{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:04:03Z","timestamp":1790258643073,"version":"4.1.0"},"reference-count":184,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,27]],"date-time":"2027-08-27T00:00:00Z","timestamp":1819324800000},"content-version":"am","delay-in-days":299,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-21-1-2201"],"award-info":[{"award-number":["N00014-21-1-2201"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG059809"],"award-info":[{"award-number":["R01AG059809"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA056813"],"award-info":[{"award-number":["R21DA056813"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience &amp; Biobehavioral Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.neubiorev.2026.106924","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:35:21Z","timestamp":1787700921000},"page":"106924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oxytocin as regulator of stress and inflammation in aging"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-5630","authenticated-orcid":false,"given":"Kylie A.","family":"Wright","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Horta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie C.","family":"Ebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2026.106924_bib1","doi-asserted-by":"crossref","DOI":"10.1177\/2470547017704763","article-title":"Chronic pain and chronic stress: two sides of the same coin?","volume":"1","author":"Abdallah","year":"2017","journal-title":"Chronic Stress."},{"key":"10.1016\/j.neubiorev.2026.106924_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exger.2010.08.023","article-title":"HPA axis responsiveness to stress: implications for healthy aging","volume":"46","author":"Aguilera","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/ijms23020616","article-title":"Neuroinflammation: A potential risk for dementia","volume":"23","author":"Ahmad","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.euroneuro.2020.11.014","article-title":"Changes in endogenous oxytocin levels after intranasal oxytocin treatment in adult men with autism: An exploratory study with long-term follow-up","volume":"43","author":"Alaerts","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1134\/S002209301904001X","article-title":"Microglia of the brain: origin, structure, functions","volume":"55","author":"Alekseeva","year":"2019","journal-title":"J. Evolut. Biochem. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1037\/amp0000597","article-title":"Charting adult development through (historically changing) daily stress processes","volume":"75","author":"Almeida","year":"2020","journal-title":"Am. Psychol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00018-023-04775-y","article-title":"Aging microglia","volume":"80","author":"Antignano","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.11.011","article-title":"Behavioral insights from mouse models of forebrain- and amygdala-specific glucocorticoid receptor genetic disruption","volume":"336","author":"Arnett","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib9","article-title":"The need to better understand aging and risk factors for dementia","volume":"2","author":"Arvanitakis","year":"2023","journal-title":"Front. Dement."},{"key":"10.1016\/j.neubiorev.2026.106924_bib10","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1210\/jc.2018-02036","article-title":"Endogenous oxytocin levels in relation to food intake, menstrual phase, and age in females","volume":"104","author":"Aulinas","year":"2018","journal-title":"J. Clin. Endocrinol. & Metab."},{"key":"10.1016\/j.neubiorev.2026.106924_bib11","first-page":"301","article-title":"Social effects of oxytocin in humans: context and person matter","volume":"15","author":"Bartz","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2046-2395-2-8","article-title":"Understanding how we age: insights into inflammaging","volume":"2","author":"Baylis","year":"2013","journal-title":"Longev. & Health"},{"key":"10.1016\/j.neubiorev.2026.106924_bib13","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fimmu.2014.00136","article-title":"The HPA \u2013 immune axis and the immunomodulatory actions of glucocorticoids in the brain","volume":"5","author":"Bellavance","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.psyneuen.2019.03.027","article-title":"Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males","volume":"106","author":"Berends","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yfrne.2011.01.002","article-title":"v. Acute effects of steroid hormones and neuropeptides on human social\u2013emotional behavior: A review of single administration studies","volume":"33","author":"Bos","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer's disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ddr.21343","article-title":"Effects of intranasal oxytocin on long-term memory in healthy humans: A systematic review","volume":"77","author":"Brambilla","year":"2016","journal-title":"Drug. Dev. Res."},{"key":"10.1016\/j.neubiorev.2026.106924_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41514-023-00120-6","article-title":"Assessing cognitive decline in the aging brain: lessons from rodent and human studies","volume":"9","author":"Brito","year":"2023","journal-title":"npj Aging"},{"key":"10.1016\/j.neubiorev.2026.106924_bib19","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.tins.2024.08.015","article-title":"The multiple roles of chronic stress and glucocorticoids in Alzheimer's disease pathogenesis","volume":"47","author":"Burke","year":"2024","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112704","article-title":"Oxytocin reduces post-stress sweet snack intake in women without attenuating salivary cortisol","volume":"212","author":"Burmester","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neubiorev.2026.106924_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/7854_2017_6","article-title":"Molecular basis of oxytocin receptor