{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:35:02Z","timestamp":1793932502108,"version":"4.8.0"},"reference-count":246,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.neubiorev.2026.106658","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:37:36Z","timestamp":1774658256000},"page":"106658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The role of blood-brain barrier integrity in the pathophysiology and progression of psychiatric disorders"],"prefix":"10.1016","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-1633","authenticated-orcid":false,"given":"Gerasimos N.","family":"Konstantinou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry J.","family":"Warsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2026.106658_bib1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2174\/187153012800493477","article-title":"Cerebrovascular complications of diabetes: focus on stroke","volume":"12","author":"Adviye","year":"2012","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.neubiorev.2026.106658_bib2","unstructured":"American College of, R, 2024. ACR Manual on Contrast Media 2024 ACR Committee on Drugs and Contrast Media."},{"key":"10.1016\/j.neubiorev.2026.106658_bib3","doi-asserted-by":"crossref","first-page":"15271","DOI":"10.3390\/ijms232315271","article-title":"Blood\u2013brain barrier disruption and its involvement in neurodevelopmental and neurodegenerative disorders","volume":"23","author":"Arag\u00f3n-Gonz\u00e1lez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12987-024-00528-6","article-title":"C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity","volume":"21","author":"Arag\u00f3n-Gonz\u00e1lez","year":"2024","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neubiorev.2026.106658_bib5","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1172\/JCI60842","article-title":"Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease","volume":"122","author":"Argaw","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neubiorev.2026.106658_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mri.2010.09.002","article-title":"Use of dynamic contrast-enhanced MRI to measure subtle blood\u2013brain barrier abnormalities","volume":"29","author":"Armitage","year":"2011","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.neubiorev.2026.106658_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cyto.2011.10.016","article-title":"TNF-alpha induced NF\u03baB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells","volume":"57","author":"Aslam","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.neubiorev.2026.106658_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/TA.0000000000002866","article-title":"The neuroprotective effect of quetiapine in critically ill traumatic brain injury patients","volume":"89","author":"Asmar","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.neubiorev.2026.106658_bib10","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1177\/0271678X16683961","article-title":"Chronic depletion of gonadal testosterone leads to blood\u2013brain barrier dysfunction and inflammation in male mice","volume":"37","author":"Atallah","year":"2017","journal-title":"J. Cereb. Blood Flow. & Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1192\/bjp.141.3.273","article-title":"Impairment of the Blood-Brain Barrier as an Aetiological Factor in Paranoid Psychosis","volume":"141","author":"Axelsson","year":"1982","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/13651501.2020.1801754","article-title":"Serum zonulin and claudin-5 levels in children with attention-deficit\/hyperactivity disorder","volume":"25","author":"Aydo\u011fan Av\u015far","year":"2021","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.neubiorev.2026.106658_bib13","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/mrm.27145","article-title":"Measurement of blood-brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging with reduced scan time","volume":"80","author":"Bae","year":"2018","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib14","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.3390\/ijms22168370","article-title":"Reviewing the Significance of Blood\u2013Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment","volume":"22","author":"Balasa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.08.007","article-title":"The blood-brain barrier in neuroimmunology: Tales of separation and assimilation","volume":"44","author":"Banks","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib16","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1038\/s41380-023-02065-4","article-title":"Insulin effects on core neurotransmitter pathways involved in schizophrenia neurobiology: a meta-analysis of preclinical studies. Implications for the treatment","volume":"28","author":"de Bartolomeis","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2014.00392","article-title":"\u201cYou Shall Not Pass\u201d-tight junctions of the blood brain barrier","author":"Bauer","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1017\/S1461145708009498","article-title":"Neuroprogression: Pathways to progressive brain changes in bipolar disorder","volume":"12","author":"Berk","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/wps.20441","article-title":"Staging in bipolar disorder: from theoretical framework to clinical utility","volume":"16","author":"Berk","year":"2017","journal-title":"World Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.594672","article-title":"Pathophysiology of Blood\u2013Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery","author":"Bernardo-Castro","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2017.08.001","article-title":"Th17 cells in depression","volume":"69","author":"Beurel","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12975-018-0614-2","article-title":"Interleukin 6-Mediated Endothelial Barrier Disturbances Can Be Attenuated by Blockade of the IL6 Receptor Expressed in Brain Microvascular Endothelial Cells","volume":"9","author":"Blecharz-Lang","year":"2018","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1160426","article-title":"The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review","author":"Boccara","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16250-3","article-title":"Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis","volume":"7","author":"Brilha","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106658_bib25","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12974-016-0760-y","article-title":"Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit","volume":"13","author":"Brown","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neubiorev.2026.106658_bib26","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1038\/s41386-020-0683-2","article-title":"The association between lithium use and neurocognitive performance in patients with bipolar disorder","volume":"45","author":"Burdick","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106658_bib27","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.636174","article-title":"Insulin Resistance and Blood-Brain Barrier Dysfunction Underlie Neuroprogression in Bipolar Disorder","author":"Calkin","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/bdi.13199","article-title":"Reversal of insulin resistance is associated with repair of blood\u2013brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression","volume":"24","author":"Calkin","year":"2022","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1002\/jgm.1211","article-title":"RNAi-mediated reversible opening of the blood-brain