{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:43:53Z","timestamp":1778661833172,"version":"3.51.4"},"reference-count":270,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.neubiorev.2021.104516","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T11:15:39Z","timestamp":1640776539000},"page":"104516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Reviewing the role of the orexinergic system and stressors in modulating mood and reward-related behaviors"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-9887","authenticated-orcid":false,"given":"Salar","family":"Vaseghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Zarrabian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-180X","authenticated-orcid":false,"given":"Abbas","family":"Haghparast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2021.104516_bib0005","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fnbeh.2015.00324","article-title":"Comprehensive behavioral analysis of male ox1r (-\/-) mice showed implication of orexin receptor-1 in mood, anxiety, and social behavior","volume":"9","author":"Abbas","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2019.104584","article-title":"Orexinergic modulation of serotonin neurons in the dorsal raphe of a diurnal rodent, Arvicanthis niloticus","volume":"116","author":"Adidharma","year":"2019","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2017.09.007","article-title":"Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats","volume":"660","author":"Alizamini","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.peptides.2018.10.011","article-title":"Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats","volume":"110","author":"Alizamini","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.npep.2004.06.004","article-title":"Stereological analysis of the hypothalamic hypocretin\/orexin neurons in an animal model of depression","volume":"38","author":"Allard","year":"2004","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1037\/a0031442","article-title":"Depressive behavior and activation of the orexin\/hypocretin system","volume":"127","author":"Arendt","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112090","article-title":"Role of orexin-1 and -2 receptors within the nucleus accumbens in the acquisition of sensitization to morphine in rats","volume":"373","author":"Assar","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2013.07.012","article-title":"Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats","volume":"47","author":"Azhdari-Zarmehri","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2018.12.029","article-title":"Involvement of orexin-2 receptor in the ventral tegmental area in stress- and drug priming-induced reinstatement of conditioned place preference in rats","volume":"696","author":"Azizbeigi","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0050","first-page":"373","article-title":"Role of orexin-1 receptor within the ventral tegmental area in mediating stress- and morphine priming-induced reinstatement of conditioned place preference in rats","volume":"10","author":"Azizbeigi","year":"2019","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0055","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/WNR.0000000000000660","article-title":"The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat","volume":"27","author":"Bahaaddini","year":"2016","journal-title":"Neuroreport"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nlm.2018.11.009","article-title":"Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits","volume":"157","author":"Bahramzadeh Zoeram","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0065","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/s12276-020-00532-4","article-title":"Stress and the dopaminergic reward system","volume":"52","author":"Baik","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0070","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1523\/JNEUROSCI.4385-14.2015","article-title":"Orexin signaling in the VTA gates morphine-induced synaptic plasticity","volume":"35","author":"Baimel","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0075","doi-asserted-by":"crossref","first-page":"10568","DOI":"10.1523\/JNEUROSCI.3044-06.2007","article-title":"Stimulation of lateral septum CRF2 receptors promotes anorexia and stress-like behaviors: functional homology to CRF1 receptors in basolateral amygdala","volume":"27","author":"Bakshi","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0080","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bbrc.2006.01.158","article-title":"Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets","volume":"342","author":"Beck","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0085","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2006.08.075","article-title":"Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator","volume":"144","author":"Bennur","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/cne.902990206","article-title":"Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum","volume":"299","author":"Berendse","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0095","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/adb.12553","article-title":"Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine","volume":"23","author":"Bernstein","year":"2018","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0100","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1523\/JNEUROSCI.20-14-05564.2000","article-title":"A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function","volume":"20","author":"Bhatnagar","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.0007-1331.2002.00792.x","article-title":"Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint","volume":"14","author":"Bhatnagar","year":"2002","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0110","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8111887","article-title":"Neurocircuitry of reward and addiction: potential impact of dopamine-glutamate Co-release as future target in substance use disorder","volume":"8","author":"Bimpisidis","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0115","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.neuroscience.2006.07.018","article-title":"Excitatory action of hypocretin\/orexin on neurons of the central medial amygdala","volume":"142","author":"Bisetti","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0120","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/jpet.114.220392","article-title":"A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects","volume":"352","author":"Bonaventure","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fphar.2017.00357","article-title":"Evaluation of JNJ-54717793 a novel brain penetrant selective orexin 1 receptor antagonist in two rat models of panic attack provocation","volume":"8","author":"Bonaventure","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0130","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","article-title":"Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine","volume":"49","author":"Borgland","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0135","doi-asserted-by":"crossref","first-page":"19168","DOI":"10.1073\/pnas.0507480102","article-title":"Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior","volume":"102","author":"Boutrel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0140","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/(SICI)1096-9861(19981228)402:4<460::AID-CNE3>3.0.CO;2-S","article-title":"Hypocretin\/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems","volume":"402","author":"Broberger","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0145","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/cne.903380209","article-title":"The patterns of afferent innervation of the core and shell in the \u201caccumbens\u201d part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold","volume":"338","author":"Brog","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.neuron.2010.11.022","article-title":"Dopamine in motivational control: rewarding, aversive, and alerting","volume":"68","author":"Bromberg-Martin","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0155","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1017\/S1461145713000333","article-title":"Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats","volume":"16","author":"Brown","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0160","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/adb.12251","article-title":"Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats","volume":"21","author":"Brown","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0165","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.euroneuro.2007.01.005","article-title":"Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder","volume":"17","author":"Brundin","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jad.2008.04.011","article-title":"Increased