{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:32:46Z","timestamp":1792701166301,"version":"4.5.0"},"reference-count":201,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018551","name":"Science and Technology Innovation Talents in Universities of Henan Province","doi-asserted-by":"publisher","award":["241111520200"],"award-info":[{"award-number":["241111520200"]}],"id":[{"id":"10.13039\/501100018551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371234"],"award-info":[{"award-number":["82371234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.neubiorev.2025.106162","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T19:14:42Z","timestamp":1744658082000},"page":"106162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The persistent pain enigma: Molecular drivers behind acute-to-chronic transition"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-3500","authenticated-orcid":false,"given":"Abdul","family":"Nasir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Afridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ome Kalsoom","family":"Afridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Arif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2025.106162_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109178","article-title":"Modulation of TRPV1 channel function by natural products in the treatment of pain","volume":"330","author":"Abbas","year":"2020","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc3419","article-title":"WNT signalling pathways as therapeutic targets in cancer","volume":"13","author":"Anastas","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib3","first-page":"241","article-title":"The role of sleep in the transition from acute to chronic musculoskeletal pain in youth\u2014a narrative review","volume":"8","author":"Andreucci","year":"2021"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib4","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S1044-7431(03)00236-7","article-title":"Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn","volume":"24","author":"Baba","year":"2003","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1744-8069-3-15","article-title":"Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain","volume":"3","author":"Bai","year":"2007","journal-title":"Mol. Pain."},{"issue":"5-6","key":"10.1016\/j.neubiorev.2025.106162_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/FBP.0b013e328349aae4","article-title":"The complex role of serotonin and 5-HT receptors in chronic pain","volume":"22","author":"Bardin","year":"2011","journal-title":"Behav. Pharm."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib8","article-title":"Advances in targeting central sensitization and brain plasticity in chronic pain","volume":"58","author":"Bazzari","year":"2022","journal-title":"J. o. N. Psychiatry Neurosurg."},{"key":"10.1016\/j.neubiorev.2025.106162_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fpain.2021.698157","article-title":"Mediators of neuropathic pain; focus on spinal microglia, CSF-1, BDNF, CCL21, TNF-\u03b1, Wnt ligands, and interleukin 1\u03b2","volume":"2","author":"Boakye","year":"2021","journal-title":"Front. Pain. Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.20041918","article-title":"Inhibition of astroglial nuclear factor \u03baB reduces inflammation and improves functional recovery after spinal cord injury","volume":"202","author":"Brambilla","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2025.106162_bib11","series-title":"The gift of pain: Why we hurt and what we can do about it","author":"Brand","year":"2020"},{"key":"10.1016\/j.neubiorev.2025.106162_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-13-1229","article-title":"The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care","volume":"13","author":"Breivik","year":"2013","journal-title":"BMC Public Health"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039220","article-title":"Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations","volume":"7","author":"Byun","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pain.2003.11.010","article-title":"Norepinephrine and pain","volume":"107","author":"Canavero","year":"2004","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib15","article-title":"The gut-brain axis: interactions between enteric microbiota","volume":"28","author":"Carabotti","year":"2015","journal-title":"Cent. Enteric Nerv. Syst."},{"key":"10.1016\/j.neubiorev.2025.106162_bib16","author":"Centeno","year":"2023","journal-title":"Long. -range Action HDAC Inhib. treats Chronic Pain. a spared nerve Inj. Rat. Model"},{"key":"10.1016\/j.neubiorev.2025.106162_bib17","article-title":"Potential role of traditional Chinese medicines by wnt\/\u03b2-catenin pathway compared with targeted small molecules in colorectal cancer therapy","volume":"12","author":"Chang","year":"2021"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2014.03.001","article-title":"Mast cells: versatile gatekeepers of pain","volume":"63","author":"Chatterjea","year":"2015","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib19","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and therapeutic relevance of neuro-immune communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity"},{"issue":"19","key":"10.1016\/j.neubiorev.2025.106162_bib20","first-page":"10370","article-title":"Specialized pro-resolving lipid mediators: the future of chronic pain therapy?","volume":"22","author":"Ch\u00e1vez-Castillo","year":"2021"},{"key":"10.1016\/j.neubiorev.2025.106162_bib21","article-title":"The causal connections between gut microbiota and chronic pain and pain phenotypes through the gut-brain axis: a Mendelian randomization study and mediation analysis","volume":"2024","author":"Chen","year":"2024","journal-title":"medRxiv"},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib22","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/ejn.12516","article-title":"BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals","volume":"39","author":"Chen","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib23","article-title":"\u03b2-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain","volume":"7","author":"Chen","year":"2016"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-025-03400-y","article-title":"Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis","volume":"22","author":"Chi","year":"2025","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib25","article-title":"Reconsidering the International Association for the Study of Pain definition of pain","volume":"3","author":"Cohen","year":"2018","journal-title":"Pain. Rep."