barrier","volume":"10","author":"Campbell","year":"2008","journal-title":"J. Gene Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib31","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ncomms1852","article-title":"Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury","volume":"3","author":"Campbell","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib32","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/jon.12894","article-title":"7 T dynamic contrast-enhanced MRI for the detection of subtle blood-brain barrier leakage","volume":"31","author":"Canjels","year":"2021","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijerph18052683","article-title":"Alcohol-induced blood-brain barrier impairment: An in vitro study","volume":"18","author":"Carrino","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.neubiorev.2026.106658_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1471-4159.2009.06319.x","article-title":"The blood-brain barrier in neurodegenerative disease: A rhetorical perspective","volume":"111","author":"Carvey","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2026.106658_bib35","doi-asserted-by":"crossref","first-page":"11562","DOI":"10.3390\/ijms231911562","article-title":"A Pathophysiological Intersection of Diabetes and Alzheimer\u2019s Disease","volume":"23","author":"\u010cater","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib36","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bpsc.2022.06.006","article-title":"Increased Blood-Brain Barrier Permeability of the Thalamus Correlated With Symptom Severity and Brain Volume Alterations in Patients With Schizophrenia","volume":"7","author":"Cheng","year":"2022","journal-title":"Biological Psychiatry Cognitive Neuroscience Neuroimaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/pr.111.005512","article-title":"Therapeutic potential of mood stabilizers lithium and valproic acid: Beyond bipolar disorder","volume":"65","author":"Chiu","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40345-019-0142-3","article-title":"Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives","volume":"7","author":"Coello","year":"2019","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib39","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib40","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.2147\/NDT.S106479","article-title":"A new look at an old drug: Neuroprotective effects and therapeutic potentials of lithium salts","volume":"12","author":"Dell\u2019Osso","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neubiorev.2026.106658_bib41","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/HYPERTENSIONAHA.123.22617","article-title":"Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7 T DCE-MRI Study","volume":"81","author":"van den Kerkhof","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.neubiorev.2026.106658_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3727\/000000007783464731","article-title":"Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy","volume":"16","author":"Desai","year":"2007","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neubiorev.2026.106658_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2016.00008","article-title":"Fluoxetine Requires the Endfeet Protein Aquaporin-4 to Enhance Plasticity of Astrocyte Processes","author":"Di Benedetto","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.706025","article-title":"Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions","author":"Ding","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41467-021-27604-x","article-title":"Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue","volume":"13","author":"Dion-Albert","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib46","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.3390\/ijms25115601","article-title":"The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies","volume":"25","author":"Dithmer","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib47","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1007\/s00204-025-04124-x","article-title":"Gadolinium toxicity: mechanisms, clinical manifestations, and nanoparticle role","volume":"99","author":"Domingo","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib48","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1073\/pnas.1914655117","article-title":"Molecular adaptations of the blood\u2013brain barrier promote stress resilience vs. depression","volume":"117","author":"Dudek","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.nbd.2019.01.020","article-title":"Multi-faceted therapeutic strategy for treatment of Alzheimer's disease by concurrent administration of etodolac and \u03b1-tocopherol","volume":"125","author":"Elfakhri","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2026.106658_bib50","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.brainres.2014.08.011","article-title":"Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood\u2013brain barrier","volume":"1583","author":"Elmorsy","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2016.10.020","article-title":"The effect of systemic inflammation on human brain barrier function","volume":"62","author":"Elwood","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue","volume":"81","author":"Enache","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.04.003","article-title":"Microglia: Lifelong patrolling immune cells of the brain","volume":"179","author":"Eyo","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.17.2.375","article-title":"Junctional complexes in varioius epithelia","volume":"17","author":"Farquhar","year":"1963","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00362","article-title":"The impact of microglial activation on blood-brain barrier in brain diseases","author":"da Fonseca","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.867452","article-title":"Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging","author":"Ford","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib58","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/s41423-021-00757-x","article-title":"The blood\u2013brain barrier in systemic infection and inflammation","volume":"18","author":"Galea","year":"2021","journal-title":"Cell. & Mol. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1176\/appi.focus.130110","article-title":"Staging Models in Bipolar Disorder","volume":"13","author":"Galvez","year":"2015","journal-title":"Focus"},{"key":"10.1016\/j.neubiorev.2026.106658_bib60","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.rbp.2012.09.001","article-title":"Staging and neuroprogression in bipolar disorder: A systematic review of the literature","volume":"35","author":"Gama","year":"2013","journal-title":"Rev. Bras. De. Psiquiatr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib61","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70992","article-title":"Wnt signaling mediates acquisition of blood\u2013brain barrier properties in na\u00efve endothelium derived from human pluripotent stem cells","volume":"10","author":"Gastfriend","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.neubiorev.2026.106658_bib62","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/alz.12357","article-title":"Water exchange rate across the blood-brain barrier is associated with CSF amyloid-\u03b2 42 in healthy older adults","volume":"17","author":"Gold","year":"2021","journal-title":"Alzheimer's. & Dement."