{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:33:05Z","timestamp":1782880385903,"version":"3.54.5"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["NS065789"],"award-info":[{"award-number":["NS065789"]}]},{"name":"NIH","award":["AG026389"],"award-info":[{"award-number":["AG026389"]}]},{"name":"NIH","award":["P01HL114453"],"award-info":[{"award-number":["P01HL114453"]}]},{"name":"NIH","award":["U19AI068021"],"award-info":[{"award-number":["U19AI068021"]}]},{"name":"NIH","award":["ES020693"],"award-info":[{"award-number":["ES020693"]}]},{"name":"NIH","award":["HFSP-RGP0013"],"award-info":[{"award-number":["HFSP-RGP0013"]}]},{"name":"NIH","award":["HL082511"],"award-info":[{"award-number":["HL082511"]}]},{"name":"NIH","award":["NS077897"],"award-info":[{"award-number":["NS077897"]}]},{"name":"NIH","award":["NIH-PP-AG14930"],"award-info":[{"award-number":["NIH-PP-AG14930"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.neuint.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T20:12:35Z","timestamp":1456344755000},"page":"32-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Mild mitochondrial metabolic deficits by \u03b1-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease"],"prefix":"10.1016","volume":"96","author":[{"given":"Kalpita","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyabrata","family":"Munshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charleen T.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerian E.","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis T.","family":"Denton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Y.","family":"Tyurina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Fei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2016.02.011_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/cyto.a.20896","article-title":"Quantifying co-localization by correlation: the pearson correlation coefficient is superior to the mander's overlap coefficient","volume":"77","author":"Adler","year":"2010","journal-title":"Cytom. A"},{"key":"10.1016\/j.neuint.2016.02.011_bib2","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1016\/S0021-9258(19)34062-1","article-title":"Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers","volume":"265","author":"Andree","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuint.2016.02.011_bib3","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.bbadis.2012.08.006","article-title":"Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells","volume":"1822","author":"Arsikin","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neuint.2016.02.011_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/JAD-2006-9204","article-title":"Mitochondrial alterations in Alzheimer's disease","volume":"9","author":"Baloyannis","year":"2006","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.neuint.2016.02.011_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-015-1631-0","article-title":"Abnormal glucose metabolism in Alzheimer's disease: relation to autophagy\/mitophagy and therapeutic approaches","author":"Banerjee","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/878935","article-title":"Dopamine cytotoxicity involves both oxidative and nonoxidative pathways in SH-SY5Y cells: potential role of alpha-synuclein overexpression and proteasomal inhibition in the etiopathogenesis of Parkinson's disease","author":"Banerjee","year":"2014","journal-title":"Parkinson's Dis."},{"key":"10.1016\/j.neuint.2016.02.011_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.20474","article-title":"Mitochondrial abnormalities in Alzheimer brain: mechanistic implications","volume":"57","author":"Bubber","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuint.2016.02.011_bib8","doi-asserted-by":"crossref","first-page":"10552","DOI":"10.1021\/bi0503100","article-title":"Phosphonate analogues of \u03b1-ketoglutarate inhibit the activity of the \u03b1-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells","volume":"44","author":"Bunik","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuint.2016.02.011_bib9","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuint.2016.02.011_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib11","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ncb2837","article-title":"Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells","volume":"15","author":"Chu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib12","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1111\/bph.12515","article-title":"Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes","volume":"171","author":"Clerc","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuint.2016.02.011_bib13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/sj.cdd.4402107","article-title":"Inhibiting Drp1- mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis","volume":"14","author":"Estaquier","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neuint.2016.02.011_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuint.2016.02.011_bib15","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.bbamcr.2012.08.007","article-title":"Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner","volume":"1823","author":"Frank","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Cell Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neurobiolaging.2010.03.011","article-title":"Cognition, glucose metabolism and amyloid burden in Alzheimer's disease","volume":"33","author":"Furst","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2016.02.011_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005309","article-title":"The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells","author":"Gama","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.neuint.2016.02.011_bib18","first-page":"2031","article-title":"Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis","volume":"13","author":"Ghibelli","year":"1999","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"1121","key":"10.1016\/j.neuint.2016.02.011_bib19","first-page":"e13","article-title":"Deficits