{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:39:24Z","timestamp":1789871964925,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100018502","name":"Kanazawa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["14658267"],"award-info":[{"award-number":["14658267"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["15922093"],"award-info":[{"award-number":["15922093"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["16027218"],"award-info":[{"award-number":["16027218"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["18209053"],"award-info":[{"award-number":["18209053"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.neuint.2007.01.011","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T07:05:52Z","timestamp":1171004752000},"page":"741-748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Early downregulation of IGF-I decides the fate of rat retinal ganglion cells after optic nerve injury"],"prefix":"10.1016","volume":"50","author":[{"given":"Keiko","family":"Homma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Koriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Mawatari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2007.01.011_bib1","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/00001756-199707070-00034","article-title":"IGF-I enhances neurite regeneration but is not required for its survival in adult DRG explant","volume":"8","author":"Akahori","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neuint.2007.01.011_bib2","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","article-title":"Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats","volume":"14","author":"Berkelaar","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib3","first-page":"1459","article-title":"Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye","volume":"37","author":"Burren","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuint.2007.01.011_bib4","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","article-title":"Regulation of cell death protease caspase-9 by phosphorylation","volume":"282","author":"Cardone","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.neuint.2007.01.011_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0169-328X(99)00032-7","article-title":"Caspase inhibitors block the retinal ganglion cell death following optic nerve transection","volume":"67","author":"Chaudhary","year":"1999","journal-title":"Mol. Brain. Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0168-0102(01)00251-6","article-title":"Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development","volume":"40","author":"Devadas","year":"2001","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib7","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1523\/JNEUROSCI.5119-03.2004","article-title":"Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state","volume":"24","author":"Fischer","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib8","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.92.10.4304","article-title":"Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death","volume":"92","author":"Gonz\u00e1lez-Garc\u00eda","year":"1995","journal-title":"PNAS"},{"key":"10.1016\/j.neuint.2007.01.011_bib9","first-page":"163","article-title":"A mouse model of elevated intraocular pressure: retina and optic nerve findings","volume":"101","author":"Gross","year":"2003","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.neuint.2007.01.011_bib10","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1460-9568.1997.tb01534.x","article-title":"Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat","volume":"9","author":"Isenmann","year":"1997","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0962-8924(98)01321-X","article-title":"Bcl-2-family proteins: the role of the BH3 domain in apoptosis","volume":"8","author":"Kelekar","year":"1998","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuint.2007.01.011_bib12","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1523\/JNEUROSCI.18-12-04656.1998","article-title":"Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo","volume":"18","author":"Kermer","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1523\/JNEUROSCI.20-02-00722.2000","article-title":"Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 in vivo","volume":"20","author":"Kermer","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2005.07.005","article-title":"Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program","volume":"1057","author":"Kim","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-2999(02)02789-9","article-title":"Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons","volume":"458","author":"Koriyama","year":"2003","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.neuint.2007.01.011_bib16","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuint.2007.01.012","article-title":"Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration","volume":"50","author":"Koriyama","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2007.01.011_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","article-title":"The proto-oncogene Bcl-2 and its role in regulating apoptosis","volume":"3","author":"Kroemer","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuint.2007.01.011_bib18","first-page":"45","article-title":"Des(1-3)IGF-1 treatment normalizes type 1 IGF receptor and phospho-Akt (Thr 308) immunoreactivity in predegenerative retina of diabetic rats","volume":"4","author":"Kummer","year":"2003","journal-title":"Int. J. Exp. Diabesity Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib19","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1523\/JNEUROSCI.12-12-04737.1992","article-title":"Coordinate expression of insulin-like growth factor system components by neurons and neuroglia during retinal and cerebellar development","volume":"12","author":"Lee","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2007.01.011_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.jbchem.a002947","article-title":"Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1","volume":"130","author":"Matsuzawa","year":"2001","journal-title":"J. Biochem."},{"key":"10.1016\/j.neuint.2007.01.011_bib21","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1167\/iovs.04-1339","article-title":"Transcorneal electrical stimulation rescues axotomized retinal ganglion cells by activating endogenous retinal IGF-1 system","volume":"46","author":"Morimoto","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neuint.2007.01.011_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1076\/ceyr.26.1.55.14254","article-title":"Intrinsic activation of PI3K\/Akt signaling pathway and its neuroprotective effect against retinal injury","volume":"26","author":"Nakazawa","year":"2003","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molbrainres.2003.09.016","article-title":"Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection","volume":"120","author":"N\u00e4p\u00e4nkangas","year":"2003","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"74","author":"Oltvai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2007.01.011_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/ajpendo.00507.2002","article-title":"Characterization of insulin signaling in rat retina in vivo and ex vivo","volume":"285","author":"Reiter","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuint.2007.01.011_bib26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/02713680490517872","article-title":"Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity","volume":"29","author":"Schuettauf","year":"2004","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.neuint.2007.01.011_bib27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.neuroscience.2006.07.042","article-title":"Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration","volume":"142","author":"Sugitani","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2007.01.011_bib28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","article-title":"Prevention of apoptosis by Bcl-2: release of cytochrome C from mitochondria blocked","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neuint.2007.01.011_bib29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1083\/jcb.151.3.483","article-title":"Akt regulates cell survival and apoptosis at a postmitochondrial level","volume":"151","author":"Zhou","year":"2000","journal-title":"J. Cell Biol."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018607000368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018607000368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:49:24Z","timestamp":1762264164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018607000368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0197018607000368"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2007.01.011","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early downregulation of IGF-I decides the fate of rat retinal ganglion cells after optic nerve injury","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2007.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}