},{"key":"10.1016\/j.neubiorev.2026.106658_bib63","first-page":"1565","article-title":"Bipolar Disorder and the Vascular System: Mechanisms and New Prevention Opportunities","volume":"33","author":"Goldstein","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib64","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/schbul\/sbad057","article-title":"Evidence of Neurovascular Water Exchange and Endothelial Vascular Dysfunction in Schizophrenia: An Exploratory Study","volume":"49","author":"Goldwaser","year":"2023","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.neubiorev.2026.106658_bib65","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11064-025-04483-y","article-title":"When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder","volume":"50","author":"Gonz\u00e1lez-Arias","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib66","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1038\/mp.2017.156","article-title":"Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia","volume":"23","author":"Greene","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12987-019-0123-z","article-title":"Claudin-5: Gatekeeper of neurological function","volume":"16","author":"Greene","year":"2019","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neubiorev.2026.106658_bib68","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41398-020-01054-3","article-title":"Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders","volume":"10","author":"Greene","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082041","article-title":"What Guides Peripheral Immune Cells into the Central Nervous System?","author":"Greiner","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.neubiorev.2026.106658_bib70","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.3390\/ijms24119144","article-title":"Microglia and the Blood\u2013Brain Barrier: An External Player in Acute and Chronic Neuroinflammatory Conditions","volume":"24","author":"Gullotta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib71","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.3233\/JAD-2012-120487","article-title":"Adiposity and Cognitive Decline: Underlying Mechanisms","volume":"30","author":"Gustafson","year":"2012","journal-title":"J. Alzheimer's. Dis."},{"key":"10.1016\/j.neubiorev.2026.106658_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00224","article-title":"Development and function of the blood-brain barrier in the context of metabolic control","author":"Haddad-T\u00f3volli","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib73","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00259-022-05997-1","article-title":"vivo methods for imaging blood\u2013brain barrier function and dysfunction","volume":"50","author":"Harris","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib74","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1248\/bpb.b21-00408","article-title":"Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier","volume":"44","author":"Hashimoto","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neubiorev.2026.106658_bib75","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.nicl.2014.09.002","article-title":"Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI. A systematic review","volume":"6","author":"Heye","year":"2014","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.neubiorev.2026.106658_bib76","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbi.2023.01.015","article-title":"Serum claudin-5 levels among patients with unipolar and bipolar depression in relation to the pro-inflammatory cytokine tumor necrosis factor-alpha levels","volume":"109","author":"Hochman","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib77","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-016-0002-0","article-title":"The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?","volume":"3","author":"Houser","year":"2017","journal-title":"npj Park. 's. Dis."},{"key":"10.1016\/j.neubiorev.2026.106658_bib78","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cns.13569","article-title":"Peripheral inflammation and blood\u2013brain barrier disruption: effects and mechanisms","volume":"27","author":"Huang","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neubiorev.2026.106658_bib79","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12974-024-03261-x","article-title":"Compromised endothelial Wnt\/\u03b2-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia","volume":"21","author":"Huang","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neubiorev.2026.106658_bib80","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/jcbfm.2013.76","article-title":"The APOE \u03b54\/\u03b54 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients","volume":"33","author":"Hultman","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib81","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106658_bib82","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.3390\/ijerph18157756","article-title":"The Present State of Lithium for the Prevention of Dementia Related to Alzheimer\u2019s Dementia in Clinical and Epidemiological Studies: A Critical Review","volume":"18","author":"Ishii","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.neubiorev.2026.106658_bib83","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/08039488.2020.1715474","article-title":"Serum zonulin and claudin-5 levels in children with obsessive\u2013compulsive disorder","volume":"74","author":"I\u015f\u0131k","year":"2020","journal-title":"Nord. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib84","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neurobiolaging.2016.11.017","article-title":"Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype","volume":"51","author":"Janelidze","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101333","article-title":"Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease","author":"Jeon","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108474","article-title":"Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt\/\u03b2-catenin signaling in mice","volume":"186","author":"Ji","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2026.106658_bib87","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163-164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib88","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib89","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neubiorev.2026.106658_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.102049","article-title":"Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression","volume":"26","author":"Kamintsky","year":"2020","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.neubiorev.2026.106658_bib91","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/1516-4446-2014-3605","article-title":"Neuroprogression and staging in psychiatry: Historical considerations","volume":"36","author":"Kapczinski","year":"2014","journal-title":"Rev. Bras. De. Psiquiatr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib92","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neubiorev.2007.10.005","article-title":"Allostatic load in bipolar disorder: Implications for pathophysiology and treatment","volume":"32","author":"Kapczinski","year":"2008","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib93","article-title":"Autoregulated paracellular clearance of amyloid-\u03b2 across the blood-brain barrier","volume":"1","author":"Keaney","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neubiorev.2026.106658_bib94","doi-asserted-by":"crossref","first-page":"273","DOI":"10.24869\/psyd.2022.273","article-title":"Serum claudin-5, but not zonulin, may be associated with Obsessive-Compulsive Disorder","volume":"34","author":"Kilic","year":"2022","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.neubiorev.2026.106658_bib95","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jad.2020.01.117","article-title":"Serum