orexin levels in the cerebrospinal fluid the first year after a suicide attempt","volume":"113","author":"Brundin","year":"2009","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0175","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1523\/JNEUROSCI.22-07-02862.2002","article-title":"Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin\/Orexin peptides: implications for wakefulness and narcolepsy","volume":"22","author":"Burlet","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0180","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/jnc.14279","article-title":"Increased acetylcholine and glutamate efflux in the prefrontal cortex following intranasal orexin-A (hypocretin-1)","volume":"145","author":"Calva","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/gbb.12236","article-title":"Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats","volume":"14","author":"Calvez","year":"2015","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0190","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/bph.13530","article-title":"Sex-specific effects of relaxin-3 on food intake and body weight gain","volume":"174","author":"Calvez","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0195","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1177\/0269881120959638","article-title":"Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking","volume":"34","author":"Campbell","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0200","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.neures.2006.11.009","article-title":"Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats","volume":"57","author":"Chang","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0205","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1124\/mol.108.051417","article-title":"Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue","volume":"75","author":"Chartoff","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108492","article-title":"A comparison of dopaminergic and cholinergic populations reveals unique contributions of VTA dopamine neurons to short-term memory","volume":"33","author":"Choi","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0215","doi-asserted-by":"crossref","first-page":"RC168","DOI":"10.1523\/JNEUROSCI.21-19-j0003.2001","article-title":"Orexin (hypocretin) neurons contain dynorphin","volume":"21","author":"Chou","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41398-020-0698-9","article-title":"Significance of the orexinergic system in modulating stress-related responses in an animal model of post-traumatic stress disorder","volume":"10","author":"Cohen","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0225","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s13311-017-0525-z","article-title":"Reward circuitry in addiction","volume":"14","author":"Cooper","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0230","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1126\/science.1150605","article-title":"BOLD responses reflecting dopaminergic signals in the human ventral tegmental area","volume":"319","author":"D\u2019Ardenne","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0235","first-page":"404","article-title":"Glutamatergic transmission in drug reward: implications for drug addiction","volume":"9","author":"D\u2019Souza","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(99)00317-4","article-title":"Distribution of orexin\/hypocretin in the rat median eminence and pituitary","volume":"76","author":"Date","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/1073858406295854","article-title":"The nucleus accumbens and Pavlovian reward learning","volume":"13","author":"Day","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0250","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00213-003-1511-1","article-title":"Haloperidol increases the disruptive effect of alcohol on spatial working memory in rats: a dopaminergic modulation in the medial prefrontal cortex","volume":"170","author":"de Oliveira","year":"2003","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0260","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuroscience.2014.04.069","article-title":"Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency","volume":"272","author":"Deats","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0265","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuroscience.2010.11.067","article-title":"Hypocretin-1 (orexin A) prevents the effects of hypoxia\/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus","volume":"175","author":"Dergacheva","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0270","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1037\/a0013276","article-title":"Steady-state methadone effect on generalized arousal in male and female mice","volume":"122","author":"Devidze","year":"2008","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0275","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hipo.450020409","article-title":"Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation","volume":"2","author":"Diamond","year":"1992","journal-title":"Hippocampus"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0280","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnsys.2013.00057","article-title":"Opposite modulation of brain stimulation reward by NMDA and AMPA receptors in the ventral tegmental area","volume":"7","author":"Ducrot","year":"2013","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2018.11.008","article-title":"High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss","volume":"157","author":"Duffy","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0290","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0893-133X(01)00358-X","article-title":"Regulation of adult neurogenesis by antidepressant treatment","volume":"25","author":"Duman","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0295","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12707","article-title":"Orexin deficiency modulates cognitive flexibility in a sex-dependent manner","volume":"20","author":"Durairaja","year":"2021","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0300","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1037\/bne0000112","article-title":"Differential roles of orexin receptors within the dentate gyrus in stress- and drug priming-induced reinstatement of conditioned place preference in rats","volume":"130","author":"Ebrahimian","year":"2016","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0305","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2018.06.016","article-title":"Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats","volume":"142","author":"Edalat","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0310","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0301-0511(01)00092-8","article-title":"Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis","volume":"57","author":"Ehlert","year":"2001","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0315","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41398-021-01235-8","article-title":"Orexin receptor antagonists reverse aberrant dopamine neuron activity and related behaviors in a rodent model of stress-induced psychosis","volume":"11","author":"Elam","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0320","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1460-9568.2009.07065.x","article-title":"The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system","volume":"31","author":"Espana","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0325","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-010-2048-8","article-title":"Hypocretin 1\/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration","volume":"214","author":"Espana","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0330","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0306-4522(02)00017-9","article-title":"Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area","volume":"111","author":"Fadel","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0335","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.npep.2017.08.003","article-title":"Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats","volume":"66","author":"Farahimanesh","year":"2017","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0340","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2017.12.017","article-title":"Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats","volume":"101","author":"Farahimanesh","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0345","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2018.08.021","article-title":"Involvement