{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:27:26Z","timestamp":1790735246950,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hoansha Foundation"},{"DOI":"10.13039\/100012131","name":"Brain Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012131","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Japan Health Foundation"},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MEXT KAKENHI","award":["23117714"],"award-info":[{"award-number":["23117714"]}]},{"name":"JSPS KAKENHI","award":["26670036"],"award-info":[{"award-number":["26670036"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.neuint.2014.09.002","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T21:34:27Z","timestamp":1409952867000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice"],"prefix":"10.1016","volume":"78","author":[{"given":"Mizuki","family":"Nobunaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-2344","authenticated-orcid":false,"given":"Kanae","family":"Obukuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kurauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Hisatsune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Katsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2014.09.002_bib0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tem.2008.08.007","article-title":"Sleep and metabolism: shared circuits, new connections","volume":"19","author":"Adamantidis","year":"2008","journal-title":"Trends Endocrinol. Metab"},{"key":"10.1016\/j.neuint.2014.09.002_bib0015","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1016\/j.febslet.2012.07.023","article-title":"Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications","volume":"586","author":"Andreu","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuint.2014.09.002_bib0020","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1210\/en.2014-1121","article-title":"Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study","volume":"155","author":"Berkseth","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuint.2014.09.002_bib0025","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrn2214","article-title":"Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity","volume":"8","author":"Calabrese","year":"2007","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1016\/j.neuint.2014.09.002_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tins.2012.12.005","article-title":"Hypothalamic control of energy balance: insights into the role of synaptic plasticity","volume":"36","author":"Dietrich","year":"2013","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuint.2014.09.002_bib0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.regpep.2011.02.005","article-title":"Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa","volume":"168","author":"Janas-Kozik","year":"2012","journal-title":"Regul. Pept"},{"key":"10.1016\/j.neuint.2014.09.002_bib0040","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase","volume":"81","author":"MacMicking","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.neuint.2014.09.002_bib0045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neuint.2014.09.002_bib0050","doi-asserted-by":"crossref","first-page":"e36139","DOI":"10.1371\/journal.pone.0036139","article-title":"Shift of circadian feeding pattern by high-fat diets is coincident with reward deficits in obese mice","volume":"7","author":"Morales","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neuint.2014.09.002_bib0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/en.2012-1643","article-title":"AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice","volume":"154","author":"Newton","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuint.2014.09.002_bib0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.neuroscience.2010.06.081","article-title":"Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats","volume":"170","author":"Obukuro","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuint.2014.09.002_bib0065","doi-asserted-by":"crossref","first-page":"12557","DOI":"10.1523\/JNEUROSCI.0595-13.2013","article-title":"Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase","volume":"33","author":"Obukuro","year":"2013","journal-title":"J. Neurosci"},{"key":"10.1016\/j.neuint.2014.09.002_bib0070","doi-asserted-by":"crossref","first-page":"605","DOI":"10.5665\/sleep.1812","article-title":"Daytime sleepiness in obesity: mechanisms beyond obstructive sleep apnea \u2013 a review","volume":"35","author":"Panossian","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.neuint.2014.09.002_bib0075","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.tips.2011.03.007","article-title":"Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal","volume":"32","author":"Sakurai","year":"2011","journal-title":"Trends Pharmacol. Sci"},{"key":"10.1016\/j.neuint.2014.09.002_bib0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.neuint.2014.09.002_bib0085","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"Thannickal","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.neuint.2014.09.002_bib0090","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/brain\/awm097","article-title":"Hypocretin (orexin) cell loss in Parkinson's disease","volume":"130","author":"Thannickal","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.neuint.2014.09.002_bib0095","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature04782","article-title":"S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration","volume":"441","author":"Uehara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2014.09.002_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2009.04.002","article-title":"Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet","volume":"35","author":"White","year":"2009","journal-title":"Neurobiol. Dis"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701861400206X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019701861400206X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T01:52:50Z","timestamp":1589248370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019701861400206X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":19,"alternative-id":["S019701861400206X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2014.09.002","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2014.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}