{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T12:46:35Z","timestamp":1758458795650,"version":"3.44.0"},"reference-count":11,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochirurgie"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.neuchi.2022.06.006","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T07:45:24Z","timestamp":1656661524000},"page":"560-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Why are surgical trials so difficult to accomplish, and then considered so definitive?"],"prefix":"10.1016","volume":"68","author":[{"given":"J.","family":"Raymond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Obaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.E.","family":"Darsaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuchi.2022.06.006_bib0060","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0140-6736(96)90137-3","article-title":"Surgical research or comic opera: questions, but few answers","volume":"347","author":"Horton","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0065","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3171\/2014.12.JNS142465","article-title":"Randomized controlled trials and neurosurgery: the ideal fit or should alternative methodologies be considered?","volume":"124","author":"Mansouri","year":"2016","journal-title":"J Neurosurg"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0070","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJM200108023450501","article-title":"Effectiveness, efficiency of surgery for temporal lobe epilepsy study g. a randomized, controlled trial of surgery for temporal-lobe epilepsy","volume":"345","author":"Wiebe","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0075","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/jama.2012.220","article-title":"Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial","volume":"307","author":"Engel","year":"2012","journal-title":"JAMA: the journal of the American Medical Association"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuchi.2022.06.005","article-title":"Understanding the problems with recruitment in surgical randomized trials: A lesson from landmark trials on temporal lobe epilepsy","author":"Obaid","year":"2022","journal-title":"Neuro-Chirurgie In Press"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0085","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMoa1615335","article-title":"Surgery for drug-resistant epilepsy in children","volume":"377","author":"Dwivedi","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0090","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial","volume":"360","author":"Molyneux","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuchi.2012.02.020","article-title":"Ruptured aneurysms and the International Subarachnoid Aneurysm Trial (ISAT): What is known and what remains to be questioned","volume":"58","author":"Raymond","year":"2012","journal-title":"Neuro-Chirurgie"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0100","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.3171\/2017.2.JNS162751","article-title":"The Treatment of Brain AVMs Study (TOBAS): an all-inclusive framework to integrate clinical care and research","volume":"128","author":"Magro","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/s13063-015-1019-0","article-title":"Treatment of Brain AVMs (TOBAS): study protocol for a pragmatic randomized controlled trial","volume":"16","author":"Darsaut","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.neuchi.2022.06.006_bib0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13063-021-05084-0","article-title":"Ethical care requires pragmatic care research to guide medical practice under uncertainty","volume":"22","author":"Darsaut","year":"2021","journal-title":"Trials"}],"container-title":["Neurochirurgie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377022001060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377022001060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:35:22Z","timestamp":1758436522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028377022001060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0028377022001060"],"URL":"https:\/\/doi.org\/10.1016\/j.neuchi.2022.06.006","relation":{},"ISSN":["0028-3770"],"issn-type":[{"type":"print","value":"0028-3770"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why are surgical trials so difficult to accomplish, and then considered so definitive?","name":"articletitle","label":"Article Title"},{"value":"Neurochirurgie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuchi.2022.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}