of orexinergic receptors in the nucleus accumbens, in the effect of forced swim stress on the reinstatement of morphine seeking behaviors","volume":"356","author":"Farzinpour","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0350","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pbb.2015.02.023","article-title":"Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation","volume":"132","author":"Fatahi","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0355","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1177\/0269881106082899","article-title":"Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine","volume":"22","author":"Feng","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0360","first-page":"1","article-title":"Irreversible hippocampal changes induced by high fructose diet in rats","author":"Fierros-Campuzano","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0365","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1523\/JNEUROSCI.5952-09.2010","article-title":"Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis","volume":"30","author":"Fox","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0370","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111722","article-title":"Chronic consumption of fructose induces behavioral alterations by increasing orexin and dopamine levels in the rat brain","volume":"10","author":"Franco-Perez","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0375","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1210\/jc.2005-0296","article-title":"The number of hypothalamic hypocretin (orexin) neurons is not affected in Prader-Willi syndrome","volume":"90","author":"Fronczek","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0380","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1460-9568.2009.06952.x","article-title":"Hypocretin\/orexin contributes to the expression of some but not all forms of stress and arousal","volume":"30","author":"Furlong","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0385","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuroscience.2021.03.003","article-title":"The dual orexin receptor antagonist DORA-22 improves mild stress-induced sleep disruption during the natural sleep phase of nocturnal rats","volume":"463","author":"Gamble","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0390","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1037\/a0023165","article-title":"Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disorders","volume":"125","author":"Gamo","year":"2011","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0395","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1523\/JNEUROSCI.1714-04.2005","article-title":"The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance","volume":"25","author":"Georgescu","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0400","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2017.11.009","article-title":"Orexin-A\/hypocretin-1 immunoreactivity in the lateral hypothalamus is reduced in genetically obese but not in diet-induced obese mice","volume":"369","author":"Gonzalez","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0405","doi-asserted-by":"crossref","first-page":"13208","DOI":"10.1073\/pnas.0605180103","article-title":"Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects","volume":"103","author":"Govindarajan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0410","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.yfrne.2018.06.003","article-title":"Orexins and stress","volume":"51","author":"Grafe","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0415","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.biopsych.2016.10.013","article-title":"Orexins mediate sex differences in the stress response and in cognitive flexibility","volume":"81","author":"Grafe","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0420","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroscience.2017.02.038","article-title":"Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress","volume":"348","author":"Grafe","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0425","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuroscience.2019.08.026","article-title":"Sex- and stress-dependent effects on dendritic morphology and spine densities in putative orexin neurons","volume":"418","author":"Grafe","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0430","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/mp.2013.175","article-title":"Hippocampal gene expression changes underlying stress sensitization and recovery","volume":"19","author":"Gray","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0435","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0306-4522(87)90275-2","article-title":"Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin","volume":"23","author":"Groenewegen","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0440","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/adb.12236","article-title":"Orexin A-mediated AKT signaling in the dentate gyrus contributes to the acquisition, expression and reinstatement of morphine-induced conditioned place preference","volume":"21","author":"Guo","year":"2016","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0445","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/npp.2009.129","article-title":"The reward circuit: linking primate anatomy and human imaging","volume":"35","author":"Haber","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0450","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1007\/s00213-020-05651-4","article-title":"The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues","volume":"237","author":"Haight","year":"2020","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0455","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature04071","article-title":"A role for lateral hypothalamic orexin neurons in reward seeking","volume":"437","author":"Harris","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0460","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1210\/en.2011-1652","article-title":"Orexins\/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress","volume":"152","author":"Heydendael","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0465","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00213-015-4151-3","article-title":"Ventral tegmental area dopamine revisited: effects of acute and repeated stress","volume":"233","author":"Holly","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0470","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2019.04.060","article-title":"Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats","volume":"706","author":"Hooshmand","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0475","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/cne.21934","article-title":"Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin, and corticotropin-releasing hormone in macaque monkeys","volume":"512","author":"Hsu","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0480","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fnbeh.2014.00073","article-title":"Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood","volume":"8","author":"Hsu","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0485","doi-asserted-by":"crossref","first-page":"H1075","DOI":"10.1152\/ajpheart.00822.2016","article-title":"Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension","volume":"313","author":"Huber","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0490","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/FBP.0b013e328343d761","article-title":"Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward","volume":"22","author":"Hutcheson","year":"2011","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0495","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresrev.2007.05.004","article-title":"Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex","volume":"56","author":"Ikemoto","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0500","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11906-017-0729-y","article-title":"Role of orexin-A in hypertension and