{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:23:24Z","timestamp":1785165804837,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.neuint.2015.08.007","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T06:18:13Z","timestamp":1439965093000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Intravenous nanosomes of quercetin improve brain function and hemodynamic instability after severe hypoxia in newborn piglets"],"prefix":"10.1016","volume":"89","author":[{"given":"Fernanda","family":"Blasina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Vaamonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Silvera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Claudio","family":"Tedesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Dajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2015.08.007_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jep.2003.11.012","article-title":"Cytoprotection by Achyrocline satureioides (Lam) D.C. and some of its main flavonoids against oxidative stress","volume":"91","author":"Arredondo","year":"2004","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.neuint.2015.08.007_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.107.3.480","article-title":"Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia","volume":"107","author":"Battin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuint.2015.08.007_bib3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2006.04.119","article-title":"Hypoxic\/Ischemic models in newborn piglet: comparison of constant FiO2 versus variable FiO2 delivery","volume":"1100","author":"Bjorkman","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/156720105774370195","article-title":"Phospholipid nanosomes","volume":"2","author":"Castor","year":"2005","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.neuint.2015.08.007_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2012.07.005","article-title":"Life or death: neuroprotective and anticancer effects of quercetin","volume":"143","author":"Dajas","year":"2012","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.neuint.2015.08.007_bib6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1871524911313010005","article-title":"Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features","volume":"13","author":"Dajas","year":"2013","journal-title":"Central Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.neuint.2015.08.007_bib7","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1590\/S0100-879X2003001200002","article-title":"Neuroprotection by flavonoids","volume":"36","author":"Dajas","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/BF03033172","article-title":"Cell culture protection and in\u00a0vivo neuroprotective capacity of flavonoids","volume":"5","author":"Dajas","year":"2003","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1874306401206010089","article-title":"Lung injury in asphyxiated newborn pigs resuscitated from cardiac arrest \u2013 the Impact of supplementary oxygen, longer ventilation intervals and chest compressions at different compression-to-ventilation ratios","volume":"6","author":"Dannevig","year":"2012","journal-title":"Open Respir. Med. J."},{"key":"10.1016\/j.neuint.2015.08.007_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.neuint.2015.08.007_bib11","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1136\/adc.2005.071787","article-title":"Therapeutic hypothermia following perinatal asphyxia","volume":"91","author":"Edwards","year":"2006","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.neuint.2015.08.007_bib12","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin reduces blood pressure in hypertensive subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.neuint.2015.08.007_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.6061\/clinics\/2012(05)16","article-title":"Hypoxia\/reoxygenation-induced myocardial lesions in newborn piglets are related to interindividual variability and not to oxygen concentration","volume":"67","author":"Faa","year":"2012","journal-title":"Clin. (Sao Paulo)"},{"key":"10.1016\/j.neuint.2015.08.007_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0006-8993(01)03011-6","article-title":"An improved survival model of hypoxia\/ischaemia in the piglet suitable for neuroprotection studies","volume":"919","author":"Foster","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib15","first-page":"37","article-title":"Nanotechnology in blood brain barrier: a review","volume":"1","author":"Gandhi","year":"2010","journal-title":"Int. J. Pharm. Biol. Arch."},{"key":"10.1016\/j.neuint.2015.08.007_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1388-2457(00)00499-5","article-title":"Electrocortical brain activity, cerebral haemodynamics and oxygenation during progressive hypotension in newborn piglets. Clinical neurophysiology","volume":"112","author":"Gavilanes","year":"2001","journal-title":"Off. J. Int. Fed. Clin. Neurophysiol."