{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:25:07Z","timestamp":1793107507374,"version":"4.5.0"},"reference-count":347,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.neubiorev.2022.104961","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T10:19:15Z","timestamp":1668421155000},"page":"104961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":120,"special_numbering":"C","title":["Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments"],"prefix":"10.1016","volume":"144","author":[{"given":"Muneeb U.","family":"Rehman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouroz","family":"Sehar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawab John","family":"Dar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andleeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azher","family":"Arafah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summya","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzada Mudasir","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid Ahmad","family":"Ganaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bbrc.2018.06.114","article-title":"Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster","volume":"503","author":"Abolaji","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib2","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/med.21794","article-title":"Neurodegenerative disorders\u2014searching for targets and new ways of diseases treatment","volume":"41","author":"Abramov","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.neubiorev.2022.104961_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnagi.2020.00252","article-title":"Mitochondrial dysfunction and Alzheimer\u2019s disease: role of microglia","volume":"12","author":"Agrawal","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2015.00054","article-title":"Molecular diagnostics of neurodegenerative disorders","volume":"2","author":"Agrawal","year":"2015","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109328","article-title":"The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell","volume":"333","author":"Almalki","year":"2021","journal-title":"Chem. -Biol. Interact."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-017-0174-z","article-title":"The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity","volume":"12","author":"Ando","year":"2017","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s42003-022-03312-0","article-title":"Failure of DNA double-strand break repair by tau mediates Alzheimer\u2019s disease pathology in vitro","volume":"5","author":"Asada-Utsugi","year":"2022","journal-title":"Commun. Biol."},{"issue":"7652","key":"10.1016\/j.neubiorev.2022.104961_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature22078","article-title":"Polyglutamine tracts regulate beclin 1-dependent autophagy","volume":"545","author":"Ashkenazi","year":"2017","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.neubiorev.2022.104961_bib9","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1523\/JNEUROSCI.2385-16.2017","article-title":"Inhibition of Drp1 ameliorates synaptic depression, A\u03b2 deposition, and cognitive impairment in an Alzheimer\u2019s disease model","volume":"37","author":"Baek","year":"2017","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib10","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/cells11040706","article-title":"Interaction of mitochondrial calcium and ROS in neurodegeneration","volume":"11","author":"Baev","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib11","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4103\/1673-5374.336869","article-title":"Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer\u2019s disease","volume":"17","author":"Bajwa","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13195-018-0352-4","article-title":"Amyloid \u03b2-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition","volume":"10","author":"Bartolome","year":"2018","journal-title":"Alzheimer\u2019s Res. Ther."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease","volume":"28","author":"Baum","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/ana.20624","article-title":"Mitochondria take center stage in aging and neurodegeneration","volume":"58","author":"Beal","year":"2005","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0166-2236(93)90117-5","article-title":"Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?","volume":"16","author":"Beal","year":"1993","journal-title":"Trends Neurosci."},{"issue":"23","key":"10.1016\/j.neubiorev.2022.104961_bib16","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.3390\/ijms21238924","article-title":"Peripheral glycolysis in neurodegenerative diseases","volume":"21","author":"Bell","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.neubiorev.2022.104961_bib17","first-page":"11405","article-title":"Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions","volume":"46","author":"Benhelli-Mokrani","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/med.21714","article-title":"Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson\u2019s disease","volume":"41","author":"Bento-Pereira","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib19","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1038\/s41598-017-07181-0","article-title":"Mitochondrial division inhibitor-1 is neuroprotective in the A53T-\u03b1-synuclein rat model of Parkinson\u2019s disease","volume":"7","author":"Bido","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2022.104961_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105222","article-title":"Pioglitazone transiently stimulates paraoxonase-2 expression in male nonhuman primate brain: Implications for sex-specific therapeutics in neurodegenerative disorders","volume":"152","author":"Blackburn","year":"2022","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neubiorev.2022.104961_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson\u2019s disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"issue":"4\u20135","key":"10.1016\/j.neubiorev.2022.104961_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2010.04.005","article-title":"Oxidative stress in Alzheimer disease: A possibility for prevention","volume":"59","author":"Bonda","year":"2010","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2165\/11532140-000000000-00000","article-title":"Mitochondrial dynamics in Alzheimer\u2019s disease: opportunities for future treatment strategies","volume":"27","author":"Bonda","year":"2010","journal-title":"Drugs Aging"},{"issue":"Suppl 1","key":"10.1016\/j.neubiorev.2022.104961_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/jnc.13731","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"139","author":"Bose","year":"2016","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41467-017-00633-1","article-title":"A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival","volume":"8","author":"Bou Samra","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib26","series-title":"Physiology and Pharmacology of the Blood-Brain Barrier","year":"2012"},{"issue":"5\u20136","key":"10.1016\/j.neubiorev.2022.104961_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000347140","article-title":"Adherence to cholinesterase inhibitors in Alzheimer\u2019s disease: a review","volume":"35","author":"Brady","year":"2013","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","article-title":"Oxidative stress in Huntington\u2019s disease","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol. (Zur., Switz. )"},{"key":"10.1016\/j.neubiorev.2022.104961_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2014.06.006","article-title":"The 2013 SFRBM discovery award: Selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment","volume":"74","author":"Butterfield","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib30","doi-asserted-by":"crossref","first-page":"10444","DOI":"10.1038\/s41598-020-67229-6","article-title":"Overexpression of PGC-1\u03b1 influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells","volume":"10","author":"Cai","year":"2020","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.neubiorev.2022.104961_bib31","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1093\/hmg\/ddr381","article-title":"Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"20","author":"Calkins","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-018-0299-8","article-title":"Advances in developing novel therapeutic strategies for Alzheimer\u2019s disease","volume":"13","author":"Cao","year":"2018","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0197-4580(03)00033-2","article-title":"Cytochrome c oxidase is decreased in Alzheimer\u2019s disease platelets","volume":"25","author":"Cardoso","year":"2004","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1474-4422(18)30232-1","article-title":"The role of TREM2 in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"17","author":"Carmona","year":"2018","journal-title":"Lancet Neurol."},{"issue":"15","key":"10.1016\/j.neubiorev.2022.104961_bib35","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.2174\/15680266113139990135","article-title":"The multifactorial nature of Alzheimer's disease for developing potential therapeutics","volume":"13","author":"Carreiras","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.neubiorev.2022.104961_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.freeradbiomed.2018.03.002","article-title":"Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2","volume":"120","author":"Cassagnes","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0925-4439(97)00070-7","article-title":"Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson\u2019s disease","volume":"1362","author":"Cassarino","year":"1997","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/jm7009364","article-title":"Multi-target-directed ligands to combat neurodegenerative diseases","volume":"51","author":"Cavalli","year":"2008","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib39","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1038\/s41467-020-19547-6","article-title":"Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer\u2019s disease mouse model","volume":"11","author":"Cen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib40","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fphar.2019.00902","article-title":"Mitochondria as potential targets in alzheimer disease therapy: an update","volume":"10","author":"Cenini","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib41","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1038\/s41598-021-90094-w","article-title":"Intranasal delivery of mitochondria for treatment of Parkinson\u2019s Disease model rats lesioned with 6-hydroxydopamine","volume":"11","author":"Chang","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2022.104961_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fcell.2020.00200","article-title":"Mitophagy: an emerging role in aging and age-associated diseases","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2021\/2319412","article-title":"Baicalein mediates mitochondrial autophagy via miR-30b and the NIX\/BNIP3 signaling pathway in Parkinson\u2019s disease","volume":"2021","author":"Chen","year":"2021","journal-title":"Biochem. Res. Int."