{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:41:25Z","timestamp":1792341685678,"version":"4.4.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023020601012303"],"award-info":[{"award-number":["2023020601012303"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0529200"],"award-info":[{"award-number":["2024ZD0529200"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271278"],"award-info":[{"award-number":["82271278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience & Biobehavioral Reviews"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neubiorev.2026.106970","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:42:32Z","timestamp":1789195352000},"page":"106970","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ROR\u03b1 as a context-dependent transcriptional stabilizer in the nervous system"],"prefix":"10.1016","volume":"191","author":[{"given":"Huaqing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanshu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neubiorev.2026.106970_bib1","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1038\/s41467-022-32326-9","article-title":"Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals","volume":"13","author":"Abe","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106970_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neuroscience.2006.09.030","article-title":"Melatonin affects nuclear orphan receptors mRNA in the rat suprachiasmatic nuclei","volume":"144","author":"Agez","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neubiorev.2026.106970_bib3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/s41586-022-05309-5","article-title":"Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota","volume":"610","author":"Akagbosu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106970_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nsmb925","article-title":"The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1","volume":"12","author":"Akashi","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41531-023-00563-4","article-title":"Neuroprotective role for RORA in Parkinson\u2019s disease revealed by analysis of post-mortem brain and a dopaminergic cell line","volume":"9","author":"Al-Zaid","year":"2023","journal-title":"NPJ Park. Dis."},{"key":"10.1016\/j.neubiorev.2026.106970_bib6","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1093\/emboj\/17.14.3867","article-title":"Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice","volume":"17","author":"Andr\u00e9","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.neubiorev.2026.106970_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbamcr.2006.05.006","article-title":"Intracellular localization of RORalpha is isoform and cell line-dependent","volume":"1763","author":"Aschrafi","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neubiorev.2026.106970_bib8","first-page":"1550","article-title":"Coactivators for the orphan nuclear receptor RORalpha","volume":"13","author":"Atkins","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jsmc.2024.07.010","article-title":"Effects of Sleep Deficiency on Risk, Course, and Treatment of Psychopathology","volume":"19","author":"Atwood","year":"2024","journal-title":"Sleep. Med. Clin."},{"key":"10.1016\/j.neubiorev.2026.106970_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11064-025-04510-y","article-title":"Progressive Blood-Brain Barrier Disruption in Sleep-Restricted Young Mice: Cellular Senescence and Neuroinflammation Crosstalk","volume":"50","author":"Avilez-Avilez","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib11","first-page":"271","article-title":"The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker","volume":"20","author":"Ayatollahi","year":"2020","journal-title":"Pharm. J."},{"key":"10.1016\/j.neubiorev.2026.106970_bib12","doi-asserted-by":"crossref","first-page":"AP524","DOI":"10.1161\/circ.149.suppl_1.P524","article-title":"Abstract P524: Prolonged Mild Sleep Restriction Results in Specific Alterations in Genome-Wide DNA Methylation: A Randomized Crossover Trial","volume":"149","author":"Barragan","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.neubiorev.2026.106970_bib13","article-title":"Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial","volume":"0","author":"Barrag\u00e1n","year":"2026","journal-title":"Aging Dis."},{"key":"10.1016\/j.neubiorev.2026.106970_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1606242","article-title":"Peripheral clocks and systemic zeitgeber interactions: from molecular mechanisms to circadian precision medicine","volume":"16","author":"Bautista","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101358","article-title":"The nuclear receptor ROR\u03b1 preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy","volume":"297","author":"Beak","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib16","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1523\/JNEUROSCI.4636-05.2006","article-title":"Retinoid-related orphan receptor alpha controls the early steps of Purkinje cell dendritic differentiation","volume":"26","author":"Boukhtouche","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib17","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1111\/j.1471-4159.2006.03708.x","article-title":"Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis","volume":"96","author":"Boukhtouche","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/14734220600750184","article-title":"RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing","volume":"5","author":"Boukhtouche","year":"2006","journal-title":"Cerebellum"},{"key":"10.1016\/j.neubiorev.2026.106970_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-8104-5-18","article-title":"Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires ROR\u03b1","volume":"5","author":"Boukhtouche","year":"2010","journal-title":"Neural Dev."