signalling in the brain: What we know and what we need to know","volume":"35","author":"Busnelli","year":"2018","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3233\/JAD-191092","article-title":"The prevalence of dementia: A systematic review and meta-analysis","volume":"73","author":"Cao","year":"2020","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.neubiorev.2026.106924_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.psyneuen.2014.07.014","article-title":"A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health","volume":"49","author":"Cardoso","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib24","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jagp.2018.05.004","article-title":"Perceived stress is associated with accelerated monocyte\/macrophage aging trajectories in clinically normal adults","volume":"26","author":"Casaletto","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/c105dab8-59b8-467a-9223-5bd92936e49a","article-title":"Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA\u2081 receptor knockout mice","volume":"6","author":"Castilla-Ortega","year":"2011","journal-title":"PLoS. One"},{"key":"10.1016\/j.neubiorev.2026.106924_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.01.017","article-title":"Chronic peripheral inflammation, hippocampal neurogenesis, and behavior","volume":"58","author":"Chesnokova","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.biopsych.2013.08.029","article-title":"Learning about oxytocin: Pharmacologic and behavioral issues","volume":"76","author":"Chini","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12877-023-03848-8","article-title":"Midlife perceived stress is associated with cognitive decline across three decades","volume":"23","author":"Christensen","year":"2023","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.neubiorev.2026.106924_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2008.07.002","article-title":"Molecular inflammation: Underpinnings of aging and age-related diseases","volume":"8","author":"Chung","year":"2009","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib30","doi-asserted-by":"crossref","first-page":"E686","DOI":"10.1152\/ajpendo.90263.2008","article-title":"Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men","volume":"295","author":"Clodi","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2026.106924_bib31","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1080\/10826084.2019.1608250","article-title":"The relationship between tobacco smoking, cortisol secretion, and sleep continuity","volume":"54","author":"Cohen","year":"2019","journal-title":"Subst. Use & Misuse"},{"key":"10.1016\/j.neubiorev.2026.106924_bib32","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1080\/17470919.2017.1418428","article-title":"Oxytocin regulates social approach","volume":"13","author":"Cohen","year":"2018","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib33","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk","volume":"109","author":"Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2509977122","article-title":"Oxytocin varies across the life course in a sex-specific way in a human subsistence population","volume":"122","author":"Colby","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib36","first-page":"1","article-title":"Ambulatory assessment: Methods for studying everyday life","author":"Conner","year":"2015","journal-title":"Emerg. Trends Social. Behav. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib37","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/REVNEURO.2008.19.6.395","article-title":"Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis","volume":"19","author":"Conrad","year":"2008","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib38","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/REVNEURO.2008.19.6.395","article-title":"Chronic stress-induced hippocampal vulnerability: The glucocorticoid vulnerability hypothesis","volume":"19","author":"Conrad","year":"2008","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib39","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fnhum.2022.736688","article-title":"Chronic Pain in the Elderly: mechanisms and perspectives","volume":"16","author":"Dagnino","year":"2022","journal-title":"Front. Human. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/0269881111400642","article-title":"Anxiolytic-like effect of oxytocin in the simulated public speaking test","volume":"26","author":"de Oliveira","year":"2012","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib41","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.neubiorev.2010.11.007","article-title":"The Adaptive Calibration Model of stress responsivity","volume":"35","author":"Del Giudice","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib42","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/biomedicines13020279","article-title":"Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer\u2019s Disease Therapeutics","volume":"13","author":"Dias","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.neubiorev.2026.106924_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.669891","article-title":"Glucocorticoids as regulators of macrophage-mediated tissue homeostasis","volume":"12","author":"Diaz-Jimenez","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2022.08.011","article-title":"Effects of intranasal oxytocin and positive couple interaction on immune factors in skin wounds","volume":"107","author":"Ditzen","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11920-019-0993-4","article-title":"Links between stress, sleep, and inflammation: Are there sex differences?","volume":"21","author":"Dolsen","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neubiorev.2026.106924_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fnagi.2015.00175","article-title":"Oxytocin modulates meta-mood as a function of age and sex","volume":"7","author":"Ebner","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.psyneuen.2016.03.013","article-title":"Oxytocin\u2019s effect on resting-state functional connectivity varies by age and sex","volume":"69","author":"Ebner","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib48","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fnhum.2013.00487","article-title":"Oxytocin and socioemotional aging: Current knowledge and future trends","volume":"7","author":"Ebner","year":"2013","journal-title":"Front. Human. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib49","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fpsyg.2014.01595","article-title":"Hormones as \u201cdifference makers\u201d in cognitive and socioemotional aging processes","volume":"5","author":"Ebner","year":"2015","journal-title":"Front. Psychol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib50","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s11064-022-03624-x","article-title":"Intranasal Oxytocin attenuates cognitive impairment, \u03b2-amyloid burden and tau deposition in female rats with Alzheimer's disease: interplay of ERK1\/2\/GSK3\u03b2\/Caspase-3","volume":"47","author":"El-Ganainy","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2026.106924_bib51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s43066-021-00111-w","article-title":"Hepatic ischemia reperfusion injury: effect of moderate intensity exercise and oxytocin compared to l-arginine in a rat model","volume":"11","author":"Elkady","year":"2021","journal-title":"Egypt. Liver J."},{"key":"10.1016\/j.neubiorev.2026.106924_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2021.101985","article-title":"Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation","volume":"86","author":"Ellis","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib53","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/npp.2015.123","article-title":"Amygdala\u2013hippocampal connectivity changes during acute psychosocial stress: Joint effect of early life stress and oxytocin","volume":"40","author":"Fan","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib54","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1212\/WNL.0000000000001133","article-title":"Oxytocin for frontotemporal dementia","volume":"84","author":"Finger","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib55","series-title":"Stress: Concepts, Cognition, Emotion, and Behavior","first-page":"3","author":"Fink","year":"2016"},{"key":"10.1016\/j.neubiorev.2026.106924_bib56","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. New. Y. Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib57","doi-asserted-by":"crossref","unstructured":"Franceschi, C. et al. 2018 Inflammaging : an update and a model. Seminars in immunology. 1-5. https:\/\/doi.org\/10.1016\/j.smim.2018.10.008.","DOI":"10.1016\/j.smim.2018.10.008"},{"key":"10.1016\/j.neubiorev.2026.106924_bib58","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nurpra.2014.08.005","article-title":"Inflammaging: a concept analysis","volume":"11","author":"Frank","year":"2015","journal-title":"J. Nurse Pract."},{"key":"10.1016\/j.neubiorev.2026.106924_bib59","doi-asserted-by":"crossref","first-page":"10250","DOI":"10.3390\/ijms221910250","article-title":"Targeting the oxytocinergic system: a possible pharmacological strategy for the treatment of inflammation occurring in different chronic diseases","volume":"22","author":"Friuli","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib60","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: structure, function, and regulation","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib61","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fendo.2013.00026","article-title":"Stress responsiveness of the hypothalamic-pituitary-adrenal axis: age-related features of the vasopressinergic regulation","volume":"4","author":"Goncharova","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib62","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s11482-024-10274-4","article-title":"Why do middle-aged adults report worse mental health and wellbeing than younger adults? An exploratory network analysis of the Swiss Household Panel Data","volume":"19","author":"Gondek","year":"2024","journal-title":"Appl. Res. Qual. Life"},{"key":"10.1016\/j.neubiorev.2026.106924_bib63","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2021.0059","article-title":"Oxytocin and microglia in the development of social behaviour","volume":"377","author":"Gonzalez","year":"2022","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib64","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib65","series-title":"Models, Molecules and Mechanisms in Biogerontology: Physiological Abnormalities, Diseases and Interventions","first-page":"241","article-title":"Role of stress and hormones of the hypothalamic-pituitary-adrenal (hpa) axis in aging","author":"Gupta","year":"2019"},{"key":"10.1016\/j.neubiorev.2026.106924_bib66","first-page":"1495","article-title":"Hypothalamic-pituitary-adrenal (HPA) axis and aging","author":"Gupta","year":"2014","journal-title":"Compr. Physiol. 4"},{"key":"10.1016\/j.neubiorev.2026.106924_bib67","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0006-3223(03)00465-7","article-title":"Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress","volume":"54","author":"Heinrichs","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41577-024-01104-7","article-title":"Neuroinflammation in Alzheimer disease","volume":"25","author":"Heneka","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib69","article-title":"Stressful life events across the lifespan and inflammation: An integrative data analysis","volume":"41","author":"Hillmann","year":"2024","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.neubiorev.2026.106924_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2019.10.012","article-title":"Chronic oxytocin administration as a tool for investigation and treatment: A cross-disciplinary systematic review","volume":"108","author":"Horta","year":"2020","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib71","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/cns.13262","article-title":"Update of inflammasome activation in microglia\/macrophage in aging and aging-related disease","volume":"25","author":"Hu","year":"2019","journal-title":"CNS Neurosci. & Ther."