},{"key":"10.1016\/j.neubiorev.2025.106162_bib26","unstructured":"Collaborators, G. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017."},{"key":"10.1016\/j.neubiorev.2025.106162_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1230633","article-title":"Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia","volume":"14","author":"Cui","year":"2023","journal-title":"Front Pharm."},{"issue":"11","key":"10.1016\/j.neubiorev.2025.106162_bib28","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1523\/JNEUROSCI.5938-08.2009","article-title":"Glial modulation of pain: a step beyond","volume":"29","author":"Cunha","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib29","doi-asserted-by":"crossref","DOI":"10.15585\/mmwr.mm6736a2","article-title":"Prevalence of chronic pain and high-impact chronic pain among adults\u2014United States, 2016","volume":"67","author":"Dahlhamer","year":"2018","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/BF02147990","article-title":"Localization of monoamines in the lower brain stem","volume":"20","author":"Dahlstr\u00f6m","year":"1964","journal-title":"Experientia"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib31","article-title":"Neuromodulation techniques\u2013From non-invasive brain stimulation to deep brain stimulation","volume":"21","author":"Davidson","year":"2024"},{"issue":"8","key":"10.1016\/j.neubiorev.2025.106162_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.biopsych.2023.03.015","article-title":"DNMT1 mediates chronic pain-related depression by inhibiting gabaergic neuronal activation in the central amygdala","volume":"94","author":"Ding","year":"2023","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejpain.2010.06.004","article-title":"Epigenetics in pain and analgesia: an imminent research field","volume":"15","author":"Doehring","year":"2011","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.neubiorev.2025.106162_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12659\/MSMBR.893093","article-title":"Mast cells and neuroinflammation","volume":"20","author":"Dong","year":"2014","journal-title":"Med. Sci. Monit. Basic Res."},{"issue":"15","key":"10.1016\/j.neubiorev.2025.106162_bib35","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2016.1464","article-title":"CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016","volume":"315","author":"Dowell","year":"2016","journal-title":"Jama"},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib36","first-page":"2510","article-title":"Dietary patterns and interventions to alleviate chronic pain","volume":"12","author":"Dragan","year":"2020"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/bja\/75.2.125","article-title":"Inflammatory mediators of pain","volume":"75","author":"Dray","year":"1995","journal-title":"Br. J. Anaesth."},{"issue":"30","key":"10.1016\/j.neubiorev.2025.106162_bib38","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1523\/JNEUROSCI.1642-11.2011","article-title":"Peripheral nerve injury alters blood\u2013spinal cord barrier functional and molecular integrity through a selective inflammatory pathway","volume":"31","author":"Echeverry","year":"2011","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib39","article-title":"Biomarkers for chronic pain: significance and summary of recent advances","volume":"2022","author":"Eldabe","year":"2022"},{"key":"10.1016\/j.neubiorev.2025.106162_bib40","doi-asserted-by":"crossref","unstructured":"Evancho, A., Tyler, W.J., and McGregor, K.J.Fihn. (2023). A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation. 17, 1151218.","DOI":"10.3389\/fnhum.2023.1151218"},{"key":"10.1016\/j.neubiorev.2025.106162_bib41","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.3389\/fimmu.2018.02596","article-title":"Expression and function of IL-33\/ST2 axis in the central nervous system under normal and diseased conditions","volume":"9","author":"Fairlie-Clarke","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2025.106162_bib42","article-title":"On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review","volume":"139","author":"Fakhri","year":"2021"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib44","volume":"2023","author":"Ferraro","year":"2023","journal-title":"Ketamine Other NMDA Recept. Antagon. Chronic Pain."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-4547(19990701)57:1<39::AID-JNR5>3.0.CO;2-M","article-title":"Sodium channel expression in NGF-overexpressing transgenic mice","volume":"57","author":"Fjell","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"12","key":"10.1016\/j.neubiorev.2025.106162_bib46","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awl296","article-title":"The cellular inflammatory response in human spinal cords after injury","volume":"129","author":"Fleming","year":"2006","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib47","first-page":"1065","article-title":"Fibromyalgia: one year in review 2022","volume":"40","author":"Giorgi","year":"2022","journal-title":"Clin. Exp. Rheuma"},{"issue":"8","key":"10.1016\/j.neubiorev.2025.106162_bib48","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1097\/j.pain.0000000000002549","article-title":"Long-term neuropathic pain behaviors correlate with synaptic plasticity and limbic circuit alteration: a comparative observational study in mice","volume":"163","author":"Guida","year":"2022","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.neubiorev.2025.106162_bib49","first-page":"637","article-title":"Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential","volume":"123","author":"Guo","year":"2019"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004958","article-title":"Tissue-specific effects of genetic and epigenetic variation on gene regulation and