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027865","article-title":"A novel neurotrophic drug for cognitive enhancement and Alzheimer\u2019s disease","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib45","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/jnc.15239","article-title":"Variability of mitochondrial energy balance across brain regions","volume":"157","author":"Cheng","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2022.104961_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104741","article-title":"Mitochondrial fission in Huntington\u2019s disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis","volume":"136","author":"Cherubini","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1212\/WNL.0000000000000610","article-title":"The global burden of neurologic diseases","volume":"83","author":"Chin","year":"2014","journal-title":"Neurology"},{"issue":"14","key":"10.1016\/j.neubiorev.2022.104961_bib48","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib49","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1046\/j.1460-9568.2002.02255.x","article-title":"Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons: Efficient DA differentiation of genetically engineered ES cells","volume":"16","author":"Chung","year":"2002","journal-title":"Eur. J. Neurosci."},{"issue":"20","key":"10.1016\/j.neubiorev.2022.104961_bib50","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1111\/bph.14471","article-title":"Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, \u03b1-synuclein, amyloid-\u03b2 and insulin resistance in neurodegenerative diseases: newer rationales for anti-TNF therapy of neurodegenerative diseases","volume":"175","author":"Clark","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib51","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3390\/brainsci10120946","article-title":"Tau and DNA damage in neurodegeneration","volume":"10","author":"Colnaghi","year":"2020","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib52","doi-asserted-by":"crossref","first-page":"16441","DOI":"10.1038\/s41598-017-16637-2","article-title":"Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson\u2019s disease models","volume":"7","author":"Cooper","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib53","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/antiox10111664","article-title":"Key mechanisms and potential implications of hericium erinaceus in NLRP3 inflammasome activation by reactive oxygen species during Alzheimer\u2019s disease","volume":"10","author":"Cordaro","year":"2021","journal-title":"Antioxidants"},{"issue":"7604","key":"10.1016\/j.neubiorev.2022.104961_bib54","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature18015","article-title":"Synchronized mitochondrial and cytosolic translation programs","volume":"533","author":"Couvillion","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib55","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: An emerging therapeutic concept for neurodegenerative disorders of ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib56","doi-asserted-by":"crossref","first-page":"2005.e15","DOI":"10.1016\/j.neurobiolaging.2015.02.014","article-title":"Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study","volume":"36","author":"Cuyvers","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib57","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.molcel.2018.11.034","article-title":"The RNA-Binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging","volume":"73","author":"D\u2019Amico","year":"2019","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib58","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood\u2013brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib59","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/hmg\/ddg044","article-title":"Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death","volume":"12","author":"Darios","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"25","key":"10.1016\/j.neubiorev.2022.104961_bib60","doi-asserted-by":"crossref","first-page":"23802","DOI":"10.1074\/jbc.M500356200","article-title":"Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice","volume":"280","author":"David","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib61","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3390\/biology10111155","article-title":"Inflammatory Response modulation by vitamin C in an MPTP mouse model of Parkinson\u2019s disease","volume":"10","author":"De Nuccio","year":"2021","journal-title":"Biology"},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib62","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/cbic.201402718","article-title":"Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer\u2019s disease","volume":"16","author":"Derrick","year":"2015","journal-title":"ChemBioChem"},{"issue":"40","key":"10.1016\/j.neubiorev.2022.104961_bib63","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.2174\/0929867324666170616110111","article-title":"The role of mitochondrial dysfunction in the progression of alzheimer\u2019s disease","volume":"25","author":"Desler","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib64","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"Detmer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib65","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2174\/1567205018666211118144602","article-title":"Neuroprotective effect of fucoxanthin against intracerebroventricular streptozotocin (ICV-STZ) induced cognitive impairment in experimental rats","volume":"18","author":"Dhami","year":"2021","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib66","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12035-021-02612-6","article-title":"Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer\u2019s disease","volume":"59","author":"Dhapola","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib67","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinson\u2019s Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib68","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/antiox11030504","article-title":"Oxidative stress in neurodegenerative diseases","volume":"11","author":"Domanskyi","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.neubiorev.2022.104961_bib69","first-page":"90","article-title":"Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson\u2019s disease patients","volume":"2","author":"Doorn","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib70","doi-asserted-by":"crossref","first-page":"11857","DOI":"10.1038\/s41598-017-12072-5","article-title":"A synthetic cell permeable antioxidant protects neurons against acute oxidative stress","volume":"7","author":"Drummond","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib71","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/brain\/awx258","article-title":"PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"140","author":"Du","year":"2017","journal-title":"Brain: A J. Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12035-014-8663-3","article-title":"Mitochondrial membrane fluidity is consistently increased in different models of huntington disease: restorative effects of olesoxime","volume":"50","author":"Eckmann","year":"2014","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib73","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuron.2018.07.039","article-title":"Tau protein disrupts nucleocytoplasmic transport in Alzheimer\u2019s disease","volume":"99","author":"Eftekharzadeh","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib74","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/hmg\/ddx394","article-title":"HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo","volume":"27","author":"Ehrnhoefer","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib75","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imr.12896","article-title":"The role of innate immunity in Alzheimer\u2019s disease","volume":"297","author":"Ennerfelt","year":"2020","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib76","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033118","article-title":"Clinical neurology and epidemiology of the major neurodegenerative diseases","volume":"10","author":"Erkkinen","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7","key":"10.1016\/j.neubiorev.2022.104961_bib77","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.3390\/ijms22073330","article-title":"Alzheimer\u2019s disease pathogenesis: role of autophagy and mitophagy focusing in microglia","volume":"22","author":"Eshraghi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"45","key":"10.1016\/j.neubiorev.2022.104961_bib78","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","article-title":"Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin","volume":"27","author":"Exner","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib79","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.parkreldis.2017.07.020","article-title":"The 200-year journey of Parkinson disease: reflecting on the past and looking towards the future","volume":"46","author":"Fahn","year":"2018","journal-title":"Park. Relat. Disord."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib80","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.neubiorev.2022.104961_bib81","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jns.2012.05.030","article-title":"Mitochondria, oxidative stress and neurodegeneration","volume":"322","author":"Federico","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib82","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"Global, regional, and national burden of neurological disorders during 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"16","author":"Feigin","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib83","first-page":"165","article-title":"Burden of neurological disorders across the US from 1990-2017: a global burden of disease study","author":"Feigin","year":"2021"},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib84","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1111\/ejn.14699","article-title":"Update on the association between alpha-synuclein and tau with mitochondrial dysfunction: implications for Parkinson\u2019s disease","volume":"53","author":"Feng","year":"2021","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24966\/AND-9608\/100045","article-title":"NLRP3 inflammasome and Alzheimer\u2019s disease","volume":"6","author":"Feng","year":"2020","journal-title":"J. Alzheimer\u2019s Neurodegener. Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib86","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2008.02.003","article-title":"The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway","volume":"30","author":"Ferreiro","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib87","doi-asserted-by":"crossref","first-page":"32656","DOI":"10.1038\/srep32656","article-title":"Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson\u2019s disease model induced by MPTP","volume":"6","author":"Filichia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2022.104961_bib88","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mcn.2019.06.009","article-title":"Mitochondrial dynamics and transport in Alzheimer\u2019s disease","volume":"98","author":"Flannery","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib89","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/cncr.22450","article-title":"Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in the treatment of cerebral metastasis","volume":"109","author":"Fortin","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.neubiorev.2022.104961_bib90","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fnins.2018.00342","article-title":"Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson\u2019s disease and huntington\u2019s disease","volume":"12","author":"Franco-Iborra","year":"2018","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib91","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease","volume":"17","author":"Franco-Iborra","year":"2021","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib92","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1515\/BC.2006.193","article-title":"Mitochondrial morphology and distribution in mammalian cells","volume":"387","author":"Frazier","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.neubiorev.2022.104961_bib93","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mcn.2018.06.005","article-title":"Sex-dependent co-occurrence of hypoxia and \u03b2-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 \u00d7 Tg-AD mouse model of Alzheimer\u2019s disease","volume":"92","author":"Fronti\u00f1\u00e1n-Rubio","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib94","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41593-018-0298-7","article-title":"A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology","volume":"22","author":"Fu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib95","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/428010","article-title":"Mechanism of oxidative stress in neurodegeneration","volume":"2012","author":"Gandhi","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib96","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-associated Parkinson\u2019s disease is caused by neuronal vulnerability to calcium-induced cell death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neubiorev.2022.104961_bib97","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162152","article-title":"Deconstructing mitochondrial dysfunction in Alzheimer disease","volume":"2013","author":"Garc\u00eda-Escudero","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib98","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/1061186X.2014.997736","article-title":"Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid- \u03b2 -induced impairment of long-term potentiation in rat hippocampal slices","volume":"23","author":"Genrikhs","year":"2015","journal-title":"J. Drug Target."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib99","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1096\/fj.201902277RR","article-title":"Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction","volume":"34","author":"Ghosh","year":"2020","journal-title":"FASEB J."},{"issue":"Suppl 2","key":"10.1016\/j.neubiorev.2022.104961_bib100","doi-asserted-by":"crossref","first-page":"S591","DOI":"10.3233\/JAD-2010-100336","article-title":"A mitocentric view of Alzheimer\u2019s disease suggests multi-faceted treatments","volume":"20","author":"Gibson","year":"2010","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib101","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12715","article-title":"The mitochondrial ATP synthase is a shared drug target for aging and dementia","volume":"17","author":"Goldberg","year":"2018","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib102","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-019-1450-3","article-title":"Urolithin A attenuates memory impairment and neuroinflammation in APP\/PS1 mice","volume":"16","author":"Gong","year":"2019","journal-title":"J. Neuroinflamm."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib103","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/cdd.2012.18","article-title":"Inhibition of Drp1 provides neuroprotection in vitro and in vivo","volume":"19","author":"Grohm","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neubiorev.2022.104961_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104621","article-title":"Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases","volume":"134","author":"Gubert","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"21","key":"10.1016\/j.neubiorev.2022.104961_bib105","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054914","article-title":"Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer\u2019s neurons","volume":"8","author":"Guo","year":"2013","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib107","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of mitochondrial fragmentation diminishes Huntington\u2019s disease-associated neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neubiorev.2022.104961_bib108","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1038\/ncomms12646","article-title":"VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington\u2019s disease","volume":"7","author":"Guo","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib109","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1523\/JNEUROSCI.3263-04.2005","article-title":"Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice","volume":"25","author":"Halverson","year":"2005","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"issue":"17","key":"10.1016\/j.neubiorev.2022.104961_bib110","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1093\/hmg\/ddv209","article-title":"Oxidative metabolism in YAC128 mouse model of Huntington\u2019s disease","volume":"24","author":"Hamilton","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib111","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/md17020123","article-title":"Astaxanthin ameliorates lipopolysaccharide-induced neuroinflammation, oxidative stress and memory dysfunction through inactivation of the signal transducer and activator of transcription 3 pathway","volume":"17","author":"Han","year":"2019","journal-title":"Mar. Drugs"},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib112","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.3390\/ijms22115887","article-title":"Glucose metabolic dysfunction in neurodegenerative diseases-new mechanistic insights and the potential of hypoxia as a prospective therapy targeting metabolic reprogramming","volume":"22","author":"Han","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101911","article-title":"Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: Implications in Parkinson\u2019s disease","volume":"41","author":"Han","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib114","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/10717544.2020.1745328","article-title":"Neuronal mitochondria-targeted therapy for Alzheimer\u2019s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems","volume":"27","author":"Han","year":"2020","journal-title":"Drug Deliv."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib116","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neubiorev.2022.104961_bib117","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2012.10.011","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease and monogenic parkinsonism","volume":"51","author":"Hauser","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib118","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1074\/jbc.M110.146738","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons","volume":"286","author":"Hellman","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2022.104961_bib119","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroscience.2015.07.025","article-title":"Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6\/1 model of Huntington\u2019s disease","volume":"303","author":"Herbst","year":"2015","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib120","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1602\/neurorx.2.4.627","article-title":"New prospects and strategies for drug target discovery in neurodegenerative disorders","volume":"2","author":"Hilbush","year":"2005","journal-title":"NeuroRX"},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/biom9090441","article-title":"\u03b2-Carotene: a natural compound improves cognitive impairment and oxidative stress in a mouse model of streptozotocin-induced Alzheimer\u2019s disease","volume":"9","author":"Hira","year":"2019","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib122","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer\u2019s disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"issue":"7\u20138","key":"10.1016\/j.neubiorev.2022.104961_bib123","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s007020200082","article-title":"The aging brain. Changes in the neuronal insulin\/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review","volume":"109","author":"Hoyer","year":"2002","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neubiorev.2022.104961_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/175062","article-title":"Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer\u2019s disease","volume":"2014","author":"Hroudov\u00e1","year":"2014","journal-title":"BioMed. Res. Int."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib125","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3390\/biom12050661","article-title":"Hyperbaric oxygen therapy improves Parkinson\u2019s disease by promoting mitochondrial biogenesis via the SIRT-1\/PGC-1\u03b1 pathway","volume":"12","author":"Hsu","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib126","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1038\/s41467-021-25651-y","article-title":"Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington\u2019s disease","volume":"12","author":"Hu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib127","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.746873","article-title":"Mitochondrial quality control strategies: potential therapeutic targets for neurodegenerative diseases","volume":"15","author":"Hu","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib128","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neuropharm.2017.02.022","article-title":"Neuroprotective effects of Kukoamine A on neurotoxin-induced Parkinson\u2019s model through apoptosis inhibition and autophagy enhancement","volume":"117","author":"Hu","year":"2017","journal-title":"Neuropharmacology"},{"issue":"14","key":"10.1016\/j.neubiorev.2022.104961_bib129","doi-asserted-by":"crossref","first-page":"17356","DOI":"10.18632\/oncotarget.7861","article-title":"Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin","volume":"7","author":"Hu","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib130","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41467-017-01435-1","article-title":"PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib131","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/br.2016.630","article-title":"Role of oxidative stress in Alzheimer\u2019s disease","volume":"4","author":"Huang","year":"2016","journal-title":"Biomed. Rep."