{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:04:06Z","timestamp":1790258646187,"version":"4.1.0"},"reference-count":214,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007912","name":"Australian Government Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194910"],"award-info":[{"award-number":["1194910"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP200100757"],"award-info":[{"award-number":["DP200100757"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT250100563"],"award-info":[{"award-number":["FT250100563"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP260104251"],"award-info":[{"award-number":["DP260104251"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007631","name":"CIFAR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.neubiorev.2026.106933","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:27:43Z","timestamp":1787786863000},"page":"106933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The pathophysiology of depression in Huntington\u2019s disease"],"prefix":"10.1016","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0880-1558","authenticated-orcid":false,"given":"Tamrin","family":"Barta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Glikmann-Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McColgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Razi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1176\/appi.neuropsych.20220033","article-title":"Frequency and pathophysiology of apathy in huntington disease: a systematic review and meta-analysis","volume":"35","author":"Abdollah Zadegan","year":"2022","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.nurt.2008.01.008","article-title":"Symptomatic treatment of huntington disease","volume":"5","author":"Adam","year":"2008","journal-title":"Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1034\/j.1399-0004.2003.00157.x","article-title":"Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington\u2019s disease: psychological consequences after HD test","volume":"64","author":"Almqvist","year":"2003","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neubiorev.2026.106933_bib4","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association [APA] (Ed.). (2013). Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed). American Psychiatric Association.","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry-the methods","volume":"11","author":"Ashburner","year":"2000","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib6","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/s41467-021-23620-z","article-title":"A multicentre validation study of the diagnostic value of plasma neurofilament light","volume":"12","author":"Ashton","year":"2021","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib7","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/ejhg.2016.36","article-title":"22 Years of predictive testing for Huntington\u2019s disease: the experience of the UK Huntington\u2019s Prediction Consortium","volume":"24","author":"Baig","year":"2016","journal-title":"Eur. J. Human. Genet."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00702-012-0787-x","article-title":"Huntington\u2019s disease from the patient, caregiver and physician\u2019s perspectives: three sides of the same coin?","volume":"119","author":"Banaszkiewicz","year":"2012","journal-title":"J. Neural Transm."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41583-021-00513-0","article-title":"Sex differences in anxiety and depression: circuits and mechanisms","volume":"22","author":"Bangasser","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3233\/JHD-170246","article-title":"Analysis of participant withdrawal in huntington disease clinical trials","volume":"6","author":"Banno","year":"2017","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/08919887221090213","article-title":"Towards defining the neuroanatomical basis of late-onset psychiatric symptoms","volume":"35","author":"Barker","year":"2022","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/mds.70075","article-title":"Depression in premanifest huntington\u2019s disease: aberrant effective connectivity of striatum and default mode network","volume":"41","author":"Barta","year":"2025","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neubiorev.2026.106933_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"8","key":"10.1016\/j.neubiorev.2026.106933_bib14","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1038\/s41380-024-02524-6","article-title":"Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls","volume":"29","author":"Bavato","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib15","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.psychres.2010.04.030","article-title":"Earliest functional declines in Huntington disease","volume":"178","author":"Beglinger","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2026.106933_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroimage.2014.09.027","article-title":"Does resting-state connectivity reflect depressive rumination? A tale of two analyses","volume":"103","author":"Berman","year":"2014","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0165-1781(01)00257-8","article-title":"Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington\u2019s disease gene carriers","volume":"102","author":"Berrios","year":"2001","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3233\/JHD-220537","article-title":"The lived experiences of depression in Huntington\u2019s Disease: a qualitative study","volume":"11","author":"Bilal","year":"2022","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/acn3.52016","article-title":"Associations of inflammatory cytokines and cortisol with nonmotor features of Huntington\u2019s disease","volume":"11","author":"Bilal","year":"2024","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00415-023-11982-x","article-title":"The relationship between disease-specific psychosocial stressors and depressive symptoms in Huntington\u2019s disease","volume":"271","author":"Bilal","year":"2024","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1517\/14656566.8.2.141","article-title":"A systematic review of the treatment studies in Huntington\u2019s disease since 1990","volume":"8","author":"Bonelli","year":"2007","journal-title":"Expert. Opin. Pharmacother."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00004850-200411000-00004","article-title":"Neuroprotection in Huntington\u2019s disease: a 2-year study on minocycline","volume":"19","author":"Bonelli","year":"2004","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.biopsych.2019.03.001","article-title":"Cyclin-dependent kinase 5 dysfunction contributes to depression-like behaviors in huntington\u2019s disease by altering the DARPP-32 phosphorylation status in the nucleus accumbens","volume":"86","author":"Brito","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106933_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fnhum.2016.00317","article-title":"Corticostriatal dysfunction in Huntington\u2019s disease: the basics","volume":"10","author":"Bunner","year":"2016","journal-title":"Front. Human. Neurosci."