{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:16:11Z","timestamp":1791191771687,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"5","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.neuint.2013.08.005","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T14:53:19Z","timestamp":1377183199000},"page":"465-475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: Modulation of hypothalamic\u2013pituitary\u2013adrenal axis activity and brain-derived neurotrophic factor level"],"prefix":"10.1016","volume":"63","author":[{"given":"Ankur","family":"Jindal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Mahesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shvetank","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2013.08.005_b0005","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1016\/j.neuint.2013.08.005_b0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0168-1591(00)00133-7","article-title":"Behavioral evaluation of methods for assessing fear responses in weaned pigs","volume":"69","author":"Andersen","year":"2000","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0140525X00010633","article-title":"Depression: the predisposing influence of stress","volume":"5","author":"Anisman","year":"1982","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0020","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.pnpbp.2006.03.025","article-title":"Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women","volume":"30","author":"Aydemir","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0025","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.pnpbp.2007.02.013","article-title":"Serum brain-derived neurotrophic factor level in dysthymia: a comparative study with major depressive disorder","volume":"31","author":"Aydemir","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0030","first-page":"29","article-title":"Clinical guidelines for establishing remission in patients with depression and anxiety","volume":"60","author":"Ballenger","year":"1999","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pnpbp.2008.11.016","article-title":"Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients","volume":"33","author":"Ba\u015fterzi","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0040","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.176.4033.428","article-title":"Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety","volume":"176","author":"Beer","year":"1972","journal-title":"Science"},{"key":"10.1016\/j.neuint.2013.08.005_b0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbr.2005.01.005","article-title":"Behavioral and neurochemical effects induced by chronic mild stress applied to two different rat strains","volume":"161","author":"Bekris","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","article-title":"Measuring normal and pathological anxiety-like behavior in mice: a review","volume":"125","author":"Belzung","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0031-9384(94)90311-5","article-title":"Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety","volume":"56","author":"Belzung","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0640","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pnpbp.2007.07.006","article-title":"Calcium channel antagonists suppress cross-tolerance to the anxiogenic effects of D-amphetamine and nicotine in the mouse elevated plus maze test","volume":"32","author":"Biala","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0060","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0166-4328(02)00222-X","article-title":"The effects of chronic mild stress on male SpragueDawley and Long Evans rats: I. Biochemical and physiological analyses","volume":"136","author":"Bielajew","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0070","first-page":"212","article-title":"Action of caffeine on the spontaneous motility of the mouse","volume":"158","author":"Boissier","year":"1965","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.neuint.2013.08.005_b0075","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.npp.1301410","article-title":"Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment","volume":"33","author":"Bondi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00213-002-1155-6","article-title":"Do animal models of anxiety predict anxiolytic-like effects of antidepressants?","volume":"163","author":"Borsini","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0085","doi-asserted-by":"crossref","first-page":"E920","DOI":"10.1152\/ajpendo.00606.2009","article-title":"Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats","volume":"298","author":"Buhl","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.neuint.2013.08.005_b0090","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.psyneuen.2009.05.014","article-title":"Neuronal plasticity: a link between stress and mood disorders","volume":"34","author":"Calabrese","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuint.2013.08.005_b0095","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0091-3057(02)01072-9","article-title":"Cocaine-conditioned behavioral effects: a role for habituation processes","volume":"74","author":"Carey","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2006.08.009","article-title":"Role of neurotrophic factors in depression","volume":"7","author":"Castr\u00e9n","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0105","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.pbb.2011.02.023","article-title":"Anxiety-like behaviors and expression of SERT and TPH in the dorsal raph\u00e9 of estrogen- and fluoxetine-treated ovariectomized rats","volume":"98","author":"Charoenphandhu","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0110","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/0006-2952(72)90414-5","article-title":"1-Ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009)\u2013a potent new inhibitor of cyclic 3\u2032,5\u2032-nucleotide phosphodiesterases","volume":"21","author":"Chasin","year":"1972","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0115","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.phymed.2006.09.007","article-title":"Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the chronic mild stress model of depression in mice","volume":"14","author":"Chen","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neuint.2013.08.005_b0120","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbrc.2008.01.152","article-title":"Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats","volume":"368","author":"Chen","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2013.08.005_b0125","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex","volume":"39","author":"Chiba","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0130","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0006-2952(88)90139-6","article-title":"Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors","volume":"37","author":"Daly","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0135","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0031-9384(94)90316-6","article-title":"Effects of chronic mild stress on performance in behavioral tests relevant to anxiety and depression","volume":"56","author":"D\u2019Aquila","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"De Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10401230209147450","article-title":"The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists","volume":"14","author":"Dording","year":"2002","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0150","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.lfs.2012.05.014","article-title":"Anxiolytic effects of a novel herbal treatment in mice models of