{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:12:36Z","timestamp":1770977556204,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.neuint.2005.10.016","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T12:20:44Z","timestamp":1140783644000},"page":"441-446","source":"Crossref","is-referenced-by-count":24,"title":["Role of extracellular cGMP and of hyperammonemia in the impairment of learning in rats with chronic hepatic failure"],"prefix":"10.1016","volume":"48","author":[{"given":"Slaven","family":"Erceg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Monfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Cauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmina","family":"Montoliu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Llansola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Piedrafita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Felipo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2005.10.016_bib1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1006\/exnr.1999.7299","article-title":"Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats","volume":"161","author":"Aguilar","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuint.2005.10.016_bib2","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/hep.510290619","article-title":"Clinical features and survival of cirrhotic patients with subclinical cognitive alterations detected by the number connection test and computerized psychometric tests","volume":"29","author":"Amodio","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/B:MEBR.0000043975.01841.de","article-title":"Characteristics of minimal hepatic encephalopathy","volume":"19","author":"Amodio","year":"2004","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2005.10.016_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hep.1840100310","article-title":"A simple animal model of hyperammonemia","volume":"10","author":"Azorin","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/00001756-199601310-00050","article-title":"Hippocampal cGMP and cAMP are differentially involved in memory processing of inhibitor avoidance learning","volume":"7","author":"Bernabeu","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2005.10.016_bib6","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1097\/00001756-199707070-00026","article-title":"Further evidence for the involvement of a hippocampal cGMP\/cGMP-dependent protein kinase cascade in memory consolidation","volume":"8","author":"Bernabeu","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2005.10.016_bib7","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1097\/00001756-199705060-00040","article-title":"Memory-related changes of nitric oxide synthase activity and nitrite level in rat brain","volume":"8","author":"Chen","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2005.10.016_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1053\/jhep.2002.36365","article-title":"Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients","volume":"36","author":"Corbalan","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00008877-199508000-00007","article-title":"Modulation of learning processes by ionotropic glutamate receptor ligands","volume":"6","author":"Danysz","year":"1995","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuint.2005.10.016_bib10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/jnnp.38.8.794","article-title":"Cognitive deficit associated with chronic hepatic encephalopathy and their response to levodopa","volume":"38","author":"Elithorn","year":"1975","journal-title":"J. Neurol. Neurosurg. Psych."},{"key":"10.1016\/j.neuint.2005.10.016_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hep.20565","article-title":"Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts","volume":"41","author":"Erceg","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.brainres.2004.12.045","article-title":"Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain","volume":"1036","author":"Erceg","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2005.10.016_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0301-0082(02)00019-9","article-title":"Neurobiology of ammonia","volume":"67","author":"Felipo","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2005.10.016_bib14","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","article-title":"Hepatic encephalopathy\u2014definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna","volume":"35","author":"Ferenci","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1590\/S0100-879X2005000100019","article-title":"Evaluation of two experimental models of hepatic encephalopathy in rats","volume":"38","author":"Garcia-Moreno","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuint.2005.10.016_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/hep.510280108","article-title":"Subclinical hepatic encephalopathy impairs daily functioning","volume":"28","author":"Groeneweg","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.neuint.2005.10.016_bib17","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1572-0241.2000.02265.x","article-title":"The prognostic significance of subclinical hepatic encephalopathy","volume":"95","author":"Hartmann","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.neuint.2005.10.016_bib18","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1046\/j.1460-9568.1998.00329.x","article-title":"Chronic hyperammonemia impairs glutamate\u2013nitric oxide\u2013cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo","volume":"10","author":"Hermenegildo","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2005.10.016_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(97)01427-1","article-title":"Intraventricular injection of N-nitro-l-arginine in rats impairs learning in a 14-unit T-maze","volume":"341","author":"Ingram","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2005.10.016_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(97)01426-X","article-title":"Learning in a 14-unit T-maze is impaired in rats following the systemic treatment with N-nitro-l-arginina","volume":"341","author":"Ingram","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2005.10.016_bib21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1001\/archneur.1996.00550080076015","article-title":"Neuropsychological characterization and detection of subclinical hepatic encephalopathy","volume":"53","author":"McCrea","year":"1996","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuint.2005.10.016_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/gast.2001.21193","article-title":"Factors associated with poor health-related quality of life of patients with cirrhosis","volume":"120","author":"Marchesini","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuint.2005.10.016_bib23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s002130050512","article-title":"Combined stimulation of the glycine and polyamine sites of the NMDA receptor attenuates NMDA blockade-induced learning deficits of rats in a 14-unit-T-maze","volume":"135","author":"Meyer","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuint.2005.10.016_bib24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0306-4522(01)00128-2","article-title":"Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis","volume":"104","author":"Monfort","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2005.10.016_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0301-0082(97)00036-1","article-title":"Inhibitory learning and memory in new-born rats","volume":"53","author":"Myslivecek","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2005.10.016_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0014-2999(97)01301-0","article-title":"Possible role of nitric oxide-cyclic GMP pathway in object recognition memory: effects of 7-nitroindazole and zaprinast","volume":"337","author":"Prickaerts","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2005.10.016_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-2999(01)01614-4","article-title":"cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation","volume":"436","author":"Prickaerts","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2005.10.016_bib28","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0016-5085(78)90851-X","article-title":"Subclinical hepatic encephalopathy: detection, prevalence, and relationship to nitrogen metabolism","volume":"75","author":"Rikkers","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuint.2005.10.016_bib29","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1111\/j.1572-0241.2001.04130.x","article-title":"Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy","volume":"96","author":"Romero-Gomez","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.neuint.2005.10.016_bib30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1023\/A:1020645110880","article-title":"Neuropsychological aspects of portal-systemic encephalopathy","volume":"13","author":"Schomerus","year":"1998","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2005.10.016_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1011610427843","article-title":"Quality of life in cirrhotics with minimal hepatic encephalopathy","volume":"16","author":"Schomerus","year":"2001","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neuint.2005.10.016_bib32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/BF01367675","article-title":"Latent portasystemic encephalopathy. I. Nature of cerebral functional defects and their effect on fitness to drive","volume":"26","author":"Schomerus","year":"1981","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.neuint.2005.10.016_bib33","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1097\/00001756-200011270-00055","article-title":"A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze","volume":"11","author":"Smith","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2005.10.016_bib34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0168-8278(05)80612-9","article-title":"Fitness to drive in patients with cirrhosis and portal-systemic shunting: a pilot study evaluating driving performance","volume":"21","author":"Srivastava","year":"1994","journal-title":"J. Hepatol."},{"key":"10.1016\/j.neuint.2005.10.016_bib35","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3109\/00207458709043340","article-title":"Memory impairments concomitant with nonalcoholic cirrhosis","volume":"32","author":"Tarter","year":"1987","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neuint.2005.10.016_bib36","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1111\/j.1572-0241.2002.05876.x","article-title":"Sildenafil (viagra) is a risk factor for acute variceal bleeding","volume":"97","author":"Tzathas","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.neuint.2005.10.016_bib37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0168-8278(03)00295-2","article-title":"Memory function in early hepatic encephalopathy","volume":"39","author":"Weissenborn","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.neuint.2005.10.016_bib38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0306-4522(96)00161-3","article-title":"Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behavior in mice","volume":"74","author":"Yamada","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2005.10.016_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0028-3908(98)00042-2","article-title":"Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats","volume":"37","author":"Zou","year":"1998","journal-title":"Neuropharmacology"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018606000350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018606000350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T22:19:08Z","timestamp":1586729948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018606000350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":39,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0197018606000350"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2005.10.016","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}