{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T17:10:10Z","timestamp":1739121010470,"version":"3.37.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.neuint.2009.05.008","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T09:18:49Z","timestamp":1242897529000},"page":"529-535","source":"Crossref","is-referenced-by-count":3,"title":["AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats"],"prefix":"10.1016","volume":"55","author":[{"given":"Kazuya","family":"Kanemaru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Diksic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.neuint.2009.05.008_bib1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1176\/appi.ajp.163.9.1580","article-title":"Increased 5-HT(2A) receptor binding in euthymic medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907","volume":"163","author":"Bhagwagar","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann. Stat."},{"key":"10.1016\/j.neuint.2009.05.008_bib3","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuint.2007.08.021","article-title":"An index of 5-HT synthesis changes during early antidepressant treatment: \u03b1-[11C]methyl-l-tryptophan PET study","volume":"52","author":"Berney","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.05.008_bib4","series-title":"Federation Proceedings Abstracts, 66th Annual Meeting","first-page":"6243","article-title":"The increase an brainstem tryptophan hydroxylase (TRPH) activity induced depolarization (DEP) or phosphorylating conditions is blocked by 3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione (AGN2979)","author":"Boadle-Biber","year":"1982"},{"key":"10.1016\/j.neuint.2009.05.008_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-2952(83)90678-0","article-title":"Activation of tryptophan hydroxylase by stimulation of central serotonergic neurons","volume":"32","author":"Boadle-Biber","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuint.2009.05.008_bib6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0006-2952(86)90119-X","article-title":"AGN 2979 [3(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4,4-dimethylpiperidine-2,6-dione]. An inhibitor of the activation of tryptophan hydroxylase","volume":"35","author":"Boadle-Biber","year":"1986","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.neuint.2009.05.008_bib7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0006-8993(89)91193-1","article-title":"Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress","volume":"482","author":"Boadle-Biber","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2009.05.008_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0173(93)90005-K","article-title":"Physiopharmacological interactions between stress hormones and central serotonergic systems","volume":"18","author":"Chaouloff","year":"1993","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neuint.2009.05.008_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(24)35063-3","article-title":"Mechanism of fluoxetine block of cloned voltage-activated potassium channel Kv1.3","volume":"291","author":"Choi","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neuint.2009.05.008_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1176\/ajp.143.2.264a","article-title":"Antidepressant effect of a tryptophan hydroxylase activation inhibitor AGN 2979","volume":"143","author":"Clerc","year":"1986","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0278-5846(94)90076-0","article-title":"An evaluation of the anxiolytic SC 48,274 in generalized anxiety disorder (GAD)","volume":"18","author":"Cutler","year":"1994","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.neuint.2009.05.008_bib12","first-page":"321","article-title":"Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression","volume":"27","author":"Delgado","year":"1991","journal-title":"Psychopharmacol. Bull."},{"issue":"10","key":"10.1016\/j.neuint.2009.05.008_bib13","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0006-3223(99)00189-4","article-title":"PET imaging of serotonin 1A receptor binding in depression","volume":"46","author":"Drevets","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib14","first-page":"293","article-title":"Labelled alpha-methyl-l-tryptophan as a tracer for the study of the brain serotonergic system","volume":"26","author":"Diksic","year":"2001","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.neuint.2009.05.008_bib15","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/jcbfm.1995.101","article-title":"The regional rate of serotonin synthesis estimated by the alpha-methyl-tryptophan method in rat brain from a single time point","volume":"15","author":"Diksic","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuint.2009.05.008_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1471-4159.1991.tb02575.x","article-title":"The serotonin synthesis rate measured in living dog brain by PET","volume":"56","author":"Diksic","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2009.05.008_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jcbfm.1990.1","article-title":"A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model","volume":"10","author":"Diksic","year":"1990","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuint.2009.05.008_bib18","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1046\/j.1471-4159.2001.00536.x","article-title":"Study of the brain serotonergic system with labeled alpha-methyl-l-tryptophan","volume":"78","author":"Diksic","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2009.05.008_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0165-0173(86)90016-0","article-title":"Cholinergic mechanisms in depression","volume":"396","author":"Dilsaver","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2009.05.008_bib20","article-title":"Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure","author":"Firk","year":"2008","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuint.2009.05.008_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0165-0327(90)90140-4","article-title":"Imipramine