},{"key":"10.1016\/j.neubiorev.2026.106924_bib72","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroimage.2018.02.035","article-title":"Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males","volume":"174","author":"Ide","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.neubiorev.2026.106924_bib73","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/13607863.2020.1742656","article-title":"Stress diagnoses in midlife and risk of dementia: a register-based follow-up study","volume":"25","author":"Islamoska","year":"2021","journal-title":"Aging Ment. Health"},{"key":"10.1016\/j.neubiorev.2026.106924_bib74","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/0963721412461500","article-title":"Improving acute stress responses:the power of reappraisal","volume":"22","author":"Jamieson","year":"2013","journal-title":"Curr. Dir. Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib75","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/biomedicines8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.neubiorev.2026.106924_bib76","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1523\/JNEUROSCI.1345-14.2015","article-title":"Oxytocin Regulates Stress-induced Crf gene transcription through CREB-regulated transcription coactivator 3","volume":"35","author":"Jurek","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yebeh.2013.10.020","article-title":"Early-life stress and HPA axis trigger recurrent adulthood depression","volume":"38","author":"Juruena","year":"2014","journal-title":"Epilepsy & Behav."},{"key":"10.1016\/j.neubiorev.2026.106924_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2023.102352","article-title":"Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: A mechanistic graphical review","volume":"101","author":"Kamrani-Sharif","year":"2023","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neubiorev.2026.106924_bib79","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10787-024-01635-4","article-title":"Stimulation, regulation, and inflammaging interventions of natural compounds on nuclear factor kappa B (NF-kB) pathway: a comprehensive review","volume":"33","author":"Kannan","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib80","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209510","article-title":"A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks","volume":"16","author":"Karin","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib81","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.3390\/ijms22147737","article-title":"The effects of oxytocin on appetite regulation, food intake and metabolism in humans","volume":"22","author":"Kerem","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib82","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer's. & Dement. Transl. Res. & Clin. Interv."},{"key":"10.1016\/j.neubiorev.2026.106924_bib83","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000119004","article-title":"The \u2018Trier Social Stress Test\u2019 \u2013 A tool for investigating psychobiological stress responses in a laboratory setting","volume":"28","author":"Kirschbaum","year":"2008","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib84","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.3390\/cells12232726","article-title":"The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders","volume":"12","author":"Knezevic","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.neubiorev.2026.106924_bib85","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/ijms18040769","article-title":"Old Maids: Aging and its impact on microglia function","volume":"18","author":"Koellhoffer","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib86","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbi.2014.12.024","article-title":"Stress-induced modulation of NF-\u03baB activation, inflammation-associated gene expression, and cytokine levels in blood of healthy men","volume":"46","author":"Kuebler","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib87","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fnins.2013.00083","article-title":"Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience","volume":"7","author":"Kumsta","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpnec.2022.100166","article-title":"Serum oxytocin correlated with later logical memory in older Japanese women: A 7-year follow-up study","volume":"13","author":"Kunitake","year":"2023","journal-title":"Compr. Psychoneuroendocrinol"},{"key":"10.1016\/j.neubiorev.2026.106924_bib89","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/15427609.2015.1068048","article-title":"Mind the gap in the middle: A call to study midlife","volume":"12","author":"Lachman","year":"2015","journal-title":"Res. Hum. Dev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib90","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/JGP.0b013e31826573cf","article-title":"Stress, inflammation, and aging","volume":"20","author":"Lavretsky","year":"2012","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib91","series-title":"Perspectives in interactional psychology","first-page":"287","article-title":"Stress-related transactions between person and environment","author":"Lazarus","year":"1978"},{"key":"10.1016\/j.neubiorev.2026.106924_bib92","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/ijms26072940","article-title":"Chronic stress-associated depressive disorders: The impact of HPA axis dysregulation and neuroinflammation on the hippocampus-A mini review","volume":"26","author":"Lei","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib93","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib94","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3389\/fnhum.2017.00316","article-title":"Inflammation: The common pathway of stress-related diseases","volume":"11","author":"Liu","year":"2017","journal-title":"Front. Human. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib95","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s11121-022-01385-1","article-title":"Is stress an overlooked risk factor for dementia? A systematic review from a lifespan developmental perspective","volume":"24","author":"Luo","year":"2023","journal-title":"Prev. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib96","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.psyneuen.2011.02.015","article-title":"A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research","volume":"36","author":"MacDonald","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110600","article-title":"Identification of oxytocin expression in human and murine microglia","volume":"119","author":"Maejima","year":"2022","journal-title":"Progress. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib98","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/1073858420960111","article-title":"Oxytocin and the Neurobiology of Prosocial Behavior","volume":"27","author":"Marsh","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neubiorev.2026.106924_bib99","series-title":"Stress: Immunology and inflammation","first-page":"99","author":"Matovic","year":"2024"},{"key":"10.1016\/j.neubiorev.2026.106924_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.07.046","article-title":"Oxytocin and Ssress: neural mechanisms, stress-related disorders, and therapeutic approaches","volume":"417","author":"Matsushita","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2026.106924_bib101","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00213-019-05392-z","article-title":"The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm","volume":"237","author":"McClure","year":"2020","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib102","series-title":"Stress challenges and immunity in space: From mechanisms to monitoring and preventive strategies","first-page":"19","author":"McEwen","year":"2020"},{"key":"10.1016\/j.neubiorev.2026.106924_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.864007","article-title":"Oxytocin and related peptide hormones: Candidate anti-inflammatory therapy in early stages of sepsis","volume":"13","author":"Mehdi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib104","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.18632\/aging.102148","article-title":"Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age","volume":"11","author":"Mehdipour","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.neubiorev.2026.106924_bib105","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3233\/ADR-230013","article-title":"Pilot randomized, double-blind, placebo-controlled crossover trial evaluating the feasibility of an intranasal oxytocin in improving social cognition in individuals living with alzheimer's disease","volume":"7","author":"Michaelian","year":"2023","journal-title":"J. Alzheimers Dis. Rep."},{"key":"10.1016\/j.neubiorev.2026.106924_bib106","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1177\/1745691620921525","article-title":"How can intranasal oxytocin research be trusted? a systematic review of the interactive effects of intranasal oxytocin on psychosocial outcomes","volume":"15","author":"Mierop","year":"2020","journal-title":"Perspect. Psychol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib107","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1111\/brv.12750","article-title":"Chronic stress and Alzheimer's disease: the\u2009interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia","volume":"96","author":"Milligan Armstrong","year":"2021","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.neubiorev.2026.106924_bib108","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/bab.2216","article-title":"Chronic stress and Alzheimer's disease","volume":"69","author":"Mohammadi","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.neubiorev.2026.106924_bib109","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26146838","article-title":"Macrophages at the crossroads of chronic stress and cancer","volume":"26","author":"Mom\u010dilovi\u0107","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib110","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","article-title":"Blood-brain barrier breakdown in the aging human hippocampus","volume":"85","author":"Montagne","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106924_bib111","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3390\/biomedicines10092133","article-title":"Neuro-inflammaging and psychopathological distress","volume":"10","author":"Murdaca","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neubiorev.2026.106924_bib112","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/cimb47080632","article-title":"Oxytocin, vasopressin and stress: A hormetic perspective","volume":"47","author":"Nazarloo","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib113","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/npp.2016.185","article-title":"Microglia priming with aging and stress","volume":"42","author":"Niraula","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib114","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib115","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13049","article-title":"The oxytocin system and early-life experience-dependent plastic changes","volume":"33","author":"Onaka","year":"2021","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib116","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9050524","article-title":"Neuroinflammation in Alzheimer's Disease","volume":"9","author":"Onyango","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.neubiorev.2026.106924_bib117","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa081","article-title":"Oxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study","volume":"2","author":"Orihashi","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib118","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yfrne.2018.02.005","article-title":"The