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(Berl. )"},{"key":"10.1016\/j.neubiorev.2026.106548_bib77","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.npp.1301204","article-title":"A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study","volume":"32","author":"Grillon","year":"2007","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.neubiorev.2026.106548_bib78","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.brat.2006.07.005","article-title":"A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans","volume":"45","author":"Guastella","year":"2007","journal-title":"Behav. 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Res."},{"key":"10.1016\/j.neubiorev.2026.106548_bib125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2012.04.032","article-title":"Buspirone: What is it all about?","volume":"1461","author":"Loane","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2026.106548_bib126","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neubiorev.2017.02.026","article-title":"Don\u2019t fear \u2018fear conditioning\u2019: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear","volume":"77","author":"Lonsdorf","year":"2017","journal-title":"Neurosci. Biobehav. 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