{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:26:49Z","timestamp":1787498809436,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochirurgie"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.neuchi.2025.101665","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:10:14Z","timestamp":1743264614000},"page":"101665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rethinking age barriers in Parkinson\u2019s disease for deep brain stimulation"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-9058","authenticated-orcid":false,"given":"Roberto M.","family":"Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Rosas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuchi.2025.101665_bib0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-444-63934-9.00012-3","article-title":"Smart neuromodulation in movement disorders","volume":"168","author":"Mitchell","year":"2020","journal-title":"Handb Clin Neurol"},{"issue":"6","key":"10.1016\/j.neuchi.2025.101665_bib0010","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1212\/WNL.59.6.932","article-title":"Predictors of effective bilateral subthalamic nucleus stimulation for PD","volume":"59","author":"Charles","year":"2002","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.neuchi.2025.101665_bib0015","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1001\/jamaneurol.2014.1272","article-title":"Effect of advancing age on outcomes of deep brain stimulation for Parkinson disease","volume":"71","author":"DeLong","year":"2014","journal-title":"JAMA Neurol"},{"issue":"17","key":"10.1016\/j.neuchi.2025.101665_bib0020","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1212\/01.wnl.0000260059.77107.c2","article-title":"Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population?","volume":"68","author":"Derost","year":"2007","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neuchi.2025.101665_bib0025","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3340\/jkns.2013.54.2.118","article-title":"Factors related to outcomes of subthalamic deep brain stimulation in Parkinson\u2019s disease","volume":"54","author":"Kim","year":"2013","journal-title":"J Korean Neurosurg Soc"},{"issue":"2","key":"10.1016\/j.neuchi.2025.101665_bib0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(11)70308-8","article-title":"Subthalamic deep brain stimulation with a constant-current device in Parkinson\u2019s disease: an open-label randomised controlled trial","volume":"11","author":"Okun","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.neuchi.2025.101665_bib0035","first-page":"107","article-title":"Deep brain stimulation for the treatment of Parkinson\u2019s disease: efficacy and safety","volume":"2012","author":"Pouratian","year":"2012","journal-title":"Degener Neurol Neuromuscul Dis"},{"issue":"1","key":"10.1016\/j.neuchi.2025.101665_bib0040","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2008.929","article-title":"Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial","volume":"301","author":"Weaver","year":"2009","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.neuchi.2025.101665_bib0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/jnnp.2003.033530","article-title":"Heterogeneity of Parkinson\u2019s disease in the early clinical stages using a data driven approach","volume":"76","author":"Lewis","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"10.1016\/j.neuchi.2025.101665_bib0050","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/mds.21481","article-title":"Thirty days complication rate following surgery performed for deep-brain-stimulation","volume":"22","author":"Voges","year":"2007","journal-title":"Mov Disord"},{"issue":"1\u20134","key":"10.1016\/j.neuchi.2025.101665_bib0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000064600","article-title":"Complications of deep brain stimulation surgery","volume":"77","author":"Beric","year":"2001","journal-title":"Stereotact Funct Neurosurg"},{"issue":"1","key":"10.1016\/j.neuchi.2025.101665_bib0060","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00701-024-06330-5","article-title":"Risk factors for delirium occurring after deep brain stimulation surgery in patients with Parkinson\u2019s disease","volume":"166","author":"Ozluk","year":"2024","journal-title":"Acta Neurochirurgica"},{"key":"10.1016\/j.neuchi.2025.101665_bib0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2377-7-7","article-title":"Subthalamic nucleus deep brain stimulation in elderly patients--analysis of outcome and complications","volume":"7","author":"Vesper","year":"2007","journal-title":"BMC Neurol"},{"issue":"8","key":"10.1016\/j.neuchi.2025.101665_bib0070","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14899","article-title":"Safety and efficiency of deep brain stimulation in the elderly patients with Parkinson\u2019s