impact from the aftermath of chronic stress on hippocampal structure and function: Is there a recovery?","volume":"49","author":"Ortiz","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib119","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnagi.2019.00043","article-title":"High cortisol and the risk of dementia and alzheimer's disease: A review of the literature","volume":"11","author":"Ouanes","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib120","article-title":"Hypothalamic-pituitary-adrenal (HPA) Axis: Unveiling the potential mechanisms involved in stress-induced alzheimer\u2019s disease and depression","volume":"16","author":"P","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.neubiorev.2026.106924_bib121","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/j.2040-4603.2016.tb00722.x","article-title":"HPA axis Interactions with Behavioral Systems","volume":"6","author":"Packard","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib122","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3390\/jcm9051534","article-title":"Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin","volume":"9","author":"Panaro","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.neubiorev.2026.106924_bib123","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/00207454.2020.1831490","article-title":"Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer\u2019s patients and healthy persons","volume":"131","author":"Petekkaya","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104419","article-title":"Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition","volume":"110","author":"Plasencia","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib125","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2026.106924_bib126","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrendo.2013.183","article-title":"Glucocorticoid sensitivity in health and disease","volume":"9","author":"Quax","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib127","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.93","article-title":"Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment","volume":"5","author":"Quintana","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib128","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tics.2020.03.008","article-title":"An allostatic theory of oxytocin","volume":"24","author":"Quintana","year":"2020","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib129","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4155\/tde-2018-0002","article-title":"Evidence for intranasal oxytocin delivery to the brain: Recent advances and future perspectives","volume":"9","author":"Quintana","year":"2018","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.neubiorev.2026.106924_bib130","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/1570159X18666200807130637","article-title":"Neurodegenerative pathways in Alzheimer\u2019s Disease: A review","volume":"19","author":"Ramachandran","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib131","series-title":"Defining Prevention Science","first-page":"113","article-title":"Stressors and vulnerabilities in middle and old age: Opportunities for prevention","author":"Rebok","year":"2014"},{"key":"10.1016\/j.neubiorev.2026.106924_bib132","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbi.2024.07.001","article-title":"Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid","volume":"120","author":"Reed","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib133","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41398-024-03016-5","article-title":"The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study","volume":"14","author":"Ren","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104482","article-title":"Intranasal oxytocin enhances stress-protective effects of social support in women with negative childhood experiences during a virtual Trier Social Stress Test","volume":"111","author":"Riem","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib135","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.steroids.2016.09.010","article-title":"Glucocorticoid resistance in chronic diseases","volume":"115","author":"Rodriguez","year":"2016","journal-title":"Steroids"},{"key":"10.1016\/j.neubiorev.2026.106924_bib136","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41386-022-01305-5","article-title":"Oxytocin receptor expression patterns in the human brain across development","volume":"47","author":"Rokicki","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib137","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbi.2012.10.013","article-title":"A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation","volume":"27","author":"Rosenkranz","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106924_bib138","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00213-021-05862-3","article-title":"Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial","volume":"238","author":"Rung","year":"2021","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib139","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2016.07.005","article-title":"Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior","volume":"333","author":"S\u00e1nchez-Vida\u00f1a","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2026.106924_bib140","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.3390\/ijms21072484","article-title":"Effects of mindfulness-based interventions on biomarkers and low-grade inflammation in patients with psychiatric disorders: A meta-analytic review","volume":"21","author":"Sanada","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib141","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/edrv-7-3-284","article-title":"The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis*","volume":"7","author":"Sapolsky","year":"1986","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib142","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1001\/jamapsychiatry.2025.3705","article-title":"Intranasal oxytocin and physical intimacy for dermatological wound healing and neuroendocrine stress: A randomized clinical trial","volume":"83","author":"Schneider","year":"2026","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib143","article-title":"Microglia as central protagonists in the chronic stress response","volume":"9","author":"Schramm","year":"2022","journal-title":"Neurol. Neuroimmunol. &amp Neuroinflamm."