},{"issue":"8","key":"10.1016\/j.neubiorev.2026.106933_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S1474-4422(17)30124-2","article-title":"Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington\u2019s disease: a retrospective cohort analysis","volume":"16","author":"Byrne","year":"2017","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib26","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.3221","article-title":"Longitudinal assessment of mental health disorders and comorbidities across 4 decades among participants in the dunedin birth cohort study","volume":"3","author":"Caspi","year":"2020","journal-title":"JAMA Netw. Open."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.214","article-title":"The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders","volume":"6","author":"Cattaneo","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington\u2019s disease","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"5\u20136","key":"10.1016\/j.neubiorev.2026.106933_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pneurobio.2006.11.001","article-title":"The corticostriatal pathway in Huntington\u2019s disease","volume":"81","author":"Cepeda","year":"2007","journal-title":"Progress. Neurobiol."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib30","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","article-title":"Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene","volume":"95","author":"Cha","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ijnp\/pyab068","article-title":"Neurofilament light chain is a novel biomarker for major depression and related executive dysfunction","volume":"25","author":"Chen","year":"2021","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/clpt.2010.296","article-title":"Quantification of cerebral blood flow as biomarker of drug effect: arterial spin labeling phMRI after a single dose of oral citalopram","volume":"89","author":"Chen","year":"2011","journal-title":"Clin. Pharmacol. & Ther."},{"key":"10.1016\/j.neubiorev.2026.106933_bib33","first-page":"1","article-title":"Aripiprazole in the treatment of Huntington\u2019s disease: a case series","volume":"5","author":"Ciammola","year":"2009","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/gte.2004.8.114","article-title":"Prevalence of major depression one year after predictive testing for Huntington\u2019s disease","volume":"8","author":"Codori","year":"2004","journal-title":"Genet. Test."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1176\/appi.neuropsych.21070191","article-title":"Apathy and depression in Huntington\u2019s disease: distinct longitudinal trajectories and clinical correlates","volume":"35","author":"Connors","year":"2022","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib36","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.parkreldis.2008.05.012","article-title":"Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington\u2019s disease","volume":"15","author":"Constantinescu","year":"2009","journal-title":"Park. & Relat. Disord."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib37","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s41380-019-0464-7","article-title":"Discovery and replication of cerebral blood flow differences in major depressive disorder","volume":"25","author":"Cooper","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib39","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/molecules25030482","article-title":"Huntington\u2019s disease: a review of the known PET imaging biomarkers and targeting radiotracers","volume":"25","author":"Cybulska","year":"2020","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib40","doi-asserted-by":"crossref","first-page":"7201","DOI":"10.1007\/s12035-018-0890-6","article-title":"Brain-derived neurotrophic factor prevents depressive-like behaviors in early-symptomatic YAC128 Huntington\u2019s disease mice","volume":"55","author":"da Fons\u00eaca","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychores.2015.11.003","article-title":"Disease stage, but not sex, predicts depression and psychological distress in Huntington\u2019s disease: a European population study","volume":"80","author":"Dale","year":"2016","journal-title":"J. Psychosom. Res."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mds.22837","article-title":"Validation of self-report depression rating scales in Huntington\u2019s disease","volume":"25","author":"De Souza","year":"2010","journal-title":"Mov. Disord."},{"issue":"S2","key":"10.1016\/j.neubiorev.2026.106933_bib43","doi-asserted-by":"crossref","first-page":"57s","DOI":"10.1016\/S0924-9338(98)80015-1","article-title":"The role of serotonin in depression and anxiety","volume":"13","author":"Deakin","year":"1998","journal-title":"Eur. Psychiatry"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tins.2011.11.005","article-title":"The neurobiology of anhedonia and other reward-related deficits","volume":"35","author":"Der-Avakian","year":"2012","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029522","article-title":"Characterization of a large group of individuals with Huntington disease and their relatives enrolled in the COHORT study","volume":"7","author":"Dorsey","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.neubiorev.2026.106933_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.603594","article-title":"Altered gut microbiota related to inflammatory responses in patients with Huntington\u2019s disease","volume":"11","author":"Du","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib47","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","article-title":"Psychiatric symptoms in Huntington\u2019s disease before diagnosis: the predict-HD study","volume":"62","author":"Duff","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib48","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1176\/jnp.2010.22.2.196","article-title":"Frontal\u201d behaviors before the diagnosis of Huntington\u2019s disease and its relationship to markers of disease progression: evidence of early lack of awareness","volume":"22","author":"Duff","year":"2010","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib49","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1037\/neu0000134","article-title":"Cognitive deficits predict poorer functional capacity in Huntington\u2019s disease: but what is being measured?","volume":"29","author":"Eddy","year":"2015","journal-title":"Neuropsychology"},{"key":"10.1016\/j.neubiorev.2026.106933_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2025.106074","article-title":"Prebiotics improve motor function, cognition and gut health in a preclinical model of Huntington\u2019s disease","volume":"130","author":"Ekwudo","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.expneurol.2012.02.003","article-title":"Altered ventral striatal activation during reward and punishment processing in premanifest Huntington\u2019s disease: a functional magnetic resonance study","volume":"235","author":"Enzi","year":"2012","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib52","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2217\/nmt.11.45","article-title":"Depression in the early stages of Huntington disease","volume":"1","author":"Epping","year":"2011","journal-title":"Neurodegener. Dis. Manag."},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib53","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jpsychires.2013.05.026","article-title":"Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study","volume":"47","author":"Epping","year":"2013","journal-title":"J. Psychiatr. Res."