},{"key":"10.1016\/j.neubiorev.2026.106970_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2015.01.011","article-title":"Identification of a spinal circuit for light touch and fine motor control","volume":"160","author":"Bourane","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106970_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1042\/bj20011558","article-title":"Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells","volume":"364","author":"Chauvet","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.neubiorev.2026.106970_bib22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/07487304231178950","article-title":"Circadian Regulation of the Neuroimmune Environment Across the Lifespan: From Brain Development to Aging","volume":"38","author":"Chen","year":"2023","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.neubiorev.2026.106970_bib23","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.2147\/JPR.S455621","article-title":"A Narrative Review of the Reciprocal Relationship Between Sleep Deprivation and Chronic Pain: The Role of Oxidative Stress","volume":"17","author":"Chen","year":"2024","journal-title":"J. Pain. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib24","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1523\/JNEUROSCI.2977-12.2013","article-title":"Mature Purkinje cells require the retinoic acid-related orphan receptor-\u03b1 (ROR\u03b1) to maintain climbing fiber mono-innervation and other adult characteristics","volume":"33","author":"Chen","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jpsychires.2020.09.037","article-title":"Aberrant functional connectivity between the suprachiasmatic nucleus and the superior temporal gyrus: Bridging RORA gene polymorphism with diurnal mood variation in major depressive disorder","volume":"132","author":"Chen","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/science.1232806","article-title":"Geniculocortical Input Drives Genetic Distinctions Between Primary and Higher-Order Visual Areas","volume":"340","author":"Chou","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2026.106970_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070392","article-title":"The retinoid-related orphan receptor ROR\u03b1 promotes keratinocyte differentiation via FOXN1","volume":"8","author":"Dai","year":"2013","journal-title":"PloS. One"},{"key":"10.1016\/j.neubiorev.2026.106970_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/embo-reports\/kve007","article-title":"The orphan nuclear receptor ROR\u03b1 is a negative regulator of the inflammatory response","volume":"2","author":"Delerive","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neubiorev.2026.106970_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01677060600685832","article-title":"Cerebellar purkinje cell loss in heterozygous rora+\/- mice: a longitudinal study","volume":"20","author":"Doulazmi","year":"2006","journal-title":"J. Neurogenet."},{"key":"10.1016\/j.neubiorev.2026.106970_bib30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3132\/dvdr.2008.0014","article-title":"The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism","volume":"5","author":"Duez","year":"2008","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jns.2016.08.045","article-title":"RAR-related orphan receptor A (RORA): A new susceptibility gene for multiple sclerosis","volume":"369","author":"Eftekharian","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib32","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/jnr.20843","article-title":"Enhanced endocrine response to novel environment stress and lack of corticosterone circadian rhythm in staggerer (Rora sg\/sg) mutant mice","volume":"83","author":"Fr\u00e9d\u00e9ric","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib33","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fphys.2020.01084","article-title":"Genetic Tools to Study Cardiovascular Biology","volume":"11","author":"Garcia-Gonzalez","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/gbb.12306","article-title":"Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1\u03b1) and RORA","volume":"15","author":"Geoffroy","year":"2016","journal-title":"Genes. Brain Behav."},{"key":"10.1016\/j.neubiorev.2026.106970_bib35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/15622975.2017.1282174","article-title":"Lithium response in bipolar disorders and core clock genes expression","volume":"19","author":"Geoffroy","year":"2018","journal-title":"World J. Biol. Psychiatry Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106970_bib36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1101\/gad.8.5.538","article-title":"Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors","volume":"8","author":"Gigu\u00e8re","year":"1994","journal-title":"Genes. Dev."},{"key":"10.1016\/j.neubiorev.2026.106970_bib37","first-page":"689","article-title":"Orphan nuclear receptors: from gene to function","volume":"20","author":"Gigu\u00e8re","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neubiorev.2026.106970_bib38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0896-6273(03)00769-4","article-title":"RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways","volume":"40","author":"Gold","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106970_bib39","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0896-6273(03)00769-4","article-title":"RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways","volume":"40","author":"Gold","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106970_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2005.11.080","article-title":"ROR alpha in genetic control of cerebellum development: 50 staggering years","volume":"1140","author":"Gold","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/0748730405277232","article-title":"Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors","volume":"20","author":"Guillaumond","year":"2005","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.neubiorev.2026.106970_bib42","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2018.02.021","article-title":"Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia","volume":"102","author":"Guissart","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neubiorev.2026.106970_bib43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.yexcr.2017.02.028","article-title":"Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines","volume":"353","author":"Gulec","year":"2017","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib44","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/0748730414549239","article-title":"A