{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:47:45Z","timestamp":1778564865000,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH\/NINDS","award":["R01 NS078008"],"award-info":[{"award-number":["R01 NS078008"]}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurochemistry International"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.neuint.2017.01.001","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T19:19:49Z","timestamp":1483643989000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Oxidative metabolism and Ca 2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease"],"prefix":"10.1016","volume":"109","author":[{"given":"James","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Brustovetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nickolay","family":"Brustovetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuint.2017.01.001_bib1","article-title":"Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6\/2 mouse model","volume":"5","author":"Aidt","year":"2013","journal-title":"PLoS.Curr."},{"key":"10.1016\/j.neuint.2017.01.001_bib2","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.neuint.2017.01.001_bib3","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1091\/mbc.E05-07-0607","article-title":"Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin","volume":"17","author":"Benchoua","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.neuint.2017.01.001_bib4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.1999.79.4.1127","article-title":"Mitochondrial transport of cations: channels, exchangers, and permeability transition","volume":"79","author":"Bernardi","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuint.2017.01.001_bib5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/978-1-4020-6191-2_18","article-title":"Calcium and cell death: the mitochondrial connection","volume":"45","author":"Bernardi","year":"2007","journal-title":"Subcell. Biochem."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.001_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0301-0082(99)00005-2","article-title":"Replicating Huntington's disease phenotype in experimental animals","volume":"59","author":"Brouillet","year":"1999","journal-title":"Prog. Neurobiol."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.001_bib7","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1007\/s12035-015-9188-0","article-title":"Mutant huntingtin and elusive defects in oxidative metabolism and mitochondrial calcium handling","volume":"53","author":"Brustovetsky","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.001_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.0022-3042.2001.00671.x","article-title":"Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane","volume":"80","author":"Brustovetsky","year":"2002","journal-title":"J.\u00a0Neurochem."},{"issue":"12","key":"10.1016\/j.neuint.2017.01.001_bib9","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1523\/JNEUROSCI.23-12-04858.2003","article-title":"Increased susceptibility of striatal mitochondria to calcium-induced permeability transition","volume":"23","author":"Brustovetsky","year":"2003","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.001_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1523\/JNEUROSCI.20-01-00103.2000","article-title":"Dual responses of CNS mitochondria to elevated calcium","volume":"20","author":"Brustovetsky","year":"2000","journal-title":"J.\u00a0Neurosci."},{"issue":"21","key":"10.1016\/j.neuint.2017.01.001_bib11","doi-asserted-by":"crossref","first-page":"19062","DOI":"10.1074\/jbc.M212661200","article-title":"The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria","volume":"278","author":"Chalmers","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"issue":"14","key":"10.1016\/j.neuint.2017.01.001_bib12","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"19","key":"10.1016\/j.neuint.2017.01.001_bib13","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","article-title":"A\u00a0role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin","volume":"22","author":"Damiano","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neuint.2017.01.001_bib14","article-title":"Calcium handling by endoplasmic reticulum and mitochondria in a cell model of Huntington's disease","volume":"8","author":"De","year":"2016","journal-title":"PLoS.Curr."},{"issue":"45","key":"10.1016\/j.neuint.2017.01.001_bib15","doi-asserted-by":"crossref","first-page":"30715","DOI":"10.1074\/jbc.M709555200","article-title":"Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease rats","volume":"283","author":"Gellerich","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.neuint.2017.01.001_bib16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/biof.162","article-title":"Huntington's disease, calcium, and mitochondria","volume":"37","author":"Giacomello","year":"2011","journal-title":"Biofactors"},{"issue":"11","key":"10.1016\/j.neuint.2017.01.001_bib17","doi-asserted-by":"crossref","first-page":"e81528","DOI":"10.1371\/journal.pone.0081528","article-title":"Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease","volume":"8","author":"Gouarne","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.neuint.2017.01.001_bib18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/exnr.2000.7626","article-title":"Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production","volume":"169","author":"Guidetti","year":"2001","journal-title":"Exp. Neurol."},{"issue":"17","key":"10.1016\/j.neuint.2017.01.001_bib19","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1093\/hmg\/ddv209","article-title":"Oxidative metabolism in YAC128 mouse model of Huntington's disease","volume":"24","author":"Hamilton","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"13","key":"10.1016\/j.neuint.2017.01.001_bib20","first-page":"2762","article-title":"Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6\/2 mice, a model of Huntington's disease","volume":"25","author":"Hamilton","year":"2016","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.001_bib21","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1471-4159.2010.06672.x","article-title":"Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features","volume":"113","author":"Han","year":"2010","journal-title":"J.\u00a0Neurochem."