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib132","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.15252\/emmm.201505256","article-title":"Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington\u2019s disease","volume":"7","author":"Hwang","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.neubiorev.2022.104961_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102110","article-title":"Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington\u2019s disease","volume":"204","author":"Hyeon","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib134","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fnins.2017.00495","article-title":"Oxidative stress modifies the levels and phosphorylation state of tau protein in human fibroblasts","volume":"11","author":"Ib\u00e1\u00f1ez-Salazar","year":"2017","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/1673-5374.245463","article-title":"Multitarget therapeutic strategies for Alzheimer\u2019s disease","volume":"14","author":"Ibrahim","year":"2019","journal-title":"Neural Regen. Res."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib136","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1007\/s11064-020-02996-2","article-title":"Combination of omega 3 and coenzyme Q10 exerts neuroprotective potential against hypercholesterolemia-induced Alzheimer\u2019s-like disease in rats","volume":"45","author":"Ibrahim Fouad","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2022.104961_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135268","article-title":"Protective effects of Nrf2\u2013ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: possible involvement of heme oxygenase-1","volume":"736","author":"Inose","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2022.104961_bib138","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fncel.2019.00103","article-title":"Mitochondrial dysfunction in Huntington\u2019s disease; interplay between HSF1, p53 and PGC-1\u03b1 transcription factors","volume":"13","author":"Intihar","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib139","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging roles of oxidative stress in brain aging and Alzheimer\u2019s disease","volume":"107","author":"Ionescu-Tucker","year":"2021","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib140","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/156720510793611592","article-title":"Tau in Alzheimer disease and related tauopathies","volume":"7","author":"Iqbal","year":"2010","journal-title":"Curr. Alzheimer Res."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib141","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/cns.13609","article-title":"Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6\u2013OHDA model of Parkinson\u2019s disease","volume":"27","author":"Iravanpour","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neubiorev.2022.104961_bib142","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbi.2019.03.001","article-title":"Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington\u2019s disease: activation of the Nrf2 pathway through lysophosphatidic acid receptors","volume":"80","author":"Jang","year":"2019","journal-title":"Brain, Behav., Immun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib143","doi-asserted-by":"crossref","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","author":"Jellinger","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.neubiorev.2022.104961_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101496","article-title":"Past, present and future of therapeutic strategies against amyloid-\u03b2 peptides in Alzheimer\u2019s disease: a systematic review","volume":"72","author":"Jeremic","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1567205013666151218150004","article-title":"SS31, a small molecule antioxidant peptide, attenuates \u03b2-amyloid elevation, mitochondrial\/synaptic deterioration and cognitive deficit in SAMP8 mice","volume":"13","author":"Jia","year":"2016","journal-title":"Curr. Alzheimer Res."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib146","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.molcel.2016.06.016","article-title":"A small molecule that protects the integrity of the electron transfer chain blocks the mitochondrial apoptotic pathway","volume":"63","author":"Jiang","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neubiorev.2022.104961_bib147","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fnagi.2018.00378","article-title":"A critical role of autophagy in regulating microglia polarization in neurodegeneration","volume":"10","author":"Jin","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib148","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fphar.2019.00098","article-title":"Shortage of cellular ATP as a cause of diseases and strategies to enhance ATP","volume":"10","author":"Johnson","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib149","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0124-z","article-title":"Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson\u2019s disease models","volume":"50","author":"Kang","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib151","doi-asserted-by":"crossref","first-page":"C641","DOI":"10.1152\/ajpcell.00222.2006","article-title":"Mitochondria and neuronal activity","volume":"292","author":"Kann","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib152","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","article-title":"Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer\u2019s disease","volume":"10","author":"Kapogiannis","year":"2011","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib153","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/bcpt.13659","article-title":"Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson\u2019s disease","volume":"130","author":"Karahalil","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"28","key":"10.1016\/j.neubiorev.2022.104961_bib154","doi-asserted-by":"crossref","first-page":"37060","DOI":"10.1007\/s11356-021-14619-6","article-title":"Connecting the dots between mitochondrial dysfunction and Parkinson\u2019s disorder: Focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity","volume":"28","author":"Kaur","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib155","doi-asserted-by":"crossref","DOI":"10.3390\/cells7120274","article-title":"The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases","volume":"7","author":"Kausar","year":"2018","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib156","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib157","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.581","article-title":"PINK1-induced mitophagy promotes neuroprotection in Huntington\u2019s disease","volume":"6","author":"Khalil","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neubiorev.2022.104961_bib158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7860650","article-title":"Dietary supplementation of the antioxidant curcumin halts systemic LPS-induced neuroinflammation-associated neurodegeneration and memory\/synaptic impairment via the JNK\/NF- \u03ba B\/Akt signaling pathway in adult rats","volume":"2019","author":"Khan","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib159","doi-asserted-by":"crossref","first-page":"325","DOI":"10.5607\/en.2015.24.4.325","article-title":"The role of oxidative stress in neurodegenerative diseases","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurobiol."},{"issue":"20","key":"10.1016\/j.neubiorev.2022.104961_bib160","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial loss, dysfunction and altered dynamics in Huntington\u2019s disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2022.104961_bib161","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainresbull.2019.01.025","article-title":"Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer\u2019s disease","volume":"147","author":"Komaki","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib162","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-160205","article-title":"Oxidative stress and huntington\u2019s disease: the good, the bad, and the ugly","volume":"5","author":"Kumar","year":"2016","journal-title":"J. Huntington\u2019s Dis."},{"key":"10.1016\/j.neubiorev.2022.104961_bib163","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29985","article-title":"Structure of PINK1 and mechanisms of Parkinson\u2019s disease-associated mutations","volume":"6","author":"Kumar","year":"2017","journal-title":"ELife"},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib164","doi-asserted-by":"crossref","first-page":"147","DOI":"10.15406\/japlr.2021.10.00378","article-title":"Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review","volume":"10","author":"Kumari","year":"2021","journal-title":"J. Anal. Pharm. Res."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib165","doi-asserted-by":"crossref","DOI":"10.3390\/antiox8080261","article-title":"Lion\u2019s mane mushroom, hericium erinaceus (Bull.: Fr.) Pers. suppresses H2O2-induced oxidative damage and LPS-induced inflammation in HT22 hippocampal neurons and BV2 microglia","volume":"8","author":"Kushairi","year":"2019","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib166","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40263-019-00658-8","article-title":"Targeting mitochondria in Alzheimer disease: rationale and perspectives","volume":"33","author":"Lanzillotta","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neubiorev.2022.104961_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104469","article-title":"Microglial mitophagy mitigates neuroinflammation in Alzheimer\u2019s disease","volume":"129","author":"Lautrup","year":"2019","journal-title":"Neurochem. Int."},{"issue":"7","key":"10.1016\/j.neubiorev.2022.104961_bib168","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.cell.2010.05.008","article-title":"Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations","volume":"141","author":"Lee","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib169","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s10020-022-00456-x","article-title":"Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson\u2019s disease models in vitro and vivo","volume":"28","author":"Li","year":"2022","journal-title":"Mol. Med."},{"key":"10.1016\/j.neubiorev.2022.104961_bib170","article-title":"The role of NLRP3 inflammasome in Alzheimer\u2019s Disease and potential therapeutic targets","volume":"13","author":"Liang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib171","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","article-title":"Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1\u03b1 null mice","volume":"119","author":"Lin","year":"2004","journal-title":"Cell"},{"issue":"7113","key":"10.1016\/j.neubiorev.2022.104961_bib172","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"issue":"52","key":"10.1016\/j.neubiorev.2022.104961_bib173","doi-asserted-by":"crossref","first-page":"21730","DOI":"10.1021\/jacs.0c09390","article-title":"Targeting microglia for therapy of parkinson\u2019s disease by using biomimetic ultrasmall nanoparticles","volume":"142","author":"Liu","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib174","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.427","article-title":"Pink1 interacts with \u03b1-synuclein and abrogates \u03b1-synuclein-induced neurotoxicity by activating autophagy","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib175","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1039\/D1FO02534A","article-title":"Urolithin A protects dopaminergic neurons in experimental models of Parkinson\u2019s disease by promoting mitochondrial biogenesis through the SIRT1\/PGC-1\u03b1 signaling pathway","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.neubiorev.2022.104961_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111212","article-title":"Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease","volume":"186","author":"Liu","year":"2020","journal-title":"Mech. Ageing Dev."