disease","volume":"30","author":"Wu","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.neuchi.2025.101665_bib0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.wneu.2016.06.001","article-title":"Short- and long-term outcomes of deep brain stimulation in patients 70 years and older with Parkinson disease","volume":"97","author":"Mathkour","year":"2017","journal-title":"World Neurosurg"},{"issue":"12","key":"10.1016\/j.neuchi.2025.101665_bib0080","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"10.1016\/j.neuchi.2025.101665_bib0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.clineuro.2016.07.028","article-title":"Benefits of subthalamic stimulation for elderly parkinsonian patients aged 70 years or older","volume":"149","author":"Chiou","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"issue":"3","key":"10.1016\/j.neuchi.2025.101665_bib0090","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/ene.14147","article-title":"What predicts quality of life after subthalamic deep brain stimulation in Parkinson\u2019s disease? A systematic review","volume":"27","author":"Geraedts","year":"2020","journal-title":"Eur J Neurol"},{"issue":"3","key":"10.1016\/j.neuchi.2025.101665_bib0095","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3171\/2018.4.JNS171909","article-title":"Comparison of elderly and young patient populations treated with deep brain stimulation for Parkinson\u2019s disease: long-term outcomes with up to 7 years of follow-up","volume":"131","author":"Hanna","year":"2018","journal-title":"J Neurosurg"},{"issue":"10","key":"10.1016\/j.neuchi.2025.101665_bib0100","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1212\/01.WNL.0000144198.26309.D8","article-title":"Subthalamic nucleus deep brain stimulation in Parkinson disease patients over age 70 years","volume":"63","author":"Russmann","year":"2004","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.neuchi.2025.101665_bib0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/neuros\/nyy287","article-title":"Quality of life improvement following deep brain stimulation for Parkinson disease: development of a prognostic model","volume":"85","author":"Frizon","year":"2019","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1016\/j.neuchi.2025.101665_bib0110","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.parkreldis.2007.10.004","article-title":"Frailty in Parkinson\u2019s disease and its clinical implications","volume":"14","author":"Ahmed","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.neuchi.2025.101665_bib0115","doi-asserted-by":"crossref","first-page":"108319","DOI":"10.1016\/j.clineuro.2024.108319","article-title":"Outcomes after deep brain stimulation for elderly versus non-elderly patients with Parkinson\u2019s disease","volume":"242","author":"Zheng","year":"2024","journal-title":"Clin Neurol Neurosurg"},{"issue":"3","key":"10.1016\/j.neuchi.2025.101665_bib0120","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JPD-191604","article-title":"Frailty in Parkinson\u2019s disease: a systematic review","volume":"9","author":"Smith","year":"2019","journal-title":"J Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.neuchi.2025.101665_bib0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41531-022-00383-y","article-title":"Axial impairment and falls in Parkinson\u2019s disease: 15 years of subthalamic deep brain stimulation","volume":"8","author":"Zampogna","year":"2022","journal-title":"npj Parkinson\u2019s Disease"},{"issue":"11","key":"10.1016\/j.neuchi.2025.101665_bib0130","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12111588","article-title":"Short- and long-term efficacy and safety of deep-brain stimulation in Parkinson\u2019s disease patients aged 75 years and older","volume":"12","author":"Jiang","year":"2022","journal-title":"Brain Sci"},{"issue":"22","key":"10.1016\/j.neuchi.2025.101665_bib0135","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1212\/WNL.0000000000001640","article-title":"Central paroxysmal positional nystagmus: characteristics and possible mechanisms","volume":"84","author":"Choi","year":"2015","journal-title":"Neurology"}],"container-title":["Neurochirurgie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377025000384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0028377025000384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:10:07Z","timestamp":1747746607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0028377025000384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0028377025000384"],"URL":"https:\/\/doi.org\/10.1016\/j.neuchi.2025.101665","relation":{},"ISSN":["0028-3770"],"issn-type":[{"value":"0028-3770","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rethinking age barriers in Parkinson\u2019s disease for deep brain stimulation","name":"articletitle","label":"Article Title"},{"value":"Neurochirurgie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuchi.2025.101665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101665"}}