role for 1\u03b1,25-dihydroxyvitamin d3 in the expression of circadian genes","volume":"29","author":"Gutierrez-Monreal","year":"2014","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.neubiorev.2026.106970_bib45","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.immuni.2022.09.013","article-title":"Transcription factor ROR\u03b1 enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element","volume":"55","author":"Hall","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.neubiorev.2026.106970_bib46","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/379736a0","article-title":"Disruption of the nuclear hormone receptor RORalpha in staggerer mice","volume":"379","author":"Hamilton","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106970_bib47","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1089\/ars.2013.5655","article-title":"ROR\u03b1 decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice","volume":"21","author":"Han","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neubiorev.2026.106970_bib48","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/nar\/gkv1034","article-title":"ROR\u03b1 switches transcriptional mode of ERR\u03b3 that results in transcriptional repression of CYP2E1 under ethanol-exposure","volume":"44","author":"Han","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib49","first-page":"1737","article-title":"Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development","volume":"11","author":"Harding","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib50","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41583-018-0026-z","article-title":"Generation of circadian rhythms in the suprachiasmatic nucleus","volume":"19","author":"Hastings","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib51","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03357","article-title":"Lhx1 maintains synchrony among circadian oscillator neurons of the SCN","volume":"3","author":"Hatori","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.neubiorev.2026.106970_bib52","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cmet.2016.03.007","article-title":"The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome","volume":"23","author":"He","year":"2016","journal-title":"Cell. Metab."},{"key":"10.1016\/j.neubiorev.2026.106970_bib53","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.2147\/JIR.S344031","article-title":"Transcriptional Interactomic Inhibition of ROR\u03b1 Suppresses Th17-Related Inflammation","volume":"14","author":"Ho","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.sleep.2020.04.008","article-title":"An association study in the Taiwan Biobank reveals RORA as a novel locus for sleep duration in the Taiwanese Population","volume":"73","author":"Hou","year":"2020","journal-title":"Sleep. Med."},{"key":"10.1016\/j.neubiorev.2026.106970_bib55","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cas.15595","article-title":"ROS inhibits ROR\u03b1 degradation by decreasing its arginine methylation in liver cancer","volume":"114","author":"Im","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib56","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106970_bib57","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cne.21910","article-title":"Formation and maturation of parallel fiber-Purkinje cell synapses in the Staggerer cerebellum ex vivo","volume":"512","author":"Janmaat","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2013.00001","article-title":"Retinoic acid-related orphan receptors \u03b1 and \u03b3: key regulators of lipid\/glucose metabolism, inflammation, and insulin sensitivity","volume":"4","author":"Jetten","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib59","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/sj.cdd.4401085","article-title":"Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease","volume":"9","author":"Jetten","year":"2002","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.neubiorev.2026.106970_bib60","doi-asserted-by":"crossref","first-page":"14314","DOI":"10.1523\/JNEUROSCI.1443-11.2011","article-title":"Cell-autonomous and non-cell-autonomous neuroprotective functions of ROR\u03b1 in neurons and astrocytes during hypoxia","volume":"31","author":"Jolly","year":"2011","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib61","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12311-011-0339-1","article-title":"RORalpha, a key to the development and functioning of the brain","volume":"11","author":"Jolly","year":"2012","journal-title":"Cerebellum"},{"key":"10.1016\/j.neubiorev.2026.106970_bib62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0022-2275(20)42835-4","article-title":"Evidence for diurnal periodicity in human cholesterol synthesis","volume":"31","author":"Jones","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib63","doi-asserted-by":"crossref","first-page":"21365","DOI":"10.1073\/pnas.0911782106","article-title":"The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes","volume":"106","author":"Journiac","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2026.106970_bib64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/01677060600569762","article-title":"Quantitative analysis of microglial cells in the degenerating cerebellum of the staggerer (RORA(sg\/sg)) mutant mouse","volume":"19","author":"Journiac","year":"2005","journal-title":"J. Neurogenet."