},{"issue":"21","key":"10.1016\/j.neubiorev.2022.104961_bib177","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1073\/pnas.87.21.8422","article-title":"Identification of nuclear tau isoforms in human neuroblastoma cells","volume":"87","author":"Loomis","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neubiorev.2022.104961_bib178","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.576592","article-title":"Mitochondrial and redox modifications in huntington disease induced pluripotent stem cells rescued by CRISPR\/Cas9 CAGs targeting","volume":"8","author":"Lopes","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib179","doi-asserted-by":"crossref","first-page":"10538","DOI":"10.1038\/ncomms10538","article-title":"Mito-priming as a method to engineer Bcl-2 addiction","volume":"7","author":"Lopez","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuint.2017.03.023","article-title":"Mitochondrial respiratory chain disorganization in Parkinson\u2019s disease-relevant PINK1 and DJ1 mutants","volume":"109","author":"Lopez-Fabuel","year":"2017","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib181","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1471-4159.1999.0720771.x","article-title":"Increased DNA oxidation and decreased levels of repair products in Alzheimer\u2019s disease ventricular CSF","volume":"72","author":"Lovell","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2022.104961_bib182","first-page":"1","article-title":"Metformin ameliorates A \u03b2 pathology by insulin-degrading enzyme in a transgenic mouse model of Alzheimer\u2019s disease","volume":"2020","author":"Lu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.neubiorev.2022.104961_bib183","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.febslet.2010.02.013","article-title":"The Cvt pathway as a model for selective autophagy","volume":"584","author":"Lynch-Day","year":"2010","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib184","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/ijms23020780","article-title":"Impact of ER stress and ER-mitochondrial crosstalk in Huntington\u2019s disease","volume":"23","author":"Maity","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"25","key":"10.1016\/j.neubiorev.2022.104961_bib185","doi-asserted-by":"crossref","first-page":"7308","DOI":"10.1093\/hmg\/ddv429","article-title":"Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington\u2019s disease","volume":"24","author":"Manczak","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"45","key":"10.1016\/j.neubiorev.2022.104961_bib186","doi-asserted-by":"crossref","first-page":"E9645","DOI":"10.1073\/pnas.1707151114","article-title":"Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer\u2019s disease","volume":"114","author":"Mano","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neubiorev.2022.104961_bib187","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/5120230","article-title":"Multitarget therapeutic strategies for Alzheimer\u2019s disease: review on emerging target combinations","volume":"2020","author":"Maramai","year":"2020","journal-title":"BioMed. Res. Int."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib188","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/ars.2011.4033","article-title":"Toxin models of mitochondrial dysfunction in Parkinson\u2019s disease","volume":"16","author":"Martinez","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib189","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/jnc.15527","article-title":"Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid\u2010induced model of Huntington\u2019s disease","volume":"160","author":"Mart\u00ednez\u2010Gopar","year":"2022","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib190","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0306-4522(01)00115-4","article-title":"Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer\u2019s disease","volume":"104","author":"Matsuoka","year":"2001","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib191","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cmet.2017.12.008","article-title":"Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand","volume":"27","author":"McWilliams","year":"2018","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib192","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.neurobiolaging.2015.02.004","article-title":"Mitochondrial modulators in experimental Huntington\u2019s disease: reversal of mitochondrial dysfunctions and cognitive deficits","volume":"36","author":"Mehrotra","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2022.104961_bib193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/467180","article-title":"Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives","volume":"2011","author":"Melo","year":"2011","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib194","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.celrep.2017.08.075","article-title":"The self-inactivating kamiCas9 system for the editing of CNS disease genes","volume":"20","author":"Merienne","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neubiorev.2022.104961_bib195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"issue":"35","key":"10.1016\/j.neubiorev.2022.104961_bib196","doi-asserted-by":"crossref","first-page":"30773","DOI":"10.1074\/jbc.M504749200","article-title":"Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin","volume":"280","author":"Milakovic","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib197","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3233\/JPD-161040","article-title":"Phase IIb study of intranasal glutathione in Parkinson\u2019s disease","volume":"7","author":"Mischley","year":"2017","journal-title":"J. Parkinson\u2019s Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib198","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106013","article-title":"Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics","volume":"136","author":"Mishra","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib200","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(89)91141-8","article-title":"Deficiencies in complex I subunits of the respiratory chain in Parkinson\u2019s disease","volume":"163","author":"Mizuno","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib201","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.euroneuro.2014.06.008","article-title":"Type 3 diabetes is sporadic Alzheimer\u05f3s disease: mini-review","volume":"24","author":"de la Monte","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib202","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5607\/en.2015.24.2.103","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"24","author":"Moon","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib203","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.freeradbiomed.2020.10.022","article-title":"NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington\u2019s disease mouse model","volume":"162","author":"Moretti","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neubiorev.2022.104961_bib204","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3389\/fphar.2019.00658","article-title":"PQM130, a Novel Feruloyl\u2013Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer\u2019s Disease","volume":"10","author":"Morroni","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflamm."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib206","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3390\/antiox9080676","article-title":"SkQ1 suppresses the p38 MAPK signaling pathway involved in Alzheimer\u2019s disease-like pathology in OXYS rats","volume":"9","author":"Muraleva","year":"2020","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib207","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/antiox10081284","article-title":"Targeted ablation of primary cilia in differentiated dopaminergic neurons reduces striatal dopamine and responsiveness to metabolic stress","volume":"10","author":"Mustafa","year":"2021","journal-title":"Antioxidants"},{"issue":"Suppl 1","key":"10.1016\/j.neubiorev.2022.104961_bib208","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S1353-8020(09)70004-5","article-title":"L-dopa therapy for Parkinson\u2019s disease: past, present, and future","volume":"15","author":"Nagatsua","year":"2009","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.neubiorev.2022.104961_bib209","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2020.11.031","article-title":"Mitochondrial SIRT3 confers neuroprotection in Huntington\u2019s disease by regulation of oxidative challenges and mitochondrial dynamics","volume":"163","author":"Naia","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib210","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/NEN.0000000000000197","article-title":"Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model","volume":"74","author":"Naseri","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib211","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2017.08.015","article-title":"Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer\u2019s disease and levodopa-induced dyskinesia","volume":"67","author":"Navarro","year":"2018","journal-title":"Brain, Behav., Immun."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib212","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3390\/antiox10111654","article-title":"Neuroprotective activity of melittin\u2014the main component of bee venom\u2014against oxidative stress induced by A\u03b225\u201335 in in vitro and in vivo models","volume":"10","author":"Nguyen","year":"2021","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib213","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4103\/0253-7613.208143","article-title":"Current advances in transdermal delivery of drugs for Alzheimer\u2019s disease","volume":"49","author":"Nguyen","year":"2017","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111623","article-title":"Advances in developing therapeutic strategies for Alzheimer\u2019s disease","volume":"139","author":"Nguyen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neubiorev.2022.104961_bib215","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2010.05.084","article-title":"Regional cerebral glucose uptake in the 3xTG model of Alzheimer\u2019s disease highlights common regional vulnerability across AD mouse models","volume":"1347","author":"Nicholson","year":"2010","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib216","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","article-title":"Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation","volume":"5","author":"Norat","year":"2020","journal-title":"NPJ Regen. Med."