},{"key":"10.1016\/j.neubiorev.2026.106924_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106545","article-title":"Oxytocin attenuates microglial activation and restores social and non-social memory in APP\/PS1 Alzheimer model mice","volume":"26","author":"Selles","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.neubiorev.2026.106924_bib145","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","author":"Shea","year":"2017","journal-title":"BMJ 358"},{"key":"10.1016\/j.neubiorev.2026.106924_bib146","article-title":"The Hypothalamic-pituitary-adrenal axis: Development, programming actions of hormones, and maternal-fetal interactions","volume":"14","author":"Sheng","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib147","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2012.06633.x","article-title":"Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction","volume":"1261","author":"Silverman","year":"2012","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib148","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40675-025-00322-2","article-title":"Sleep across the lifespan: A neurobehavioral perspective","volume":"11","author":"Simon","year":"2025","journal-title":"Curr. Sleep. Med. Rep."},{"key":"10.1016\/j.neubiorev.2026.106924_bib149","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/me.2005-0031","article-title":"Internalization and desensitization of the oxytocin receptor is inhibited by dynamin and clathrin mutants in human embryonic kidney 293 Cells","volume":"20","author":"Smith","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib150","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Bmj"},{"key":"10.1016\/j.neubiorev.2026.106924_bib151","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1038\/srep03440","article-title":"Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans","volume":"3","author":"Striepens","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106924_bib152","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fnagi.2014.00153","article-title":"Cortisol, cytokines, and hippocampal volume interactions in the elderly","volume":"6","author":"Sudheimer","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib153","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41380-021-01136-8","article-title":"Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective","volume":"27","author":"Surget","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib154","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1152\/ajpendo.00346.2016","article-title":"Regulation of the macrophage oxytocin receptor in response to inflammation","volume":"312","author":"Szeto","year":"2017","journal-title":"Am. J. Physiol. -Endocrinol. Metab."},{"key":"10.1016\/j.neubiorev.2026.106924_bib155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41380-022-01719-z","article-title":"Advances in human oxytocin measurement: challenges and proposed solutions","volume":"28","author":"Tabak","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106924_bib156","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/ijms23010150","article-title":"Roles of oxytocin in stress responses, allostasis and resilience","volume":"23","author":"Takayanagi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106924_bib157","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential roles of M1 and M2 microglia in neurodegenerative diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib158","first-page":"109","article-title":"Social responses to stress: The tend-and-befriend model","volume":"101","author":"Taylor","year":"2011","journal-title":"handbook stress science Biology psychology health"},{"key":"10.1016\/j.neubiorev.2026.106924_bib159","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/glia.22287","article-title":"Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices","volume":"60","author":"Tremblay","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.neubiorev.2026.106924_bib160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/EJPI.EJPI-D-23-00037","article-title":"The role of central oxytocin in autonomic regulation","volume":"67","author":"Tsai","year":"2024","journal-title":"J. Physiol. Investig."},{"key":"10.1016\/j.neubiorev.2026.106924_bib161","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/cen3.12307","article-title":"Microglia communication: Parallels between aging and Alzheimer's disease","volume":"7","author":"Udeochu","year":"2016","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib162","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1272270","article-title":"The Yin and Yang of the oxytocin and stress systems: opposites, yet interdependent and intertwined determinants of lifelong health trajectories","volume":"15","author":"Uvn\u00e4s-Moberg","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.neubiorev.2026.106924_bib163","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/brain\/aws371","article-title":"The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans","volume":"136","author":"Vachon-Presseau","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2026.106924_bib164","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-170239","article-title":"Impact of neuroinflammation on hippocampal neurogenesis: relevance to aging and Alzheimer\u2019s