in the mitochondrial enzyme alpha-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation","volume":"33","author":"Gibson","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuint.2016.02.011_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/jnc.13096","article-title":"Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines","volume":"134","author":"Gibson","year":"2015","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuint.2016.02.011_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1385\/MN:31:1-3:043","article-title":"The alpha-ketoglutarate-dehydrogenase complex","volume":"31","author":"Gibson","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuint.2016.02.011_bib22","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1001\/archneur.1988.00520320022009","article-title":"Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease","volume":"45","author":"Gibson","year":"1988","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuint.2016.02.011_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbabio.2006.03.016","article-title":"Multiple pathways of cytochrome c release from mitochondria in apoptosis","volume":"1757","author":"Gogvadze","year":"2006","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Bioenerg."},{"key":"10.1016\/j.neuint.2016.02.011_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbamcr.2012.02.012","article-title":"Mitochondrial morphology in mitophagy and macroautophagy","volume":"1833","author":"Gomes","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Cell Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuint.2016.02.011_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2015.03.007","article-title":"A\u00a0cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies","author":"Harris-White","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2016.02.011_bib27","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1586\/ern.10.136","article-title":"Cerebral glucose metabolism in preclinical and prodromal Alzheimer's disease","volume":"10","author":"Herholz","year":"2010","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neuint.2016.02.011_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jnr.10756","article-title":"Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death","volume":"74","author":"Huang","year":"2003","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib29","first-page":"19304","article-title":"Nicotinamide-induced mitophagy: event mediated by high NAD+\/NADH ratio and SIRT1 protein activation","volume":"287","author":"Jang","year":"2012","journal-title":"J.\u00a0BiolChem."},{"key":"10.1016\/j.neuint.2016.02.011_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nchembio727","article-title":"Cytochrome c acts as a cardiolipinoxygenase required for release of proapoptotic factors","volume":"1","author":"Kagan","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib31","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.15252\/embj.201488658","article-title":"Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain","volume":"33","author":"Kageyama","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.neuint.2016.02.011_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuint.2008.10.008","article-title":"Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's Disease","volume":"54","author":"Karuppagounder","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuint.2016.02.011_bib33","doi-asserted-by":"crossref","first-page":"19102","DOI":"10.1074\/jbc.M011579200","article-title":"Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway","volume":"276","author":"Kim","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuint.2016.02.011_bib34","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1046\/j.1471-4159.2003.02263.x","article-title":"Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity","volume":"88","author":"Klivenyi","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuint.2016.02.011_bib35","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.112.265819","article-title":"Mitochondria and mitophagy: the yin and yang of cell death control","volume":"111","author":"Kubli","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","article-title":"Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging","volume":"8","author":"Lemasters","year":"2005","journal-title":"Rejuvenat. Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib37","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1523\/JNEUROSCI.0346-04.2004","article-title":"A\u00a0syntaxin 1, galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization","volume":"24","author":"Li","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.neuint.2016.02.011_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1152\/advan.00052.2006","article-title":"PGC-1\u03b1: a key regulator of energy metabolism","volume":"30","author":"Liang","year":"2006","journal-title":"Adv. Physiol. Educ."