anxiety","volume":"90","author":"Doron","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejphar.2010.02.036","article-title":"Etazolate improves performance in a foraging and homing task in aged rats","volume":"634","author":"Drott","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0278-5846(03)00051-4","article-title":"Effects of the selective nonpeptide corticotrophin releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice","volume":"27","author":"Ducottet","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0165","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1523\/JNEUROSCI.19-21-09550.1999","article-title":"Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli","volume":"19","author":"Dulawa","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0170","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0175","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0006-3223(00)00935-5","article-title":"Neuronal plasticity and survival in mood disorders","volume":"48","author":"Duman","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0180","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.pnpbp.2009.01.004","article-title":"Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats","volume":"33","author":"Garcia","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0185","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI22831","article-title":"Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment","volume":"114","author":"Gong","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuint.2013.08.005_b0190","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.mp.4002055","article-title":"Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression","volume":"13","author":"Goshen","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0195","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejphar.2009.03.076","article-title":"Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain","volume":"612","author":"Guo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0200","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1471-4159.2009.06345.x","article-title":"Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression","volume":"111","author":"Haenisch","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2013.08.005_b0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbr.2008.07.037","article-title":"Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour","volume":"196","author":"Hageman","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0210","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yebeh.2005.10.012","article-title":"Adolescent depression: description, causes, and interventions","volume":"8","author":"Hankin","year":"2006","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2826.2005.01390.x","article-title":"Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter","volume":"18","author":"Hansson","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neuint.2013.08.005_b0220","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.bbrc.2008.09.059","article-title":"Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1","volume":"376","author":"Hayashi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuint.2013.08.005_b0225","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/026988110001400110","article-title":"Selective serotonin reuptake inhibitors in post-traumatic stress disorder","volume":"14","author":"Hidalgo","year":"2000","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0230","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0091-3057(95)02126-4","article-title":"A review of the validity and variability of the elevated plusmaze as an animal model of anxiety","volume":"54","author":"Hogg","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","article-title":"The corticosteroid receptor hypothesis of depression","volume":"23","author":"Holsboer","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0240","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0033-3182(72)71443-7","article-title":"Cyclic AMP and anxiety","volume":"13","author":"Horovitz","year":"1972","journal-title":"Psychomatics"},{"key":"10.1016\/j.neuint.2013.08.005_b0245","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0079-6603(01)69049-4","article-title":"PDE4 cAMP-specific phosphodiesterases","volume":"69","author":"Houslay","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.neuint.2013.08.005_b0250","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbr.2011.03.038","article-title":"Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior","volume":"222","author":"Huynh","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0255","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2012.05.051","article-title":"Antidepressant-like effect of etazolate, a cyclic nucleotide phosphodiesterase 4 inhibitor \u2013 an approach using rodent behavioral antidepressant tests battery","volume":"689","author":"Jindal","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pbb.2013.01.020","article-title":"Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage","volume":"105","author":"Jindal","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0265","first-page":"444","article-title":"Anxiolytic-like effect of etazolate, a type 4 phosphodiesterase inhibitor in experimental models of anxiety","volume":"51","author":"Jindal","year":"2013","journal-title":"Indian J. Exp. Bio."},{"key":"10.1016\/j.neuint.2013.08.005_b0270","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbr.2005.11.019","article-title":"Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor","volume":"2","author":"Johnson","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0275","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0304-3940(02)00529-3","article-title":"Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets","volume":"328","author":"Karege","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuint.2013.08.005_b0280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbrainres.2004.12.020","article-title":"Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs","volume":"136","author":"Karege","year":"2005","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0285","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuint.2013.08.005_b0290","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00008877-199912000-00007","article-title":"Behavioural consequences of repeated social defeat in the mouse:preliminary evaluation of a potential animal model of depression","volume":"10","author":"Keeney","year":"1999","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0295","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00005053-199811000-00001","article-title":"Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity","volume":"186","author":"Kendler","year":"1998","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.neuint.2013.08.005_b0300","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1176\/ajp.156.6.837","article-title":"Causal relationship between stressful life events and the onset of major depression","volume":"156","author":"Kendler","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0305","first-page":"42","article-title":"Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling","volume":"47","author":"Klodzinska","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0310","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbr.2008.06.008","article-title":"Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats","volume":"193","author":"Kompagne","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0315","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2003.08.047","article-title":"Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared","volume":"992","author":"Konkle","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0320","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00213-010-2094-2","article-title":"Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences","volume":"214","author":"Kumar","year":"2011","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuint.2013.08.005_b0325","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1819.2010.02135.x","article-title":"Interface