Disease","volume":"60","author":"Valero","year":"2017","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.neubiorev.2026.106924_bib165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neubiorev.2017.04.017","article-title":"The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis","volume":"78","author":"Valstad","year":"2017","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib166","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1080\/13607860802343134","article-title":"Diurnal cortisol patterns and stress reactivity in child Holocaust survivors reaching old age","volume":"12","author":"van der Hal-Van Raalte","year":"2008","journal-title":"Aging & Ment. Health"},{"key":"10.1016\/j.neubiorev.2026.106924_bib167","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ntr\/nty159","article-title":"effects of intranasal oxytocin on stress-induced cigarette craving in daily smokers","volume":"22","author":"Van Hedger","year":"2020","journal-title":"Nicotine & Tob. Res."},{"key":"10.1016\/j.neubiorev.2026.106924_bib168","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jesp.2016.03.004","article-title":"Pre-registration in social psychology\u2014A discussion and suggested template","volume":"67","author":"van 't Veer","year":"2016","journal-title":"J. Exp. Social. Psychol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib169","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6391686","article-title":"Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration","volume":"2016","author":"Vyas","year":"2016","journal-title":"Neural Plast."},{"key":"10.1016\/j.neubiorev.2026.106924_bib170","doi-asserted-by":"crossref","DOI":"10.1177\/17590914221100706","article-title":"Neural functions of hypothalamic oxytocin and its regulation","volume":"14","author":"Wang","year":"2022","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neubiorev.2026.106924_bib171","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3390\/cells11132091","article-title":"Microglia Phenotypes in Aging and Neurodegenerative Diseases","volume":"11","author":"Wendimu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.neubiorev.2026.106924_bib172","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106924_bib173","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1210\/endo.138.7.5255","article-title":"Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats","volume":"138","author":"Windle","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib174","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00441-018-2866-2","article-title":"The interplay between oxytocin and the CRF system: regulation of the stress response","volume":"375","author":"Winter","year":"2019","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.neubiorev.2026.106924_bib175","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s40750-014-0010-4","article-title":"Hormones, stress, and cognition: The effects of glucocorticoids and oxytocin on memory","volume":"1","author":"Wirth","year":"2015","journal-title":"Adapt. Human. Behav. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106924_bib176","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000381023","article-title":"Effects of intranasal oxytocin on steroid hormones in men and women","volume":"71","author":"Wirth","year":"2015","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neubiorev.2026.106924_bib177","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/cells9010070","article-title":"Autophagy and macrophage functions: Inflammatory response and phagocytosis","volume":"9","author":"Wu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neubiorev.2026.106924_bib178","doi-asserted-by":"crossref","first-page":"21822","DOI":"10.1021\/acsami.2c00007","article-title":"Oxytocin nanogels inhibit innate inflammatory response for early intervention in Alzheimer's disease","volume":"14","author":"Ye","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.neubiorev.2026.106924_bib179","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/jts.20228","article-title":"Ten-year follow-up study of cortisol levels in aging holocaust survivors with and without PTSD","volume":"20","author":"Yehuda","year":"2007","journal-title":"J. Trauma. Stress."},{"key":"10.1016\/j.neubiorev.2026.106924_bib180","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jpsychires.2008.12.003","article-title":"Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors","volume":"43","author":"Yehuda","year":"2009","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2026.106924_bib181","first-page":"83","article-title":"Chapter Three - Oxytocin and vasopressin in the hippocampus","volume":"118","author":"Zagrean","year":"2022"},{"key":"10.1016\/j.neubiorev.2026.106924_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101171","article-title":"Cortisol hypersecretion and the risk of Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"64","author":"Zheng","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neubiorev.2026.106924_bib183","article-title":"The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.neubiorev.2026.106924_bib184","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/10673220902996734","article-title":"The hypothalamic-pituitary-adrenal axis in borderline personality disorder: a review","volume":"17","author":"Zimmerman","year":"2009","journal-title":"Harv. Rev. Psychiatry"}],"container-title":["Neuroscience &amp; Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426003817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426003817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:39:15Z","timestamp":1790257155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763426003817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":184,"alternative-id":["S0149763426003817"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106924","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxytocin as regulator of stress and inflammation in aging","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106924"}}