zonulin and claudin-5 levels in patients with bipolar disorder","volume":"266","author":"K\u0131l\u0131\u00e7","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib96","doi-asserted-by":"crossref","first-page":"256","DOI":"10.13104\/imri.2022.26.4.256","article-title":"Dynamic Contrast-Enhanced MRI and Its Applications in Various Central Nervous System Diseases","volume":"26","author":"Kim","year":"2022","journal-title":"Invest. Magn. Reson Imaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib97","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3390\/antiox13121462","article-title":"Role of Oxidative Stress in Blood\u2013Brain Barrier Disruption and Neurodegenerative Diseases","volume":"13","author":"Kim","year":"2024","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106658_bib98","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1528-1167.2012.03701.x","article-title":"Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis","volume":"53","author":"Kim","year":"2012","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2026.106658_bib99","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/s41467-025-56720-1","article-title":"Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through \u03b2-Catenin signaling","volume":"16","author":"Kim","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib100","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib101","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.neubiorev.2026.106658_bib103","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56075-w","article-title":"Modulation of Wnt\/\u03b2-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells","volume":"9","author":"Laksitorini","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106658_bib104","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1111\/epi.13222","article-title":"The role of SLC2A1 mutations in myoclonic astatic epilepsy and absence epilepsy, and the estimated frequency of GLUT1 deficiency syndrome","volume":"56","author":"Larsen","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.neubiorev.2026.106658_bib105","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1089\/ars.2011.3923","article-title":"Oxidative stress and blood-brain barrier dysfunction under particular consideration of matrix metalloproteinases","volume":"15","author":"Lehner","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neubiorev.2026.106658_bib106","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948070","article-title":"Emerging links between cerebrovascular and neurodegenerative diseases\u2014a special role for pericytes","volume":"20","author":"Lendahl","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neubiorev.2026.106658_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/neu.2019.17","article-title":"Inflammation, insulin resistance and neuroprogression in depression","volume":"32","author":"Leonard","year":"2020","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib108","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2009.01.070","article-title":"Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion","volume":"1266","author":"Leung","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib109","article-title":"Development of Novel Therapeutics Targeting the Blood\u2013Brain Barrier: From Barrier to Carrier","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib110","doi-asserted-by":"crossref","first-page":"8281","DOI":"10.3390\/ijms23158281","article-title":"Actions of Metformin in the Brain: A New Perspective of Metformin Treatments in Related Neurological Disorders","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib111","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200806024","article-title":"Wnt\/\u03b2-catenin signaling controls development of the blood\u2013brain barrier","volume":"183","author":"Liebner","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib112","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/mrm.28687","article-title":"Noncontrast assessment of blood\u2013brain barrier permeability to water: Shorter acquisition, test\u2013retest reproducibility, and comparison with contrast-based method","volume":"86","author":"Lin","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib113","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s41747-023-00365-6","article-title":"Dynamic contrast-enhanced MRI shows altered blood\u2013brain barrier function of deep gray matter structures in neuroborreliosis: a case\u2013control study","volume":"7","author":"Lindland","year":"2023","journal-title":"Eur. Radiol. Exp."},{"key":"10.1016\/j.neubiorev.2026.106658_bib114","article-title":"Interaction of Microglia and Astrocytes in the Neurovascular Unit","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111560","article-title":"Microbiota-gut-brain axis and Alzheimer's disease: Implications of the blood-brain barrier as an intervention target","volume":"199","author":"Liu","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib116","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1038\/s41380-023-02255-0","article-title":"Brain microvascular endothelial cells and blood-brain barrier dysfunction in psychotic disorders","volume":"28","author":"Lizano","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib117","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1208\/s12248-017-0076-6","article-title":"Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System","volume":"19","author":"Lochhead","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.neubiorev.2026.106658_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00914","article-title":"Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders","author":"Lochhead","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib119","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41392-024-01743-1","article-title":"Microbiota\u2013gut\u2013brain axis and its therapeutic applications in neurodegenerative diseases","volume":"9","author":"Loh","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.neubiorev.2026.106658_bib120","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","article-title":"Microglial Activation and Chronic Neurodegeneration","volume":"7","author":"Lull","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neubiorev.2026.106658_bib121","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.848495","article-title":"The Interplay Between Brain Vascular Calcification and Microglia","author":"Maheshwari","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.719676","article-title":"Robust Multi-TE ASL-Based Blood\u2013Brain Barrier Integrity Measurements","author":"Mahroo","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib123","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1002\/jmri.28874","article-title":"Blood-Brain Barrier Permeability to Water Measured Using Multiple Echo Time Arterial Spin Labeling MRI in the Aging Human Brain","volume":"59","author":"Mahroo","year":"2024","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib124","doi-asserted-by":"crossref","DOI":"10.1007\/s10334-024-01219-x","article-title":"New physiological insights using multi-TE ASL MRI measuring blood\u2013brain barrier water exchange after caffeine intake","author":"Mahroo","year":"2025","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib125","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/jnr.24611","article-title":"GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood\u2013brain