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Connect."},{"key":"10.1016\/j.neubiorev.2026.106975_bib100","doi-asserted-by":"crossref","first-page":"39681","DOI":"10.1074\/jbc.C500398200","article-title":"A role for hypothalamic malonyl-CoA in the control of food intake","volume":"280","author":"Hu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neubiorev.2026.106975_bib101","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1472-6882-14-203","article-title":"Effect of transcutaneous auricular vagus nerve stimulation on impaired glucose tolerance: a pilot randomized study","volume":"14","author":"Huang","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.neubiorev.2026.106975_bib102","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.cmet.2025.10.014","article-title":"Body-wide multi-omic counteraction of aging with GLP-1R agonism","volume":"37","author":"Huang","year":"2025","journal-title":"Cell. 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Adv."},{"key":"10.1016\/j.neubiorev.2026.106975_bib106","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41467-025-56328-5","article-title":"Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice","volume":"16","author":"Hwang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neubiorev.2026.106975_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002865","article-title":"The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet","volume":"22","author":"Hwang","year":"2024","journal-title":"PLoS. Biol."},{"key":"10.1016\/j.neubiorev.2026.106975_bib108","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s12276-021-00705-9","article-title":"Autonomic control of energy balance and glucose homeostasis","volume":"54","author":"Hyun","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.neubiorev.2026.106975_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112059","article-title":"Select microbial metabolites in the small intestinal lumen regulate vagal activity via receptor-mediated signaling","volume":"28","author":"Jameson","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.neubiorev.2026.106975_bib110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2020.06.008","article-title":"FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake","volume":"32","author":"Jensen-Cody","year":"2020","journal-title":"Cell. 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Rep."},{"key":"10.1016\/j.neubiorev.2026.106975_bib119","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.adj2537","article-title":"GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans","volume":"385","author":"Kim","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.neubiorev.2026.106975_bib120","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.brs.2019.07.020","article-title":"The effects of repetitive transcranial magnetic stimulation on body weight and food consumption in obese adults: A randomized controlled study","volume":"12","author":"Kim","year":"2019","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neubiorev.2026.106975_bib121","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.brs.2017.11.020","article-title":"The effects of repetitive transcranial magnetic stimulation on eating behaviors and body weight in obesity: A randomized controlled study","volume":"11","author":"Kim","year":"2018","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neubiorev.2026.106975_bib122","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.brs.2017.03.011","article-title":"Persistent blood glucose reduction upon repeated transcranial electric stimulation in men","volume":"10","author":"Kistenmacher","year":"2017","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neubiorev.2026.106975_bib123","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.2147\/JPR.S463383","article-title":"Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes","volume":"17","author":"Klonoff","year":"2024","journal-title":"J. Pain. Res."},{"key":"10.1016\/j.neubiorev.2026.106975_bib124","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neubiorev.2026.106975_bib125","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cmet.2010.09.013","article-title":"Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis","volume":"12","author":"Kong","year":"2010","journal-title":"Cell. Metab."},{"key":"10.1016\/j.neubiorev.2026.106975_bib126","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cmet.2007.05.004","article-title":"Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production","volume":"5","author":"K\u00f6nner","year":"2007","journal-title":"Cell. 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Metab."},{"key":"10.1016\/j.neubiorev.2026.106975_bib132","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3389\/fphys.2019.01036","article-title":"Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT\/CD36 in the Regulation of Food Intake","volume":"10","author":"Le Foll","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106975_bib133","doi-asserted-by":"crossref","first-page":"R655","DOI":"10.1152\/ajpregu.00223.2009","article-title":"Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing","volume":"297","author":"Le Foll","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neubiorev.2026.106975_bib134","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s42255-024-01079-8","article-title":"Obesity-induced inflammation: connecting the periphery to the brain","volume":"6","author":"Le Thuc","year":"2024","journal-title":"Nat. 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Behav."},{"key":"10.1016\/j.neubiorev.2026.106975_bib181","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.3579","article-title":"Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis","volume":"20","author":"Perry","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neubiorev.2026.106975_bib182","article-title":"Long-term efficacy of 10\u2009kHz spinal cord stimulation in managing painful diabetic neuropathy: A post-study survey","volume":"25","author":"Petersen","year":"2025","journal-title":"Pain. Pract."},{"key":"10.1016\/j.neubiorev.2026.106975_bib183","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.127428","article-title":"Identification of molecular changes in organs of obese rats following transcranial direct current stimulation (tDCS) - studies by FTIR microspectroscopy and chemometrics","volume":"350","author":"Piana","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.neubiorev.2026.106975_bib184","doi-asserted-by":"crossref","first-page":"G175","DOI":"10.1152\/ajpgi.00368.2020","article-title":"Musings on the wanderer: What's new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism","volume":"320","author":"Pitra","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neubiorev.2026.106975_bib185","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/s42255-021-00499-0","article-title":"Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity","volume":"3","author":"Porniece Kumar","year":"2021","journal-title":"Nat. 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Physiol."},{"key":"10.1016\/j.neubiorev.2026.106975_bib196","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1523\/JNEUROSCI.3306-14.2015","article-title":"Brown adipose tissue has sympathetic-sensory feedback circuits","volume":"35","author":"Ryu","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106975_bib197","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.2337\/db07-1824","article-title":"Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake","volume":"57","author":"Sandoval","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.neubiorev.2026.106975_bib198","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41574-021-00498-x","article-title":"Brain insulin signalling in metabolic homeostasis and disease","volume":"17","author":"Scherer","year":"2021","journal-title":"Nat. Rev. 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(Lond. )"},{"key":"10.1016\/j.neubiorev.2026.106975_bib202","article-title":"The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions","volume":"14","author":"Sheng","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106975_bib203","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.cmet.2009.09.013","article-title":"Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system","volume":"10","author":"Shiuchi","year":"2009","journal-title":"Cell. Metab."},{"key":"10.1016\/j.neubiorev.2026.106975_bib204","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1152\/jn.1998.79.4.1733","article-title":"Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons","volume":"79","author":"Silver","year":"1998","journal-title":"J. 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