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Sci."},{"key":"10.1016\/j.neubiorev.2026.106982_bib157","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neurol.2019.09.008","article-title":"The effects of diet and sex in amyotrophic lateral sclerosis","volume":"176","author":"Pape","year":"2020","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.neubiorev.2026.106982_bib158","doi-asserted-by":"crossref","first-page":"S371","DOI":"10.3233\/JAD-240388","article-title":"Hypercholesterolemia and Alzheimer\u2019s Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies","volume":"101","author":"Pappolla","year":"2024","journal-title":"J. Alzheimer\u2019S. 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Mass. )"},{"key":"10.1016\/j.neubiorev.2026.106982_bib168","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.metabol.2016.05.018","article-title":"Role of metabolism in neurodegenerative disorders","volume":"65","author":"Procaccini","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.neubiorev.2026.106982_bib169","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.biopsych.2009.02.013","article-title":"Meta-analysis of Alzheimer\u2019s disease risk with obesity, diabetes, and related disorders","volume":"67","author":"Profenno","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neubiorev.2026.106982_bib170","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.3390\/ijms242015430","article-title":"The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity","volume":"24","author":"Provenzano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106982_bib171","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.3390\/ijms242015430","article-title":"The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity","volume":"24","author":"Provenzano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neubiorev.2026.106982_bib172","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF","volume":"9","author":"Pun","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106982_bib173","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s42255-024-01189-3","article-title":"Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer\u2019s disease model","volume":"7","author":"Rabah","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.neubiorev.2026.106982_bib174","first-page":"306","article-title":"Brain FDG-PET changes in ALS and ALS-FTD","volume":"111","author":"Renard","year":"2011","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.neubiorev.2026.106982_bib175","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12974-020-01956-5","article-title":"Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"17","author":"Robison","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neubiorev.2026.106982_bib176","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.neurobiolaging.2012.12.027","article-title":"vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography","volume":"34","author":"Rojas","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neubiorev.2026.106982_bib177","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jshs.2020.01.004","article-title":"Physical exercise in the prevention and treatment of Alzheimer\u2019s disease","volume":"9","author":"Rosa","year":"2020","journal-title":"J. Sport. 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Neurosci."},{"key":"10.1016\/j.neubiorev.2026.106982_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.ensci.2025.100590","article-title":"Meta meta-analysis of cardiovascular risk factors in Alzheimer\u2019s disease","volume":"41","author":"Saiz-Vazquez","year":"2025","journal-title":"ENeurologicalSci"},{"key":"10.1016\/j.neubiorev.2026.106982_bib183","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fncel.2014.00025","article-title":"A plural role for lipids in motor neuron diseases: energy, signaling and structure","volume":"8","author":"Schmitt","year":"2014","journal-title":"Front. Cell. 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