barrier","volume":"98","author":"Malik","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib126","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1002\/mrm.28833","article-title":"Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage","volume":"86","author":"Manning","year":"2021","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib127","doi-asserted-by":"crossref","first-page":"17146","DOI":"10.3390\/ijms242417146","article-title":"Astrocyte Involvement in Blood\u2013Brain Barrier Function: A Critical Update Highlighting Novel, Complex, Neurovascular Interactions","volume":"24","author":"Manu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib128","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbi.2024.11.006","article-title":"Claudin-5 and occludin levels in patients with psychiatric disorders \u2212 A systematic review","volume":"123","author":"Maridaki","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib129","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","article-title":"The Brain-Gut-Microbiome Axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib130","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12928","article-title":"The impact of insulin on the serotonergic system and consequences on diabetes-associated mood disorders","volume":"33","author":"Martin","year":"2021","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib131","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/hs0901.94259","article-title":"Protective Effect of Endothelin Type A Receptor Antagonist on Brain Edema and Injury After Transient Middle Cerebral Artery Occlusion in Rats","volume":"32","author":"Matsuo","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.neubiorev.2026.106658_bib132","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1360195","article-title":"Microglia at the blood brain barrier in health and disease","volume":"18","author":"Mayer","year":"2024","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib133","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00018-013-1378-1","article-title":"Wnt and lithium: A common destiny in the therapy of nervous system pathologies?","volume":"71","author":"Meffre","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib134","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib135","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/ijms20030571","article-title":"Dual roles of astrocyte-derived factors in regulation of blood-brain barrier function after brain damage","volume":"20","author":"Michinaga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.869779","article-title":"Astroglia in the Vulnerability to and Maintenance of Stress-Mediated Neuropathology and Depression","author":"Miguel-Hidalgo","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib137","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/s41598-017-01922-x","article-title":"Quantification of blood-brain barrier permeability by dynamic contrast-enhanced NIRS","volume":"7","author":"Milej","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106658_bib138","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00947","article-title":"Interleukin-17 in Chronic Inflammatory Neurological Diseases","author":"Milovanovic","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib139","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awz024","article-title":"Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects","volume":"142","author":"Mishra","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2026.106658_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010127","article-title":"Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease","author":"Mizuta","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.neubiorev.2026.106658_bib141","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00401-016-1570-0","article-title":"Brain imaging of neurovascular dysfunction in Alzheimer\u2019s disease","volume":"131","author":"Montagne","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib142","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 leads to blood\u2013brain barrier dysfunction predicting cognitive decline","volume":"581","author":"Montagne","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106658_bib143","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.5256","article-title":"Measurement of blood\u2013brain barrier water exchange rate using diffusion-prepared and multi-echo arterial spin labelling: Comparison of quantitative values and age dependence","volume":"37","author":"Morgan","year":"2024","journal-title":"NMR Biomed."},{"key":"10.1016\/j.neubiorev.2026.106658_bib144","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/0091217419838105","article-title":"Role of quetiapine in protection of neurodegeneration after traumatic brain injury","volume":"55","author":"Morra","year":"2019","journal-title":"Int. J. Psychiatry Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib145","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1132077","article-title":"Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective","author":"Moyaert","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000470802","article-title":"Neuroprogression in Schizophrenia and Psychotic Disorders: The Possible Role of Inflammation","volume":"31","author":"M\u00fcller","year":"2017","journal-title":"Mod. Trends Pharm."},{"key":"10.1016\/j.neubiorev.2026.106658_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2017.00118","article-title":"Insulin resistance as a link between amyloid-beta and tau pathologies in Alzheimer's disease","author":"Mullins","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib148","doi-asserted-by":"crossref","first-page":"747","DOI":"10.30773\/pi.2018.05.26","article-title":"The staging of major mood disorders: Clinical and neurobiological correlates","volume":"15","author":"Muneer","year":"2018","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.neubiorev.2026.106658_bib149","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11154-012-9229-1","article-title":"Role of insulin resistance in endothelial dysfunction","volume":"14","author":"Muniyappa","year":"2013","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/apha.12250","article-title":"The neurovascular unit \u2013 concept review","volume":"210","author":"Muoio","year":"2014","journal-title":"Acta Physiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib151","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1007\/s00018-019-03174-6","article-title":"MMPs and ADAMs in neurological infectious diseases and multiple sclerosis","volume":"76","author":"Muri","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33160\/yam.2024.02.001","article-title":"Roles of Microglia in Neurodegenerative Diseases","volume":"67","author":"Nakaso","year":"2024","journal-title":"Yonago Acta Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib153","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib154","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1476-5381.2011.01557.x","article-title":"Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: Clinical significance of in vitro and in vivo findings","volume":"165","author":"O'Brien","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib155","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.2174\/1570159X18666200528143301","article-title":"The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target","volume":"18","author":"Okada","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib156","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1743-8977-10-62","article-title":"Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice","volume":"10","author":"Oppenheim","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib157","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nn.3161","article-title":"Immune