splicing","volume":"11","author":"Gutierrez-Arcelus","year":"2015","journal-title":"PLoS Genet"},{"issue":"16","key":"10.1016\/j.neubiorev.2025.106162_bib51","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","article-title":"Activated microglia contribute to the maintenance of chronic pain after spinal cord injury","volume":"26","author":"Hains","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib52","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.phrs.2018.06.030","article-title":"Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain","volume":"134","author":"Haleem","year":"2018","journal-title":"Pharm. Res"},{"issue":"8","key":"10.1016\/j.neubiorev.2025.106162_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/genes15081003","article-title":"Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review","volume":"15","author":"Hassan","year":"2024","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.neubiorev.2025.106162_bib54","first-page":"606","volume":"10","author":"Haustrate","year":"2019","journal-title":"Monoclon. antibodies Target. Ion.-. Channels their Ther. Potential"},{"issue":"1-2","key":"10.1016\/j.neubiorev.2025.106162_bib55","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pain.2004.04.026","article-title":"Prostaglandin E2 in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla","volume":"110","author":"Heinricher","year":"2004","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib56","first-page":"S73","article-title":"The use of NMDA-receptor antagonists in the treatment of chronic pain","volume":"16","author":"Hewitt","year":"2000"},{"key":"10.1016\/j.neubiorev.2025.106162_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2022.1014768","article-title":"Endogenous opioid systems alterations in pain and opioid use disorder","volume":"16","author":"Higginbotham","year":"2022","journal-title":"Front Syst. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10571-021-01108-0","article-title":"The role of epigenomic regulatory pathways in the gut-brain axis and visceral hyperalgesia","volume":"42","author":"Higgins","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2025.106162_bib59","article-title":"Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain","volume":"959","author":"H\u00f6sch","year":"2023"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib60","article-title":"Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats","volume":"6","author":"Hsieh","year":"2016"},{"key":"10.1016\/j.neubiorev.2025.106162_bib61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fimmu.2016.00293","article-title":"Neuroimmune interaction in the regulation of peripheral opioid-mediated analgesia in inflammation","volume":"7","author":"Hua","year":"2016","journal-title":"Front Immunol."},{"key":"10.1016\/j.neubiorev.2025.106162_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-1021-4","article-title":"IL-33\/ST2 signaling contributes to radicular pain by modulating MAPK and NF-\u03baB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation","volume":"15","author":"Huang","year":"2018","journal-title":"J. Neuroinflamm."},{"issue":"16","key":"10.1016\/j.neubiorev.2025.106162_bib63","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.neubiorev.2025.106162_bib64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00296-016-3481-8","article-title":"An overview of treatment approaches for chronic pain management","volume":"37","author":"Hylands-White","year":"2017","journal-title":"Rheumatol. Int."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40265-020-01429-2","article-title":"TRPV1-targeted drugs in development for human pain conditions","volume":"81","author":"Iftinca","year":"2021","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.neubiorev.2025.106162_bib66","article-title":"Interleukin-1\u03b2 induces substance P release from primary afferent neurons through the cyclooxygenase-2 system","volume":"73","author":"Inoue","year":"1999","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib67","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib68","article-title":"Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors","volume":"187","author":"Inoue","year":"2021"},{"key":"10.1016\/j.neubiorev.2025.106162_bib69","first-page":"1","article-title":"Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach","author":"Jayathilake","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neubiorev.2025.106162_bib70","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain\u00ae"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib71","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd4334","article-title":"Emerging targets in neuroinflammation-driven chronic pain","volume":"13","author":"Ji","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neubiorev.2025.106162_bib73","article-title":"Inflammation and histone modification in chronic pain","volume":"13","author":"Jiang","year":"2023"},{"key":"10.1016\/j.neubiorev.2025.106162_bib74","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076036","article-title":"Chronic Pain: Definitions and Diagnosis","author":"Kang","year":"2023","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib75","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153558","article-title":"Nociception and pain in humans lacking a functional TRPV1 channel","volume":"133","author":"Katz","year":"2023","journal-title":"J. Clin. Invest"},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib76","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1515\/revneuro-2017-0007","article-title":"Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology","volume":"28","author":"Kaur","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib77","doi-asserted-by":"crossref","unstructured":"Kawabata, A.J.B., and Bulletin, P. (2011). Prostaglandin E2 and pain\u2013an update. 