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib54","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1093\/brain\/awad275","article-title":"Genetic topography and cortical cell loss in Huntington\u2019s disease link development and neurodegeneration","volume":"146","author":"Estevez-Fraga","year":"2023","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib55","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1038\/s41467-025-60556-0","article-title":"Cell-specific mechanisms drive connectivity across the time course of Huntington\u2019s disease","volume":"16","author":"Estevez-Fraga","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib56","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000327754","article-title":"Suicidal behavior in prodromal Huntington disease","volume":"8","author":"Fiedorowicz","year":"2011","journal-title":"Neurodegener. Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.biopsych.2014.07.021","article-title":"Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress","volume":"77","author":"Francis","year":"2015","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib58","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1176\/appi.neuropsych.17080173","article-title":"Relationships among apathy, health-related quality of life, and function in Huntington\u2019s disease","volume":"30","author":"Fritz","year":"2018","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106933_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101900","article-title":"Specific patterns of brain alterations underlie distinct clinical profiles in Huntington\u2019s disease","volume":"23","author":"Garcia-Gorro","year":"2019","journal-title":"NeuroImage Clin."},{"issue":"24","key":"10.1016\/j.neubiorev.2026.106933_bib60","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant Huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/JHD-150160","article-title":"Neuropsychiatry and white matter microstructure in Huntington\u2019s disease","volume":"4","author":"Gregory","year":"2015","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"8","key":"10.1016\/j.neubiorev.2026.106933_bib62","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1111\/j.1460-9568.2005.04365.x","article-title":"Cognitive disorders and neurogenesis deficits in Huntington\u2019s disease mice are rescued by fluoxetine","volume":"22","author":"Grote","year":"2005","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib63","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac205","article-title":"Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington\u2019s disease mice","volume":"4","author":"Gubert","year":"2022","journal-title":"Brain Commun."},{"key":"10.1016\/j.neubiorev.2026.106933_bib64","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbi.2023.12.023","article-title":"Dietary fibre confers therapeutic effects in a preclinical model of Huntington\u2019s disease","volume":"116","author":"Gubert","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib65","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41583-019-0221-6","article-title":"The future of rodent models in depression research","volume":"20","author":"Gururajan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1186\/s12888-024-06051-0","article-title":"Neurofilament light chain as a promising biomarker for depression diagnosis: a systematic review and meta-analysis","volume":"24","author":"Habibzadeh","year":"2024","journal-title":"BMC Psychiatry"},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib67","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S2215-0366(15)00362-4","article-title":"Neurodevelopment and ages of onset in depressive disorders","volume":"2","author":"Hagan","year":"2015","journal-title":"Lancet Psychiatry"},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2190\/OM.65.4.e","article-title":"Accounts of Suicidality in the Huntington Disease Community","volume":"65","author":"Halpin","year":"2012","journal-title":"OMEGA - J. Death Dying"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12915-018-0539-y","article-title":"Synaptopathy, circuitopathy and the computational biology of Huntington\u2019s disease","volume":"16","author":"Hannan","year":"2018","journal-title":"BMC Biol."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib70","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3233\/JHD-180318","article-title":"Increased serotonin transporter expression in Huntington\u2019s disease patients is not consistently replicated in murine models","volume":"8","author":"He","year":"2019","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib71","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S2215-0366(14)70220-2","article-title":"The neurobiology of suicide","volume":"1","author":"Heeringen","year":"2014","journal-title":"Lancet Psychiatry"},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib72","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.biopsych.2019.09.012","article-title":"Stress and neurodevelopment in adolescent depression","volume":"86","author":"Ho","year":"2019","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib73","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/mds.23747","article-title":"The structural involvement of the cingulate cortex in premanifest and early Huntington\u2019s disease","volume":"26","author":"Hobbs","year":"2011","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib74","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3233\/JHD-240016","article-title":"Neuroimaging to facilitate clinical trials in Huntington\u2019s disease: current opinion from the EHDN imaging working group","volume":"13","author":"Hobbs","year":"2024","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib75","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/YIC.0b013e3283348018","article-title":"Combating depression in Huntington\u02bcs disease: effective antidepressive treatment with venlafaxine XR","volume":"25","author":"Holl","year":"2010","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib76","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.2147\/NDT.S188340","article-title":"Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder","volume":"14","author":"Huang","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib77","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/jne.12255","article-title":"Hypothalamic-pituitary-adrenal axis functioning in Huntington\u2019s disease and its association with depressive symptoms and suicidality","volume":"27","author":"Hubers","year":"2015","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib78","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JHD-160188","article-title":"Suicidality in Huntington\u2019s disease: a qualitative study on coping styles and support strategies","volume":"5","author":"Hubers","year":"2016","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"17","key":"10.1016\/j.neubiorev.2026.106933_bib79","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1093\/hmg\/ddt203","article-title":"Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington\u2019s disease","volume":"22","author":"Hult Lundh","year":"2013","journal-title":"Human. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2026.106933_bib80","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.clinpsy.3.022806.091532","article-title":"The diagnosis of mental disorders: the problem of reification","volume":"6","author":"Hyman","year":"2010","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib81","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2013.01.071","article-title":"Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington\u2019s disease","volume":"238","author":"Jahanshahi","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2026.106933_bib82","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib83","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/jnnp.2006.103309","article-title":"Psychiatric disorders in preclinical Huntington\u2019s disease","volume":"78","author":"Julien","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib84","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s00415-008-0050-4","article-title":"Basal ganglia volume and clinical correlates in \u2018preclinical\u2019 Huntington\u2019s disease","volume":"255","author":"Jurgens","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jad.2019.03.043","article-title":"Suicidal ideation and behavior in Huntington\u2019s disease: systematic review and recommendations","volume":"250","author":"Kachian","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neubiorev.2026.106933_bib86","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","article-title":"Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat","volume":"82","author":"Kelly","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2026.106933_bib87","article-title":"Medication use in early-HD participants in track-HD: an investigation of its effects on clinical performance","volume":"8","author":"Keogh","year":"2016","journal-title":"PLoS. Curr."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib88","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. General. Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib89","first-page":"170","article-title":"Raised serum proinflammatory cytokines in Alzheimer\u2019s disease with depression","volume":"5","author":"Khemka","year":"2014","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib90","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1037\/neu0000199","article-title":"Multivariate clustering of progression profiles reveals different depression patterns in prodromal Huntington disease","volume":"29","author":"Kim","year":"2015","journal-title":"Neuropsychology"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib91","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.genhosppsych.2007.11.005","article-title":"Behavioural problems in Huntington\u2019s disease using the problem behaviours assessment","volume":"30","author":"Kingma","year":"2008","journal-title":"General. Hosp. Psychiatry"},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib92","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ebiom.2015.08.002","article-title":"Compensation in preclinical Huntington\u2019s disease: evidence from the track-On HD Study","volume":"2","author":"Kl\u00f6ppel","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neubiorev.2026.106933_bib93","article-title":"Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington\u2019s disease","volume":"135","author":"Kong","year":"2020","journal-title":"Neurobiol. Dis. Micro Neurol. Psychiatr. Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib94","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1503\/jpn.100067","article-title":"Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography","volume":"36","author":"Krogias","year":"2011","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106933_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101913","article-title":"Cortical neurodevelopment in pre-manifest Huntington\u2019s disease","volume":"23","author":"Kubera","year":"2019","journal-title":"NeuroImage Clin."},{"issue":"1\u20132","key":"10.1016\/j.neubiorev.2026.106933_bib96","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jnr.23980","article-title":"Sex-specific effects of the Huntington gene on normal neurodevelopment","volume":"95","author":"Lee","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"8","key":"10.1016\/j.neubiorev.2026.106933_bib97","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1176\/appi.ajp.159.8.1306","article-title":"Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington\u2019s disease","volume":"159","author":"Leroi","year":"2002","journal-title":"Am. J. Psychiatry"},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib98","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/cercor\/bhj043","article-title":"Apathy and the functional anatomy of the prefrontal cortex\u2013basal ganglia circuits","volume":"16","author":"Levy","year":"2006","journal-title":"Cereb. Cortex"},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib99","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/cns.12998","article-title":"A brain network model for depression: from symptom understanding to disease intervention","volume":"24","author":"Li","year":"2018","journal-title":"CNS Neurosci. & Ther."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib100","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21243-x","article-title":"Prevalence of depression in the community from 30 countries between 1994 and 2014","volume":"8","author":"Lim","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106933_bib101","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2013.07.007","article-title":"Cerebrospinal fluid inflammatory markers in Parkinson\u2019s disease \u2013 associations with depression, fatigue, and cognitive impairment","volume":"33","author":"Lindqvist","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neubiorev.2026.106933_bib102","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature06976","article-title":"What we can do and what we cannot do with fMRI","volume":"453","author":"Logothetis","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106933_bib103","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib104","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/WCO.0000000000001376","article-title":"Disparities in Huntington\u2019s disease care and research","volume":"38","author":"Madera","year":"2025","journal-title":"Curr. Opin. Neurol."},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114569","article-title":"Prodromal Huntington disease as a model for functional compensation of early neurodegeneration","volume":"9","author":"Malejko","year":"2014","journal-title":"PLOS ONE"},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib106","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/13803395.2021.2002824","article-title":"The structure of mental health symptoms in Huntington\u2019s disease: comparisons with healthy populations","volume":"43","author":"Maltby","year":"2021","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102211","article-title":"Neocortical morphometry in Huntington\u2019s disease: indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes","volume":"26","author":"Mangin","year":"2020","journal-title":"NeuroImage Clin."