obesity","volume":"19","author":"Imperatore","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0505","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hipo.10207","article-title":"Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats","volume":"14","author":"Isgor","year":"2004","journal-title":"Hippocampus"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0510","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neuroscience.2008.09.042","article-title":"I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation","volume":"157","author":"Ito","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0515","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1248\/bpb.32.1716","article-title":"A possible mechanism underlying an antidepressive-like effect of Kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice","volume":"32","author":"Ito","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0520","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2826.2010.01988.x","article-title":"The brainstem noradrenergic systems in stress, anxiety and depression","volume":"22","author":"Itoi","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0525","first-page":"851","article-title":"Intra-accumbal orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain","volume":"15","author":"Jahangirvand","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0530","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbr.2014.05.030","article-title":"Increased number of orexin\/hypocretin neurons with high and prolonged external stress-induced depression","volume":"272","author":"Jalewa","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0535","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1017\/S1461145711000423","article-title":"Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking","volume":"14","author":"James","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0540","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnbeh.2014.00244","article-title":"Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats","volume":"8","author":"James","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0545","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41380-018-0127-0","article-title":"Orexin prevents depressive-like behavior by promoting stress resilience","volume":"24","author":"Ji","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0550","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nm.2075","article-title":"A key role for orexin in panic anxiety","volume":"16","author":"Johnson","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0555","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-444-59489-1.00009-4","article-title":"Orexin, stress, and anxiety\/panic states","volume":"198","author":"Johnson","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0560","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.physbeh.2012.04.016","article-title":"Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network","volume":"107","author":"Johnson","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0565","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/da.22403","article-title":"Orexin 1 and 2 receptor involvement in Co2 -Induced panic-associated behavior and autonomic responses","volume":"32","author":"Johnson","year":"2015","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0570","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2014.01.045","article-title":"Forced swim stress but not exogenous corticosterone could induce the reinstatement of extinguished morphine conditioned place preference in rats: involvement of glucocorticoid receptors in the basolateral amygdala","volume":"264","author":"Karimi","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0575","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1007\/s11064-020-03084-1","article-title":"Differential roles of intra-accumbal orexin receptors in acquisition and expression of methamphetamine-induced conditioned place preference in the rats","volume":"45","author":"Khosrowabadi","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0580","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1523\/JNEUROSCI.2335-09.2009","article-title":"The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety","volume":"29","author":"Kim","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0585","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nbd.2015.04.004","article-title":"Antidepressant effects of exercise are produced via suppression of hypocretin\/orexin and melanin-concentrating hormone in the basolateral amygdala","volume":"79","author":"Kim","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0590","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0196-9781(02)00109-2","article-title":"Arousal effects of orexin-A correlate with GLU release from the locus coeruleus in rats","volume":"23","author":"Kodama","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0595","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2009.03.038","article-title":"Brain stress systems in the amygdala and addiction","volume":"1293","author":"Koob","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0600","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/fcp.12249","article-title":"SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats","volume":"31","author":"Kordi Jaz","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0605","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","article-title":"Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins","volume":"23","author":"Korotkova","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0610","doi-asserted-by":"crossref","first-page":"C1567","DOI":"10.1152\/ajpcell.00055.2002","article-title":"Functions of the orexinergic\/hypocretinergic system","volume":"283","author":"Kukkonen","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0615","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.autneu.2010.08.004","article-title":"Orexin links emotional stress to autonomic functions","volume":"161","author":"Kuwaki","year":"2011","journal-title":"Auton. Neurosci."},{"issue":"Pt B","key":"10.1016\/j.neubiorev.2021.104516_bib0620","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2013.03.019","article-title":"Reward and aversion in a heterogeneous midbrain dopamine system","volume":"76","author":"Lammel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0625","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/mp.2016.68","article-title":"Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant","volume":"22","author":"Lau","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0630","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1210\/en.2014-1961","article-title":"A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice","volume":"156","author":"Lemus","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0635","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1210\/en.2014-1743","article-title":"Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats","volume":"156","author":"Lenglos","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0640","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cne.21502","article-title":"Projections from the paraventricular nucleus of the thalamus to the forebrain, with special emphasis on the extended amygdala","volume":"506","author":"Li","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0645","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0896-6273(02)01132-7","article-title":"Hypocretin\/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system","volume":"36","author":"Li","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0650","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pbb.2009.12.016","article-title":"Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus","volume":"95","author":"Li","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0655","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00213-010-1948-y","article-title":"Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats","volume":"212","author":"Li","year":"2010","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105317","article-title":"Orexin 2 receptor in the nucleus accumbens is critical for the modulation of acute stress-induced anxiety","volume":"131","author":"Li","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0665","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1113\/JP275177","article-title":"Short-term high-fat diet primes excitatory synapses for long-term depression in orexin