273","article-title":"Polymorphisms in genes related to oxidative stress are associated with inferior cognitive function after therapy for childhood acute lymphoblastic leukemia","volume":"33","author":"Cole","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pcl.2014.09.006","article-title":"Treatment of pediatric acute lymphoblastic leukemia","volume":"62","author":"Cooper","year":"2015","journal-title":"Pediatr. Clin. North Am."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0155","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/CEJ.0b013e3283307770","article-title":"Life after childhood cancer: marriage and offspring in adult long-term survivors--a population-based study in the Piedmont region, Italy","volume":"18","author":"Dama","year":"2009","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0160","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain behaviors in rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0165","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/(SICI)1096-8652(199608)52:4<254::AID-AJH3>3.0.CO;2-R","article-title":"Vincristine-induced alterations in Schwann cells of mouse peripheral nerve","volume":"52","author":"Djaldetti","year":"1996","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jnc.13008","article-title":"Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity","volume":"132","author":"Doll","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0175","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/aps.2009.24","article-title":"Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases","volume":"30","author":"Dong","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0180","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/pbc.24644","article-title":"Dexamethasone exposure and memory function in adult survivors of childhood acute lymphoblastic leukemia: a report from the SJLIFE cohort","volume":"60","author":"Edelmann","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0185","first-page":"35","article-title":"HRQOL implications of treatment with dexamethasone for children with acute lymphoblastic leukemia (ALL)","volume":"46","author":"Eiser","year":"2006","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0190","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pbb.2010.08.019","article-title":"Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents","volume":"97","author":"Fardell","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0195","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/jnci\/djy089","article-title":"Brain activity associated with attention deficits following chemotherapy for childhood acute lymphoblastic leukemia","volume":"111","author":"Fellah","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0200","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/pr.2015.19","article-title":"Dexamethasone but not the equivalent doses of hydrocortisone induces neurotoxicity in neonatal rat brain","volume":"77","author":"Feng","year":"2015","journal-title":"Pediatric Research"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0205","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1002\/ijc.30696","article-title":"Employment status and occupational level of adult survivors of childhood cancer in Great Britain: the British childhood cancer survivor study","volume":"140","author":"Frobisher","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.14336\/AD.2015.1022","article-title":"The role of oxidative stress in etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-\u201cChemobrain\u201d","volume":"7","author":"Gaman","year":"2016","journal-title":"Aging Dis."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.04.032","article-title":"Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment","author":"Geraghty","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11764-015-0453-z","article-title":"Educational attainment among long-term survivors of cancer in childhood and adolescence: a Norwegian population-based cohort study","volume":"10","author":"Ghaderi","year":"2016","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0225","first-page":"254","article-title":"Potential toxicities of prophylactic cranial irradiation","volume":"1","author":"Giordano","year":"2012","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0230","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1200\/EDBK_201179","article-title":"Cognitive changes in Cancer survivors","volume":"38","author":"Hardy","year":"2018","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0235","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0969-9961(03)00070-6","article-title":"Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine","volume":"14","author":"Ho","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0240","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2013.05.087","article-title":"Compound K is able to ameliorate the impaired cognitive function and hippocampal neurogenesis following chemotherapy treatment","volume":"436","author":"Hou","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0245","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1001\/jama.290.12.1583","article-title":"Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer survivor Study","volume":"290","author":"Hudson","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0250","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1002\/cncr.10999","article-title":"Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia","volume":"95","author":"Iuvone","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0255","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00221-006-0499-2","article-title":"Vincristine-induced neuropathy in rat: electrophysiological and histological study","volume":"173","author":"Ja\u2019afer","year":"2006","journal-title":"Exp Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0260","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S2215-0366(16)30283-8","article-title":"Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study","volume":"3","author":"Jacola","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0265","article-title":"Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model","volume":"8","author":"Ji","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0270","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0387-7604(95)00079-Q","article-title":"Neurotransmitters and vulnerability of the developing brain","volume":"17","author":"Johnston","year":"1995","journal-title":"Brain Dev."