},{"key":"10.1016\/j.neubiorev.2026.106970_bib65","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20241671","article-title":"Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis","volume":"222","author":"Kabil","year":"2025","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neubiorev.2026.106970_bib66","doi-asserted-by":"crossref","first-page":"14033","DOI":"10.1074\/jbc.M400302200","article-title":"Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A","volume":"279","author":"Kallen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib67","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/S0969-2126(02)00912-7","article-title":"X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha","volume":"10","author":"Kallen","year":"2002","journal-title":"Structure"},{"key":"10.1016\/j.neubiorev.2026.106970_bib68","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.febslet.2011.03.021","article-title":"Circadian disruption and SCN control of energy metabolism","volume":"585","author":"Kalsbeek","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neubiorev.2026.106970_bib69","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(95)90334-8","article-title":"Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice","volume":"81","author":"Kashiwabuchi","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106970_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121798","article-title":"Intestinal clock system regulates skeletal homeostasis","volume":"4","author":"Kawai","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.neubiorev.2026.106970_bib71","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.3390\/nu15183919","article-title":"The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and I\u03baB\u03b1\/NF-\u03baB Signaling in Adipocytes","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.neubiorev.2026.106970_bib72","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hep.25529","article-title":"Retinoic acid receptor-related orphan receptor \u03b1-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis","volume":"55","author":"Kim","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.neubiorev.2026.106970_bib73","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1038\/s41598-017-12344-0","article-title":"ROR\u03b12 requires LSD1 to enhance tumor progression in breast cancer","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106970_bib74","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1210\/endo.140.3.6562","article-title":"ROR alpha augments thyroid hormone receptor-mediated transcriptional activation","volume":"140","author":"Koibuchi","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.neubiorev.2026.106970_bib75","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrd4100","article-title":"REV-ERB and ROR nuclear receptors as drug targets","volume":"13","author":"Kojetin","year":"2014","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.neubiorev.2026.106970_bib76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/cb1002762","article-title":"Identification of SR3335 (ML-176): a synthetic ROR\u03b1 selective inverse agonist","volume":"6","author":"Kumar","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib77","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1242\/dev.069963","article-title":"Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex","volume":"139","author":"Kwan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.neubiorev.2026.106970_bib78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fnana.2014.00143","article-title":"Embryonic development of circadian clocks in the mammalian suprachiasmatic nuclei","volume":"8","author":"Landgraf","year":"2014","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neubiorev.2026.106970_bib79","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13078","article-title":"Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer\u2019s disease","volume":"19","author":"Lee","year":"2020","journal-title":"Aging Cell."},{"key":"10.1016\/j.neubiorev.2026.106970_bib80","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s12276-021-00679-8","article-title":"Unraveling the physiological roles of retinoic acid receptor-related orphan receptor \u03b1","volume":"53","author":"Lee","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neubiorev.2026.106970_bib81","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41531-022-00352-5","article-title":"Melatonin ameliorates Parkinson\u2019s disease via regulating microglia polarization in a ROR\u03b1-dependent pathway","volume":"8","author":"Li","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"10.1016\/j.neubiorev.2026.106970_bib82","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/15230864251399609","article-title":"Retinoic Acid Receptor-related Orphan Receptor \u03b1 Drives Glucose Reprogramming and Mitochondrial Rescue Mitigate Subarachnoid Hemorrhage-Induced Early Brain Injury","volume":"44","author":"Li","year":"2026","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neubiorev.2026.106970_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109696","article-title":"Nobiletin promotes lipolysis of white adipose tissue in a circadian clock-dependent manner","volume":"132","author":"Li","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib84","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2015.10.003","article-title":"The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through ROR\u03b1 and SRC-2 coactivator transcriptional activity","volume":"419","author":"Madsen","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib85","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1248\/bpb.b21-00426","article-title":"Identification of the ROR\u03b1 Transcriptional Network Contributes to the Search for Therapeutic Targets in Atherosclerosis","volume":"44","author":"Matsuoka","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neubiorev.2026.106970_bib86","first-page":"441","article-title":"The retinoic acid receptor-related orphan receptor \u03b1 positively regulates tight junction protein claudin domain-containing 1 mRNA expression in human brain endothelial cells","volume":"161","author":"Matsuoka","year":"2017","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.neubiorev.2026.106970_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.90","article-title":"Genetic and clinical factors predict lithium\u2019s effects on PER2 gene expression rhythms in cells from bipolar disorder patients","volume":"3","author":"McCarthy","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106970_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2024.115948","article-title":"Sex-specific associations between circadian-related genes and depression in UK Biobank participants highlight links to glucose metabolism, inflammation and neuroplasticity