34(8), 1170-1173.","DOI":"10.1248\/bpb.34.1170"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib78","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nm1723","article-title":"Distinct roles of matrix metalloproteases in the early-and late-phase development of neuropathic pain","volume":"14","author":"Kawasaki","year":"2008","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib79","first-page":"2595","article-title":"IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels","volume":"146","author":"Khan","year":"2023"},{"issue":"4","key":"10.1016\/j.neubiorev.2025.106162_bib80","first-page":"499","article-title":"Functional and structural plasticity in the primary somatosensory cortex associated with chronic pain","volume":"141","author":"Kim","year":"2017"},{"key":"10.1016\/j.neubiorev.2025.106162_bib81","unstructured":"Kimourtzis, G.P. (2023). Cellular, molecular and synaptic properties of pain: A microfluidic approach. King\u2019s College London."},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib82","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/cn500171p","article-title":"No gain, no pain: NaV1.7 as an analgesic target","volume":"5","author":"King","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/d41573-019-00065-0","article-title":"Nav1.7 withholds its pain potential","author":"Kingwell","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib84","first-page":"826","article-title":"P2X3-containing receptors as targets for the treatment of chronic pain","volume":"17","author":"Krajewski","year":"2020"},{"key":"10.1016\/j.neubiorev.2025.106162_bib85","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/JPR.S33408","article-title":"NGF\u2013the TrkA to successful pain treatment","author":"Kumar","year":"2012","journal-title":"J. Pain. Res."},{"key":"10.1016\/j.neubiorev.2025.106162_bib86","first-page":"1","article-title":"The transition from acute to chronic pain: might intensive care unit patients be at risk?","volume":"2","author":"Kyranou","year":"2012"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib87","first-page":"5736","article-title":"The role of the insular cortex in pain","volume":"24","author":"Labrakakis","year":"2023"},{"key":"10.1016\/j.neubiorev.2025.106162_bib88","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pharmthera.2017.10.006","article-title":"Toll-like receptors and their role in persistent pain","volume":"184","author":"Lacagnina","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib89","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.nbd.2010.10.023","article-title":"Reactive astrocytes and Wnt\/\u03b2-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine model of Parkinson's disease","volume":"41","author":"L'Episcopo","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2025.106162_bib90","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s12035-022-03196-5","article-title":"Intraperitoneal 5-azacytidine alleviates nerve injury-induced pain in rats by modulating DNA methylation","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2025.106162_bib91","series-title":"in Ion Channels in Biophysics and Physiology","first-page":"249","article-title":"\"TRPV1 in pain and itch","author":"Li","year":"2022"},{"key":"10.1016\/j.neubiorev.2025.106162_bib92","article-title":"NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain","volume":"16","author":"Liu","year":"2022"},{"key":"10.1016\/j.neubiorev.2025.106162_bib93","article-title":"Interaction of microglia and astrocytes in the neurovascular unit","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.neubiorev.2025.106162_bib94","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1097\/j.pain.0000000000000366","article-title":"Wnt\/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats","volume":"156","author":"Liu","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.neubiorev.2025.106162_bib95","article-title":"Gut microbiota in chronic pain: novel insights into mechanisms and promising therapeutic strategies","volume":"115","author":"Liu","year":"2023"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib96","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13041-022-00960-5","article-title":"Toll-like receptors and their role in neuropathic pain and migraine","volume":"15","author":"Liu","year":"2022","journal-title":"Mol. Brain"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib97","first-page":"1","article-title":"Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis","volume":"14","author":"Liu","year":"2024"},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib98","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/j.pain.0000000000001837","article-title":"Peripheral and central nervous system alterations in a rat model of inflammatory arthritis","volume":"161","author":"Locke","year":"2020","journal-title":"Pain"},{"issue":"11S","key":"10.1016\/j.neubiorev.2025.106162_bib99","first-page":"S58","article-title":"Neuroinflammation\u201d: does it have a role in chronic pain? Evidence from human imaging","volume":"165","author":"Loggia","year":"2024"},{"issue":"18","key":"10.1016\/j.neubiorev.2025.106162_bib100","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2174\/156802606778522159","article-title":"Serotonergic modulation of spinal sensory circuits","volume":"6","author":"Lopez-Garcia","year":"2006","journal-title":"Curr. Top. Med Chem."},{"key":"10.1016\/j.neubiorev.2025.106162_bib101","first-page":"191","article-title":"Insular cortex is critical for the perception, modulation, and chronification of pain","volume":"32","author":"Lu","year":"2016"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib102","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tins.2014.04.002","article-title":"Synaptic plasticity in pathological pain","volume":"37","author":"Luo","year":"2014","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib103","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/ALN.0000000000000265","article-title":"Noncoding RNAs: new players in chronic pain","volume":"121","author":"Lutz","year":"2014","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.neubiorev.2025.106162_bib104","first-page":"299","article-title":"The role of oligodendrocytes in chronic pain: cellular and molecular mechanisms","volume":"70","author":"Malta","year":"2019","journal-title":"J. Physiol. Pharm."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib105","first-page":"129","article-title":"Chronic pain: the role of learning and brain plasticity","volume":"32","author":"Mansour","year":"2014","journal-title":"Restor. Neurol. Neurosci."