},{"issue":"s1","key":"10.1016\/j.neubiorev.2022.104961_bib217","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.3233\/JAD-190048","article-title":"Molecular basis of Alzheimer\u2019s disease: focus on mitochondria","volume":"72","author":"Oliver","year":"2019","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.neubiorev.2022.104961_bib218","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbi.2017.12.009","article-title":"Metformin treatment prevents amyloid plaque deposition and memory impairment in APP\/PS1 mice","volume":"69","author":"Ou","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib219","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s12035-019-01847-8","article-title":"Neuroprotective effects of doxycycline in the R6\/2 mouse model of Huntington\u2019s disease","volume":"57","author":"Paldino","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib220","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/1673-5374.317957","article-title":"Deciphering the role of PGC-1\u03b1 in neurological disorders: from mitochondrial dysfunction to synaptic failure","volume":"17","author":"Panes","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"1\u20133","key":"10.1016\/j.neubiorev.2022.104961_bib221","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0169-409X(95)00003-P","article-title":"Transport of small molecules through the blood-brain barrier: biology and methodology","volume":"15","author":"Pardridge","year":"1995","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.neubiorev.2022.104961_bib222","doi-asserted-by":"crossref","first-page":"21772","DOI":"10.1038\/srep21772","article-title":"Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib223","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/jnc.12361","article-title":"Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells","volume":"127","author":"Park","year":"2013","journal-title":"J. Neurochem."},{"issue":"47","key":"10.1016\/j.neubiorev.2022.104961_bib224","doi-asserted-by":"crossref","first-page":"23426","DOI":"10.1073\/pnas.1916318116","article-title":"N, N \u2032-Diacetyl- p -phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer\u2019s disease transgenic mice","volume":"116","author":"Park","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.neubiorev.2022.104961_bib225","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1021\/acschemneuro.1c00235","article-title":"Dual inhibitors of amyloid-\u03b2 and tau aggregation with amyloid-\u03b2 disaggregating properties: extended In Cellulo, In Silico, and kinetic studies of multifunctional Anti-Alzheimer\u2019s agents","volume":"12","author":"Pasieka","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib226","first-page":"49","article-title":"Mitochondria in multiple sclerosis: molecular mechanisms of pathogenesis","volume":"Vol. 328","author":"Patergnani","year":"2017"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib227","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acschemneuro.9b00123","article-title":"Antagonistic activity of naphthoquinone-based hybrids toward amyloids associated with Alzheimer\u2019s disease and type-2 diabetes","volume":"10","author":"Paul","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib228","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1111\/j.1582-4934.2009.00892.x","article-title":"Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis","volume":"13","author":"Pavlov","year":"2009","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib229","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009332","article-title":"Mitochondrial biology and Parkinson\u2019s disease","volume":"2","author":"Perier","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib230","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3233\/JHD-210518","article-title":"Progressive mitochondrial dysfunction of striatal synapses in r6\/2 mouse model of Huntington\u2019s disease","volume":"11","author":"Petersen","year":"2022","journal-title":"J. Huntington\u2019s Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib231","doi-asserted-by":"crossref","first-page":"8100","DOI":"10.1038\/s41598-017-08722-3","article-title":"Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation","volume":"7","author":"Pintado","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2022.104961_bib232","series-title":"Oxidoreductase","article-title":"Neurodegeneration: diagnosis, prevention, and therapy","author":"Poddar","year":"2021"},{"key":"10.1016\/j.neubiorev.2022.104961_bib233","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101191","article-title":"Defective mitophagy in Alzheimer\u2019s disease","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2022.104961_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135493","article-title":"Ursodeoxycholic acid protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis in MPTP\/MPP+-induced Parkinson\u2019s disease","volume":"741","author":"Qi","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neubiorev.2022.104961_bib235","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2021.12.263","article-title":"Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy","volume":"179","author":"Qiu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib236","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"New Engl. J. Med."},{"issue":"23","key":"10.1016\/j.neubiorev.2022.104961_bib237","doi-asserted-by":"crossref","first-page":"E4676","DOI":"10.1073\/pnas.1614943114","article-title":"KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington\u2019s disease patients","volume":"114","author":"Quinti","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 3","key":"10.1016\/j.neubiorev.2022.104961_bib238","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.3233\/JAD-132738","article-title":"Apoptosis and oxidative stress in neurodegenerative diseases","volume":"42","author":"Radi","year":"2014","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"issue":"42","key":"10.1016\/j.neubiorev.2022.104961_bib239","doi-asserted-by":"crossref","first-page":"23780","DOI":"10.1039\/C8RA03620A","article-title":"Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer\u2019s disease","volume":"8","author":"Rajasekhar","year":"2018","journal-title":"RSC Adv."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib240","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1021\/acschemneuro.8b00033","article-title":"Hybrid multifunctional modulators inhibit multifaceted A\u03b2 toxicity and prevent mitochondrial damage","volume":"9","author":"Rajasekhar","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib241","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s11011-019-00451-y","article-title":"Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: Behavioural and biochemical evidence","volume":"34","author":"Rao","year":"2019","journal-title":"Metab. Brain Dis."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib242","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/hmg\/ddab091","article-title":"Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer\u2019s disease","volume":"30","author":"Reddy","year":"2021","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib243","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/ddx052","article-title":"Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer\u2019s disease","volume":"26","author":"Reddy","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib244","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3233\/JAD-170988","article-title":"Synergistic protective effects of mitochondrial division inhibitor 1 and mitochondria-targeted small peptide SS31 in Alzheimer\u2019s disease","volume":"62","author":"Reddy","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib245","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers","volume":"88","author":"Reitz","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib246","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mcn.2017.12.009","article-title":"Perturbations in the p53\/miR-34a\/SIRT1 pathway in the R6\/2 Huntington\u2019s disease model","volume":"88","author":"Reynolds","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"issue":"47","key":"10.1016\/j.neubiorev.2022.104961_bib247","doi-asserted-by":"crossref","first-page":"20057","DOI":"10.1073\/pnas.0905529106","article-title":"Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer\u2019s disease mice","volume":"106","author":"Rhein","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib248","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/biom11050718","article-title":"Alpha-synuclein and mitochondrial dysfunction in Parkinson\u2019s disease: the emerging role of VDAC","volume":"11","author":"Risiglione","year":"2021","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib249","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tins.2021.12.002","article-title":"LRRK2 and idiopathic Parkinson\u2019s disease","volume":"45","author":"Rocha","year":"2022","journal-title":"Trends Neurosci."},{"issue":"S7","key":"10.1016\/j.neubiorev.2022.104961_bib250","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib251","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tibs.2015.02.003","article-title":"Mitochondrial dysfunction and mitophagy in Parkinson\u2019s: from familial to sporadic disease","volume":"40","author":"Ryan","year":"2015","journal-title":"Trends Biochem. Sci."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib252","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1021\/acschemneuro.9b00216","article-title":"Small molecule inhibits metal-dependent and -independent multifaceted toxicity of Alzheimer\u2019s disease","volume":"10","author":"Samanta","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib253","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/ph15050545","article-title":"Unveiling the multitarget anti-alzheimer drug discovery landscape: a bibliometric analysis","volume":"15","author":"Sampietro","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"17","key":"10.1016\/j.neubiorev.2022.104961_bib254","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1111\/j.1742-4658.2008.06562.x","article-title":"Huntington\u2019s disease: degradation of mutant huntingtin by autophagy: Degradation of mutant huntingtin by autophagy","volume":"275","author":"Sarkar","year":"2008","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib255","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1021\/acs.chemrev.8b00138","article-title":"Development of multifunctional molecules as potential therapeutic candidates for Alzheimer\u2019s disease, Parkinson\u2019s disease, and amyotrophic lateral sclerosis in the last decade","volume":"119","author":"Savelieff","year":"2019","journal-title":"Chem. Rev."},{"issue":"8649","key":"10.1016\/j.neubiorev.2022.104961_bib256","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(89)92366-0","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"1","author":"Schapira","year":"1989","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib257","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1474-4422(07)70327-7","article-title":"Mitochondria in the aetiology and pathogenesis of Parkinson\u2019s disease","volume":"7","author":"Schapira","year":"2008","journal-title":"Lancet Neurol."},{"issue":"7683","key":"10.1016\/j.neubiorev.2022.104961_bib258","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature24645","article-title":"Structure of PINK1 in complex with its substrate ubiquitin","volume":"552","author":"Schubert","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2022.104961_bib259","first-page":"65","article-title":"The biological function of the Huntingtin protein and its relevance to Huntington\u2019s Disease pathology","volume":"5","author":"Schulte","year":"2011","journal-title":"Curr. Trends Neurol."