pathways","volume":"337","author":"Minbay","year":"2024","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib89","doi-asserted-by":"crossref","first-page":"52511","DOI":"10.1074\/jbc.M308152200","article-title":"The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation","volume":"278","author":"Moraitis","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib90","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0168-0102(97)00042-4","article-title":"Prominent expression of nuclear hormone receptor ROR alpha in Purkinje cells from early development","volume":"28","author":"Nakagawa","year":"1997","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib91","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000072271","article-title":"Dynamic patterned expression of orphan nuclear receptor genes RORalpha and RORbeta in developing mouse forebrain","volume":"25","author":"Nakagawa","year":"2003","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib92","first-page":"122","article-title":"Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system","volume":"565","author":"Nakajima","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neubiorev.2026.106970_bib93","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.2147\/NSS.S561326","article-title":"Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Perspective and Therapeutic Potential","volume":"17","author":"Namgyal","year":"2025","journal-title":"Nat. Sci. Sleep."},{"key":"10.1016\/j.neubiorev.2026.106970_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207374","article-title":"ROR\u03b1 controls inflammatory state of human macrophages","volume":"13","author":"Nejati Moharrami","year":"2018","journal-title":"PloS. One"},{"key":"10.1016\/j.neubiorev.2026.106970_bib95","first-page":"3036","article-title":"Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain","volume":"24","author":"Nguyen","year":"2010","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib96","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41398-025-03525-x","article-title":"Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner","volume":"15","author":"Ni","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106970_bib97","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1038\/s41467-019-11926-y","article-title":"Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge","volume":"10","author":"Nohara","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106970_bib98","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1073\/pnas.79.9.3037","article-title":"Mevalonic acid in human plasma: relationship of concentration and circadian rhythm to cholesterol synthesis rates in man","volume":"79","author":"Parker","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2026.106970_bib99","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib100","doi-asserted-by":"crossref","first-page":"37154","DOI":"10.1074\/jbc.M113.485987","article-title":"Retinoic acid-related orphan receptor \u03b1 regulates diurnal rhythm and fasting induction of sterol 12\u03b1-hydroxylase in bile acid synthesis","volume":"288","author":"Pathak","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib101","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1111\/ejn.14534","article-title":"Transcriptional profiling aligned with in situ expression image analysis reveals mosaically expressed molecular markers for GABA neuron sub-groups in the ventral tegmental area","volume":"50","author":"Paul","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib102","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1073\/pnas.1916539117","article-title":"pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis","volume":"117","author":"Petrenko","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2026.106970_bib103","unstructured":"PMC. (n.d.) https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3873570\/."},{"key":"10.1016\/j.neubiorev.2026.106970_bib104","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/0748730411401579","article-title":"Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)","volume":"26","author":"Poliandri","year":"2011","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.neubiorev.2026.106970_bib105","first-page":"810","article-title":"The expression pattern of nuclear receptors during cerebellar development","volume":"236","author":"Qin","year":"2007","journal-title":"Dev. Dyn. Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.neubiorev.2026.106970_bib106","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1089\/thy.2008.0336","article-title":"Retinoic Acid receptor-related orphan receptor alpha-enhanced thyroid hormone receptor-mediated transcription requires its ligand binding domain which is not, by itself, sufficient: possible direct interaction of two receptors","volume":"19","author":"Qiu","year":"2009","journal-title":"Thyroid. Off. J. Am. Thyroid. Assoc."},{"key":"10.1016\/j.neubiorev.2026.106970_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1436966","article-title":"Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases","volume":"18","author":"Rowe","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib108","article-title":"RORA polymorphisms are associated with ischemic stroke","volume":"39","author":"Samadian","year":"2025","journal-title":"Gene Rep."