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Med Biol."},{"key":"10.1016\/j.neubiorev.2022.104998_bib145","first-page":"11","article-title":"A Bridge between the Breath and the Brain: Synchronization of Respiration, a Pupillometric Marker of the Locus Coeruleus, and an EEG Marker of Attentional Control State","author":"Melnychuk","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.neubiorev.2022.104998_bib146","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1176\/ajp.156.12.1871","article-title":"PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders","volume":"156","author":"Meltzer","year":"1999","journal-title":"Am. J. 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Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2022.104998_bib153","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.neuroimage.2018.06.068","article-title":"1\/f electrophysiological spectra in resting and drug-induced states can be explained by the dynamics of multiple oscillatory relaxation processes","volume":"179","author":"Muthukumaraswamy","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.neubiorev.2022.104998_bib154","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2967\/jnumed.117.190975","article-title":"Noradrenergic Deficits in Parkinson Disease Imaged with (11)C-MeNER","volume":"59","author":"Nahimi","year":"2018","journal-title":"J. Nucl. 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Neurophysiol."},{"key":"10.1016\/j.neubiorev.2022.104998_bib158","first-page":"70","article-title":"Basal forebrain metabolism in Alzheimer's disease continuum: relationship with education. Neurobiol","volume":"87","author":"Nicolas","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2022.104998_bib159","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2116507119","article-title":"Distinct ensembles in the noradrenergic locus coeruleus are associated with diverse cortical states","volume":"119","author":"Noei","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2022.104998_bib160","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nrneurol.2009.217","article-title":"The use of PET in Alzheimer disease","volume":"6","author":"Nordberg","year":"2010","journal-title":"Nat. Rev. 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J. Neural Syst."},{"key":"10.1016\/j.neubiorev.2022.104998_bib177","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuroimage.2017.07.045","article-title":"High-resolution in vivo imaging of human locus coeruleus by magnetization transfer MRI at 3T and 7T","volume":"168","author":"Priovoulos","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.neubiorev.2022.104998_bib178","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s00429-020-02153-z","article-title":"Unraveling the contributions to the neuromelanin-MRI contrast","volume":"225","author":"Priovoulos","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neubiorev.2022.104998_bib179","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1038\/s41467-022-28986-2","article-title":"Lower novelty-related locus coeruleus function is associated with A\u03b2-related cognitive decline in clinically healthy individuals","volume":"13","author":"Prokopiou","year":"2022","journal-title":"Nat. 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Neurobiol."},{"key":"10.1016\/j.neubiorev.2022.104998_bib187","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3233\/JAD-161102","article-title":"Alzheimer\u2019s disease: characterization of the brain sites of the initial tau cytoskeletal pathology will improve the success of novel immunological anti-tau treatment approaches","volume":"57","author":"R\u00fcb","year":"2017","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.neubiorev.2022.104998_bib188","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/brain\/awy099","article-title":"Cognitive correlates of alpha4beta2 nicotinic acetylcholine receptors in mild Alzheimer's dementia","volume":"141","author":"Sabri","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2022.104998_bib189","first-page":"13","article-title":"The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography","author":"Sanchez","year":"2021","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.neubiorev.2022.104998_bib190","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1073\/pnas.92.13.6032","article-title":"Inhibitory influence of frontal cortex on locus coeruleus neurons","volume":"92","author":"Sara","year":"1995","journal-title":"Proc. Natl. Acad. 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