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0275","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pain.2005.12.010","article-title":"Mitochondrial electron transport in models of neuropathic and inflammatory pain","volume":"121","author":"Joseph","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0280","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1200\/JCO.2009.23.5408","article-title":"Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia","volume":"27","author":"Kadan-Lottick","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0285","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/pon.3255","article-title":"Slower processing speed after treatment for pediatric brain tumor and acute lymphoblastic leukemia","volume":"22","author":"Kahalley","year":"2013","journal-title":"Psychooncology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0290","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","article-title":"Oxidative stress and apoptosis","volume":"7","author":"Kannan","year":"2000","journal-title":"Pathophysiology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0295","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","article-title":"Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer\u2019s disease","volume":"10","author":"Kapogiannis","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0300","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/1673-5374.128217","article-title":"Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage","volume":"9","author":"Ke","year":"2014","journal-title":"Neural Regen. Res."},{"issue":"Suppl","key":"10.1016\/j.neubiorev.2021.07.033_bib0305","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.bbi.2012.05.017","article-title":"Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors","volume":"30","author":"Kesler","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2004.07.093","article-title":"Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro","volume":"1027","author":"Kim","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0315","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbr.2015.06.007","article-title":"Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation","volume":"292","author":"Kitamura","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0320","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1073\/pnas.0910658107","article-title":"Nuclear factor-\u03baB is a critical mediator of stress-impaired neurogenesis and depressive behavior","volume":"107","author":"Koo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0325","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1200\/JCO.2012.48.2315","article-title":"Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the St Jude lifetime cohort study","volume":"31","author":"Krull","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0330","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/pon.628","article-title":"Educational achievement, employment and living situation in long-term young adult survivors of childhood cancer in the Netherlands","volume":"12","author":"Langeveld","year":"2003","journal-title":"Psychooncology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2016.02.009","article-title":"Dexamethasone-induced acute excitotoxic cell death in the developing brain","volume":"91","author":"Lanshakov","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0340","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0345","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainresbull.2008.07.010","article-title":"Cytosine arabinoside treatment impairs the remote spatial memory function and induces dendritic retraction in the anterior cingulate cortex of rats","volume":"77","author":"Li","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2018.05.019","article-title":"Longitudinal assessment of chemotherapy-induced changes in brain and cognitive functioning: a systematic review","author":"Li","year":"2018","journal-title":"Neurosci Biobeh Rev"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0355","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pbb.2010.03.003","article-title":"Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine","volume":"95","author":"Li","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0360","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nbd.2013.09.004","article-title":"Role of the NMDA receptor in cognitive deficits, anxiety and depressive-like behavior in juvenile and adult mice after neonatal dexamethasone exposure","volume":"62","author":"Li","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0365","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.pbb.2009.10.008","article-title":"Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats","volume":"94","author":"Li","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0370","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jpain.2014.04.001","article-title":"Toll-like receptor 4 signaling contributes to paclitaxel-induced peripheral neuropathy","volume":"15","author":"Li","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0375","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1651-2227.2008.01055.x","article-title":"Cognitive outcome in children and adolescents treated for acute lymphoblastic leukaemia with chemotherapy only","volume":"98","author":"Lofstad","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0380","doi-asserted-by":"crossref","DOI":"10.3791\/55718","article-title":"Novel object recognition test for the investigation of learning and memory in mice","author":"Lueptow","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0385","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1038\/srep04227","article-title":"Survival improvement by decade of patients aged 0\u201314 years with acute lymphoblastic leukemia: a SEER analysis","volume":"4","author":"Ma","year":"2014","journal-title":"Sci Rep"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0390","doi-asserted-by":"crossref","first-page":"37486","DOI":"10.1038\/srep37486","article-title":"Folic acid supplementation improves cognitive function by reducing the levels of peripheral inflammatory cytokines in elderly Chinese subjects with MCI","volume":"6","author":"Ma","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0395","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11065-017-9365-1","article-title":"Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes","volume":"28","author":"Marusak","year":"2018","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0400","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1046\/j.1460-9568.2000.00259.x","article-title":"Activation of nicotinic acetylcholine receptors induces long-term potentiation in vivo in the intact mouse dentate gyrus","volume":"12","author":"Matsuyama","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0405","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jadohealth.2017.04.004","article-title":"Anxiety among adolescent survivors of pediatric