},{"issue":"2&3","key":"10.1016\/j.neubiorev.2025.106162_bib106","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/FBP.0000000000000558","article-title":"Peripherally acting opioid analgesics and peripherally-induced analgesia","volume":"31","author":"Mart\u00ednez","year":"2020","journal-title":"Behav. Pharm."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib107","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12035-011-8175-3","article-title":"Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives","volume":"43","author":"Matthys","year":"2011","journal-title":"Mol. Neurobiol."},{"issue":"16","key":"10.1016\/j.neubiorev.2025.106162_bib108","first-page":"2613","article-title":"Role of epigenetic mechanisms in chronic pain","volume":"11","author":"Mauceri","year":"2022"},{"key":"10.1016\/j.neubiorev.2025.106162_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2024.102870","article-title":"TRPV1: receptor structure, activation, modulation and role in neuro-immune interactions and pain","volume":"119","author":"Maximiano","year":"2024","journal-title":"Cell Calcium"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12630-013-0087-4","article-title":"The transition from acute to chronic pain: understanding how different biological systems interact","volume":"61","author":"Mifflin","year":"2013","journal-title":"Can. J. Anesth. J. Can. D. Anesth."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib111","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"Millan","year":"2002","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib112","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1016\/j.bja.2019.03.023","article-title":"Chronic pain: a review of its epidemiology and associated factors in population-based studies","volume":"123","author":"Mills","year":"2019","journal-title":"Br. J. Anaesth."},{"issue":"1-3","key":"10.1016\/j.neubiorev.2025.106162_bib113","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pain.2007.03.021","article-title":"Cutaneous endothelin-A receptors elevate post-incisional pain","volume":"133","author":"Mujenda","year":"2007","journal-title":"PAIN\u00ae"},{"key":"10.1016\/j.neubiorev.2025.106162_bib114","article-title":"From gut to gray matter: the surprising links between the microbiome and brain","volume":"44","author":"Mukhopadhyay","year":"2023"},{"issue":"11","key":"10.1016\/j.neubiorev.2025.106162_bib115","first-page":"2357","article-title":"Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals","volume":"121","author":"Murakami","year":"2007","journal-title":"J. o. C."},{"issue":"21","key":"10.1016\/j.neubiorev.2025.106162_bib116","article-title":"TRPA1 expression and pathophysiology in immune cells","volume":"22","author":"Naert","year":"2021"},{"key":"10.1016\/j.neubiorev.2025.106162_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107076","article-title":"Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants","author":"Nasir","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.105454","article-title":"Pharmacological and computational evaluation of an isoxazolone derivative for mitigating cisplatin-induced neuropathic pain","volume":"17","author":"Nasir","year":"2024","journal-title":"Arab. J. Chem."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib119","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/1570159X22999240730154422","article-title":"Vitamin B6 Via p-JNK\/Nrf-2\/NF-\u03baB signaling ameliorates cadmium chloride-induced oxidative stress mediated memory deficits in mice hippocampus","volume":"23","author":"Nasir","year":"2025","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017360","article-title":"IL-1\u03b2 stimulates COX-2 dependent PGE2 synthesis and CGRP release in rat trigeminal ganglia cells","volume":"6","author":"Neeb","year":"2011","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib121","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1385\/MN:34:3:243","article-title":"Is there a role for T-type calcium channels in peripheral and central pain sensitization?","volume":"34","author":"Nelson","year":"2006","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib122","first-page":"644","article-title":"Personalized multimodal lifestyle intervention as the best-evidenced treatment for chronic pain: state-of-the-art clinical perspective","volume":"13","author":"Nijs","year":"2024"},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib123","article-title":"Epigenetics and pain: new insights to an old problem","volume":"14","author":"Nirvanie-Persaud","year":"2022","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib124","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib125","first-page":"33","article-title":"Biomarkers for chronic neuropathic pain and their potential application in spinal cord stimulation: a review","volume":"1","author":"Nwagwu","year":"2016","journal-title":"Transl. Perioper. Pain. Med"},{"key":"10.1016\/j.neubiorev.2025.106162_bib126","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s11689-011-9083-6","article-title":"Synaptic Wnt signaling\u2014a contributor to major psychiatric disorders?","volume":"3","author":"Okerlund","year":"2011","journal-title":"J. Neurodev. Disord."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib127","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"Ossipov","year":"2014","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"10.1016\/j.neubiorev.2025.106162_bib128","first-page":"1","article-title":"Pharmacology and mechanism of action of suzetrigine, a potent and selective NaV1. 8 pain signal inhibitor for the treatment of moderate to severe pain","author":"Osteen","year":"2025","journal-title":"Pain. Ther."