},{"key":"10.1016\/j.neubiorev.2026.106970_bib109","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2040-2392-4-14","article-title":"Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder","volume":"4","author":"Sarachana","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neubiorev.2026.106970_bib110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017116","article-title":"Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism","volume":"6","author":"Sarachana","year":"2011","journal-title":"PloS. One"},{"key":"10.1016\/j.neubiorev.2026.106970_bib111","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2004.07.018","article-title":"A functional genomics strategy reveals Rora as a component of the mammalian circadian clock","volume":"43","author":"Sato","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.neubiorev.2026.106970_bib112","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1111\/j.1460-9568.1997.tb01698.x","article-title":"The expression pattern of the orphan nuclear receptor RORbeta in the developing and adult rat nervous system suggests a role in the processing of sensory information and in circadian rhythm","volume":"9","author":"Schaeren-Wiemers","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib113","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.mcn.2006.11.013","article-title":"A promoter element with enhancer properties, and the orphan nuclear receptor RORalpha, are required for Purkinje cell-specific expression of a Gi\/o modulator","volume":"34","author":"Serinagaoglu","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib114","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cell.2006.09.036","article-title":"RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice","volume":"127","author":"Serra","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106970_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.902895","article-title":"Association Between Sleep Duration and Parkinson\u2019s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes","volume":"16","author":"Shao","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib116","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/s41593-025-02067-1","article-title":"A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging","volume":"28","author":"Sheehan","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib117","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13474","article-title":"Targeting ROR\u03b1 in macrophages to boost diabetic bone regeneration","volume":"56","author":"Shen","year":"2023","journal-title":"Cell. Prolif."},{"key":"10.1016\/j.neubiorev.2026.106970_bib118","first-page":"2775","article-title":"ROR\u03b1 and ROR \u03b3 are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D","volume":"28","author":"Slominski","year":"2014","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib119","doi-asserted-by":"crossref","first-page":"11434","DOI":"10.1038\/s41598-017-10202-7","article-title":"Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols","volume":"7","author":"Slominski","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neubiorev.2026.106970_bib120","article-title":"Is Vitamin D Signaling Regulated by and Does It Regulate Circadian Rhythms?","volume":"39","author":"Slominski","year":"2025","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117711","article-title":"Metabolic activation of lumisterol to biologically active metabolites and their mechanism of action","volume":"246","author":"Slominski","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib122","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature10075","article-title":"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand","volume":"472","author":"Solt","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106970_bib123","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tem.2012.05.012","article-title":"Action of RORs and their ligands in (patho)physiology","volume":"23","author":"Solt","year":"2012","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.1016\/j.neubiorev.2026.106970_bib124","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13024-015-0007-x","article-title":"A\u03b2-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer\u2019s disease","volume":"10","author":"Song","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neubiorev.2026.106970_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1592737","article-title":"ROR\u03b1-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis","volume":"16","author":"Song","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib126","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/ejn.15551","article-title":"Transcriptional regulation of neuronal identity","volume":"55","author":"Sousa","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib127","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s13577-025-01288-7","article-title":"Melatonin, ROR-\u03b1 and circadian rhythm in liver","volume":"38","author":"Srinivasa","year":"2025","journal-title":"Hum. Cell."},{"key":"10.1016\/j.neubiorev.2026.106970_bib128","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1073\/pnas.95.7.3960","article-title":"staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice","volume":"95","author":"Steinmayr","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neubiorev.2026.106970_bib129","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1126\/science.288.5475.2369","article-title":"Requirement for RORgamma in thymocyte survival and lymphoid organ development","volume":"288","author":"Sun","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2026.106970_bib130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.neubiorev.2026.106970_bib131","doi-asserted-by":"crossref","first-page":"12518","DOI":"10.1523\/JNEUROSCI.0075-15.2015","article-title":"ROR\u03b1 Regulates Multiple Aspects of Dendrite Development in Cerebellar Purkinje Cells In Vivo","volume":"35","author":"Takeo","year":"2015","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib132","article-title":"RORA-neurodevelopmental disorder: A unique triad of developmental disabilities, cerebellar anomalies, and myoclonic seizures","volume":"27","author":"Talarico","year":"2025","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"10.1016\/j.neubiorev.2026.106970_bib133","first-page":"67","article-title":"Exosomal miRNAs in tumor microenvironment","volume":"39","author":"Tan","year":"2020","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.neubiorev.2026.106970_bib134","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.biopsych.2010.06.030","article-title":"Genome-wide association scan of trait depression","volume":"68","author":"Terracciano","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106970_bib135","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1523\/JNEUROSCI.5385-10.2011","article-title":"Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus","volume":"31","author":"VanDunk","year":"2011","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib136","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1093\/cercor\/bhx262","article-title":"ROR\u03b1 