},{"issue":"18","key":"10.1016\/j.neubiorev.2022.104961_bib260","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.3390\/ijms22189987","article-title":"Insulin and insulin resistance in Alzheimer\u2019s disease","volume":"22","author":"S\u0119dzikowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib261","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/ars.2013.5801","article-title":"Does high-dose coenzyme Q10 improve oxidative damage and clinical outcomes in Parkinson\u2019s disease?","volume":"21","author":"Seet","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib262","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s40478-019-0723-5","article-title":"Early neuronal accumulation of DNA double strand breaks in Alzheimer\u2019s disease","volume":"7","author":"Shanbhag","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib263","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/cc.23067","article-title":"Early detection of neurodegenerative diseases: circulating brain-enriched microRNA","volume":"12","author":"Sheinerman","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neubiorev.2022.104961_bib264","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exger.2014.08.007","article-title":"Coenzyme Q10 and \u03b1-tocopherol reversed age-associated functional impairments in mice","volume":"58","author":"Shetty","year":"2014","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib265","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant huntingtin\u2019s interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington\u2019s disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib266","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ana.410360305","article-title":"Alterations in glutathione levels in Parkinson\u2019s disease and other neurodegenerative disorders affecting basal ganglia","volume":"36","author":"Sian","year":"1994","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib267","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer\u2019s disease and other tauopathies, and possible neuroprotective strategies","volume":"6","author":"\u0160imi\u0107","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.neubiorev.2022.104961_bib268","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2018.06.010","article-title":"LRRK2 and mitochondria: recent advances and current views","volume":"1702","author":"Singh","year":"2019","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.neubiorev.2022.104961_bib269","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4103\/1673-5374.211194","article-title":"Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity","volume":"12","author":"Singh","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neubiorev.2022.104961_bib270","series-title":"Atherosclerosis","first-page":"379","article-title":"Roles of reactive oxygen species in physiology and pathology","author":"Song","year":"2015"},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib271","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1074\/jbc.M112.430801","article-title":"Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila","volume":"288","author":"Song","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib272","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"issue":"7684","key":"10.1016\/j.neubiorev.2022.104961_bib273","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib274","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13059-022-02732-9","article-title":"Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes","volume":"23","author":"Soto","year":"2022","journal-title":"Genome Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib275","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/324968","article-title":"New insights in the amyloid-Beta interaction with mitochondria","volume":"2012","author":"Spuch","year":"2012","journal-title":"J. Aging Res."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib276","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1083\/jcb.200108057","article-title":"Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress","volume":"156","author":"Stamer","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib277","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3984906","article-title":"Suppression of Alzheimer\u2019s disease-like pathology progression by mitochondria-targeted antioxidant SkQ1: a transcriptome profiling study","volume":"2019","author":"Stefanova","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib278","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JAD-201015","article-title":"Partial inhibition of mitochondrial complex i reduces tau pathology and improves energy homeostasis and synaptic function in 3xTg-AD mice","volume":"79","author":"Stojakovic","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib279","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s42003-020-01584-y","article-title":"Partial inhibition of mitochondrial complex I ameliorates Alzheimer\u2019s disease pathology and cognition in APP\/PS1 female mice","volume":"4","author":"Stojakovic","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174202","article-title":"Mitochondrial dysfunction and apoptosis are attenuated through activation of AMPK\/GSK-3\u03b2\/PP2A pathway in Parkinson\u2019s disease","volume":"907","author":"Su","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib281","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nn.3356","article-title":"Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-\u03b2","volume":"16","author":"Suberbielle","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib282","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The mitochondrial basis of aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib283","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood\u2013brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib284","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria and mitochondrial cascades in Alzheimer\u2019s disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","article-title":"A \u201cmitochondrial cascade hypothesis\u201d for sporadic Alzheimer\u2019s disease","volume":"63","author":"Swerdlow","year":"2004","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib286","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/nar\/gku1356","article-title":"DNA polymerase \u03b2 deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes","volume":"43","author":"Sykora","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib287","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12993-022-00187-3","article-title":"The interplay between oxidative stress and autophagy: focus on the development of neurological diseases","volume":"18","author":"Talebi","year":"2022","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.neubiorev.2022.104961_bib288","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.3389\/fnins.2019.01372","article-title":"Editorial: mitochondrial dysfunction and neurodegeneration","volume":"13","author":"Tapias","year":"2019","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib289","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1461-5347(00)00258-3","article-title":"Brain drug delivery technologies: novel approaches for transporting therapeutics","volume":"3","author":"Temsamani","year":"2000","journal-title":"Pharm. Sci. Technol. Today"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib290","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12035-020-02109-8","article-title":"DNA double-strand break accumulation in Alzheimer\u2019s disease: evidence from experimental models and postmortem human brains","volume":"58","author":"Thadathil","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"20","key":"10.1016\/j.neubiorev.2022.104961_bib291","doi-asserted-by":"crossref","first-page":"10528","DOI":"10.1074\/jbc.M116.719286","article-title":"Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein","volume":"291","author":"Tien","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"7850","key":"10.1016\/j.neubiorev.2022.104961_bib292","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-021-03269-w","article-title":"Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance","volume":"591","author":"Tigano","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2022.104961_bib293","article-title":"Defective autophagy and mitophagy in aging and Alzheimer\u2019s disease","volume":"14","author":"Tran","year":"2020","journal-title":"Front. Neurosci."},{"issue":"142","key":"10.1016\/j.neubiorev.2022.104961_bib294","doi-asserted-by":"crossref","first-page":"142ra97","DOI":"10.1126\/scitranslmed.3003799","article-title":"PGC-1\u03b1 rescues Huntington\u2019s disease proteotoxicity by preventing oxidative stress and promoting TFEB function","volume":"4","author":"Tsunemi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neubiorev.2022.104961_bib295","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson\u2019s disease","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib296","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/cns.13429","article-title":"Development of early diagnosis of Parkinson\u2019s disease: Illusion or reality?","volume":"26","author":"Ugrumov","year":"2020","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib297","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib298","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s12035-021-02711-4","article-title":"Pharmacological modulation of TRPM2 channels via PARP pathway leads to neuroprotection in MPTP-induced Parkinson\u2019s disease in sprague dawley rats","volume":"59","author":"Vaidya","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"5674","key":"10.1016\/j.neubiorev.2022.104961_bib299","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson\u2019s disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Sci. (N. Y., N. Y. )"},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib300","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011072","article-title":"Mechanisms of mitochondrial fission and fusion","volume":"5","author":"van der Bliek","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib301","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41593-018-0075-7","article-title":"Striatal neurons directly converted from Huntington\u2019s disease patient fibroblasts recapitulate age-associated disease phenotypes","volume":"21","author":"Victor","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2022.104961_bib302","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2017.10.021","article-title":"Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer\u2019s disease","volume":"282","author":"Wang","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib303","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1007\/s12035-020-01955-w","article-title":"Upregulation of AMPK Ameliorates Alzheimer\u2019s Disease-Like Tau Pathology and Memory Impairment","volume":"57","author":"Wang","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib304","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.MR0818-319R","article-title":"Microglia in Alzheimer\u2019s disease: a target for immunotherapy","author":"Wang","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"21","key":"10.1016\/j.neubiorev.2022.104961_bib305","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1093\/hmg\/ddx299","article-title":"Inhibition