},{"issue":"4","key":"10.1016\/j.neubiorev.2025.106162_bib129","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41583-022-00673-7","article-title":"Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors","volume":"24","author":"Ovsepian","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib130","first-page":"13","author":"Patel","year":"2010","journal-title":"Physiol. Pain. Guide Pain. Manag. Low. -Resour. Settings"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib131","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nchembio.767","article-title":"Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin","volume":"8","author":"Patti","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib132","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-immunol-042617-053158","article-title":"Molecular and functional neuroscience in immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib133","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/14656566.2021.1901885","article-title":"Can NSAIDs and acetaminophen effectively replace opioid treatment options for acute pain?","volume":"22","author":"Pergolizzi","year":"2021","journal-title":"Expert Opin. Pharm."},{"key":"10.1016\/j.neubiorev.2025.106162_bib134","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clim.2016.06.017","article-title":"The contribution of neutrophils to CNS autoimmunity","volume":"189","author":"Pierson","year":"2018","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron\u2013immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol."},{"issue":"7-8","key":"10.1016\/j.neubiorev.2025.106162_bib136","first-page":"763","article-title":"Epigenetic and miRNA expression changes in people with pain","volume":"21","author":"Polli","year":"2020","journal-title":"a Syst. Rev."},{"key":"10.1016\/j.neubiorev.2025.106162_bib137","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbi.2014.08.002","article-title":"Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury","volume":"44","author":"Pomeshchik","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"14","key":"10.1016\/j.neubiorev.2025.106162_bib138","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.3390\/ijms25147903","article-title":"TRPA1, TRPV1, and caffeine: pain and analgesia","volume":"25","author":"Puthumana","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122954","article-title":"Current insights and therapeutic strategies for targeting TRPV1 in neuropathic pain management","author":"Rahman","year":"2024","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib140","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised international association for the study of pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.neubiorev.2025.106162_bib141","doi-asserted-by":"crossref","unstructured":"Rakv\u00e5g, T.T., Ross, J.R., Sato, H., Skorpen, F., Kaasa, S., and Klepstad, P.J.Mp (2008). Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. 4, 1744-8069-1744-1764.","DOI":"10.1186\/1744-8069-4-64"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib142","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000001529","article-title":"Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain","volume":"160","author":"Reckziegel","year":"2019","journal-title":"Pain"},{"issue":"1473","key":"10.1016\/j.neubiorev.2025.106162_bib143","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways","volume":"361","author":"Reichardt","year":"2006","journal-title":"Philos. Trans. R. Soc. B: Biol. Sci."},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib144","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/jcbfm.2011.197","article-title":"Neurological diseases in relation to the blood\u2013brain barrier","volume":"32","author":"Rosenberg","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"issue":"7321","key":"10.1016\/j.neubiorev.2025.106162_bib145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature09611","article-title":"Developmental genetics of vertebrate glial\u2013cell specification","volume":"468","author":"Rowitch","year":"2010","journal-title":"Nature"},{"issue":"32","key":"10.1016\/j.neubiorev.2025.106162_bib146","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.2174\/0929867324666170216113756","article-title":"Gut-brain axis: role of lipids in the regulation of inflammation, pain and CNS diseases","volume":"25","author":"Russo","year":"2018","journal-title":"Curr. Med. Chem."},{"issue":"10","key":"10.1016\/j.neubiorev.2025.106162_bib147","first-page":"2488","article-title":"Nociceptor signalling through ion channel regulation via GPCRs","volume":"20","author":"Salzer","year":"2019"},{"issue":"19","key":"10.1016\/j.neubiorev.2025.106162_bib148","article-title":"Monoclonal antibodies for chronic pain treatment: present and future","volume":"22","author":"S\u00e1nchez-Robles","year":"2021"},{"key":"10.1016\/j.neubiorev.2025.106162_bib149","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.imlet.2020.11.010","article-title":"Gut microbiota, immunity and pain","volume":"229","author":"Santoni","year":"2021","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.neubiorev.2025.106162_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1533335","article-title":"IL-33\/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential","volume":"16","author":"Sheng","year":"2025","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.neubiorev.2025.106162_bib151","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1471-4159.2010.07131.x","article-title":"Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid \u03b2-peptide","volume":"116","author":"Shruster","year":"2011","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib152","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4049\/jimmunol.1400807","article-title":"Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis","volume":"193","author":"Simmons","year":"2014","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.neubiorev.2025.106162_bib153","first-page":"1413","volume":"109","author":"Simonetti","year":"2021","journal-title":"Locus Reveal.: Painlessness via loss NaV1. 7 Cent. Termin. Sens. Neurons"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib154","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1385\/MN:30:2:117","article-title":"Serotonin in pain and analgesia: actions in the periphery","volume":"30","author":"Sommer","year":"2004","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11916-006-0020-4","article-title":"Is serotonin hyperalgesic or analgesic?","volume":"10","author":"Sommer","year":"2006","journal-title":"Curr. Pain. Headache Rep."