},{"issue":"2","key":"10.1016\/j.neuint.2017.01.001_bib22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2014.04.005","article-title":"Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells","volume":"391","author":"Ismailoglu","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neuint.2017.01.001_bib23","series-title":"Isolation and Characterization of Synaptic and Nonsynaptic Mitochondria from Mammalian Brain","first-page":"43","author":"Lai","year":"1989"},{"issue":"8","key":"10.1016\/j.neuint.2017.01.001_bib24","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1371\/journal.pgen.0030135","article-title":"Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism","volume":"3","author":"Lee","year":"2007","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.neuint.2017.01.001_bib25","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1074\/jbc.M704704200","article-title":"Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease","volume":"283","author":"Lim","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"issue":"13","key":"10.1016\/j.neuint.2017.01.001_bib26","first-page":"2813","article-title":"Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress","volume":"25","author":"Lou","year":"2016","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.neuint.2017.01.001_bib27","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A\u00a0novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.neuint.2017.01.001_bib28","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"issue":"46","key":"10.1016\/j.neuint.2017.01.001_bib29","doi-asserted-by":"crossref","first-page":"34785","DOI":"10.1074\/jbc.M603845200","article-title":"Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences","volume":"281","author":"Milakovic","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.neuint.2017.01.001_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/bmj.c3109","article-title":"Huntington's disease","volume":"340","author":"Novak","year":"2010","journal-title":"BMJ"},{"issue":"19","key":"10.1016\/j.neuint.2017.01.001_bib31","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1111\/j.1742-4658.2008.06612.x","article-title":"Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice","volume":"275","author":"Olah","year":"2008","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.001_bib32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1471-4159.2006.04361.x","article-title":"Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice","volume":"101","author":"Oliveira","year":"2007","journal-title":"J.\u00a0Neurochem."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.001_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-9861(02)00585-4","article-title":"In\u00a0vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease","volume":"410","author":"Panov","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.neuint.2017.01.001_bib34","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.neuint.2017.01.001_bib35","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/jnc.13165","article-title":"Ca2+ handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease","volume":"134","author":"Pellman","year":"2015","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.neuint.2017.01.001_bib36","article-title":"The chicken or the egg: mitochondrial dysfunction and oxidative damage as a cause or consequence of toxicity in Huntington's disease","author":"Polyzos","year":"2016","journal-title":"Mech. Ageing Dev."},{"issue":"10","key":"10.1016\/j.neuint.2017.01.001_bib37","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/hmg\/dds037","article-title":"Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice","volume":"21","author":"Pouladi","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.neuint.2017.01.001_bib38","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1073\/pnas.0609833104","article-title":"Selective defect of in\u00a0vivo glycolysis in early Huntington's disease striatum","volume":"104","author":"Powers","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"1386","key":"10.1016\/j.neuint.2017.01.001_bib39","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1098\/rstb.1999.0456","article-title":"Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease","volume":"354","author":"Reddy","year":"1999","journal-title":"Philos.Trans.R.Soc. Lond B Biol.Sci."},{"key":"10.1016\/j.neuint.2017.01.001_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-4419-6448-9_5","article-title":"Huntington's disease","volume":"685","author":"Roze","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"issue":"25","key":"10.1016\/j.neuint.2017.01.001_bib41","doi-asserted-by":"crossref","first-page":"18057","DOI":"10.1074\/jbc.M702134200","article-title":"Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release","volume":"282","author":"Shalbuyeva","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"issue":"13","key":"10.1016\/j.neuint.2017.01.001_bib42","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.001_bib43","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1531-8249(200001)47:1<80::AID-ANA13>3.0.CO;2-K","article-title":"Mitochondrial dysfunction and free radical damage in the Huntington R6\/2 transgenic mouse","volume":"47","author":"Tabrizi","year":"2000","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.001_bib44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.neuint.2017.01.001_bib45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.neuint.2017.01.001_bib46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0005-2728(69)90091-7","article-title":"Inhibitory action of oxaloacetate on succinate oxidation in rat-liver mitochondria and the mechanism of its reversal","volume":"172","author":"Wojtczak","year":"1969","journal-title":"Biochim.Biophys. Acta"},{"issue":"6","key":"10.1016\/j.neuint.2017.01.001_bib47","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nn.3721","article-title":"Inhibition of mitochondrial protein import by mutant huntingtin","volume":"17","author":"Yano","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.neuint.2017.01.001_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nmeth.3336","article-title":"High-speed label-free functional photoacoustic microscopy of mouse brain in action","volume":"12","author":"Yao","year":"2015","journal-title":"Nat. Methods"}],"container-title":["Neurochemistry International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018616304612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0197018616304612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T16:04:20Z","timestamp":1718985860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0197018616304612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":48,"alternative-id":["S0197018616304612"],"URL":"https:\/\/doi.org\/10.1016\/j.neuint.2017.01.001","relation":{},"ISSN":["0197-0186"],"issn-type":[{"value":"0197-0186","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"Neurochemistry International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuint.2017.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}