surveillance in the central nervous system","volume":"15","author":"Ousman","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib158","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neurobiolaging.2024.12.012","article-title":"Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study","volume":"147","author":"Padrela","year":"2025","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib159","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1017\/S1092852921000018","article-title":"Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review","volume":"27","author":"Palagini","year":"2022","journal-title":"CNS Spectr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrn3468","article-title":"Aquaporin water channels in the nervous system","volume":"14","author":"Papadopoulos","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib161","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/19490976.2019.1638722","article-title":"Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health","volume":"11","author":"Parker","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neubiorev.2026.106658_bib162","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/acps.12581","article-title":"Areas of controversy in neuroprogression in bipolar disorder","volume":"134","author":"Passos","year":"2016","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.neubiorev.2026.106658_bib163","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/708306","article-title":"Disruption in the blood-brain barrier: The missing link between brain and body inflammation in bipolar disorder?","author":"Patel","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.neubiorev.2026.106658_bib164","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1503\/jpn.220218","article-title":"Barrier\u2013environment interactions along the gut\u2013brain axis and their influence on cognition and behaviour throughout the lifespan","volume":"48","author":"Paton","year":"2023","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2316006121","article-title":"Synergistic induction of blood\u2013brain barrier properties","volume":"121","author":"Porkol\u00e1b","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib166","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neubiorev.2007.04.003","article-title":"Kindling and sensitization as models for affective episode recurrence, cyclicity, and tolerance phenomena","volume":"31","author":"Post","year":"2007","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib167","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jpsychires.2012.02.004","article-title":"Neurobiological correlates of illness progression in the recurrent affective disorders","volume":"46","author":"Post","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib168","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn.4475","article-title":"The role of peripheral immune cells in the CNS in steady state and disease","volume":"20","author":"Prinz","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib169","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190062","article-title":"The blood\u2013brain barrier in health and disease: Important unanswered questions","volume":"217","author":"Profaci","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib170","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1504555","article-title":"Neuroinflammation and major depressive disorder: astrocytes at the crossroads","author":"Puentes-Orozco","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib171","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10715760902751902","article-title":"Involvement of ROS in BBB dysfunction","volume":"43","author":"Pun","year":"2009","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib172","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241226551","article-title":"Recent advances in tissue repair of the blood-brain barrier after stroke","author":"Qi","year":"2024","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.neubiorev.2026.106658_bib173","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2174\/13894501113149990156","article-title":"Astrocyte pathology in Major Depressive Disorder: Insights from human postmortem brain tissue","volume":"14","author":"Rajkowska","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neubiorev.2026.106658_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183330","article-title":"Post-translational modifications of tight junction transmembrane proteins and their direct effect on barrier function","volume":"1862","author":"Reiche","year":"2020","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Biomembr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib175","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1177\/0271678X16655551","article-title":"Matrix metalloproteinases in the brain and blood-brain barrier: Versatile breakers and makers","volume":"36","author":"Rempe","year":"2016","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib176","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/TA.0000000000002011","article-title":"Quetiapine protects the blood-brain barrier in traumatic brain injury","volume":"85","author":"Robinson","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.neubiorev.2026.106658_bib177","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/s41598-020-64349-x","article-title":"Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles","volume":"10","author":"Rom","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106658_bib178","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1177\/0271678X20951995","article-title":"Regulation of blood\u2013brain barrier integrity by microglia in health and disease: A therapeutic opportunity","volume":"40","author":"Ronaldson","year":"2020","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib179","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106658_bib180","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12987-023-00499-0","article-title":"Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures","volume":"20","author":"Rowsthorn","year":"2023","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neubiorev.2026.106658_bib181","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.2147\/NDT.S177973","article-title":"Neuroprogression: The hidden mechanism of depression","volume":"14","author":"Ruiz","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neubiorev.2026.106658_bib182","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biocel.2015.04.005","article-title":"Glycolysis-mediated control of blood-brain barrier development and function","volume":"64","author":"Salmina","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib183","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib184","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/brain\/awf257","article-title":"Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain","volume":"125","author":"Schoch","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2026.106658_bib185","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.ajpath.2021.03.015","article-title":"Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases","volume":"191","author":"Schoemaker","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib186","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tins.2020.12.002","article-title":"Blood\u2013Brain Barrier Dynamics to Maintain Brain Homeostasis","volume":"44","author":"Segarra","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib187","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jconrel.2022.08.051","article-title":"Recent