},{"key":"10.1016\/j.neubiorev.2025.106162_bib156","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s13142-012-0110-2","article-title":"The future of pain research, education, and treatment: a summary of the IOM report \u201cRelieving pain in America: a blueprint for transforming prevention, care, education, and research","volume":"2","author":"Steglitz","year":"2012","journal-title":"Transl. Behav. Med."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib157","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/SPC.0000000000000495","article-title":"Opioid analgesia: recent developments","volume":"14","author":"Stein","year":"2020","journal-title":"Curr. Opin. Support Palliat. Care"},{"issue":"10","key":"10.1016\/j.neubiorev.2025.106162_bib158","first-page":"1906","article-title":"Correlation between DNA methylation of TRPA1 and chronic pain states in human whole blood cells","volume":"17","author":"Sukenaga","year":"2016"},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib159","first-page":"1153","article-title":"Nerve injury\u2013induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons","volume":"158","author":"Sun","year":"2017"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib160","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0306-4522(99)00365-6","article-title":"Hyperalgesia due to nerve injury: role of prostaglandins","volume":"94","author":"Syriatowicz","year":"1999","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.neubiorev.2025.106162_bib161","article-title":"Association between neuropathic pain characteristics and DNA methylation of transient receptor potential ankyrin 1 in human peripheral blood","volume":"99","author":"Takenaka","year":"2020"},{"issue":"8","key":"10.1016\/j.neubiorev.2025.106162_bib162","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/biomedicines9080897","article-title":"Co-Players in Chronic Pain: Neuroinflammation and the Tryptophan-Kynurenine Metabolic Pathway","volume":"9","author":"Tanaka","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib163","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12017-021-08700-z","article-title":"Wnt signaling pathways: a role in pain processing","volume":"24","author":"Tang","year":"2022","journal-title":"Neuromolecular Med."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib164","first-page":"191","article-title":"Potential therapeutic effects of short-chain fatty acids on chronic pain","volume":"22","author":"Tang","year":"2024"},{"key":"10.1016\/j.neubiorev.2025.106162_bib165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2014.05.002","article-title":"Modulating the delicate glial\u2013neuronal interactions in neuropathic pain: promises and potential caveats","volume":"45","author":"Tiwari","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.neubiorev.2025.106162_bib166","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2019.02.019","article-title":"Composite pain biomarker signatures for objective assessment and effective treatment","volume":"101","author":"Tracey","year":"2019","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib167","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"pain"},{"key":"10.1016\/j.neubiorev.2025.106162_bib168","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fnmol.2017.00381","article-title":"Roles of glial cells in sculpting inhibitory synapses and neural circuits","volume":"10","author":"Um","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib169","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.3389\/fimmu.2019.03009","article-title":"Cytokines in pain: harnessing endogenous anti-inflammatory signaling for improved pain management","volume":"10","author":"Vanderwall","year":"2019","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.neubiorev.2025.106162_bib170","first-page":"1423","volume":"19","author":"Vieira","year":"2019","journal-title":"Pain. Polymorph. opioids: Evid. Based Rev."},{"key":"10.1016\/j.neubiorev.2025.106162_bib171","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1590\/S0102-311X2012000800005","article-title":"Chronic pain, associated factors, and impact on daily life: are there differences between the sexes?","volume":"28","author":"Vieira","year":"2012","journal-title":"Cad. De. Saude Publica"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib172","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1523\/JNEUROSCI.23-02-00708.2003","article-title":"Absence of thermal hyperalgesia in serotonin transporter-deficient mice","volume":"23","author":"Vogel","year":"2003","journal-title":"J. Neurosci."},{"issue":"_1","key":"10.1016\/j.neubiorev.2025.106162_bib173","doi-asserted-by":"crossref","first-page":"i69","DOI":"10.1093\/bja\/aeq323","article-title":"When does acute pain become chronic?","volume":"105","author":"Voscopoulos","year":"2010","journal-title":"Br. J. Anaesth."},{"issue":"4","key":"10.1016\/j.neubiorev.2025.106162_bib174","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/med.21787","article-title":"Direct targeting of \u03b2-catenin in the Wnt signaling pathway: current progress and perspectives","volume":"41","author":"Wang","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.neubiorev.2025.106162_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122283","article-title":"TET1-mediated epigenetic regulation of tumor necrosis factor-\u03b1 in trigeminal ganglia contributes to chronic temporomandibular joint pain","volume":"336","author":"Wang","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.neubiorev.2025.106162_bib176","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"42","key":"10.1016\/j.neubiorev.2025.106162_bib177","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1523\/JNEUROSCI.3593-08.2008","article-title":"Supraspinal glial\u2013neuronal interactions contribute to descending pain facilitation","volume":"28","author":"Wei","year":"2008","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib178","article-title":"Upregulated spinal histone deacetylases induce nociceptive sensitization by inhibiting the GABA system in chronic constriction injury\u2013induced neuropathy in rats","volume":"9","author":"Wen","year":"2024"},{"issue":"7","key":"10.1016\/j.neubiorev.2025.106162_bib179","doi-asserted-by":"crossref","DOI":"10.3390\/cells12071058","article-title":"EZH2 methyltransferase regulates neuroinflammation and neuropathic pain","volume":"12","author":"Weng","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib180","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00000542-200408000-00029","article-title":"Changes in tissue pH and temperature after incision indicate acidosis may contribute to postoperative pain","volume":"101","author":"Woo","year":"2004","journal-title":"J. Am. Soc. Anesthesiol."