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib108","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1212\/WNL.54.2.452","article-title":"Rate of functional decline in Huntington\u2019s disease","volume":"54","author":"Marder","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib109","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1001\/archneur.64.1.116","article-title":"Specific psychiatric manifestations among preclinical Huntington disease mutation carriers","volume":"64","author":"Marshall","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.parkreldis.2016.02.008","article-title":"Neuropsychiatric symptoms are very common in premanifest and early stage Huntington\u2019s Disease","volume":"25","author":"Mart\u00ednez-Horta","year":"2016","journal-title":"Park. & Relat. Disord."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib111","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/mds.27395","article-title":"Structural and metabolic brain correlates of apathy in Huntington\u2019s disease","volume":"33","author":"Mart\u00ednez-Horta","year":"2018","journal-title":"Mov. Disord."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib112","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JHD-140133","article-title":"Rating Apathy in Huntington\u2019s Disease: patients and Companions Agree","volume":"4","author":"Mason","year":"2015","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib113","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.42.9.1791","article-title":"Paralimbic frontal lobe hypometabolism in depression associated with Huntington\u2019s disease","volume":"42","author":"Mayberg","year":"1992","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib114","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.410200613","article-title":"Correlates of early disability in Huntington\u2019s disease","volume":"20","author":"Mayeux","year":"1986","journal-title":"Ann. Neurol."},{"issue":"19","key":"10.1016\/j.neubiorev.2026.106933_bib115","doi-asserted-by":"crossref","first-page":"e2395","DOI":"10.1212\/WNL.0000000000011893","article-title":"Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease","volume":"96","author":"McAllister","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib116","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s disease: a clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib117","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1002\/hbm.23527","article-title":"Structural and functional brain network correlates of depressive symptoms in premanifest Huntington\u2019s disease","volume":"38","author":"McColgan","year":"2017","journal-title":"Human. Brain Mapp."},{"key":"10.1016\/j.neubiorev.2026.106933_bib118","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1176\/appi.ajp.2009.08111744","article-title":"Familial aggregation of suicide explained by cluster b traits: a three-group family study of suicide controlling for major depressive disorder","volume":"166","author":"McGirr","year":"2009","journal-title":"Am. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib119","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/mds.27787","article-title":"Insensitivity to loss predicts apathy in huntington\u2019s disease","volume":"34","author":"McLauchlan","year":"2019","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib120","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac278","article-title":"Different depression: motivational anhedonia governs antidepressant efficacy in Huntington\u2019s disease","volume":"4","author":"McLauchlan","year":"2022","journal-title":"Brain Commun."},{"issue":"S8","key":"10.1016\/j.neubiorev.2026.106933_bib121","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1192\/S0007125000291733","article-title":"Serotonergic dysfunction in depression","volume":"155","author":"Meltzer","year":"1989","journal-title":"Br. J. Psychiatry"},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib122","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/mds.26675","article-title":"Rating scales for behavioral symptoms in Huntington\u2019s disease: critique and recommendations","volume":"31","author":"Mestre","year":"2016","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib123","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1017\/S1355617719000067","article-title":"Apathy is related to cognitive control and striatum volumes in prodromal Huntington\u2019s disease","volume":"25","author":"Misiura","year":"2019","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neubiorev.2026.106933_bib124","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.nbd.2014.05.004","article-title":"High stress hormone levels accelerate the onset of memory deficits in male Huntington\u2019s disease mice","volume":"69","author":"Mo","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008025","article-title":"Formation of polyglutamine inclusions in a wide range of Non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington\u2019s disease","volume":"4","author":"Moffitt","year":"2009","journal-title":"PLOS ONE"},{"key":"10.1016\/j.neubiorev.2026.106933_bib126","doi-asserted-by":"crossref","first-page":"825532","DOI":"10.3389\/fpsyt.2021.825532","article-title":"Improving Mood and Cognitive Symptoms in Huntington\u2019s Disease With Cariprazine Treatment","volume":"12","author":"Molnar","year":"2021","journal-title":"Front Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib127","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1399-0004.2010.01538.x","article-title":"Uptake of Huntington disease predictive testing in a complete population","volume":"80","author":"Morrison","year":"2011","journal-title":"Clin. Genet."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib128","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1176\/jnp.2009.21.3.266","article-title":"Apathy Is not depression in Huntington\u2019s disease","volume":"21","author":"Naarding","year":"2009","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib129","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/brain\/awab367","article-title":"Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntington\u2019s disease","volume":"145","author":"Nair","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.neubiorev.2026.106933_bib130","first-page":"321","article-title":"Chapter 18-Serotonin regulation of striatal function","volume":"31","author":"Nair","year":"2020"},{"issue":"8","key":"10.1016\/j.neubiorev.2026.106933_bib131","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neurogastroenterol. & Motil."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib132","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2003.08.053","article-title":"Molecular and behavioral analysis of the r6\/1 huntington\u2032s disease transgenic mouse","volume":"122","author":"Naver","year":"2003","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib133","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/01.nmd.0000106004.67587.57","article-title":"Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity","volume":"192","author":"Nehl","year":"2004","journal-title":"J. Nerv. & Ment. Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib134","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/jnp.13.3.342","article-title":"Effects of depression on working memory in presymptomatic Huntington\u2019s disease","volume":"13","author":"Nehl","year":"2001","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib135","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1037\/0021-843X.107.2.305","article-title":"Comorbid mental disorders: implications for treatment and sample selection","volume":"107","author":"Newman","year":"1998","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2022.111023","article-title":"The effects of antidepressants on depressive symptoms in manifest Huntington\u2019s disease","volume":"162","author":"Ogilvie","year":"2022","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.neubiorev.2026.106933_bib137","doi-asserted-by":"crossref","first-page":"RRN1184","DOI":"10.1371\/currents.RRN1184","article-title":"Observing Huntington\u2019s disease: the European Huntington\u2019s Disease Network\u2019s REGISTRY","volume":"2","author":"Orth","year":"2011","journal-title":"PLoS. Curr."