advances in drug delivery and targeting to the brain","volume":"350","author":"Sethi","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.neubiorev.2026.106658_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2023.111761","article-title":"Higher Blood-brain barrier permeability in patients with major depressive disorder identified by DCE-MRI imaging","volume":"337","author":"Shang","year":"2024","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib189","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1002\/mrm.27632","article-title":"Mapping water exchange across the blood\u2013brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI","volume":"81","author":"Shao","year":"2019","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib190","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.571480","article-title":"Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort","author":"Shao","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib191","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mric.2020.09.003","article-title":"High-Resolution Neurovascular Imaging at 7 T: Arterial Spin Labeling Perfusion, 4-Dimensional MR Angiography, and Black Blood MR Imaging","volume":"29","author":"Shao","year":"2021","journal-title":"Magn. Reson. Imaging Clin. North Am."},{"key":"10.1016\/j.neubiorev.2026.106658_bib192","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/mrm.29581","article-title":"Quantification of blood\u2013brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling","volume":"89","author":"Shao","year":"2023","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib193","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101297R","article-title":"Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues","volume":"36","author":"Sheikh","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.neubiorev.2026.106658_bib194","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.neubiorev.2026.106658_bib195","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/JLB.1RU1117-428R","article-title":"Blood\u2013brain barrier and its function during inflammation and autoimmunity","volume":"103","author":"Sonar","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib196","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162497","article-title":"Mechanisms Underlying Interferon-\u03b3-Induced Priming of Microglial Reactive Oxygen Species Production","volume":"11","author":"Spencer","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.neubiorev.2026.106658_bib197","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib198","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41398-024-02740-2","article-title":"Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids","volume":"14","author":"Stankovic","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib199","doi-asserted-by":"crossref","DOI":"10.2214\/AJR.23.30036","article-title":"Update on Gadolinium-Based Contrast Agent Safety, From the AJR Special Series on Contrast Media","volume":"223","author":"Starekova","year":"2024","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib200","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nn.4288","article-title":"Pericytes of the neurovascular unit: Key functions and signaling pathways","volume":"19","author":"Sweeney","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib201","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/s41593-018-0234-x","article-title":"The role of brain vasculature in neurodegenerative disorders","volume":"21","author":"Sweeney","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib202","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain Barrier: From Physiology to Disease and Back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib203","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.bbrc.2013.03.036","article-title":"Metformin induces up-regulation of blood\u2013brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells","volume":"433","author":"Takata","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neubiorev.2026.106658_bib204","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/bdi.12962","article-title":"Regulatory effect of lithium on hippocampal blood-brain barrier integrity in a rat model of depressive-like behavior","volume":"23","author":"Taler","year":"2021","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib206","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cardiores.2004.12.002","article-title":"The biology of vascular endothelial growth factors","volume":"65","author":"Tammela","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib207","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.2147\/IDR.S254403","article-title":"The impact of gut microbiota disorders on the blood\u2013brain barrier","volume":"13","author":"Tang","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.neubiorev.2026.106658_bib208","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12272-021-01332-8","article-title":"Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders","volume":"44","author":"Uprety","year":"2021","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/j.neubiorev.2026.106658_bib209","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00406-020-01152-9","article-title":"Serum zonulin and claudin-5 levels in patients with schizophrenia","volume":"271","author":"Usta","year":"2021","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib210","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00930","article-title":"Impact of metabolic syndrome on neuroinflammation and the blood\u2013brain barrier","author":"Van Dyken","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib211","doi-asserted-by":"crossref","first-page":"H693","DOI":"10.1152\/ajpheart.00570.2017","article-title":"Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer\u2019s disease and vascular cognitive impairment","volume":"314","author":"Van Skike","year":"2017","journal-title":"Am. J. Physiol. -Heart Circ. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib212","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1176\/appi.ajp.2012.12050620","article-title":"Metabolic syndrome and metabolic abnormalities in bipolar disorder: a meta-analysis of prevalence rates and moderators","volume":"170","author":"Vancampfort","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106658_bib213","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143407","article-title":"Functional characterization of germline mutations in PDGFB and PDGFRB in primary familial brain calcification","volume":"10","author":"Vanlandewijck","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neubiorev.2026.106658_bib214","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1113\/JP276887","article-title":"Blood\u2013brain barrier permeability measured using dynamic contrast-enhanced magnetic resonance imaging: a validation study","volume":"597","author":"Varatharaj","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/imag_a_00324","article-title":"Measurement variability of blood\u2013brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging","volume":"2","author":"Varatharaj","year":"2024","journal-title":"Imaging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib216","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0271678X211056395","article-title":"Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development","volume":"42","author":"Vazquez-Liebanas","year":"2022","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib217","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jmri.28989","article-title":"Blood\u2013brain barrier