neurons","volume":"596","author":"Linehan","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.100977","article-title":"High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus","volume":"36","author":"Linehan","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0675","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/jn.00873.2006","article-title":"Adenosine inhibits activity of hypocretin\/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect","volume":"97","author":"Liu","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0680","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1523\/JNEUROSCI.22-21-09453.2002","article-title":"Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions","volume":"22","author":"Liu","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0685","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3389\/fnins.2018.00835","article-title":"Orexin-A exerts neuroprotective effects via OX1R in Parkinson\u2019s disease","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0690","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/10253890500492787","article-title":"Modulation of anxiety circuits by serotonergic systems","volume":"8","author":"Lowry","year":"2005","journal-title":"Stress"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0695","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.physbeh.2012.05.019","article-title":"Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats","volume":"107","author":"Lungwitz","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0700","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1523\/JNEUROSCI.5584-07.2008","article-title":"Orexin signaling mediates the antidepressant-like effect of calorie restriction","volume":"28","author":"Lutter","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0705","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1523\/JNEUROSCI.16-10-03534.1996","article-title":"Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews","volume":"16","author":"Magarinos","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0710","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00213-012-2681-5","article-title":"Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats","volume":"226","author":"Mahler","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0715","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/FBP.0000000000000587","article-title":"The orexin receptors in the ventral tegmental area are involved in the development of sensitization to expression of morphine-induced preference in rats","volume":"31","author":"Mahmoudi","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173433","article-title":"Chemical stimulation of the lateral hypothalamus induced seeking behaviors in rats: involvement of orexin receptors in the ventral tegmental area","volume":"886","author":"Mahmoudi","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0725","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/FBP.0000000000000602","article-title":"Blockade of orexin receptors in the ventral tegmental area reduced the extinction period of the lateral hypothalamic-induced conditioned place preference in rats","volume":"32","author":"Mahmoudi","year":"2021","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0730","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0735","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0167-0115(01)00354-8","article-title":"Interaction of the hypocretins with neurotransmitters in the nucleus accumbens","volume":"104","author":"Martin","year":"2002","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0740","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nlm.2017.10.014","article-title":"Orexin\/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice","volume":"146","author":"Mavanji","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0745","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.neuro.22.1.105","article-title":"Stress and hippocampal plasticity","volume":"22","author":"McEwen","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0750","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2015.12.043","article-title":"Stress-induced remodeling of hippocampal CA3 pyramidal neurons","volume":"1645","author":"McEwen","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0755","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-med-052209-100430","article-title":"Stress- and allostasis-induced brain plasticity","volume":"62","author":"McEwen","year":"2011","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0760","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuron.2013.06.028","article-title":"The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course","volume":"79","author":"McEwen","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0765","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0083-6729(08)61045-6","article-title":"Stress and the brain: a paradoxical role for adrenal steroids","volume":"51","author":"McEwen","year":"1995","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0770","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/nn.4086","article-title":"Mechanisms of stress in the brain","volume":"18","author":"McEwen","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0775","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/npp.2015.171","article-title":"Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex","volume":"41","author":"McEwen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2019.07.069","article-title":"Orexin in the posterior paraventricular thalamus mediates hunger-related signals in the nucleus accumbens core","volume":"29","author":"Meffre","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0785","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.alcohol.2018.01.008","article-title":"Forced ethanol ingestion by Wistar rats from a juvenile age increased voluntary alcohol consumption in adulthood, with the involvement of orexin-A","volume":"70","author":"Mendoza-Ruiz","year":"2018","journal-title":"Alcohol"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0790","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3389\/fpsyg.2014.00997","article-title":"Orexin-A controls sympathetic activity and eating behavior","volume":"5","author":"Messina","year":"2014","journal-title":"Front. Psychol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0795","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1515\/jbcpp-2015-0133","article-title":"Exercise increases the level of plasma orexin A in humans","volume":"27","author":"Messina","year":"2016","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0800","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.brainresrev.2007.01.002","article-title":"The dorsal raphe nucleus--from silver stainings to a role in depression","volume":"55","author":"Michelsen","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0805","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.npep.2011.07.010","article-title":"Increased numbers of orexin\/hypocretin neurons in a genetic rat depression model","volume":"45","author":"Mikrouli","year":"2011","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0810","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1523\/JNEUROSCI.0255-19.2019","article-title":"Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil","volume":"39","author":"Mohammadkhani","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0815","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/ejn.13170","article-title":"Orexin\/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner","volume":"43","author":"Moorman","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0820","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2016.10.018","article-title":"Orexin\/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats","volume":"1654","author":"Moorman","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0825","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0830","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.peptides.2010.10.023","article-title":"Electrophysiological effects of orexin-B and dopamine on rat nucleus accumbens shell neurons in vitro","volume":"32","author":"Mori","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0835","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1523\/JNEUROSCI.1027-04.2004","article-title":"Serotonergic regulation of the orexin\/hypocretin neurons through the 5-HT1A