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib138","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1399-0004.2010.01603.x","article-title":"Huntington\u2019s disease in Greece: the experience of 14 years","volume":"80","author":"Panas","year":"2011","journal-title":"Clin. Genet."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib139","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/hmg\/ddn385","article-title":"Altered serotonin receptor expression is associated with depression-related behavior in the R6\/1 transgenic mouse model of Huntington\u2019s disease","volume":"18","author":"Pang","year":"2009","journal-title":"Human. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pscychresns.2007.04.001","article-title":"Neural bases of dysphoria in early Huntington\u2019s disease","volume":"162","author":"Paradiso","year":"2008","journal-title":"Psychiatry Res. Neuroimag."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib141","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib142","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13099-023-00536-1","article-title":"Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson\u2019s disease: a meta-analysis of randomized controlled trials","volume":"15","author":"Park","year":"2023","journal-title":"Gut Pathog."},{"key":"10.1016\/j.neubiorev.2026.106933_bib143","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.parkreldis.2021.04.017","article-title":"Plasma neurofilament light in Huntington\u2019s disease: a marker for disease onset, but not symptom progression","volume":"87","author":"Parkin","year":"2021","journal-title":"Park. & Relat. Disord."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib144","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp.71.3.310","article-title":"Neuropsychiatric aspects of Huntington\u2019s disease","volume":"71","author":"Paulsen","year":"2001","journal-title":"J. Neurol. Neurosurg. & Psychiatry"},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib145","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1176\/jnp.17.4.496","article-title":"Depression and stages of Huntington\u2019s disease","volume":"17","author":"Paulsen","year":"2005","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib146","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archneur.63.6.883","article-title":"Preparing for preventive clinical trials: the predict-HD study","volume":"63","author":"Paulsen","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib147","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00078","article-title":"Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: a decade of the PREDICT-HD Study","volume":"6","author":"Paulsen","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib148","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib149","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3233\/JHD-150154","article-title":"Functional brain correlates of neuropsychiatric symptoms in presymptomatic Huntington\u2019s disease: the IMAGE-HD study","volume":"4","author":"Poudel","year":"2015","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib150","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/brain\/awp006","article-title":"Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin","volume":"132","author":"Pouladi","year":"2009","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib151","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/jnr.24522","article-title":"Compartmental function and modulation of the striatum","volume":"97","author":"Prager","year":"2019","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib152","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/cge.12893","article-title":"Factors Related to genetic testing in adults at risk for huntington disease: the prospective huntington at-risk observational study (PHAROS)","volume":"91","author":"Quaid","year":"2017","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neubiorev.2026.106933_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-19285-7_1","article-title":"The neuropathology of Huntington\u00b4s disease: classical findings, recent developments and correlation to functional neuroanatomy","volume":"217","author":"R\u00fcb","year":"2015","journal-title":"Adv. Anat. Embryol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib154","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington\u2019s disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"R\u00fcb","year":"2016","journal-title":"Brain Pathol."},{"issue":"13","key":"10.1016\/j.neubiorev.2026.106933_bib155","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/mds.25984","article-title":"Cerebellar abnormalities in Huntington\u2019s disease: a role in motor and psychiatric impairment?","volume":"29","author":"Rees","year":"2014","journal-title":"Mov. Disord."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib156","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022133","article-title":"Sexually dimorphic serotonergic dysfunction in a mouse model of huntington\u2019s disease and depression","volume":"6","author":"Renoir","year":"2011","journal-title":"PLOS ONE"},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib157","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1476-5381.2011.01567.x","article-title":"Treatment of depressive-like behaviour in Huntington\u2019s disease mice by chronic sertraline and exercise","volume":"165","author":"Renoir","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib158","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JHD-120039","article-title":"Antidepressant-Like effect of the norepinephrine-dopamine reuptake inhibitor bupropion in a mouse model of Huntington\u2019s disease with dopaminergic dysfunction","volume":"1","author":"Renoir","year":"2012","journal-title":"J. Huntingt. \u2019S. Dis."},{"key":"10.1016\/j.neubiorev.2026.106933_bib159","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1176\/jnp.23.4.jnp399","article-title":"Discriminant analysis of beck depression inventory and hamilton rating scale for depression in Huntington\u2019s disease","volume":"23","author":"Rickards","year":"2011","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib160","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/mdc3.12502","article-title":"Survival, mortality, causes and places of death in a European Huntington\u2019s disease prospective cohort","volume":"4","author":"Rodrigues","year":"2017","journal-title":"Mov. Disord. Clin. Pract."