{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:15:55Z","timestamp":1790241355590,"version":"4.1.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochirurgie"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.neuchi.2023.101408","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T06:34:25Z","timestamp":1674542065000},"page":"101408","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Understanding how the primary endpoint impacts the interpretation of trial results: The Japanese Adult Moyamoya bypass trial"],"prefix":"10.1016","volume":"69","author":[{"given":"A.R.","family":"Rheaume","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Olijnyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.","family":"Lecaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"Darsaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuchi.2023.101408_bib0085","article-title":"Understanding explanatory and pragmatic trials: examples from randomized controlled trials on vertebroplasty","author":"Eneling","year":"2022","journal-title":"Neuro-Chirurgie"},{"key":"10.1016\/j.neuchi.2023.101408_bib0090","series-title":"Three treatises on the nature of science: on the sects for beginners, an outline for empiricism, on medical experience1736","author":"Galen","year":"1985"},{"key":"10.1016\/j.neuchi.2023.101408_bib0095","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.neuchi.2022.02.004","article-title":"Understanding how to move from dogmatic to outcome-based neurosurgical care: Lessons from past surgical studies on ruptured aneurysm patients","volume":"68","author":"Raymond","year":"2022","journal-title":"Neuro-Chirurgie"},{"key":"10.1016\/j.neuchi.2023.101408_bib0100","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1474-4422(08)70240-0","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"Kuroda","year":"2008","journal-title":"Lancet neurology"},{"key":"10.1016\/j.neuchi.2023.101408_bib0105","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/2009.01.FOCUS08293","article-title":"Surgical management of moyamoya disease: a review","volume":"26","author":"Baaj","year":"2009","journal-title":"Neurosurgical focus"},{"key":"10.1016\/j.neuchi.2023.101408_bib0110","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/STROKEAHA.113.004386","article-title":"Effects of extracranial-intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial","volume":"45","author":"Miyamoto","year":"2014","journal-title":"Stroke; a journal of cerebral circulation"},{"key":"10.1016\/j.neuchi.2023.101408_bib0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2176\/nmc.44.218","article-title":"Study design for a prospective randomized trial of extracranial-intracranial bypass surgery for adults with moyamoya disease and hemorrhagic onset--the Japan Adult Moyamoya Trial Group","volume":"44","author":"Miyamoto","year":"2004","journal-title":"Neurologia medico-chirurgica"},{"key":"10.1016\/j.neuchi.2023.101408_bib0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12916-020-01706-7","article-title":"How to design a pre-specified statistical analysis approach to limit p-hacking in clinical trials: the Pre-SPEC framework","volume":"18","author":"Kahan","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.neuchi.2023.101408_bib0125","article-title":"Understanding power in randomized trials: The example of vertebroplasty","author":"Eneling","year":"2023","journal-title":"Neuro-Chirurgie. In Press"},{"key":"10.1016\/j.neuchi.2023.101408_bib0130","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1001\/jama.289.19.2554","article-title":"Composite outcomes in randomized trials: greater precision but with greater uncertainty?","volume":"289","author":"Freemantle","year":"2003","journal-title":"JAMA J Amer Med Assoc"},{"key":"10.1016\/j.neuchi.2023.101408_bib0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.neuchi.2023.101408_bib0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","article-title":"Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies","volume":"13","author":"Greving","year":"2014","journal-title":"Lancet neurol"},{"key":"10.1016\/j.neuchi.2023.101408_bib0145","doi-asserted-by":"crossref","first-page":"e770","DOI":"10.1016\/j.wneu.2020.06.018","article-title":"Comprehensive Aneurysm Management (CAM): An all-inclusive care trial for unruptured intracranial aneurysms","volume":"141","author":"Darsaut","year":"2020","journal-title":"World Neurosurg"},{"key":"10.1016\/j.neuchi.2023.101408_bib0150","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuchi.2022.04.004","article-title":"Understanding the reliability of trial outcome measures: The example of angiographic results of surgical or endovascular treatments of aneurysms","volume":"68","author":"Raymond","year":"2022","journal-title":"Neuro-Chirurgie"},{"key":"10.1016\/j.neuchi.2023.101408_bib0155","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuchi.2022.04.003","article-title":"Inter-rater reliability of the simplified Modified Rankin Scale as an outcome measure for treated cerebral aneurysm patients","volume":"68","author":"Bacchus","year":"2022","journal-title":"Neuro-Chirurgie"},{"key":"10.1016\/j.neuchi.2023.101408_bib0160","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jclinepi.2014.04.010","article-title":"Pragmatic trials can be designed as optimal medical care: principles and methods of care trials","volume":"67","author":"Raymond","year":"2014","journal-title":"J Clin Epidemiol"}],"container-title":["Neurochirurgie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002837702300005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002837702300005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:32:55Z","timestamp":1758436375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002837702300005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S002837702300005X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuchi.2023.101408","relation":{},"ISSN":["0028-3770"],"issn-type":[{"value":"0028-3770","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding how the primary endpoint impacts the interpretation of trial results: The Japanese Adult Moyamoya bypass trial","name":"articletitle","label":"Article Title"},{"value":"Neurochirurgie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuchi.2023.101408","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"101408"}}