receptor","volume":"24","author":"Muraki","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0840","doi-asserted-by":"crossref","first-page":"E1648","DOI":"10.1073\/pnas.1315542111","article-title":"Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area","volume":"111","author":"Muschamp","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0845","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0850","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0855","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuropharm.2018.11.014","article-title":"Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex","volume":"152","author":"Navarro","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0860","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.heares.2016.09.001","article-title":"Dopaminergic projections of the subparafascicular thalamic nucleus to the auditory brainstem","volume":"341","author":"Nevue","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0865","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuint.2014.09.002","article-title":"High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice","volume":"78","author":"Nobunaga","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0870","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2012.05.033","article-title":"The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus","volume":"218","author":"Nocjar","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0875","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neuropharm.2011.04.022","article-title":"Activation of orexin neurons in dorsomedial\/perifornical hypothalamus and antidepressant reversal in a rodent model of depression","volume":"61","author":"Nollet","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0880","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1038\/npp.2012.70","article-title":"Neurogenesis-independent antidepressant-like effects on behavior and stress axis response of a dual orexin receptor antagonist in a rodent model of depression","volume":"37","author":"Nollet","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0885","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.neuron.2015.09.038","article-title":"Accumbal D1R neurons projecting to lateral hypothalamus authorize feeding","volume":"88","author":"O\u2019Connor","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0890","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.peptides.2008.10.011","article-title":"Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY","volume":"30","author":"Olszewski","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0895","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0168-0102(02)00042-1","article-title":"Fos expression in afferents to the rat midline thalamus following immobilization stress","volume":"43","author":"Otake","year":"2002","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0900","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuropharm.2011.08.037","article-title":"A time-dependent role of midline thalamic nuclei in the retrieval of fear memory","volume":"62","author":"Padilla-Coreano","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0905","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pbb.2011.12.011","article-title":"Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: a c-Fos study","volume":"101","author":"Panhelainen","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0910","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4142\/jvs.2004.5.4.295","article-title":"Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats","volume":"5","author":"Park","year":"2004","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0915","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2016.03.006","article-title":"Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats","volume":"1639","author":"Parsania","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0920","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/cne.21224","article-title":"Functional and anatomical connection between the paraventricular nucleus of the thalamus and dopamine fibers of the nucleus accumbens","volume":"500","author":"Parsons","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0925","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0306-4522(95)94332-S","article-title":"Hippocampal homosynaptic long-term depression\/depotentiation induced by adrenal steroids","volume":"68","author":"Pavlides","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0930","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0006-8993(96)00776-7","article-title":"Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices","volume":"738","author":"Pavlides","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0935","doi-asserted-by":"crossref","first-page":"E865","DOI":"10.1152\/ajpendo.00119.2012","article-title":"Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity","volume":"303","author":"Perez-Leighton","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0940","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0945","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pbb.2007.10.014","article-title":"A top-down perspective on dopamine, motivation and memory","volume":"90","author":"Phillips","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0950","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.physbeh.2010.09.023","article-title":"Effects of undernourishment on the hypothalamic orexinergic system","volume":"102","author":"Pinos","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0955","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112155","article-title":"Involvement of orexin receptors within the hippocampal dentate gyrus in morphine-induced reinstatement in food-deprived rats","volume":"375","author":"Pourhamzeh","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0960","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.npep.2018.12.001","article-title":"Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats","volume":"73","author":"Pourrahimi","year":"2019","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib0965","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/FBP.0000000000000646","article-title":"Orexin-2 receptor antagonism in the cornu ammonis 1 region of hippocampus prevented the antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in the animal model of persistent pain","volume":"32","author":"Pourreza","year":"2021","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.113015","article-title":"Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: behavioural and neurochemical analyses","volume":"399","author":"Prajapati","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0975","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuint.2009.08.012","article-title":"The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization","volume":"56","author":"Quarta","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0980","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2014.10.051","article-title":"Role of intra-hippocampal orexin 1 and orexin 2 receptors in conditioned place preference induced by chemical stimulation of the lateral hypothalamus","volume":"279","author":"Rashidy-Pour","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135946","article-title":"Blockade of orexin receptors in the hippocampal dentate gyrus reduced the extinction latency of morphine-induced place preference in male rats","volume":"756","author":"RayatSanati","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0990","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopha.2017.03.053","article-title":"A review of the role of orexin system in pain modulation","volume":"90","author":"Razavi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neubiorev.2021.104516_bib0995","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/FBP.0b013e3283635ee9","article-title":"Role of dorsal hippocampal orexin-1 receptors in associating morphine reward with contextual stimuli","volume":"24","author":"Riahi","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1000","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00213-006-0345-z","article-title":"Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice","volume":"185","author":"Ribeiro Do Couto","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1005","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nlm.2013.07.012","article-title":"Consolidation of object recognition memory requires simultaneous activation of dopamine D1\/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus","volume":"106","author":"Rossato","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jad.2010.12.004","article-title":"Orexin expression and promoter-methylation in peripheral blood of patients suffering from major depressive disorder","volume":"131","author":"Rotter","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1015","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s00213-016-4280-3","article-title":"Effects