of mitochondrial fragmentation protects against Alzheimer\u2019s disease in rodent model","volume":"26","author":"Wang","year":"2017","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib306","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib307","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3390\/antiox10101564","article-title":"An unrecognized fundamental relationship between neurotransmitters: glutamate protects against catecholamine oxidation","volume":"10","author":"Wang","year":"2021","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.neubiorev.2022.104961_bib308","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2353\/ajpath.2008.071208","article-title":"Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer\u2019s disease patients","volume":"173","author":"Wang","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"28","key":"10.1016\/j.neubiorev.2022.104961_bib309","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1523\/JNEUROSCI.1357-09.2009","article-title":"Impaired balance of mitochondrial fission and fusion in Alzheimer\u2019s disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib310","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib311","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-022-00524-0","article-title":"Solving neurodegeneration: Common mechanisms and strategies for new treatments","volume":"17","author":"Wareham","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neubiorev.2022.104961_bib312","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.687157","article-title":"Insulin resistance exacerbates Alzheimer disease via multiple mechanisms","volume":"15","author":"Wei","year":"2021","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib313","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbadis.2009.08.013","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"1802","author":"Winklhofer","year":"2010","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.neubiorev.2022.104961_bib314","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.14336\/AD.2019.1125","article-title":"Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer\u2019s Disease","volume":"11","author":"Wong","year":"2020","journal-title":"Aging Dis."},{"issue":"7","key":"10.1016\/j.neubiorev.2022.104961_bib315","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1039\/C5IB00031A","article-title":"Systems biology of neurodegenerative diseases","volume":"7","author":"Wood","year":"2015","journal-title":"Integr. Biol."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib316","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.131","article-title":"N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6\/1 mouse model of Huntington\u2019s disease","volume":"5","author":"Wright","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"14","key":"10.1016\/j.neubiorev.2022.104961_bib317","first-page":"2923","article-title":"N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington\u2019s disease","volume":"25","author":"Wright","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2022.104961_bib318","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.expneurol.2017.03.020","article-title":"2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington\u2019s disease","volume":"293","author":"Wu","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib319","first-page":"1","article-title":"Fucoxanthin prevents 6-OHDA-induced neurotoxicity by targeting keap1","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib320","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.bbadis.2018.05.018","article-title":"MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1\u03b1","volume":"1864","author":"Xi","year":"2018","journal-title":"Biochim. Et. Biophys. Acta BBA Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib321","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41551-021-00819-5","article-title":"Amelioration of Alzheimer\u2019s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow","volume":"6","author":"Xie","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.neubiorev.2022.104961_bib322","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2013.10.011","article-title":"Inhibition of mitochondrial fission attenuates A\u03b2-induced microglia apoptosis","volume":"256","author":"Xie","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2022.104961_bib323","first-page":"163","article-title":"Models of LRRK2-associated Parkinson\u2019s disease","volume":"Vol. 14","author":"Xiong","year":"2017"},{"key":"10.1016\/j.neubiorev.2022.104961_bib324","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fnagi.2017.00308","article-title":"DJ-1 inhibits \u03b1-synuclein aggregation by regulating chaperone-mediated autophagy","volume":"9","author":"Xu","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib325","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3\u03b2-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer\u2019s disease","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"17","key":"10.1016\/j.neubiorev.2022.104961_bib326","doi-asserted-by":"crossref","first-page":"16852","DOI":"10.18632\/aging.103578","article-title":"Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans","volume":"12","author":"Yang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2022.104961_bib327","article-title":"Role of Nrf2 in Parkinson\u2019s disease: toward new perspectives","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.neubiorev.2022.104961_bib328","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nn.3721","article-title":"Inhibition of mitochondrial protein import by mutant huntingtin","volume":"17","author":"Yano","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib329","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000509268","article-title":"Mesenchymal stem cells: a potential therapeutic strategy for neurodegenerative diseases","volume":"83","author":"Yao","year":"2020","journal-title":"Eur. Neurol."},{"issue":"8","key":"10.1016\/j.neubiorev.2022.104961_bib330","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1113\/JP270541","article-title":"Mitochondrial function in ageing: coordination with signalling and transcriptional pathways","volume":"594","author":"Yin","year":"2016","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib331","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1089\/ars.2010.3286","article-title":"Mitochondrial dynamics in diabetes","volume":"14","author":"Yoon","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib332","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","article-title":"Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model","volume":"53","author":"Yoshiyama","year":"2007","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib333","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neubiorev.2022.104961_bib334","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2019.103409","article-title":"The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice","volume":"101","author":"Young","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2022.104961_bib335","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s13311-013-0187-4","article-title":"Developing therapeutic antibodies for neurodegenerative disease","volume":"10","author":"Yu","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neubiorev.2022.104961_bib336","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8872296","article-title":"Pretreatment of ascorbic acid inhibits MPTP-induced astrocytic oxidative stress through suppressing NF-\u03baB Signaling","volume":"2020","author":"Zeng","year":"2020","journal-title":"Neural Plast."},{"issue":"4","key":"10.1016\/j.neubiorev.2022.104961_bib337","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ebiom.2015.03.009","article-title":"Modulation of mitochondrial complex I Activity averts cognitive decline in multiple animal models of familial Alzheimer\u2019s disease","volume":"2","author":"Zhang","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neubiorev.2022.104961_bib338","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuropharm.2017.12.021","article-title":"Citalopram restores short-term memory deficit and non-cognitive behaviors in APP\/PS1 mice while halting the advance of Alzheimer\u2019s disease-like pathology","volume":"131","author":"Zhang","year":"2018","journal-title":"Neuropharmacology"},{"issue":"49","key":"10.1016\/j.neubiorev.2022.104961_bib339","doi-asserted-by":"crossref","first-page":"eabb8680","DOI":"10.1126\/sciadv.abb8680","article-title":"Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer\u2019s disease","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neubiorev.2022.104961_bib340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2021.02.002","article-title":"Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission","volume":"84","author":"Zhang","year":"2021","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.neubiorev.2022.104961_bib341","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a mitochondria-targeted hydrogen sulfide donor, supports cellular bioenergetics and protects against Alzheimer\u2019s disease by preserving mitochondrial function in APP\/PS1 mice and neurons","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neubiorev.2022.104961_bib342","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/316523","article-title":"Oxidative stress and the pathogenesis of Alzheimer\u2019s disease","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.neubiorev.2022.104961_bib343","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s41467-019-09291-x","article-title":"ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2022.104961_bib344","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fnagi.2018.00395","article-title":"TREM2 in Alzheimer\u2019s disease: microglial survival and energy metabolism","volume":"10","author":"Zheng","year":"2018","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.neubiorev.2022.104961_bib345","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/hmg\/ddy061","article-title":"Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington\u2019s disease","volume":"27","author":"Zhou","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.neubiorev.2022.104961_bib346","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.2174\/1570159X17666190726115623","article-title":"Emerging perspectives on DNA double-strand breaks in neurodegenerative diseases","volume":"17","author":"Zhu","year":"2019","journal-title":"Curr. Neuropharmacol."},{"issue":"10","key":"10.1016\/j.neubiorev.2022.104961_bib347","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.biocel.2009.02.004","article-title":"Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes","volume":"41","author":"Zorzano","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976342200450X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014976342200450X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:21:47Z","timestamp":1758968507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014976342200450X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":347,"alternative-id":["S014976342200450X"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2022.104961","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2022.104961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104961"}}