{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:48:17Z","timestamp":1768412897178,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.neuint.2009.11.002","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T09:38:05Z","timestamp":1258105085000},"page":"301-307","source":"Crossref","is-referenced-by-count":37,"title":["Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice"],"prefix":"10.1016","volume":"56","author":[{"given":"Neetu","family":"Tyagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanth","family":"Givvimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natia","family":"Qipshidze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumi","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shray","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan C.","family":"Vacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2009.11.002_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2009.11.002_bib2","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/sj.onc.1206292","article-title":"Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors","volume":"22","author":"Ahonen","year":"2003","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.neuint.2009.11.002_bib3","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI1584","article-title":"Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis","volume":"101","author":"Baker","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuint.2009.11.002_bib4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1108581","article-title":"H2S induces a suspended animation-like state in mice","volume":"308","author":"Blackstone","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuint.2009.11.002_bib5","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1749-6632.1999.tb07777.x","article-title":"TIMP-4 is regulated by vascular injury in rats","volume":"878","author":"Dollery","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2009.11.002_bib6","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia\u2013reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neuint.2009.11.002_bib7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/jat\/13.2.105","article-title":"Determination of sulfide in brain tissue by gas dialysis\/ion chromatography: post-mortem studies and two case reports","volume":"13","author":"Goodwin","year":"1989","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.neuint.2009.11.002_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/bbrc.1997.6878","article-title":"The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide","volume":"237","author":"Hosoki","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2009.11.002_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20040243","article-title":"Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression","volume":"381","author":"Ishii","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuint.2009.11.002_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tox.2006.12.023","article-title":"Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension","volume":"232","author":"Kubo","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.neuint.2009.11.002_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuint.2008.07.008","article-title":"Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery","volume":"53","author":"Kumar","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.11.002_bib12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3181\/0807-RM-230","article-title":"Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow","volume":"234","author":"Li","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.neuint.2009.11.002_bib13","doi-asserted-by":"crossref","first-page":"H1206","DOI":"10.1152\/ajpheart.00376.2005","article-title":"Homocysteine causes cerebrovascular leakage in mice","volume":"290","author":"Lominadze","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neuint.2009.11.002_bib14","doi-asserted-by":"crossref","first-page":"29871","DOI":"10.1074\/jbc.R400005200","article-title":"Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations","volume":"279","author":"Miles","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuint.2009.11.002_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"January (1\u20132)","key":"10.1016\/j.neuint.2009.11.002_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2009.11.002_bib17","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1096\/fj.08-109306","article-title":"Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1\/2-dependent cyclin E expression","volume":"22","author":"Rabaneda","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.neuint.2009.11.002_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.neuint.2009.11.002_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0009-8981(99)00245-4","article-title":"A new method for the determination of sulphide in gastrointestinal contents and whole blood by microdistillation and ion chromatography","volume":"293","author":"Richardson","year":"2000","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neuint.2009.11.002_bib20","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuroscience.2005.03.034","article-title":"Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus","volume":"133","author":"Robert","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2009.11.002_bib21","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1212\/WNL.58.10.1539","article-title":"Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals","volume":"58","author":"Sachdev","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.neuint.2009.11.002_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neures.2005.09.001","article-title":"Plasma homocysteine levels are not increased in murine models of Alzheimer's disease","volume":"53","author":"Santiard-Baron","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuint.2009.11.002_bib23","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1053\/j.gastro.2006.08.035","article-title":"Hydrogen sulfide is a novel prosecretory neuromodulator in the guinea-pig and human colon","volume":"131","author":"Schicho","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuint.2009.11.002_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","article-title":"Homocysteine metabolism","volume":"19","author":"Selhub","year":"1999","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.neuint.2009.11.002_bib25","doi-asserted-by":"crossref","first-page":"C1779","DOI":"10.1152\/ajpcell.00207.2007","article-title":"Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells","volume":"293","author":"Sen","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neuint.2009.11.002_bib26","doi-asserted-by":"crossref","first-page":"F410","DOI":"10.1152\/ajprenal.00145.2009","article-title":"Hydrogen sulfide ameliorates hyperhomocysteinemia-associated chronic renal failure","volume":"297","author":"Sen","year":"2009","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"December (3\/4)","key":"10.1016\/j.neuint.2009.11.002_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"10.1016\/j.neuint.2009.11.002_bib28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/152308602760598954","article-title":"Generation of nitrotyrosine precedes activation of metalloproteinase in myocardium of hyperhomocysteinemic rats","volume":"4","author":"Sood","year":"2002","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.neuint.2009.11.002_bib29","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/cvr\/cvn140","article-title":"Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes","volume":"79","author":"Sun","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neuint.2009.11.002_bib30","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1124\/mol.105.017467","article-title":"Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells","volume":"68","author":"Tang","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuint.2009.11.002_bib31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/sj.bjp.0704858","article-title":"The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility","volume":"137","author":"Teague","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2009.11.002_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/03602530600959607","article-title":"Molecular mechanisms of hydrogen sulfide toxicity","volume":"38","author":"Truong","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.neuint.2009.11.002_bib33","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1515\/CCLM.2007.342","article-title":"Differential expression of gamma-aminobutyric acid receptor A (GABA(A)) and effects of homocysteine","volume":"45","author":"Tyagi","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.neuint.2009.11.002_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/ars.2008.2073","article-title":"H2S protects against methionine-induced oxidative stress in brain endothelial cells","volume":"11","author":"Tyagi","year":"2009","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.neuint.2009.11.002_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/10623320701746164","article-title":"\u03b3-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability","volume":"14","author":"Tyagi","year":"2007","journal-title":"Endothelium"},{"issue":"4","key":"10.1016\/j.neuint.2009.11.002_bib36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/1097-4644(20010315)80:4<512::AID-JCB1005>3.0.CO;2-N","article-title":"Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts","volume":"80","author":"Tummalapalli","year":"2001","journal-title":"J. Cell Biochem."},{"issue":"March\u2013April (2)","key":"10.1016\/j.neuint.2009.11.002_bib37","first-page":"173","article-title":"Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator","volume":"22","author":"Wagner","year":"2009","journal-title":"J. Nephrol."},{"key":"10.1016\/j.neuint.2009.11.002_bib38","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.neuint.2009.11.002_bib39","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.neuint.2009.11.002_bib40","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2004.11.110","article-title":"Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?","volume":"326","author":"Whiteman","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.neuint.2009.11.002_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.bbrc.2006.10.058","article-title":"Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells","volume":"15","author":"Yan","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"October (5901)","key":"10.1016\/j.neuint.2009.11.002_bib42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.neuint.2009.11.002_bib43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/jphysiol.2005.097642","article-title":"Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms","volume":"569","author":"Yang","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuint.2009.11.002_bib44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2006.12.011","article-title":"Hydrogen sulfide inhibits human platelet aggregation","volume":"559","author":"Zagli","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2009.11.002_bib45","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018609003052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018609003052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T16:46:28Z","timestamp":1590252388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018609003052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0197018609003052"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2009.11.002","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}