},{"issue":"574","key":"10.1016\/j.neubiorev.2026.106933_bib161","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc2888","article-title":"Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington\u2019s disease","volume":"12","author":"Rodrigues","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib162","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/s41588-022-01245-2","article-title":"Exploring the genetic overlap between twelve psychiatric disorders","volume":"54","author":"Romero","year":"2022","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib163","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0033-3182(00)71170-4","article-title":"Neuropsychiatry of Huntington\u2019s Disease and Other Basal Ganglia Disorders","volume":"41","author":"Rosenblatt","year":"2000","journal-title":"Psychosomatics"},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib164","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib165","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/mdc3.12808","article-title":"Movement disorder society task force viewpoint: Huntington\u2019s disease diagnostic categories","volume":"6","author":"Ross","year":"2019","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.neubiorev.2026.106933_bib166","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.psychres.2011.09.005","article-title":"Patterns of serotonergic antidepressant usage in prodromal Huntington disease","volume":"196","author":"Rowe","year":"2012","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2026.106933_bib167","article-title":"Longitudinal analysis of neuropsychiatric symptoms in a large cohort of early-moderate manifest Huntington\u2019s disease patients","volume":"106","author":"Ruiz-Idiago","year":"2022","journal-title":"Park. & Relat. Disord."},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib168","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/hmg\/8.5.813","article-title":"Formation of polyglutamine inclusions in non-CNS tissue","volume":"8","author":"Sathasivam","year":"1999","journal-title":"Human. Mol. Genet."},{"key":"10.1016\/j.neubiorev.2026.106933_bib169","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.667420","article-title":"Enroll-HD: an integrated clinical research platform and worldwide observational study for Huntington\u2019s disease","volume":"12","author":"Sathe","year":"2021","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib170","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/sj.npp.1301408","article-title":"Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression","volume":"33","author":"Schlaepfer","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib171","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41380-019-0587-x","article-title":"Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies","volume":"25","author":"Schmaal","year":"2020","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib172","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1212\/WNL.0000000000005817","article-title":"Evaluating depression and suicidality in tetrabenazine users with Huntington disease","volume":"91","author":"Schultz","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.neubiorev.2026.106933_bib173","article-title":"Long-Term Use of Tiapride and tetrabenazine in Huntington\u2019s disease: a 25-year retrospective single-center analysis","volume":"0","author":"Schwarzov\u00e1","year":"2026","journal-title":"Clin. Ther."},{"key":"10.1016\/j.neubiorev.2026.106933_bib174","series-title":"Huntington\u2019s Disease","first-page":"311","article-title":"Chapter 13\u2014Pathophysiology of synapses and circuits in Huntington disease","author":"Sepers","year":"2024"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib175","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/23279095.2015.1125904","article-title":"Everyday functioning in Huntington\u2019s disease: a laboratory-based study of financial management capacity","volume":"24","author":"Sheppard","year":"2017","journal-title":"Appl. Neuropsychol. Adult"},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib176","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.psyneuen.2012.10.020","article-title":"Cortisol and depression in pre-diagnosed and early stage Huntington\u2019s disease","volume":"38","author":"Shirbin","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib177","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1037\/a0029218","article-title":"Depressive symptom severity is related to poorer cognitive performance in prodromal Huntington disease","volume":"26","author":"Smith","year":"2012","journal-title":"Neuropsychology"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib178","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JHD-231515","article-title":"Stress in Huntington\u2019s disease: characteristics and correlates in patients and at-risk individuals","volume":"13","author":"Snow","year":"2024","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib179","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3233\/JHD-240027","article-title":"Coping with Huntington\u2019s disease in patients and at-risk individuals","volume":"13","author":"Snow","year":"2024","journal-title":"J. Huntingt. \u2019S. Dis."},{"key":"10.1016\/j.neubiorev.2026.106933_bib180","doi-asserted-by":"crossref","DOI":"10.1038\/srep28322","article-title":"Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington\u2019s disease","volume":"6","author":"Soylu-Kucharz","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib181","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1017\/S003329171300247X","article-title":"The neuroanatomy of subthreshold depressive symptoms in Huntington\u2019s disease: a combined diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) study","volume":"44","author":"Sprengelmeyer","year":"2014","journal-title":"Psychol. Med."},{"issue":"5757","key":"10.1016\/j.neubiorev.2026.106933_bib182","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1117571","article-title":"Alterations in 5-HT1B receptor function by p11 in depression-like states","volume":"311","author":"Svenningsson","year":"2006","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.neubiorev.2026.106933_bib183","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib184","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib185","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","article-title":"Potential endpoints for clinical trials in premanifest and early Huntington\u2019s disease in the TRACK-HD study: analysis of 24 month observational data","volume":"11","author":"Tabrizi","year":"2012","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib186","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neubiorev.2026.106933_bib187","first-page":"00121","article-title":"Potential disease-modifying therapies for Huntington\u2019s disease: lessons learned and future opportunities","volume":"22","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol. 21(7) 645658"},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib188","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1474-4422(22)00120-X","article-title":"A biological classification of Huntington\u2019s disease: the integrated staging system","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib189","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1176\/appi.neuropsych.11030057","article-title":"Longitudinal evaluation of neuropsychiatric symptoms in Huntington\u2019s disease","volume":"24","author":"Thompson","year":"2012","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib190","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.neuroimage.2004.07.037","article-title":"Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution","volume":"23","author":"Tournier","year":"2004","journal-title":"NeuroImage"},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib191","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrn3839","article-title":"The molecular bases of the suicidal brain","volume":"15","author":"Turecki","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib192","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib193","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pscychresns.2012.01.002","article-title":"Depressive symptoms in prodromal Huntington\u2019s Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex","volume":"203","author":"Unschuld","year":"2012","journal-title":"Psychiatry Res. Neuroimag."