cancer","volume":"61","author":"McDonnell","year":"2017","journal-title":"J. Adolesc. Health"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0410","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/mpo.2950170523","article-title":"Psychosocial status of young adult survivors of childhood cancer: a survey","volume":"17","author":"Meadows","year":"1989","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0415","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0420","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.tins.2013.07.001","article-title":"Sugar for the brain: the role of glucose in physiological and pathological brain function","volume":"36","author":"Mergenthaler","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0425","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/08830738050200020901","article-title":"Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol","volume":"20","author":"Montour-Proulx","year":"2005","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0430","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/1099800416644780","article-title":"Effects of intraventricular methotrexate on neuronal injury and gene expression in a rat model: findings from an exploratory study","volume":"18","author":"Moore","year":"2016","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0435","first-page":"2416","article-title":"Vincristine-induced peripheral neuropathy in pediatric cancer patients","volume":"6","author":"Mora","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0440","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/pbc.23060","article-title":"Neurobehavioral side effects of corticosteroids during active treatment for acute lymphoblastic leukemia in children are age\u2010dependent: Report from Dana\u2010Farber Cancer Institute ALL Consortium Protocol 00\u201001","volume":"57","author":"Mrakotsky","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0445","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1158\/1078-0432.CCR-18-0551","article-title":"Brain development and heart function after systemic single-agent chemotherapy in a mouse model of childhood leukemia treatment","volume":"24","author":"Noakes","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0450","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/pbc.21226","article-title":"Employment status among adult survivors in the childhood cancer survivor Study","volume":"50","author":"Pang","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0455","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa050151","article-title":"Vitamin E and donepezil for the treatment of mild cognitive impairment","volume":"352","author":"Petersen","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0460","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3324\/haematol.2010.036129","article-title":"Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP off-therapy registry","volume":"96","author":"Pivetta","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0465","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1056\/NEJMoa0900386","article-title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation","volume":"360","author":"Pui","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0470","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1200\/JCO.1997.15.8.2800","article-title":"Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer","volume":"15","author":"Quinn","year":"1997","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0475","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1093\/ajcn\/82.6.1346","article-title":"Low folate status is associated with impaired cognitive function and dementia in the sacramento area latino study on aging","volume":"82","author":"Ramos","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0480","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.3174\/ajnr.A5791","article-title":"The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only","volume":"39","author":"Sabin","year":"2018","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0485","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1124\/jpet.116.237503","article-title":"Oxidative stress and the central nervous system","volume":"360","author":"Salim","year":"2017","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0490","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejcsup.2013.07.007","article-title":"Chemotherapy-related changes in cognitive functioning","volume":"11","author":"Schagen","year":"2013","journal-title":"EJC Suppl."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0495","first-page":"201","article-title":"Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives","author":"Saykin","year":"2003","journal-title":"Semin Clin Neuropsychiatry"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0500","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/j.pain.0000000000000953","article-title":"Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat","volume":"158","author":"Schappacher","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0505","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2007.08.004","article-title":"Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat","volume":"186","author":"Seigers","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0510","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2009.02.025","article-title":"Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats","volume":"201","author":"Seigers","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0515","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbr.2009.10.009","article-title":"Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release","volume":"207","author":"Seigers","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0520","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1139\/y11-132","article-title":"Profound destructive effects of adolescent exposure to vincristine accompanied with some sex differences in motor and memory performance","volume":"90","author":"Shabani","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0525","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1213\/01.ane.0000204318.35194.ed","article-title":"Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy","volume":"102","author":"Siau","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0530","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17101733","article-title":"The molecular and cellular effect of homocysteine metabolism imbalance on human health","volume":"17","author":"Skovierova","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0535","doi-asserted-by":"crossref","unstructured":"Siegel, D. A. et al. Rates and trends of pediatric acute lymphoblastic leukemia\u2014United States. Morbidity and Mortality Weekly Report. 