between hypothalamic\u2013pituitary\u2013adrenal axis and brain-derived neurotrophic factor in depression","volume":"64","author":"Kunugi","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0330","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jpsychires.2010.01.005","article-title":"Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment","volume":"44","author":"Larsen","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0335","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/JGP.0b013e3181ec806c","article-title":"Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram","volume":"19","author":"Lenze","year":"2011","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0345","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/npp.2009.66","article-title":"Antidepressant-and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0350","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0355","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/156720208786413406","article-title":"Chronic mild stress paradigm reduces sweet food intake in rats without affecting brain derived neurotrophic factor protein levels","volume":"5","author":"Lucca","year":"2008","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0360","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0306-4522(95)00259-L","article-title":"Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons, involvement of glucocorticoid secretion and excitatory amino acid receptors","volume":"69","author":"Magari\u00f1os","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2013.08.005_b0365","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/ncb1007","article-title":"Cross-talk between Rap1 and Rac regulates secretion of sAPP alpha","volume":"5","author":"Maillet","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuint.2013.08.005_b0370","first-page":"35","article-title":"Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics","volume":"5","author":"Manji","year":"2001","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.neuint.2013.08.005_b0375","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.psyneuen.2008.03.002","article-title":"Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder","volume":"33","author":"Mantella","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuint.2013.08.005_b0380","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.pnpbp.2009.07.002","article-title":"Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor","volume":"33","author":"Mao","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0385","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1471-4159.2008.05396.x","article-title":"Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing","volume":"106","author":"Marcade","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuint.2013.08.005_b0390","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0306-4530(01)00092-0","article-title":"Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior","volume":"27","author":"Maslova","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuint.2013.08.005_b0395","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.physbeh.2006.12.006","article-title":"The delayed effects of chronic unpredictable stress on anxiety measures","volume":"90","author":"Matuszewich","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0400","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2005.01.008","article-title":"Glucocorticoids, depression, and mood disorders: structural remodeling in the brain","volume":"54","author":"McEwen","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.neuint.2013.08.005_b0405","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0410","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1601-183X.2010.00619.x","article-title":"Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?","volume":"9","author":"Middeldorp","year":"2010","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0415","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jpsychires.2011.11.009","article-title":"Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress","volume":"46","author":"Moretti","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0420","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1323140","article-title":"Functional modulation of GABA receptors by cAMP-dependent protein phosphorylation","volume":"257","author":"Moss","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.neuint.2013.08.005_b0425","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neures.2005.06.008","article-title":"Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly","volume":"53","author":"Murakami","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0430","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2008.01.014","article-title":"Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice","volume":"583","author":"Murray","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0435","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuroscience.2005.12.028","article-title":"Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats","volume":"139","author":"Naert","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2013.08.005_b0440","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpsychires.2006.05.008","article-title":"The burden of severe depression: a review of diagnostic challenges and treatment alternatives","volume":"41","author":"Nemeroff","year":"2007","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0445","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2013.08.005_b0450","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","article-title":"Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus","volume":"16","author":"Nibuya","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0455","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-6147(91)90484-A","article-title":"Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes","volume":"12","author":"Nicholson","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0460","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1472-6882-8-15","article-title":"Evaluation of behavioural and antioxidant activity of Cytisus scoparius Linn in rats exposed to chronic unpredictable mild stress","volume":"8","author":"Nirmal","year":"2008","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.neuint.2013.08.005_b0465","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tips.2004.01.003","article-title":"Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)","volume":"25","author":"O\u2019Donnell","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0470","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","article-title":"Transport of brain derived neurotrophic factor across the blood-brain barrier","volume":"37","author":"Pan","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0475","first-page":"e367","article-title":"Confounding by severity and indication in observational studies of antidepressant effectiveness","volume":"15","author":"Patten","year":"2008","journal-title":"Can. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0480","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open: closed arm entries in an elevated plus maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuint.2013.08.005_b0485","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4088\/JCP.08m04756","article-title":"Duloxetine in the prevention of depressive recurrences: a randomized, double-blind, placebo-controlled trial","volume":"70","author":"Perahia","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0490","first-page":"370","article-title":"Recovering from depression: a matter of objective and determination","volume":"65","author":"Pitchot","year":"2010","journal-title":"Rev. Med. Liege."},{"key":"10.1016\/j.neuint.2013.08.005_b0495","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1037\/0735-7044.104.1.28","article-title":"Effect of intensity on habituation and sensitization of glucocorticoid responses in rats","volume":"104","author":"Pitman","year":"1990","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0500","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2013.08.005_b0505","first-page":"269","article-title":"Behavioural and neurochemical evaluation of perment an herbal formulation in chronic unpredictable mild stress induced depressive model","volume":"49","author":"Ramanathan","year":"2011","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.neuint.2013.08.005_b0510","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00213-009-1493-8","article-title":"Depression-like deficits in rats improved by subchronic modafinil","volume":"204","author":"Regenthal","year":"2009","journal-title":"Psychopharmacology (BerlIN)"},{"key":"10.1016\/j.neuint.2013.08.005_b0515","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00213-004-1914-7","article-title":"Anxiolytic-like profile in Wistar, but not Sprague\u2013Dawley rats in the social interaction test","volume":"177","author":"Rex","year":"2004","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.neuint.2013.08.005_b0520","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0149-7634(96)00058-9","article-title":"Anxiety, defence and the elevated plus maze","volume":"21","author":"Rodgers","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuint.2013.08.005_b0525","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1210\/er.21.1.55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neuint.2013.08.005_b0530","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1097-4547(19970515)48:4<334::AID-JNR5>3.0.CO;2-C","article-title":"Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus","volume":"48","author":"Schaaf","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0535","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0006-8993(98)01010-5","article-title":"Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone","volume":"813","author":"Schaaf","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0540","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.psyneuen.2007.02.011","article-title":"Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence","volume":"32","author":"Schmidt","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuint.2013.08.005_b0545","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0006-3223(03)00181-1","article-title":"Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants","volume":"54","author":"Shimizu","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0550","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mcn.2006.07.011","article-title":"Amyloid b peptide adversely affects spine number and motility in hippocampal neurons","volume":"33","author":"Shrestha","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuint.2013.08.005_b0555","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(96)00169-4","article-title":"Antidepressant-like effect of brain derived neurotrophic factor (BDNF)","volume":"56","author":"Siuciak","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0560","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pbb.2006.01.004","article-title":"Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress","volume":"83","author":"Song","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuint.2013.08.005_b0565","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening anti-depressant drugs","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacolgy (Berlin)"},{"key":"10.1016\/j.neuint.2013.08.005_b0570","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/156720511795256053","article-title":"EHT0202\/002 study group. EHT0202 in Alzheimer\u2019s disease: a 3-month, randomized, placebo-controlled, double-blind study","volume":"8","author":"Vellas","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0575","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1053\/rvsc.2001.0456","article-title":"Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor mRNAs, in the porcine hippocampus after acute dexamethasone treatment","volume":"70","author":"Vellucci","year":"2001","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0580","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1196\/annals.1364.014","article-title":"Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder","volume":"1071","author":"Vermetten","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.neuint.2013.08.005_b0585","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/PSY.0b013e3181d2f0c8","article-title":"Salivary cortisol levels in persons with and without different anxiety disorders","volume":"72","author":"Vreeburg","year":"2010","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neuint.2013.08.005_b0595","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0645","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural- neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neuint.2013.08.005_b0600","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2006.09.009","article-title":"Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB","volume":"1122","author":"Xu","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0605","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbr.2008.04.021","article-title":"Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey","volume":"193","author":"Yalcin","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0610","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pnpbp.2008.11.010","article-title":"In vivo antioxidant status: a putative target for antidepressant action","volume":"33","author":"Zafir","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neuint.2013.08.005_b0615","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0006-8993(99)02289-1","article-title":"Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats","volume":"855","author":"Zhang","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2013.08.005_b0620","first-page":"587","article-title":"Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme","volume":"27","author":"Zhang","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuint.2013.08.005_b0630","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbr.2005.10.007","article-title":"Beneficial effects of exercise and it molecular mechanisms on depression in rats","volume":"168","author":"Zheng","year":"2006","journal-title":"Behav. Brain Res."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018613002143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018613002143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T14:22:17Z","timestamp":1563718937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018613002143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":124,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0197018613002143"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2013.08.005","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Etazolate rescues behavioral deficits in chronic unpredictable mild stress model: Modulation of hypothalamic\u2013pituitary\u2013adrenal axis activity and brain-derived neurotrophic factor level","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2013.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}