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JPN"},{"key":"10.1016\/j.neubiorev.2024.105643_bib123","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.pnpbp.2010.12.008","article-title":"Appreciating symptoms and deficits in schizophrenia: Right posterior insula and poor insight","volume":"35","author":"Palaniyappan","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2024.105643_bib124","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1001\/archneurpsyc.1937.02260220069003","article-title":"A proposed mechanism of emotion","volume":"38","author":"Papez","year":"1937","journal-title":"Arch. Neurol. 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Anxiety Disord."},{"key":"10.1016\/j.neubiorev.2024.105643_bib127","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.aan3458","article-title":"Pavlovian conditioning\u2013induced hallucinations result from overweighting of perceptual priors","volume":"357","author":"Powers","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2024.105643_bib128","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1016\/j.neuropsychologia.2010.07.027","article-title":"Anosognosia for hemiplegia as a global deficit in motor awareness: evidence from the non-paralysed limb","volume":"48","author":"Preston","year":"2010","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neubiorev.2024.105643_bib129","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2018.00100","article-title":"Structural connectivity of the anterior cingulate cortex, claustrum, and the anterior insula of the mouse","volume":"12","author":"Qadir","year":"2018","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neubiorev.2024.105643_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119453","article-title":"Cytoarchitecture, probability maps and segregation of the human insula","volume":"260","author":"Quabs","year":"2022","journal-title":"NeuroImage"},{"key":"10.1016\/j.neubiorev.2024.105643_bib131","series-title":"in Biophysics and Neurophysiology of the Sixth Sense","first-page":"59","article-title":"Cortex, Insula, and Interoception","author":"Rahmani","year":"2019"},{"key":"10.1016\/j.neubiorev.2024.105643_bib132","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1002\/hbm.22585","article-title":"Real time fMRI feedback of the anterior cingulate and posterior insular cortex in the processing of pain","volume":"35","author":"Rance","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neubiorev.2024.105643_bib133","unstructured":"Rose, Maximilian. \"Cytoarchitektonik und Myeloarchitektonik der Gro\u00dfhirnrinde.\" Handbuch der Neurologie 1 (1935): 588-778."},{"key":"10.1016\/j.neubiorev.2024.105643_bib134","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/17522439.2017.1344294","article-title":"Pain perception in people diagnosed with schizophrenia: where we are and where we are going","volume":"9","author":"Sakson-Obada","year":"2017","journal-title":"Psychosis"},{"key":"10.1016\/j.neubiorev.2024.105643_bib135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev.neuro.25.032502.111311","article-title":"The central autonomic nervous system: conscious visceral perception and autonomic pattern generation","volume":"25","author":"Saper","year":"2002","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2024.105643_bib136","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1523\/JNEUROSCI.20-19-07438.2000","article-title":"Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum\/posterior insula: an event-related functional magnetic resonance imaging study","volume":"20","author":"Sawamoto","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2024.105643_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.875200","article-title":"Interoception: a multi-sensory foundation of participation in daily life","volume":"16","author":"Schmitt","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2024.105643_bib138","doi-asserted-by":"crossref","first-page":"20160018","DOI":"10.1098\/rstb.2016.0018","article-title":"Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis","volume":"371","author":"Schulz","year":"2016","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.neubiorev.2024.105643_bib139","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1523\/JNEUROSCI.5587-06.2007","article-title":"Dissociable intrinsic connectivity networks for salience processing and executive control","volume":"27","author":"Seeley","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2024.105643_bib140","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nn.3969","article-title":"The dorsal posterior insula subserves a fundamental role in human pain","volume":"18","author":"Segerdahl","year":"2015","journal-title":"Nat. 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