2001\u20132014. 66, 950 (2017).","DOI":"10.15585\/mmwr.mm6636a3"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0540","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1200\/JCO.2006.05.9055","article-title":"Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate","volume":"24","author":"Spiegler","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0545","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fnmol.2017.00174","article-title":"Pathophysiology of chemotherapy-induced peripheral neuropathy","volume":"10","author":"Starobova","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0550","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/628094","article-title":"The role of glucocorticoid receptors in dexamethasone-induced apoptosis of neuroprogenitor cells in the hippocampus of rat pups","volume":"2013","author":"Sze","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0555","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0031-6989(86)90147-5","article-title":"Action of vinca alkaloides on calcium movements through mitochondrial membrane","volume":"18","author":"Tari","year":"1986","journal-title":"Pharmacol. Res. Commun."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0560","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26471","article-title":"Vincristine-induced peripheral neuropathy in survivors of childhood acute lymphoblastic leukaemia","volume":"64","author":"Tay","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0565","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.phrs.2016.11.019","article-title":"Therapeutic implications of toll-like receptors in peripheral neuropathic pain","volume":"115","author":"Thakur","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0570","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1148\/radiol.2017170073","article-title":"A PET\/MR imaging approach for the integrated assessment of chemotherapy-induced brain, heart, and bone injuries in pediatric cancer survivors: a pilot study","volume":"285","author":"Theruvath","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0575","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s12031-013-0095-4","article-title":"Structural and molecular alterations of primary afferent fibres in the spinal dorsal horn in vincristine-induced neuropathy in rat","volume":"51","author":"Thibault","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0580","first-page":"25","article-title":"Neurocognitive late effects of chemotherapy in survivors of acute lymphoblastic leukemia: Focus on methotrexate","volume":"24","author":"van der Plas","year":"2015","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0585","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/09297049.2017.1386170","article-title":"Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures","volume":"24","author":"Van Der Plas","year":"2018","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0590","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0595","first-page":"259","article-title":"Toxicity of CNS prophylaxis for childhood leukemia","volume":"11","author":"Waber","year":"1997","journal-title":"Oncol. (Williston Park)"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0600","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00043426-200005000-00004","article-title":"Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone","volume":"22","author":"Waber","year":"2000","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0605","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/pbc.24666","article-title":"Neuropsychological outcomes of a randomized trial of prednisone versus dexamethasone in acute lymphoblastic leukemia: findings from dana-farber cancer institute all consortium protocol 00-01","volume":"60","author":"Waber","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0610","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/pbc.24988","article-title":"Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review","volume":"61","author":"Warris","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0615","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuropharm.2018.07.007","article-title":"Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model","volume":"139","author":"Wen","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0620","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.neuropharm.2011.07.013","article-title":"Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model","volume":"61","author":"Winocur","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0625","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbr.2014.12.028","article-title":"Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis","volume":"281","author":"Winocur","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0630","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/13803395.2014.943695","article-title":"Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia","volume":"36","author":"Winter","year":"2014","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0635","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/15384047.2017.1394549","article-title":"Dexamethasone exacerbates cytotoxic chemotherapy induced lethargy and weight loss in female tumor free mice","volume":"19","author":"Wong","year":"2018","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0640","first-page":"10252","article-title":"Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats","volume":"10","author":"Wu","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0645","first-page":"273","article-title":"An animal model to detect learning deficits following treatment of the immature brain. Studies using radiation and methotrexate","volume":"10","author":"Yadin","year":"1983","journal-title":"Childs Brain"},{"key":"10.1016\/j.neubiorev.2021.07.033_bib0650","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bcp.2011.03.020","article-title":"Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro","volume":"82","author":"Yang","year":"2011","journal-title":"Biochem. Pharmacol."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763421003419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763421003419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:27:23Z","timestamp":1777490843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763421003419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":130,"alternative-id":["S0149763421003419"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.07.033","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chemotherapy for acute lymphoblastic leukemia on cognitive function in animal models of contemporary protocols: A systematic literature review","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}