Coordinates Thalamic and Cortical Maturation to Instruct Barrel Cortex Development","volume":"28","author":"Vitalis","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neubiorev.2026.106970_bib137","doi-asserted-by":"crossref","first-page":"791","DOI":"10.4103\/1673-5374.232462","article-title":"Retinoid receptor-related orphan receptor alpha: a key gene setting brain circuits","volume":"13","author":"Vitalis","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neubiorev.2026.106970_bib138","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.3390\/ijms21145071","article-title":"Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells","volume":"21","author":"Walbrecq","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110485","article-title":"Sleep deprivation modulates pain sensitivity through alterations in lncRNA and mRNA expression in the nucleus accumbens and ventral midbrain","volume":"275","author":"Wang","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neubiorev.2026.106970_bib140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41467-020-20385-9","article-title":"Genetic and pharmacological inhibition of the nuclear receptor ROR\u03b1 regulates TH17 driven inflammatory disorders","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106970_bib141","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1074\/jbc.M109.080614","article-title":"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106970_bib142","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/cb100223d","article-title":"Identification of SR1078, a synthetic agonist for the orphan nuclear receptors ROR\u03b1 and ROR\u03b3","volume":"5","author":"Wang","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib143","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.bbalip.2010.02.012","article-title":"A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)","volume":"1801","author":"Wang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neubiorev.2026.106970_bib144","article-title":"Regulation of p53 stability and apoptosis by a ROR agonist","volume":"7","author":"Wang","year":"2012","journal-title":"PloS. One"},{"key":"10.1016\/j.neubiorev.2026.106970_bib145","article-title":"The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer\u2019s disease model","volume":"36","author":"Wirianto","year":"2022","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.neubiorev.2026.106970_bib146","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3390\/cancers16101914","article-title":"Regulation of ROR\u03b1 Stability through PRMT5-Dependent Symmetric Dimethylation","volume":"16","author":"Xiong","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.neubiorev.2026.106970_bib147","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.neubiorev.2026.106970_bib148","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12974-020-1710-2","article-title":"MicroRNA-7, synergizes with ROR\u03b1, negatively controls the pathology of brain tissue inflammation","volume":"17","author":"Yue","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neubiorev.2026.106970_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165890","article-title":"The circadian nuclear receptor ROR\u03b1 negatively regulates cerebral ischemia-reperfusion injury and mediates the neuroprotective effects of melatonin","volume":"1866","author":"Zang","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.neubiorev.2026.106970_bib150","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70435","article-title":"Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets","volume":"6","author":"Zha","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.neubiorev.2026.106970_bib151","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/aps.2014.120","article-title":"ROR nuclear receptors: structures, related diseases, and drug discovery","volume":"36","author":"Zhang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neubiorev.2026.106970_bib152","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.cell.2026.01.016","article-title":"Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice","volume":"189","author":"Zhao","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.neubiorev.2026.106970_bib153","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1038\/s41467-023-43568-6","article-title":"Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development","volume":"14","author":"Zhong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106970_bib154","article-title":"Sleep Deprivation Activates a Conserved Lactate-H3K18la-ROR\u03b1 Axis Driving Neutrophilic Inflammation Across Species","volume":"12","author":"Zhou","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.neubiorev.2026.106970_bib155","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.molcel.2015.10.024","article-title":"Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading","volume":"60","author":"Zhu","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.neubiorev.2026.106970_bib156","doi-asserted-by":"crossref","DOI":"10.1038\/sj.onc.1209314","article-title":"RORA, a large common fragile site gene, is involved in cellular stress response","volume":"25","author":"Zhu","year":"2006","journal-title":"Oncogene"}],"container-title":["Neuroscience & Biobehavioral Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426004276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0149763426004276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:01:31Z","timestamp":1792339291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0149763426004276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":156,"alternative-id":["S0149763426004276"],"URL":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106970","relation":{},"ISSN":["0149-7634"],"issn-type":[{"value":"0149-7634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROR\u03b1 as a context-dependent transcriptional stabilizer in the nervous system","name":"articletitle","label":"Article Title"},{"value":"Neuroscience & Biobehavioral Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neubiorev.2026.106970","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106970"}}