of dorsal hippocampal orexin-2 receptor antagonism on the acquisition, expression, and extinction of morphine-induced place preference in rats","volume":"233","author":"Sadeghi","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbr.2015.03.055","article-title":"Role of dopamine D1-like receptor within the nucleus accumbens in acute food deprivation- and drug priming-induced reinstatement of morphine seeking in rats","volume":"287","author":"Sadeghzadeh","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pbb.2015.12.005","article-title":"Differential effects of intra-accumbal orexin-1 and -2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats","volume":"142","author":"Sadeghzadeh","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brainresbull.2017.12.008","article-title":"Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats","volume":"137","author":"Sahafzadeh","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112455","article-title":"Investigating the role of the amygdala orexin receptor 1 in memory acquisition and extinction in a rat model of PTSD","volume":"384","author":"Salehabadi","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-3223(02)01740-7","article-title":"Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects","volume":"54","author":"Salomon","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1050","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41398-020-00937-9","article-title":"Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans","volume":"10","author":"Salvadore","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-010510-100528","article-title":"Orexin receptors: pharmacology and therapeutic opportunities","volume":"51","author":"Scammell","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1060","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1038\/s41386-018-0054-4","article-title":"Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats","volume":"43","author":"Schmeichel","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1065","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/j.1460-9568.2010.07282.x","article-title":"Subjective neuronal coding of reward: temporal value discounting and risk","volume":"31","author":"Schultz","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1070","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neuroscience.2004.05.012","article-title":"Orexins\/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling","volume":"127","author":"Selbach","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1075","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-3223(03)00347-0","article-title":"Neuroimaging studies of mood disorder effects on the brain","volume":"54","author":"Sheline","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1080","first-page":"R1780","article-title":"Sympathetic and cardiovascular actions of orexins in conscious rats","volume":"277","author":"Shirasaka","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112349","article-title":"Role of orexinergic receptors in the dentate gyrus of the hippocampus in the acquisition and expression of morphine-induced conditioned place preference in rats","volume":"379","author":"Shirazy","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s002130100917","article-title":"How does stress increase risk of drug abuse and relapse?","volume":"158","author":"Sinha","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"issue":"Suppl. 3","key":"10.1016\/j.neubiorev.2021.104516_bib1095","doi-asserted-by":"crossref","first-page":"S534","DOI":"10.1002\/mds.22027","article-title":"Striatal and extrastriatal dopamine in the basal ganglia: an overview of its anatomical organization in normal and Parkinsonian brains","volume":"23","author":"Smith","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1100","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1523\/JNEUROSCI.15-03-01768.1995","article-title":"Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus","volume":"15","author":"Smith","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0006-8993(02)03048-2","article-title":"Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure","volume":"950","author":"Smith","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1110","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1115","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.neuropharm.2004.02.014","article-title":"Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus","volume":"46","author":"Soffin","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1120","first-page":"542","article-title":"Administration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat","volume":"19","author":"Soliemani","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neulet.2006.01.065","article-title":"Modulatory effects of hypocretin-1\/orexin-A with glutamate and gamma-aminobutyric acid on freshly isolated pyramidal neurons from the rat prefrontal cortex","volume":"399","author":"Song","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1130","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.brainres.2003.10.054","article-title":"Thalamic paraventricular nucleus lesions facilitate central amygdala neuronal responses to acute psychological stress","volume":"997","author":"Spencer","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112866","article-title":"Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: possible involvement of local orexin-1 and Trk receptors","volume":"395","author":"Stanquini","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.biopsych.2008.02.022","article-title":"Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal","volume":"64","author":"Surget","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1145","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/mp.2011.48","article-title":"Antidepressants recruit new neurons to improve stress response regulation","volume":"16","author":"Surget","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1150","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1196\/annals.1369.026","article-title":"Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice","volume":"1074","author":"Takamatsu","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/157015911795017236","article-title":"The selective serotonin reuptake inhibitor paroxetine, but not fluvoxamine, decreases methamphetamine conditioned place preference in mice","volume":"9","author":"Takamatsu","year":"2011","journal-title":"Curr. Neuropharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.neubiorev.2021.104516_bib1160","doi-asserted-by":"crossref","first-page":"i171","DOI":"10.1093\/cercor\/bhm069","article-title":"Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia","volume":"17","author":"Tan","year":"2007","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1165","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1111\/j.1460-9568.2005.03980.x","article-title":"Neurons expressing relaxin 3\/INSL 7 in the nucleus incertus respond to stress","volume":"21","author":"Tanaka","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1170","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.neuroscience.2006.05.027","article-title":"Differential effect of orexins (hypocretins) on serotonin release in the dorsal and median raphe nuclei of freely behaving rats","volume":"141","author":"Tao","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.peptides.2012.07.023","article-title":"Orexin A in the ventral tegmental area induces conditioned place preference in a dose-dependent manner: involvement of D1\/D2 receptors in the nucleus accumbens","volume":"37","author":"Taslimi","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1180","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41398-020-01076-x","article-title":"Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO2 inhalation in a female rat model of panic disorder","volume":"10","author":"Tenorio-Lopes","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1185","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00097.2016","article-title":"Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback","volume":"311","author":"Terrill","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2005.05.045","article-title":"Orexin A in the nucleus accumbens stimulates feeding and locomotor activity","volume":"1050","author":"Thorpe","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1195","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00429-012-0451-0","article-title":"Axonal branching patterns of ventral pallidal neurons in