and weight gain during the treatment of recurrent depression","volume":"20","author":"Frank","year":"1990","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuint.2009.05.008_bib22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0924-977X(01)00103-1","article-title":"Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats","volume":"11","author":"Gittos","year":"2001","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"8","key":"10.1016\/j.neuint.2009.05.008_bib23","first-page":"i","article-title":"The anxiolytic SC 48274 (AGN 2979; BTG 1501) in generalized anxiety disorder","volume":"18","author":"Gittos","year":"1994","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJM198808113190606","article-title":"Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress","volume":"319","author":"Gold","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuint.2009.05.008_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.brainresbull.2005.07.009","article-title":"The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-l-tryptophan: an autoradiographic study","volume":"67","author":"Hasegawa","year":"2005","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2009.05.008_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.neuint.2005.11.012","article-title":"Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study","volume":"48","author":"Hasegawa","year":"2006","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.neuint.2009.05.008_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0896-6273(92)90158-A","article-title":"G protein-coupled mechanisms and nervous signalling","volume":"9","author":"Hille","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2009.05.008_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ddr.430040202","article-title":"Cholinomimetics and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress","volume":"4","author":"Janowsky","year":"1984","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.neuint.2009.05.008_bib29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.brainresbull.2008.07.003","article-title":"Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation","volume":"77","author":"Kanemaru","year":"2008","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2009.05.008_bib30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuint.2009.01.005","article-title":"Chronic citalopram treatment elevates serotonin synthesis in flinders sensitive and flinders resistant lines of rats, with no significant effect on Sprague\u2013Dawley rats","volume":"54","author":"Kanemaru","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.05.008_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1017\/S0033291700027306","article-title":"Perceived support and adjustment to stress in a general population sample of female twins","volume":"24","author":"Kessler","year":"1994","journal-title":"Psychol. Med."},{"issue":"1\u20132","key":"10.1016\/j.neuint.2009.05.008_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2007.04.006","article-title":"Theory of active antidepressants: a nonsynaptic approach to the treatment of depression","volume":"52","author":"Kiss","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.05.008_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000117755","article-title":"Agitated and retarded depression, a clinical psychophysiological evaluation","volume":"6","author":"Lapierre","year":"1980","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuint.2009.05.008_bib34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/bmb\/65.1.193","article-title":"Modulating dysfunctional limbic\u2013cortical circuits in depression: towards development of brain based algorithms for diagnosis and optimised treatment","volume":"65","author":"Mayberg","year":"2003","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.neuint.2009.05.008_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1471-4159.2004.02850.x","article-title":"Different properties of the central and peripheral forms of human tryptophan hydroxylase","volume":"92","author":"McKinney","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2009.05.008_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/jcbfm.1990.2","article-title":"A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats","volume":"10","author":"Nagahiro","year":"1990","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuint.2009.05.008_bib37","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0928-4257(93)90028-R","article-title":"Presynaptic events involved in neurotransmission","volume":"87","author":"Nelson","year":"1993","journal-title":"J. Physiol. (Paris)"},{"issue":"4865","key":"10.1016\/j.neuint.2009.05.008_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/science.2456612","article-title":"The coupling of neurotransmitter receptors to ion channels in the brain","volume":"241","author":"Nicoll","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neuint.2009.05.008_bib39","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.brainresbull.2006.06.011","article-title":"Acute effects of moclobemide and deprenyl on 5-HT synthesis rates in the rat brain: an autoradiographic study","volume":"70","author":"Nishi","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neuint.2009.05.008_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuint.2008.12.011","article-title":"A genetic rat model of depression, Flinders Sensitive Line, has a lower density of 5-HT1A receptors, but a higher density of 5-HT1B receptors, compared to control rats","volume":"54","author":"Nishi","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.05.008_bib41","series-title":"Proceedings of the National Academy of Sciences, 94","first-page":"5308","article-title":"Differences between males and females in rates of serotonin synthesis in human brain","author":"Nishizawa","year":"1997"},{"key":"10.1016\/j.neuint.2009.05.008_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2007.08.018","article-title":"Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors","volume":"1178","author":"Ohno","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2009.05.008_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00491972","article-title":"Selective breeding for sensitivity to the anticholinesterase DFP","volume":"65","author":"Overstreet","year":"1979","journal-title":"Psychopharmacology (Berlin)"},{"issue":"5","key":"10.1016\/j.neuint.2009.05.008_bib44","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1020262205227","article-title":"Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists","volume":"32","author":"Overstreet","year":"2002","journal-title":"Behav. Genet."