},{"key":"10.1016\/j.neuint.2015.08.007_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.lfs.2008.11.001","article-title":"Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats","volume":"84","author":"Ghosh","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.neuint.2015.08.007_bib18","first-page":"3","article-title":"Mechanisms of perinatal brain injury. Seminars in neonatology","volume":"5","author":"Inder","year":"2000","journal-title":"SN"},{"key":"10.1016\/j.neuint.2015.08.007_bib19","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.3390\/molecules15117792","article-title":"Nutraceutical antioxidants as novel neuroprotective agents","volume":"15","author":"Kelsey","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.neuint.2015.08.007_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3945\/an.111.001271","article-title":"Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms","volume":"3","author":"Larson","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.neuint.2015.08.007_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/092986710789957760","article-title":"Design and development of nanovehicle-based delivery systems for preventive or therapeutic supplementation with flavonoids","volume":"17","author":"Leonarduzzi","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuint.2015.08.007_bib22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1021\/js950534b","article-title":"Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization","volume":"85","author":"Loftsson","year":"1996","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.neuint.2015.08.007_bib23","article-title":"Perinatal asphyxia","author":"McGuire","year":"2007","journal-title":"Clin. Evid."},{"key":"10.1016\/j.neuint.2015.08.007_bib24","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.braindev.2012.10.007","article-title":"Cerebral blood volume combined with amplitude-integrated EEG can be a suitable guide to control hypoxic\/ischemic insult in a piglet model","volume":"35","author":"Nakamura","year":"2013","journal-title":"Brain & Dev."},{"key":"10.1016\/j.neuint.2015.08.007_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1517\/14740330903026944","article-title":"The multiple faces of quercetin in neuroprotection","volume":"8","author":"Ossola","year":"2009","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.neuint.2015.08.007_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000072357","article-title":"Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice","volume":"69","author":"Patil","year":"2003","journal-title":"Pharmacology"},{"key":"10.1016\/j.neuint.2015.08.007_bib27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nano.2007.12.001","article-title":"Anxiety and cognitive effects of quercetin liposomes in rats","volume":"4","author":"Priprem","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.neuint.2015.08.007_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF03033562","article-title":"Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats","volume":"13","author":"Rivera","year":"2008","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/BF03033450","article-title":"Some aspects of the in\u00a0vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship","volume":"6","author":"Rivera","year":"2004","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.mad.2005.12.010","article-title":"Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain","volume":"127","author":"Sarkar","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neuint.2015.08.007_bib31","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.neuint.2015.08.007_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2008.10.046","article-title":"Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells","volume":"601","author":"Silva","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuint.2015.08.007_bib33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.freeradbiomed.2012.07.022","article-title":"Resuscitation with supplementary oxygen induces oxidative injury in the cerebral cortex","volume":"53","author":"Solberg","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2015.08.007_bib34","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","article-title":"A\u00a0piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","article-title":"The neuroprotective potential of flavonoids: a multiplicity of effects","volume":"3","author":"Vauzour","year":"2008","journal-title":"Genes & Nutr."},{"key":"10.1016\/j.neuint.2015.08.007_bib36","doi-asserted-by":"crossref","first-page":"848413","DOI":"10.1155\/2011\/848413","article-title":"Current controversies in newer therapies to treat birth asphyxia","volume":"2011","author":"Wintermark","year":"2011","journal-title":"Int. J. Pediatr."},{"key":"10.1016\/j.neuint.2015.08.007_bib37","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.freeradbiomed.2004.08.002","article-title":"Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system","volume":"37","author":"Youdim","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuint.2015.08.007_bib38","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1158\/1078-0432.CCR-05-2365","article-title":"Liposomal quercetin efficiently suppresses growth of solid tumors in murine models. Clinical cancer research","volume":"12","author":"Yuan","year":"2006","journal-title":"Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.neuint.2015.08.007_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.addr.2012.10.003","article-title":"Advanced materials and processing for drug delivery: the past and the future","volume":"65","author":"Zhang","year":"2013","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018615300358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018615300358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T15:16:21Z","timestamp":1567091781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018615300358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":39,"alternative-id":["S0197018615300358"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2015.08.007","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous nanosomes of quercetin improve brain function and hemodynamic instability after severe hypoxia in newborn piglets","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2015.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}