the rat","volume":"218","author":"Tripathi","year":"2013","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1200","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1193-05.2005","article-title":"Cholecystokinin activates orexin\/hypocretin neurons through the cholecystokinin A receptor","volume":"25","author":"Tsujino","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1205","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1523\/JNEUROSCI.3490-07.2008","article-title":"Vasopressin increases locomotion through a V1a receptor in orexin\/hypocretin neurons: implications for water homeostasis","volume":"28","author":"Tsunematsu","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1210","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1038\/ncomms12199","article-title":"Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons","volume":"7","author":"Tung","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1215","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"Tye","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1220","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1097\/00001756-200107030-00024","article-title":"Orexin-A activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area","volume":"12","author":"Uramura","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087478","article-title":"Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model","volume":"9","author":"Valdivia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1230","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbr.2014.10.028","article-title":"The orexin-1 receptor antagonist SB-334867 decreases anxiety-like behavior and c-Fos expression in the hypothalamus of rats exposed to cat odor","volume":"278","author":"Vanderhaven","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1235","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00429-014-0946-y","article-title":"Hypocretin\/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain","volume":"221","author":"Vazquez-DeRose","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1240","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(98)00228-5","article-title":"Intrinsic and extrinsic connections of the rat central extended amygdala: an in vivo electrophysiological study of the central amygdaloid nucleus","volume":"794","author":"Veinante","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1245","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.yhbeh.2011.08.017","article-title":"Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence","volume":"60","author":"von der Goltz","year":"2011","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1250","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal-ventral divide of the striatum","volume":"27","author":"Voorn","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1255","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1523\/JNEUROSCI.22-15-06810.2002","article-title":"Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons","volume":"22","author":"Vyas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1260","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1523\/JNEUROSCI.17-23-09375.1997","article-title":"Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear","volume":"17","author":"Walker","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1265","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.biopsych.2009.01.018","article-title":"Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network","volume":"65","author":"Wang","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128098","article-title":"Synthesis and biological evaluation of novel (18)F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain","volume":"43","author":"Watanabe","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1275","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2010.04.068","article-title":"Enduring and sex-specific effects of adolescent social isolation in rats on adult stress reactivity","volume":"1343","author":"Weintraub","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1280","doi-asserted-by":"crossref","first-page":"10685","DOI":"10.1073\/pnas.0702676104","article-title":"Control of hypothalamic orexin neurons by acid and CO2","volume":"104","author":"Williams","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1285","doi-asserted-by":"crossref","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","article-title":"Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response","volume":"24","author":"Winsky-Sommerer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1290","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrn1406","article-title":"Dopamine, learning and motivation","volume":"5","author":"Wise","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1295","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1523\/JNEUROSCI.16-05-01877.1996","article-title":"Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized","volume":"16","author":"Wright","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1300","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1113\/jphysiol.2006.108266","article-title":"GABA(B) receptor-mediated modulation of hypocretin\/orexin neurones in mouse hypothalamus","volume":"574","author":"Xie","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1305","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/j.cellsig.2013.07.025","article-title":"Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders","volume":"25","author":"Xu","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1310","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-291X(03)00299-7","article-title":"Regulation of orexin neurons by the monoaminergic and cholinergic systems","volume":"303","author":"Yamanaka","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1315","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2015.10.012","article-title":"Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus","volume":"139","author":"Yazdi","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1320","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0306-4522(92)90202-D","article-title":"On the significance of subterritories in the \"accumbens\" part of the rat ventral striatum","volume":"50","author":"Zahm","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1325","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.npep.2014.04.003","article-title":"Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine","volume":"48","author":"Zarepour","year":"2014","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1330","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12264-012-1297-4","article-title":"Central functions of the orexinergic system","volume":"29","author":"Zhang","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1335","doi-asserted-by":"crossref","first-page":"R1436","DOI":"10.1152\/ajpregu.00781.2002","article-title":"Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons","volume":"284","author":"Zheng","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1340","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainresrev.2006.01.003","article-title":"The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration","volume":"52","author":"Zhu","year":"2006","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neubiorev.2021.104516_bib1345","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/ijo.2017.276","article-title":"Neuromodulation of orexin neurons reduces diet-induced adiposity","volume":"42","author":"Zink","year":"2018","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.neubiorev.2021.104516_bib1350","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108719","article-title":"Age-specific treatment effects of orexin\/hypocretin-receptor antagonism on methamphetamine-seeking behavior","volume":"224","author":"Zlebnik","year":"2021","journal-title":"Drug Alcohol Depend."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976342100587X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976342100587X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:03:55Z","timestamp":1758967435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014976342100587X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":270,"alternative-id":["S014976342100587X"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.104516","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reviewing the role of the orexinergic system and stressors in modulating mood and reward-related behaviors","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2021.104516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104516"}}