},{"issue":"5472","key":"10.1016\/j.neubiorev.2025.106162_bib181","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"science"},{"key":"10.1016\/j.neubiorev.2025.106162_bib182","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-8-44","article-title":"Effects of peripheral inflammation on the blood-spinal cord barrier","volume":"8","author":"Xanthos","year":"2012","journal-title":"Mol. Pain."},{"issue":"15","key":"10.1016\/j.neubiorev.2025.106162_bib183","first-page":"8324","article-title":"Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain","volume":"25","author":"Xiong","year":"2024"},{"key":"10.1016\/j.neubiorev.2025.106162_bib184","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135844","article-title":"Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models","volume":"753","author":"Xue","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib185","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/bja\/aet336","article-title":"Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models","volume":"113","author":"Yang","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neubiorev.2025.106162_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110691","article-title":"Role of GABAergic system in the comorbidity of pain and depression","volume":"200","author":"Yang","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neubiorev.2025.106162_bib187","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9185368","article-title":"Impaired autophagy of GABAergic interneurons in neuropathic pain","volume":"2018","author":"Yin","year":"2018","journal-title":"Pain. Res. Manag"},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib188","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1097\/j.pain.0000000000002291","article-title":"Prevalence of chronic pain among adults in the United States","volume":"163","author":"Yong","year":"2022","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib189","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1096\/fj.14-267146","article-title":"Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain","volume":"30","author":"Zarpelon","year":"2016","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.neubiorev.2025.106162_bib190","first-page":"27","article-title":"Cytokines, inflammation, and pain","volume":"45","author":"Zhang","year":"2007"},{"issue":"11","key":"10.1016\/j.neubiorev.2025.106162_bib191","first-page":"1448","article-title":"Epigenetic suppression of GAD65 expression mediates persistent pain","volume":"17","author":"Zhang","year":"2011"},{"issue":"5","key":"10.1016\/j.neubiorev.2025.106162_bib192","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1172\/JCI65364","article-title":"WNT signaling underlies the pathogenesis of neuropathic pain in rodents","volume":"123","author":"Zhang","year":"2013","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib193","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jpain.2023.01.002","article-title":"Somatostatin neurons from periaqueductal gray to medulla facilitate neuropathic pain in male mice","volume":"24","author":"Zhang","year":"2023","journal-title":"J. Pain."},{"issue":"1","key":"10.1016\/j.neubiorev.2025.106162_bib194","first-page":"261","article-title":"TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases","volume":"8","author":"Zhang","year":"2023"},{"key":"10.1016\/j.neubiorev.2025.106162_bib195","article-title":"Effect of dexmedetomidine on ncRNA and mRNA profiles of cerebral ischemia-reperfusion injury in transient middle cerebral artery occlusion rats model","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neubiorev.2025.106162_bib196","doi-asserted-by":"crossref","unstructured":"Zhang, W., Xiao, D., Mao, Q., Xia, H.J.St, and therapy, t. (2023b). Role of neuroinflammation in neurodegeneration development. 8(1), 267.","DOI":"10.1038\/s41392-023-01486-5"},{"key":"10.1016\/j.neubiorev.2025.106162_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107410","article-title":"Role of histone deacetylases and their inhibitors in neurological diseases","author":"Zhang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neubiorev.2025.106162_bib198","article-title":"Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms","volume":"16","author":"Zhao","year":"2023"},{"key":"10.1016\/j.neubiorev.2025.106162_bib199","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.phrs.2018.07.002","article-title":"Minocycline as a promising therapeutic strategy for chronic pain","volume":"134","author":"Zhou","year":"2018","journal-title":"Pharm. Res."},{"issue":"13","key":"10.1016\/j.neubiorev.2025.106162_bib200","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1016\/j.celrep.2019.05.087","article-title":"Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain","volume":"27","author":"Zhou","year":"2019","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.neubiorev.2025.106162_bib201","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1111\/odi.14960","article-title":"The roles of 5-HT in orofacial pain","volume":"30","author":"Zou","year":"2024","journal-title":"Oral. Dis."}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763425001629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763425001629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:25:57Z","timestamp":1774517157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763425001629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":201,"alternative-id":["S0149763425001629"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2025.106162","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The persistent pain enigma: Molecular drivers behind acute-to-chronic transition","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2025.106162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106162"}}