disruption and perivascular spaces in small vessel disease and neurodegenerative diseases: a review on MRI methods and insights","volume":"59","author":"Voorter","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.neubiorev.2026.106658_bib218","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10061249","article-title":"One molecule for mental nourishment and more: glucose transporter type 1\u2014biology and deficiency syndrome","author":"Vulturar","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neubiorev.2026.106658_bib219","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-023-00627-2","article-title":"The role of peripheral inflammatory insults in Alzheimer\u2019s disease: a review and research roadmap","volume":"18","author":"Walker","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neubiorev.2026.106658_bib220","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.2337\/db13-0627","article-title":"Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport","volume":"62","author":"Wang","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2026.106658_bib221","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.jcbfm.9600398","article-title":"When perfusion meets diffusion: in vivo measurement of water permeability in human brain","volume":"27","author":"Wang","year":"2007","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neubiorev.2026.106658_bib222","article-title":"Increasing of Blood Brain Barrier Permeability and the Association With Depression and Anxiety in Systemic Lupus Erythematosus Patients","author":"Wang","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.neubiorev.2026.106658_bib223","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/aps.2011.140","article-title":"Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models","volume":"32","author":"Wang","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neubiorev.2026.106658_bib224","doi-asserted-by":"crossref","first-page":"673415","DOI":"10.3389\/fbioe.2021.673415","article-title":"Targeting microRNAs to Regulate the Integrity of the Blood-Brain Barrier","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib225","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.bbamem.2008.10.022","article-title":"The blood-brain barrier in brain homeostasis and neurological diseases","volume":"1788","author":"Weiss","year":"2009","journal-title":"Biochim. Et. Biophys. Acta Biomembr."},{"key":"10.1016\/j.neubiorev.2026.106658_bib226","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106658_bib227","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1537-1891(02)00200-8","article-title":"Tight junctions of the blood\u2013brain barrier: development, composition and regulation","volume":"38","author":"Wolburg","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib228","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/brainsci11020228","article-title":"Biological pathways associated with neuroprogression in bipolar disorder","volume":"11","author":"Wollenhaupt-Aguiar","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib229","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jad.2022.11.058","article-title":"Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder","volume":"323","author":"Wu","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2026.106658_bib230","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114820","article-title":"Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain","volume":"197","author":"Wu","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.neubiorev.2026.106658_bib231","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1007\/s10571-021-01153-9","article-title":"Blood\u2013brain barrier dysfunction in the pathogenesis of major depressive disorder","volume":"42","author":"Wu","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib232","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.3390\/ijms22147710","article-title":"Blood\u2013brain barrier and neurodegenerative diseases\u2014modeling with ipsc-derived brain cells","volume":"22","author":"Wu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib233","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","article-title":"Vascular and Cellular Pathophysiology of Stroke: neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neubiorev.2026.106658_bib234","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1013933","article-title":"New insight into neurological degeneration: Inflammatory cytokines and blood\u2013brain barrier","author":"Yang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib235","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1161\/STROKEAHA.110.608257","article-title":"Blood\u2013brain barrier breakdown in acute and chronic cerebrovascular disease","volume":"42","author":"Yang","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.neubiorev.2026.106658_bib236","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1286351","article-title":"Emerging diagnostic markers and therapeutic targets in post-stroke hemorrhagic transformation and brain edema","author":"Yao","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib237","article-title":"Blood\u2013brain barrier endothelial cells in neurodegenerative diseases: Signals from the \u201cbarrier","author":"Yuan","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib238","article-title":"ThE Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases","author":"Zang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106658_bib239","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106461","article-title":"T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease","volume":"193","author":"Zeng","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neubiorev.2026.106658_bib240","doi-asserted-by":"crossref","first-page":"382","DOI":"10.30773\/pi.2022.0234","article-title":"Evaluation oF Serum Zonulin and Occludin Levels in Bipolar Disorder","volume":"20","author":"Zengil","year":"2023","journal-title":"Psychiatry Investig."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106658_bib241","first-page":"1","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther. 2023"},{"key":"10.1016\/j.neubiorev.2026.106658_bib242","article-title":"Blood-brain barrier dysfunction in bipolar disorder: molecular mechanisms and clinical implications","author":"Zhao","year":"2022","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.neubiorev.2026.106658_bib243","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and dysfunction of the blood-brain barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106658_bib244","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s40262-015-0310-2","article-title":"Reliability of in vitro and in vivo methods for predicting the effect of P-glycoprotein on the delivery of antidepressants to the brain","volume":"55","author":"Zheng","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.neubiorev.2026.106658_bib245","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neubiorev.2026.106658_bib246","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426001156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426001156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:42:21Z","timestamp":1793598141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763426001156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":246,"alternative-id":["S0149763426001156"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106658","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of blood-brain barrier integrity in the pathophysiology and progression of psychiatric disorders","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106658"}}