},{"key":"10.1016\/j.neuint.2009.05.008_bib45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.pbb.2008.02.020","article-title":"Confirmation of antidepressant potential of the selective beta 3 adrenoceptor agonist amibegron in an animal model of depression","volume":"89","author":"Overstreet","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2009.05.008_bib46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neubiorev.2005.03.015","article-title":"The Flinders Sensitive Line rat: a selectively bred putative animal model of depression","volume":"29","author":"Overstreet","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"year":"1997","series-title":"The Rat Brain Atlas in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.neuint.2009.05.008_bib47"},{"key":"10.1016\/j.neuint.2009.05.008_bib48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0278-5846(89)90050-X","article-title":"Serotonin and depression: old problems and new data.","volume":"13","author":"Plaznik","year":"1989","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib49","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archpsyc.61.6.556","article-title":"Measurement of brain regional alpha-[11C]methyl-l-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression","volume":"61","author":"Rosa-Neto","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuint.2009.05.008_bib50","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","article-title":"No adjustments are needed for multiple comparisons","volume":"1","author":"Rothman","year":"1990","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.neuint.2009.05.008_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/FPC.0b013e32831a6a3a","article-title":"Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder","volume":"19","author":"Ruh\u00e9","year":"2009","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.neuint.2009.05.008_bib52","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0091-3057(82)90466-X","article-title":"Selective breeding for sensitivity to DFP: generalization of effects beyond criterion variables","volume":"17","author":"Russell","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2009.05.008_bib53","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1254\/jphs.FP0070759","article-title":"Open channel block of Kv3.1 currents by fluoxetine","volume":"106","author":"Sung","year":"2008","journal-title":"J. Pharmaceut. Sci."},{"issue":"7","key":"10.1016\/j.neuint.2009.05.008_bib54","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0197-0186(01)00132-2","article-title":"The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of alpha-methyl-l-tryptophan: an autoradiographic study","volume":"40","author":"Tohyama","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.05.008_bib55","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1046\/j.1471-4159.1995.64020624.x","article-title":"Determination of the lumped constant for the alpha-methyltryptophan method of estimating the rate of serotonin synthesis","volume":"64","author":"Vanier","year":"1995","journal-title":"J. Neurochem."},{"issue":"Suppl. A","key":"10.1016\/j.neuint.2009.05.008_bib56","first-page":"128","article-title":"Effect of paroxetine and sertraline on different tissues from guinea-pig and rat","volume":"17","author":"Velasco","year":"1995","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.neuint.2009.05.008_bib57","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1476-5381.1993.tb13931.x","article-title":"Block of potassium currents in rat isolated sympathetic neurones by tricyclic antidepressants and structurally related compounds","volume":"110","author":"Wooltorton","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2009.05.008_bib58","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1476-5381.1993.tb13931.x","article-title":"Block of potassium currents in rat isolated sympathetic neurons by tricyclic antidepressants and structurally related compounds","volume":"110","author":"Wooltorton","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2009.05.008_bib59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0301-0082(00)00018-6","article-title":"Elucidation of the neurobiology of depression: insights from a novel genetic animal model.","volume":"62","author":"Yadid","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neuint.2009.05.008_bib60","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/sj.bjp.0702955","article-title":"Inhibition of neuronal Kv potassium currents by the antidepressant drug, fluoxetine","volume":"128","author":"Yeung","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"5681","key":"10.1016\/j.neuint.2009.05.008_bib61","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018609001703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018609001703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T16:34:19Z","timestamp":1739118859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018609001703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0197018609001703"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2009.05.008","relation":{},"ISSN":["0197-0186"],"issn-type":[{"type":"print","value":"0197-0186"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}