{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:32:40Z","timestamp":1783776760729,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochirurgie"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.neuchi.2019.09.020","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T15:14:12Z","timestamp":1570115652000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reducing blood loss in pediatric craniosynostosis surgery by use of tranexamic acid"],"prefix":"10.1016","volume":"65","author":[{"given":"G.","family":"Eustache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Riffaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2\u20133 Pt2","key":"10.1016\/j.neuchi.2019.09.020_bib0155","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0028-3770(06)71222-X","article-title":"Anesthesia-resuscitation in the treatment of craniosynostosis","volume":"52","author":"Meyer","year":"2006","journal-title":"Neurochirurgie"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0160","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1460-9592.2011.03689.x","article-title":"Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery","volume":"21","author":"van Uitert","year":"2011","journal-title":"Pediatr Anesth"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0165","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/SCS.0b013e31819b9429","article-title":"Predictors of blood loss in fronto-orbital advancement and remodeling","volume":"20","author":"White","year":"2009","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/SCS.0000000000001108","article-title":"Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis","volume":"26","author":"White","year":"2015","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0175","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s003810050459","article-title":"Blood salvage in craniosynostosis surgery","volume":"15","author":"Velardi","year":"1999","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.neuchi.2019.09.020_bib2175","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/ALN.0000000000001997","article-title":"Antifibrinolytic therapy and perioperative considerations","volume":"128","author":"Levy","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0180","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00000539-200107000-00018","article-title":"A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery","volume":"93","author":"Neilipovitz","year":"2001","journal-title":"Anesth Analg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0185","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/PCC.0b013e3181956d61","article-title":"The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis","volume":"10","author":"Schouten","year":"2009","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0190","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/ALN.0b013e318210f9e3","article-title":"Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study","volume":"114","author":"Dadure","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0195","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/ALN.0b013e318210fd8f","article-title":"Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial","volume":"114","author":"Goobie","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0200","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/ALN.0b013e3182449fc8","article-title":"Reducing blood losses and transfusion requirements in craniosynostosis surgery: an endless quest?","volume":"116","author":"Vergnaud","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0205","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/pan.13076","article-title":"Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group","volume":"27","author":"Goobie","year":"2017","journal-title":"Pediatr Anesth"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0210","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3171\/2018.7.PEDS18132","article-title":"Variation in the management of isolated craniosynostosis: a survey of the Synostosis Research Group","volume":"22","author":"Kestle","year":"2018","journal-title":"J Neurosurg Pediatr"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0215","doi-asserted-by":"crossref","first-page":"788","DOI":"10.7150\/ijms.25008","article-title":"Effects of tranexamic acid based on its population pharmacokinetics in pediatric patients undergoing distraction osteogenesis for craniosynostosis: rotational thromboelastometry (ROTEM\u2122) analysis","volume":"15","author":"Kim","year":"2018","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0220","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bja.2019.02.017","article-title":"Reduced perioperative blood loss in children undergoing craniosynostosis surgery using prolonged tranexamic acid infusion: a randomised trial","volume":"122","author":"Fenger-Eriksen","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0225","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1097\/SCS.0b013e31822e6283","article-title":"Comparative analysis of tranexamic acid use in minimally invasive versus open craniosynostosis procedures","volume":"22","author":"Maugans","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/229255031502300413","article-title":"Use of tranexamic acid in craniosynostosis surgery","volume":"23","author":"Martin","year":"2015","journal-title":"Plast Surg (Oakv)"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0235","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jcms.2015.05.004","article-title":"The value of tranexamic acid during fronto-orbital advancement in isolated metopic craniosynostosis","volume":"43","author":"Engel","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0240","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/SCS.0000000000001271","article-title":"Evaluating the safety and efficacy of tranexamic acid administration in pediatric cranial vault reconstruction","volume":"26","author":"Crantford","year":"2015","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0245","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/SCS.0000000000003711","article-title":"Reducing postoperative bleeding after craniosynostosis repair utilizing a low-dose tranexamic acid infusion protocol","volume":"28","author":"Hansen","year":"2017","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0250","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/SCS.0000000000003731","article-title":"Tranexamic acid reduces blood loss in craniosynostosis surgery","volume":"28","author":"Kurnik","year":"2017","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0255","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/SCS.0000000000004196","article-title":"Craniosynostosis surgery and the impact of tranexamic acid dosing","volume":"29","author":"Kurnik","year":"2018","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0260","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/SCS.0000000000002835","article-title":"Implementation of a tranexamic acid protocol to reduce blood loss during cranial vault remodeling for craniosynostosis","volume":"27","author":"Martin","year":"2016","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0265","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00381-019-04157-5","article-title":"Minimizing transfusion in sagittal craniosynostosis surgery: the children's hospital of Minnesota protocol","volume":"35","author":"Escher","year":"2019","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0270","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s40262-013-0033-1","article-title":"Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery","volume":"52","author":"Goobie","year":"2013","journal-title":"Clin Pharmacokinet"},{"issue":"22","key":"10.1016\/j.neuchi.2019.09.020_bib0275","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1056\/NEJMoa0802395","article-title":"A comparison of aprotinin and lysine analogues in high-risk cardiac surgery","volume":"358","author":"Fergusson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0280","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/pan.13076","article-title":"Safety of antifibrinolytics in cranial vault reconstructive surgery: a report from the pediatric craniofacial collaborative group","volume":"27","author":"Goobie","year":"2017","journal-title":"Paediatr Anaesth"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0285","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.joms.2019.01.032","article-title":"The role of antifibrinolytics in reducing blood loss during craniofacial or orthognathic Surgical procedures: A meta-analysis","volume":"77","author":"Siotou","year":"2019","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0290","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/SCS.0b013e3182710232","article-title":"Tranexamic acid reducing blood transfusion in children undergoing craniosynostosis surgery","volume":"24","author":"Song","year":"2013","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0295","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0038-1649475","article-title":"Treatment with tranexamic acid during pregnancy, and the risk of thrombo-embolic complications","volume":"70","author":"Lindoff","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.neuchi.2019.09.020_bib0300","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/SCS.0000000000004905","article-title":"Ulnar artery thrombosis following tranexamic acid administration for craniosynostosis repair","volume":"30","author":"Chung","year":"2019","journal-title":"J Craniofac Surg"}],"container-title":["Neurochirurgie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377019302322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377019302322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T13:35:29Z","timestamp":1618148129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028377019302322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0028377019302322"],"URL":"https:\/\/doi.org\/10.1016\/j.neuchi.2019.09.020","relation":{},"ISSN":["0028-3770"],"issn-type":[{"value":"0028-3770","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reducing blood loss in pediatric craniosynostosis surgery by use of tranexamic acid","name":"articletitle","label":"Article Title"},{"value":"Neurochirurgie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuchi.2019.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}