},{"key":"10.1016\/j.neuint.2016.02.011_bib39","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1038\/cddis.2013.31","article-title":"Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells","volume":"4","author":"Liu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neuint.2016.02.011_bib40","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1091\/mbc.E12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Los\u00f3n","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neuint.2016.02.011_bib41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mito.2014.07.004","article-title":"Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10","volume":"17","author":"Ma","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neuint.2016.02.011_bib42","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cmet.2013.03.014","article-title":"RhebRegulates mitophagy induced by mitochondrial energetic status","volume":"17","author":"Melser","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.neuint.2016.02.011_bib43","doi-asserted-by":"crossref","first-page":"e1000612","DOI":"10.1371\/journal.pbio.1000612","article-title":"Mechanism of neuroprotective mitochondrial remodeling by PKA\/AKAP1","volume":"9","author":"Merrill","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","article-title":"Succinate: a metabolic signal in inflammation","volume":"24","author":"Mills","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.neuint.2016.02.011_bib46","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/brain\/awq069","article-title":"Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein\/presenilin-1 transgenic mice","volume":"133","author":"Pan","year":"2010","journal-title":"Brain a J. Neurol."},{"key":"10.1016\/j.neuint.2016.02.011_bib47","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/abio.1999.4359","article-title":"Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells","volume":"277","author":"Park","year":"2000","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuint.2016.02.011_bib48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jnr.20749","article-title":"Inhibitors of the \u03b1-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons","volume":"83","author":"Santos","year":"2006","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.neuint.2016.02.011_bib49","first-page":"10888","article-title":"Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity","volume":"280","author":"Shi","year":"2005","journal-title":"J.\u00a0BiolChem."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.neuint.2016.02.011_bib50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1471-4159.2009.05955.x","article-title":"Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis","volume":"109","author":"Shi","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuint.2016.02.011_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/604685","article-title":"Targeting mitochondria as therapeutic strategy for metabolic disorders","author":"Sorriento","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.neuint.2016.02.011_bib52","doi-asserted-by":"crossref","first-page":"14623","DOI":"10.1073\/pnas.0503524102","article-title":"MAP-1 is a mitochondrial effector of bax","volume":"102","author":"Tan","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuint.2016.02.011_bib53","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.celrep.2013.02.013","article-title":"Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency","volume":"3","author":"Ternette","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuint.2016.02.011_bib63","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nchem.1924","article-title":"A mitochondrial pathway for biosynthesis of lipid mediators","volume":"6","author":"Tyurina","year":"2014","journal-title":"Nat. Chem"},{"key":"10.1016\/j.neuint.2016.02.011_bib54","first-page":"5000","article-title":"Defects in mitochondrial clearance predispose human monocytes to interleukin-1beta hypersecretion","volume":"289","author":"van der Burgh","year":"2014","journal-title":"J.\u00a0BiolChem."},{"key":"10.1016\/j.neuint.2016.02.011_bib55","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1073\/pnas.0911187107","article-title":"PINK1-dependent recruitment of Parkin to mitochondria in mitophagy","volume":"107","author":"Vives-Bauza","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuint.2016.02.011_bib56","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.nbd.2009.07.023","article-title":"Mice deficient in dihydrolipoylsuccinyltransferase show increased vulnerability to mitochondrial toxins","volume":"36","author":"Yang","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neuint.2016.02.011_bib57","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.neuint.2016.02.011_bib58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1126\/science.1072221","article-title":"Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor","volume":"297","author":"Yu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neuint.2016.02.011_bib59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/abio.2001.5348","article-title":"Assessment of membrane potentials of mitochondrial populations in living cells","volume":"298","author":"Zhang","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuint.2016.02.011_bib60","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/auto.5.3.8174","article-title":"p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum","volume":"5","author":"Zhang","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.neuint.2016.02.011_bib61","doi-asserted-by":"crossref","first-page":"e36377","DOI":"10.1371\/journal.pone.0036377","article-title":"Role of alpha-synuclein protein levels in mitochondrial morphology and cell survival in cell lines","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuint.2016.02.011_bib62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuropharm.2014.07.002","article-title":"Mitochondria autophagy is induced after hypoxic\/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage","volume":"86","author":"Zuo","year":"2014","journal-title":"Neuropharmacology"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018616300201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018616300201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T01:58:47Z","timestamp":1654394327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018616300201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":63,"alternative-id":["S0197018616300201"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2016.02.011","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mild mitochondrial metabolic deficits by \u03b1-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}