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib194","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2011.05.006","article-title":"Gastrointestinal dysfunction contributes to weight loss in Huntington\u2019s disease mice","volume":"44","author":"van der Burg","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"10","key":"10.1016\/j.neubiorev.2026.106933_bib196","doi-asserted-by":"crossref","first-page":"e1021","DOI":"10.1212\/WNL.0000000000008066","article-title":"Abnormal brain development in child and adolescent carriers of mutant huntingtin","volume":"93","author":"van der Plas","year":"2019","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib197","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-200394","article-title":"The neurodevelopmental hypothesis of Huntington\u2019s Disease","volume":"9","author":"van der Plas","year":"2020","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"11","key":"10.1016\/j.neubiorev.2026.106933_bib198","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.4088\/JCP.v69n1116","article-title":"Cross-sectional study on prevalences of psychiatric disorders in mutation carriers of Huntington\u2019s disease compared with mutation-negative first-degree relatives","volume":"69","author":"van Duijn","year":"2008","journal-title":"J. Clin. Psychiatry"},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib199","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1136\/jnnp-2013-307343","article-title":"Neuropsychiatric symptoms in a European Huntington\u2019s disease cohort (REGISTRY)","volume":"8","author":"van Duijn","year":"2014","journal-title":"J. Neurol. Neurosurg. & Psychiatry"},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib200","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000287","article-title":"Selected CSF biomarkers indicate no evidence of early neuroinflammation in Huntington disease","volume":"3","author":"Vinther-Jensen","year":"2016","journal-title":"Neurol. Neuroimmunol. & Neuroinflamm."},{"issue":"4","key":"10.1016\/j.neubiorev.2026.106933_bib201","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.neuroimage.2012.03.014","article-title":"Effect of paroxetine and bupropion on human resting brain perfusion: an arterial spin labeling study","volume":"61","author":"Viviani","year":"2012","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib202","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa110","article-title":"Gut dysbiosis in Huntington\u2019s disease: associations among gut microbiota, cognitive performance and clinical outcomes","volume":"2","author":"Wasser","year":"2020","journal-title":"Brain Commun."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib203","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3233\/JHD-220556","article-title":"A randomized controlled trial of probiotics targeting gut dysbiosis in Huntington\u2019s disease","volume":"12","author":"Wasser","year":"2023","journal-title":"J. Huntingt. \u2019S. Dis."},{"issue":"1","key":"10.1016\/j.neubiorev.2026.106933_bib204","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/wps.20943","article-title":"Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum","volume":"21","author":"Watson","year":"2022","journal-title":"World Psychiatry"},{"issue":"3","key":"10.1016\/j.neubiorev.2026.106933_bib205","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.psychres.2011.05.006","article-title":"Suicidal ideation in Huntington disease: the role of comorbidity","volume":"188","author":"Wetzel","year":"2011","journal-title":"Psychiatry Res."},{"issue":"5","key":"10.1016\/j.neubiorev.2026.106933_bib206","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000617","article-title":"Revealing the timeline of structural MRI changes in premanifest to manifest Huntington disease","volume":"7","author":"Wijeratne","year":"2021","journal-title":"Neurol. Genet."},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib207","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00702-020-02187-x","article-title":"Alterations in transcranial sonography among Huntington\u2019s disease patients with psychiatric symptoms","volume":"127","author":"Witkowski","year":"2020","journal-title":"J. Neural Transm."},{"issue":"14","key":"10.1016\/j.neubiorev.2026.106933_bib208","first-page":"2923","article-title":"N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington\u2019s disease","volume":"25","author":"Wright","year":"2016","journal-title":"Human. Mol. Genet."},{"issue":"12","key":"10.1016\/j.neubiorev.2026.106933_bib209","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/scan\/nsu006","article-title":"Increased involvement of the parahippocampal gyri in a sad mood predicts future depressive symptoms","volume":"9","author":"Zamoscik","year":"2014","journal-title":"Social. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106933_bib210","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mcn.2019.02.004","article-title":"Fluid and imaging biomarkers for Huntington\u2019s disease","volume":"97","author":"Zeun","year":"2019","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106933_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118870","article-title":"Quantitative mapping of the brain\u2019s structural connectivity using diffusion MRI tractography: a review","volume":"249","author":"Zhang","year":"2022","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/j.neubiorev.2026.106933_bib212","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.neubiorev.2026.106933_bib213","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","article-title":"Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients","volume":"71","author":"Zhu","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.neubiorev.2026.106933_bib214","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","article-title":"RESEARCH ARTICLE: systematic assessment of bdnf and its receptor levels in human cortices affected by Huntington\u2019s disease","volume":"18","author":"Zuccato","year":"2008","journal-title":"Brain Pathol."}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426003908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426003908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:35:32Z","timestamp":1790256932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763426003908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":214,"alternative-id":["S0149763426003908"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106933","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pathophysiology of depression in Huntington\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106933"}}